Details for: MYC
Gene ID: 4609
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MYC
Ensembl ID: ENSG00000136997
Description: MYC proto-oncogene, bHLH transcription factor
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 42.05rCSI 34%PRS 80.06
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CSI 39.6rCSI 33.2%PRS 80.71
-
CSI 38.07rCSI 34.38%PRS 75.87
-
CSI 36.03rCSI 27.07%PRS 83.48
-
CSI 33.46rCSI 22.24%PRS 80.6
-
CSI 33.02rCSI 34.52%PRS 75.29
-
CSI 23.52rCSI 23.11%PRS 90.92
-
CSI 23.45rCSI 22.16%PRS 76.51
-
CSI 21.42rCSI 18.46%PRS 78.99
-
CSI 19.6rCSI 30.96%PRS 79.36
-
CSI 19.49rCSI 35.41%PRS 88.3
-
CSI 16.5rCSI 15.89%PRS 76.94
-
CSI 15.91rCSI 15.3%PRS 91.63
-
CSI 15.04rCSI 52.78%PRS 86.24
-
CSI 14.04rCSI 13.54%PRS 70.58
-
CSI 11.99rCSI 10.65%PRS 75.45
-
CSI 11.19rCSI 26.73%PRS 82.15
-
CSI 11.14rCSI 32.25%PRS 77.34
-
CSI 10.83rCSI 9.53%PRS 66.59
-
CSI 10.74rCSI 16.41%PRS 77.96
-
CSI 10.69rCSI 15.41%PRS 84.02
-
CSI 10.55rCSI 9.24%PRS 85.14
-
CSI 10.51rCSI 10.89%PRS 82.03
-
CSI 9.66rCSI 25.1%PRS 85.31
-
CSI 9.16rCSI 47.28%PRS 92.33
-
CSI 9.08rCSI 40.46%PRS 87.47
-
CSI 8.95rCSI 16.91%PRS 88.91
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CSI 8.47rCSI 10.65%PRS 92.96
-
CSI 8.23rCSI 6.51%PRS 65.97
-
CSI 8.22rCSI 22.58%PRS 84.81
-
CSI 8.1rCSI 5.69%PRS 91.35
-
CSI 8.1rCSI 10.39%PRS 81.11
-
CSI 7.77rCSI 7.92%PRS 87.58
-
CSI 7.69rCSI 5.74%PRS 89.85
-
CSI 7.68rCSI 22.22%PRS 84.6
-
CSI 7.66rCSI 21.55%PRS 72.69
-
CSI 7.47rCSI 31.41%PRS 83.46
-
CSI 7.31rCSI 50.19%PRS 84.82
-
CSI 7.1rCSI 16.67%PRS 78.12
-
CSI 7.08rCSI 13.76%PRS 80.86
-
CSI 6.99rCSI 12.82%PRS 82.58
-
CSI 6.93rCSI 6.36%PRS 85.58
-
CSI 6.9rCSI 8.68%PRS 86.99
-
CSI 6.73rCSI 25.22%PRS 69.97
-
CSI 6.67rCSI 6.58%PRS 90.74
-
CSI 6.61rCSI 8.66%PRS 88.26
-
CSI 6.35rCSI 5.09%PRS 91.24
-
CSI 6.31rCSI 15.16%PRS 81.34
-
CSI 6.23rCSI 5.16%PRS 78.26
-
CSI 6.2rCSI 3.66%PRS 92.44
-
CSI 6.12rCSI 5.7%PRS 78.22
-
CSI 6.11rCSI 5.65%PRS 91.79
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CSI 5.85rCSI 4.92%PRS 90.34
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CSI 5.7rCSI 11.83%PRS 74.38
-
CSI 5.65rCSI 7.83%PRS 75.16
-
CSI 5.6rCSI 3.77%PRS 90.04
-
CSI 5.59rCSI 4.15%PRS 88.34
-
CSI 5.39rCSI 24.71%PRS 82.41
-
CSI 5.32rCSI 5.57%PRS 74.97
-
CSI 5.28rCSI 13.35%PRS 83.07
-
CSI 4.97rCSI 28.93%PRS 81.91
-
CSI 4.89rCSI 3.7%PRS 89.44
-
CSI 4.86rCSI 15.89%PRS 93.22
-
CSI 4.76rCSI 6.33%PRS 83.42
-
CSI 4.75rCSI 3.68%PRS 81.2
-
CSI 4.73rCSI 4.1%PRS 81.83
-
CSI 4.65rCSI 3.44%PRS 70.97
-
CSI 4.64rCSI 20.11%PRS 83.73
-
CSI 4.58rCSI 26.91%PRS 84.39
-
CSI 4.57rCSI 25.49%PRS 81.23
-
CSI 4.53rCSI 3.25%PRS 89.91
-
CSI 4.4rCSI 5.26%PRS 92.18
-
CSI 4.38rCSI 7.48%PRS 90.58
-
CSI 4.33rCSI 3.59%PRS 80.16
-
CSI 4.32rCSI 3.23%PRS 89.89
-
CSI 4.24rCSI 5.27%PRS 79.06
-
CSI 4.22rCSI 6.48%PRS 67.89
-
CSI 4.2rCSI 24.07%PRS 83.57
-
CSI 4.17rCSI 22.5%PRS 84.67
-
CSI 4.12rCSI 5.61%PRS 69.1
-
CSI 4rCSI 4.83%PRS 85.44
-
CSI 3.95rCSI 10.02%PRS 71.05
-
CSI 3.94rCSI 6.02%PRS 85.16
-
CSI 3.85rCSI 4.53%PRS 79.43
-
CSI 3.82rCSI 20.64%PRS 94.43
-
CSI 3.75rCSI 4.29%PRS 88.64
-
CSI 3.72rCSI 3.02%PRS 77.04
-
CSI 3.72rCSI 12.05%PRS 75.59
-
CSI 3.67rCSI 2.55%PRS 88.65
-
CSI 3.66rCSI 8.31%PRS 78.56
-
CSI 3.65rCSI 2.54%PRS 91.08
-
CSI 3.61rCSI 15.62%PRS 85.34
-
CSI 3.6rCSI 6.16%PRS 84.22
-
CSI 3.59rCSI 9.8%PRS 86.1
-
CSI 3.56rCSI 7.84%PRS 81.44
-
CSI 3.52rCSI 3.63%PRS 89.58
-
CSI 3.52rCSI 6.98%PRS 83.27
-
CSI 3.49rCSI 17.22%PRS 85.63
-
CSI 3.44rCSI 9.16%PRS 57.3
-
CSI 3.4rCSI 9.76%PRS 93.45
-
CSI 0.2rCSI 3.9%PRS 94.1%
-
CSI 0.5rCSI 3.7%PRS 86.6%
-
CSI 0.7rCSI 3.4%PRS 83.9%
-
CSI 0.7rCSI 3.1%PRS 78.2%
-
CSI 0.7rCSI 3.1%PRS 93.8%
-
CSI 0.7rCSI 1.7%PRS 91.8%
-
CSI 0.7rCSI 2.6%PRS 92.1%
-
CSI 0.7rCSI 10.9%PRS 86.7%
-
CSI 0.8rCSI 3.0%PRS 92.7%
-
CSI 0.8rCSI 3.5%PRS 85.6%
-
CSI 0.9rCSI 6.8%PRS 79.8%
-
CSI 1.0rCSI 3.7%PRS 92.4%
-
CSI 1.0rCSI 3.6%PRS 95.5%
-
CSI 1.1rCSI 1.9%PRS 58.7%
-
CSI 1.1rCSI 25.8%PRS 86.7%
-
CSI 1.1rCSI 3.3%PRS 88.0%
-
CSI 1.1rCSI 7.0%PRS 87.2%
-
CSI 1.2rCSI 3.3%PRS 83.9%
-
CSI 1.2rCSI 1.9%PRS 70.5%
-
CSI 1.2rCSI 1.9%PRS 86.5%
-
CSI 1.3rCSI 1.6%PRS 86.6%
-
CSI 1.3rCSI 3.1%PRS 95.4%
-
CSI 1.3rCSI 2.9%PRS 84.5%
-
CSI 1.4rCSI 3.6%PRS 83.0%
-
CSI 1.4rCSI 7.5%PRS 85.7%
-
CSI 1.5rCSI 2.6%PRS 86.6%
-
CSI 1.5rCSI 3.1%PRS 88.0%
-
CSI 1.5rCSI 38.2%PRS 85.8%
-
CSI 1.6rCSI 4.8%PRS 82.4%
-
CSI 1.6rCSI 2.3%PRS 88.4%
-
CSI 1.6rCSI 1.7%PRS 83.1%
-
CSI 1.6rCSI 2.2%PRS 94.0%
-
CSI 1.6rCSI 2.4%PRS 87.2%
-
CSI 1.6rCSI 1.9%PRS 88.4%
-
CSI 1.6rCSI 3.8%PRS 83.6%
-
CSI 1.6rCSI 43.0%PRS 87.0%
-
CSI 1.7rCSI 2.6%PRS 88.8%
-
CSI 1.8rCSI 2.3%PRS 68.0%
-
CSI 1.8rCSI 4.8%PRS 84.0%
-
CSI 1.8rCSI 1.6%PRS 87.2%
-
CSI 1.8rCSI 14.9%PRS 71.5%
-
CSI 1.8rCSI 20.0%PRS 86.5%
-
CSI 1.9rCSI 2.8%PRS 78.6%
-
CSI 2.0rCSI 2.8%PRS 85.0%
-
CSI 2.0rCSI 1.6%PRS 93.6%
-
CSI 2.1rCSI 2.4%PRS 69.6%
-
CSI 2.1rCSI 3.8%PRS 83.3%
-
CSI 2.2rCSI 3.5%PRS 81.4%
-
CSI 2.2rCSI 16.6%PRS 88.3%
-
CSI 2.3rCSI 48.0%PRS 92.4%
-
CSI 2.4rCSI 3.2%PRS 92.0%
-
CSI 2.5rCSI 13.4%PRS 94.8%
-
CSI 2.6rCSI 3.4%PRS 76.5%
-
CSI 2.6rCSI 16.6%PRS 87.8%
-
CSI 2.6rCSI 28.5%PRS 83.5%
-
CSI 2.6rCSI 3.1%PRS 75.4%
-
CSI 2.9rCSI 2.5%PRS 82.7%
-
CSI 2.9rCSI 50.9%PRS 88.6%
-
CSI 2.9rCSI 4.0%PRS 82.1%
-
CSI 3.0rCSI 3.2%PRS 79.9%
-
CSI 3.0rCSI 3.7%PRS 75.5%
-
CSI 3.0rCSI 7.9%PRS 84.6%
-
CSI 3.0rCSI 8.8%PRS 90.4%
-
CSI 3.0rCSI 2.8%PRS 79.1%
-
CSI 3.1rCSI 4.2%PRS 86.5%
-
CSI 3.2rCSI 2.5%PRS 83.2%
-
CSI 3.2rCSI 5.7%PRS 47.4%
-
CSI 3.2rCSI 21.2%PRS 93.4%
-
CSI 3.4rCSI 8.8%PRS 89.7%
-
CSI 3.4rCSI 9.8%PRS 93.5%
-
CSI 3.4rCSI 9.2%PRS 57.3%
-
CSI 3.5rCSI 17.2%PRS 85.6%
-
CSI 3.5rCSI 7.0%PRS 83.3%
-
CSI 3.5rCSI 3.6%PRS 89.6%
-
CSI 3.6rCSI 7.8%PRS 81.4%
-
CSI 3.6rCSI 9.8%PRS 86.1%
-
CSI 3.6rCSI 6.2%PRS 84.2%
-
CSI 3.6rCSI 15.6%PRS 85.3%
-
CSI 3.7rCSI 2.5%PRS 91.1%
-
CSI 3.7rCSI 8.3%PRS 78.6%
-
CSI 3.7rCSI 2.6%PRS 88.7%
-
CSI 3.7rCSI 12.1%PRS 75.6%
-
CSI 3.7rCSI 3.0%PRS 77.0%
-
CSI 3.8rCSI 4.3%PRS 88.6%
-
CSI 3.8rCSI 20.6%PRS 94.4%
-
CSI 3.9rCSI 4.5%PRS 79.4%
-
CSI 3.9rCSI 6.0%PRS 85.2%
-
CSI 4.0rCSI 10.0%PRS 71.1%
-
CSI 4.0rCSI 4.8%PRS 85.4%
-
CSI 4.1rCSI 5.6%PRS 69.1%
-
CSI 4.2rCSI 22.5%PRS 84.7%
-
CSI 4.2rCSI 24.1%PRS 83.6%
-
CSI 4.2rCSI 6.5%PRS 67.9%
-
CSI 4.2rCSI 5.3%PRS 79.1%
-
CSI 4.3rCSI 3.2%PRS 89.9%
-
CSI 4.3rCSI 3.6%PRS 80.2%
-
CSI 4.4rCSI 7.5%PRS 90.6%
-
CSI 4.4rCSI 5.3%PRS 92.2%
-
CSI 4.5rCSI 3.3%PRS 89.9%
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CSI 4.6rCSI 25.5%PRS 81.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3381948470
Symbol: MYC_HUMAN
Name: Myc proto-oncogene protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6414718
Title: The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma.
PubMed ID: 6414718
PubMed ID: 6321164
Title: Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.
PubMed ID: 6321164
PubMed ID: 6298632
Title: Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29.
PubMed ID: 6298632
DOI: 10.1038/301722a0
PubMed ID: 6304538
Title: Nucleotide sequence of cloned cDNA of human c-myc oncogene.
PubMed ID: 6304538
DOI: 10.1038/303725a0
PubMed ID: 6419122
Title: Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma.
PubMed ID: 6419122
DOI: 10.1038/306760a0
PubMed ID: 6304729
Title: Nucleotide sequence analysis of human c-myc locus, chicken homologue, and myelocytomatosis virus MC29 transforming gene reveals a highly conserved gene product.
PubMed ID: 6304729
PubMed ID: 6547209
Title: Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.
PubMed ID: 6547209
DOI: 10.1038/309592a0
PubMed ID: 6714223
Title: Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.
PubMed ID: 6714223
PubMed ID: 8444346
Title: Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.
PubMed ID: 8444346
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3540591
Title: Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas.
PubMed ID: 3540591
PubMed ID: 3277717
Title: A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas.
PubMed ID: 3277717
PubMed ID: 2166998
Title: The pathogenesis of Burkitt's lymphoma.
PubMed ID: 2166998
PubMed ID: 1597196
Title: DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein.
PubMed ID: 1597196
PubMed ID: 8220424
Title: Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas.
PubMed ID: 8220424
DOI: 10.1038/ng0993-56
PubMed ID: 8386367
Title: Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-73 and Ser-77.
PubMed ID: 8386367
PubMed ID: 7642555
Title: c-Myc is glycosylated at threonine 58, a known phosphorylation site and a mutational hot spot in lymphomas.
PubMed ID: 7642555
PubMed ID: 9315742
Title: c-Raf kinase binds to N-terminal domain of c-Myc.
PubMed ID: 9315742
PubMed ID: 15103331
Title: Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
PubMed ID: 15103331
PubMed ID: 16126174
Title: Six lysine residues on c-Myc are direct substrates for acetylation by p300.
PubMed ID: 16126174
PubMed ID: 15723054
Title: c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.
PubMed ID: 15723054
DOI: 10.1038/ncb1224
PubMed ID: 15674325
Title: PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
PubMed ID: 15674325
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17632056
Title: CIP2A inhibits PP2A in human malignancies.
PubMed ID: 17632056
PubMed ID: 18035408
Title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
PubMed ID: 18035408
PubMed ID: 17873522
Title: Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.
PubMed ID: 17873522
DOI: 10.4161/cc.6.19.4804
PubMed ID: 17311883
Title: The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.
PubMed ID: 17311883
DOI: 10.1101/gad.1523007
PubMed ID: 17308053
Title: Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer.
PubMed ID: 17308053
PubMed ID: 17558397
Title: The ubiquitin-specific protease USP28 is required for MYC stability.
PubMed ID: 17558397
DOI: 10.1038/ncb1601
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20713526
Title: Tipping the balance: Cdk2 enables Myc to suppress senescence.
PubMed ID: 20713526
PubMed ID: 20010808
Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
PubMed ID: 20010808
DOI: 10.1038/nature08697
PubMed ID: 19966300
Title: Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
PubMed ID: 19966300
PubMed ID: 20551172
Title: Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.
PubMed ID: 20551172
DOI: 10.1101/gad.1920310
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22719065
Title: Critical function for nuclear envelope protein TMEM209 in human pulmonary carcinogenesis.
PubMed ID: 22719065
PubMed ID: 22307329
Title: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
PubMed ID: 22307329
DOI: 10.1172/jci60818
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24940000
Title: tRNA synthetase counteracts c-Myc to develop functional vasculature.
PubMed ID: 24940000
DOI: 10.7554/elife.02349
PubMed ID: 25956029
Title: The nucleolar protein GLTSCR2 is an upstream negative regulator of the oncogenic Nucleophosmin-MYC axis.
PubMed ID: 25956029
PubMed ID: 25803737
Title: AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation.
PubMed ID: 25803737
PubMed ID: 25438055
Title: AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
PubMed ID: 25438055
DOI: 10.1038/ncb3072
PubMed ID: 25775507
Title: The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.
PubMed ID: 25775507
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29779948
Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.
PubMed ID: 29779948
PubMed ID: 33208877
Title: Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen.
PubMed ID: 33208877
PubMed ID: 34342803
Title: The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4.
PubMed ID: 34342803
PubMed ID: 37478862
Title: Orphan quality control shapes network dynamics and gene expression.
PubMed ID: 37478862
PubMed ID: 9680483
Title: Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.
PubMed ID: 9680483
PubMed ID: 2069907
Title: A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.
PubMed ID: 2069907
Sequence Information:
- Length: 454
- Mass: 50565
- Checksum: 8B4107BB740689E5
- Sequence:
MDFFRVVENQ QPPATMPLNV SFTNRNYDLD YDSVQPYFYC DEEENFYQQQ QQSELQPPAP SEDIWKKFEL LPTPPLSPSR RSGLCSPSYV AVTPFSLRGD NDGGGGSFST ADQLEMVTEL LGGDMVNQSF ICDPDDETFI KNIIIQDCMW SGFSAAAKLV SEKLASYQAA RKDSGSPNPA RGHSVCSTSS LYLQDLSAAA SECIDPSVVF PYPLNDSSSP KSCASQDSSA FSPSSDSLLS STESSPQGSP EPLVLHEETP PTTSSDSEEE QEDEEEIDVV SVEKRQAPGK RSESGSPSAG GHSKPPHSPL VLKRCHVSTH QHNYAAPPST RKDYPAAKRV KLDSVRVLRQ ISNNRKCTSP RSSDTEENVK RRTHNVLERQ RRNELKRSFF ALRDQIPELE NNEKAPKVVI LKKATAYILS VQAEEQKLIS EEDLLRKRRE QLKHKLEQLR NSCA