CDC16 | ENSG00000130177 | NCBI 8881

Details for: CDC16

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Mitotic spindle
(GO:0072686)
Nucleoplasm
(GO:0005654)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein binding
(GO:0005515)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein ubiquitination
(GO:0016567)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

parietal epithelial cell CL1000452

CSI 7.08

rCSI 18.91%

PRS 40.88
mesenchymal cell CL0008019

CSI 7.07

rCSI 17.95%

PRS 43.91
group 3 innate lymphoid cell CL0001071

CSI 6.64

rCSI 4.99%

PRS 52.12
ciliated epithelial cell CL0000067

CSI 6.17

rCSI 5.43%

PRS 37.35
hematopoietic stem cell CL0000037

CSI 5.76

rCSI 3.83%

PRS 52.03
lung neuroendocrine cell CL1000223

CSI 5.73

rCSI 8.48%

PRS 53.57
granulocyte monocyte progenitor cell CL0000557

CSI 5.51

rCSI 4.77%

PRS 52.46
dendritic cell, human CL0001056

CSI 4.68

rCSI 7.18%

PRS 55.77
Kupffer cell CL0000091

CSI 4.58

rCSI 10.47%

PRS 47.75
endothelial cell of placenta CL0009092

CSI 4.42

rCSI 21.8%

PRS 60.27
cardiac neuron CL0010022

CSI 3.87

rCSI 12.38%

PRS 45.3
radial glial cell CL0000681

CSI 3.81

rCSI 5.3%

PRS 47.79
fibroblast of lung CL0002553

CSI 3.76

rCSI 3.5%

PRS 48.08
platelet CL0000233

CSI 3.57

rCSI 14.83%

PRS 57.16
interstitial cell of Cajal CL0002088

CSI 3.35

rCSI 4.26%

PRS 54.06
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.25

rCSI 2.33%

PRS 61.71
lung macrophage CL1001603

CSI 3.2

rCSI 7.14%

PRS 55.13
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.17

rCSI 1.87%

PRS 64.24
fibroblast of cardiac tissue CL0002548

CSI 3.15

rCSI 15.08%

PRS 47.21
unswitched memory B cell CL0000970

CSI 3.14

rCSI 2.64%

PRS 65.59
peripheral nervous system neuron CL2000032

CSI 3

rCSI 4.09%

PRS 41.41
pancreatic D cell CL0000173

CSI 2.97

rCSI 2.92%

PRS 50.98
pulmonary alveolar type 1 cell CL0002062

CSI 2.96

rCSI 17.08%

PRS 49.56
luminal epithelial cell of mammary gland CL0002326

CSI 2.9

rCSI 5.27%

PRS 64.76
inflammatory macrophage CL0000863

CSI 2.88

rCSI 4.93%

PRS 74.56
double negative thymocyte CL0002489

CSI 2.87

rCSI 2%

PRS 57.58
fallopian tube secretory epithelial cell CL4030006

CSI 2.87

rCSI 2.76%

PRS 48.7
megakaryocyte CL0000556

CSI 2.84

rCSI 12.31%

PRS 63.86
T follicular helper cell CL0002038

CSI 2.7

rCSI 2.02%

PRS 63.12
melanocyte CL0000148

CSI 2.69

rCSI 1.99%

PRS 41.76
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.68

rCSI 4.5%

PRS 32.14
cerebellar granule cell CL0001031

CSI 2.66

rCSI 3.9%

PRS 43.52
epithelial cell of lung CL0000082

CSI 2.63

rCSI 2.18%

PRS 47.03
naive B cell CL0000788

CSI 2.63

rCSI 2.26%

PRS 56.84
ependymal cell CL0000065

CSI 2.58

rCSI 5.23%

PRS 30.44
elicited macrophage CL0000861

CSI 2.51

rCSI 2.3%

PRS 56.19
pro-B cell CL0000826

CSI 2.5

rCSI 2.07%

PRS 49.63
ON-bipolar cell CL0000749

CSI 2.48

rCSI 3.68%

PRS 50.61
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.45

rCSI 6.33%

PRS 44.32
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.39

rCSI 1.61%

PRS 59.42
common myeloid progenitor CL0000049

CSI 2.37

rCSI 1.91%

PRS 49.16
hepatic stellate cell CL0000632

CSI 2.36

rCSI 8.83%

PRS 41.25
glutamatergic neuron CL0000679

CSI 2.34

rCSI 4.82%

PRS 41.73
secretory cell CL0000151

CSI 2.31

rCSI 2.41%

PRS 48.93
glioblast CL0000030

CSI 2.28

rCSI 3.64%

PRS 42.06
interneuron CL0000099

CSI 2.23

rCSI 4.47%

PRS 38.08
hepatocyte CL0000182

CSI 2.22

rCSI 3.97%

PRS 46.95
GABAergic neuron CL0000617

CSI 2.14

rCSI 7.17%

PRS 35.9
renal alpha-intercalated cell CL0005011

CSI 2.14

rCSI 2.86%

PRS 56.93
neural crest cell CL0011012

CSI 2.12

rCSI 1.67%

PRS 36.01
hematopoietic precursor cell CL0008001

CSI 2.12

rCSI 2.18%

PRS 66.58
ciliated cell CL0000064

CSI 2.11

rCSI 3.42%

PRS 46.62
ionocyte CL0005006

CSI 2.1

rCSI 2.25%

PRS 46.53
epithelial cell of lower respiratory tract CL0002632

CSI 2.09

rCSI 1.62%

PRS 49.07
Bergmann glial cell CL0000644

CSI 2.08

rCSI 2.85%

PRS 44.19
Mueller cell CL0000636

CSI 2.05

rCSI 4.68%

PRS 41.52
mesodermal cell CL0000222

CSI 2.04

rCSI 2.44%

PRS 46.38
rod bipolar cell CL0000751

CSI 2.01

rCSI 3.62%

PRS 41.69
myoepithelial cell CL0000185

CSI 2.01

rCSI 5.09%

PRS 56.8
CD14-positive, CD16-positive monocyte CL0002397

CSI 2.01

rCSI 2.63%

PRS 61.75
centrilobular region hepatocyte CL0019029

CSI 2.01

rCSI 5.23%

PRS 55.87
naive T cell CL0000898

CSI 1.99

rCSI 1.38%

PRS 61.6
respiratory basal cell CL0002633

CSI 1.93

rCSI 2%

PRS 54.28
type B pancreatic cell CL0000169

CSI 1.93

rCSI 4.27%

PRS 45.88
chondrocyte CL0000138

CSI 1.89

rCSI 3%

PRS 41.22
neuroblast (sensu Vertebrata) CL0000031

CSI 1.87

rCSI 2.4%

PRS 46.35
choroid plexus epithelial cell CL0000706

CSI 1.87

rCSI 3.06%

PRS 38.75
myeloid leukocyte CL0000766

CSI 1.85

rCSI 1.71%

PRS 49.12
alveolar adventitial fibroblast CL4028006

CSI 1.83

rCSI 2.9%

PRS 49.58
cerebral cortex endothelial cell CL1001602

CSI 1.82

rCSI 3.15%

PRS 39.03
dopaminergic neuron CL0000700

CSI 1.81

rCSI 10.2%

PRS 34.63
adipocyte CL0000136

CSI 1.8

rCSI 2.32%

PRS 43.37
retinal cone cell CL0000573

CSI 1.78

rCSI 2.87%

PRS 38.91
multi-ciliated epithelial cell CL0005012

CSI 1.74

rCSI 1.74%

PRS 42.42
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.71

rCSI 4.45%

PRS 47.58
pulmonary ionocyte CL0017000

CSI 1.71

rCSI 2.08%

PRS 56.13
respiratory suprabasal cell CL4033048

CSI 1.7

rCSI 2.18%

PRS 53.14
vascular leptomeningeal cell CL4023051

CSI 1.69

rCSI 2.96%

PRS 40.7
plasmablast CL0000980

CSI 1.68

rCSI 1.32%

PRS 54.85
squamous epithelial cell CL0000076

CSI 1.64

rCSI 3.9%

PRS 53.95
retinal rod cell CL0000604

CSI 1.64

rCSI 2.9%

PRS 46.38
intestinal epithelial cell CL0002563

CSI 1.63

rCSI 1.7%

PRS 47.57
duct epithelial cell CL0000068

CSI 1.63

rCSI 2.38%

PRS 51.69
pulmonary artery endothelial cell CL1001568

CSI 1.63

rCSI 2.21%

PRS 61.03
inhibitory interneuron CL0000498

CSI 1.61

rCSI 3.72%

PRS 39.38
periportal region hepatocyte CL0019026

CSI 1.61

rCSI 6.25%

PRS 56.5
colon epithelial cell CL0011108

CSI 1.55

rCSI 1.63%

PRS 45.39
VIP GABAergic cortical interneuron CL4023016

CSI 1.55

rCSI 1.85%

PRS 32.03
keratinocyte CL0000312

CSI 1.55

rCSI 1.3%

PRS 53.24
retinal bipolar neuron CL0000748

CSI 1.54

rCSI 2.89%

PRS 37.84
pvalb GABAergic cortical interneuron CL4023018

CSI 1.53

rCSI 1.9%

PRS 30.55
intestine goblet cell CL0019031

CSI 1.52

rCSI 1.35%

PRS 47.23
erythroblast CL0000765

CSI 1.52

rCSI 4.03%

PRS 61.61
placental villous trophoblast CL2000060

CSI 1.51

rCSI 2.33%

PRS 46.13
common dendritic progenitor CL0001029

CSI 1.5

rCSI 1.89%

PRS 58.35
indirect pathway medium spiny neuron CL4023029

CSI 1.49

rCSI 36.04%

PRS 32.51
direct pathway medium spiny neuron CL4023026

CSI 1.49

rCSI 35.76%

PRS 31.65
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.48

rCSI 1.71%

PRS 42.51
mucus secreting cell CL0000319

CSI 1.44

rCSI 2.29%

PRS 59.34
plasmacytoid dendritic cell, human CL0001058

CSI 1.44

rCSI 1.01%

PRS 50.37

medium spiny neuron CL1001474

CSI 0.2

rCSI 1.6%

PRS 35.9%
OFF midget ganglion cell CL4033047

CSI 0.3

rCSI 5.7%

PRS 41.7%
GABAergic interneuron CL0011005

CSI 0.3

rCSI 5.1%

PRS 52.9%
regular ventricular cardiac myocyte CL0002131

CSI 0.4

rCSI 2.5%

PRS 40.7%
ON midget ganglion cell CL4033046

CSI 0.4

rCSI 8.1%

PRS 40.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.5

rCSI 2.6%

PRS 33.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.5

rCSI 1.2%

PRS 38.6%
Cajal-Retzius cell CL0000695

CSI 0.5

rCSI 3.8%

PRS 63.8%
erythroid progenitor cell CL0000038

CSI 0.5

rCSI 2.9%

PRS 59.1%
deuterosomal cell CL4033044

CSI 0.6

rCSI 1.9%

PRS 57.0%
primitive red blood cell CL0002355

CSI 0.6

rCSI 3.1%

PRS 62.9%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.7

rCSI 2.0%

PRS 35.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.7

rCSI 2.6%

PRS 33.1%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.7

rCSI 3.5%

PRS 59.7%
tracheobronchial smooth muscle cell CL0019019

CSI 0.7

rCSI 1.3%

PRS 56.6%
mature B cell CL0000785

CSI 0.7

rCSI 0.6%

PRS 58.1%
promonocyte CL0000559

CSI 0.7

rCSI 1.2%

PRS 57.8%
retina horizontal cell CL0000745

CSI 0.7

rCSI 1.1%

PRS 44.9%
L6b glutamatergic cortical neuron CL4023038

CSI 0.8

rCSI 2.4%

PRS 33.5%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.8

rCSI 1.8%

PRS 46.5%
glial cell CL0000125

CSI 0.8

rCSI 3.1%

PRS 41.2%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.8

rCSI 3.0%

PRS 31.0%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.9

rCSI 2.1%

PRS 31.2%
GABAergic amacrine cell CL4030027

CSI 0.9

rCSI 2.9%

PRS 39.2%
regular atrial cardiac myocyte CL0002129

CSI 0.9

rCSI 2.8%

PRS 47.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.9

rCSI 1.5%

PRS 31.2%
neural progenitor cell CL0011020

CSI 0.9

rCSI 4.0%

PRS 41.4%
intestinal tuft cell CL0019032

CSI 0.9

rCSI 1.4%

PRS 53.2%
pancreatic PP cell CL0002275

CSI 1.0

rCSI 3.9%

PRS 63.8%
small intestine goblet cell CL1000495

CSI 1.0

rCSI 2.2%

PRS 58.0%
amacrine cell CL0000561

CSI 1.0

rCSI 3.0%

PRS 39.4%
retinal ganglion cell CL0000740

CSI 1.0

rCSI 2.3%

PRS 36.2%
astrocyte of the cerebral cortex CL0002605

CSI 1.0

rCSI 2.3%

PRS 33.0%
sncg GABAergic cortical interneuron CL4023015

CSI 1.1

rCSI 1.7%

PRS 34.3%
renal interstitial pericyte CL1001318

CSI 1.1

rCSI 3.0%

PRS 44.8%
cardiac muscle cell CL0000746

CSI 1.1

rCSI 1.6%

PRS 39.4%
lung pericyte CL0009089

CSI 1.1

rCSI 3.0%

PRS 56.4%
central nervous system neuron CL2000029

CSI 1.2

rCSI 8.5%

PRS 36.2%
lung secretory cell CL1000272

CSI 1.2

rCSI 2.9%

PRS 46.3%
pancreatic ductal cell CL0002079

CSI 1.2

rCSI 2.3%

PRS 50.6%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.2

rCSI 0.9%

PRS 47.4%
keratocyte CL0002363

CSI 1.2

rCSI 2.9%

PRS 58.1%
glycinergic amacrine cell CL4030028

CSI 1.2

rCSI 3.2%

PRS 47.6%
extravillous trophoblast CL0008036

CSI 1.3

rCSI 1.6%

PRS 44.2%
alveolar type 1 fibroblast cell CL4028004

CSI 1.3

rCSI 1.4%

PRS 52.3%
stem cell CL0000034

CSI 1.3

rCSI 1.2%

PRS 39.0%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.3

rCSI 1.8%

PRS 45.2%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.3

rCSI 2.4%

PRS 41.8%
sst GABAergic cortical interneuron CL4023017

CSI 1.3

rCSI 1.7%

PRS 33.1%
retinal pigment epithelial cell CL0002586

CSI 1.4

rCSI 2.7%

PRS 47.2%
lung ciliated cell CL1000271

CSI 1.4

rCSI 1.6%

PRS 38.5%
pancreatic acinar cell CL0002064

CSI 1.4

rCSI 1.8%

PRS 53.5%
intermediate monocyte CL0002393

CSI 1.4

rCSI 2.1%

PRS 50.8%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.4

rCSI 1.3%

PRS 45.0%
transit amplifying cell of colon CL0009011

CSI 1.4

rCSI 1.7%

PRS 51.7%
erythrocyte CL0000232

CSI 1.4

rCSI 3.2%

PRS 53.5%
cardiac endothelial cell CL0010008

CSI 1.4

rCSI 5.8%

PRS 46.9%
cerebral cortex GABAergic interneuron CL0010011

CSI 1.4

rCSI 4.3%

PRS 52.4%
plasmacytoid dendritic cell, human CL0001058

CSI 1.4

rCSI 1.0%

PRS 50.4%
mucus secreting cell CL0000319

CSI 1.4

rCSI 2.3%

PRS 59.3%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.5

rCSI 1.7%

PRS 42.5%
direct pathway medium spiny neuron CL4023026

CSI 1.5

rCSI 35.8%

PRS 31.7%
indirect pathway medium spiny neuron CL4023029

CSI 1.5

rCSI 36.0%

PRS 32.5%
common dendritic progenitor CL0001029

CSI 1.5

rCSI 1.9%

PRS 58.4%
placental villous trophoblast CL2000060

CSI 1.5

rCSI 2.3%

PRS 46.1%
erythroblast CL0000765

CSI 1.5

rCSI 4.0%

PRS 61.6%
intestine goblet cell CL0019031

CSI 1.5

rCSI 1.4%

PRS 47.2%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.5

rCSI 1.9%

PRS 30.6%
retinal bipolar neuron CL0000748

CSI 1.5

rCSI 2.9%

PRS 37.8%
keratinocyte CL0000312

CSI 1.6

rCSI 1.3%

PRS 53.2%
VIP GABAergic cortical interneuron CL4023016

CSI 1.6

rCSI 1.9%

PRS 32.0%
colon epithelial cell CL0011108

CSI 1.6

rCSI 1.6%

PRS 45.4%
periportal region hepatocyte CL0019026

CSI 1.6

rCSI 6.3%

PRS 56.5%
inhibitory interneuron CL0000498

CSI 1.6

rCSI 3.7%

PRS 39.4%
pulmonary artery endothelial cell CL1001568

CSI 1.6

rCSI 2.2%

PRS 61.0%
duct epithelial cell CL0000068

CSI 1.6

rCSI 2.4%

PRS 51.7%
intestinal epithelial cell CL0002563

CSI 1.6

rCSI 1.7%

PRS 47.6%
retinal rod cell CL0000604

CSI 1.6

rCSI 2.9%

PRS 46.4%
squamous epithelial cell CL0000076

CSI 1.6

rCSI 3.9%

PRS 54.0%
plasmablast CL0000980

CSI 1.7

rCSI 1.3%

PRS 54.9%
vascular leptomeningeal cell CL4023051

CSI 1.7

rCSI 3.0%

PRS 40.7%
respiratory suprabasal cell CL4033048

CSI 1.7

rCSI 2.2%

PRS 53.1%
pulmonary ionocyte CL0017000

CSI 1.7

rCSI 2.1%

PRS 56.1%
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.7

rCSI 4.5%

PRS 47.6%
multi-ciliated epithelial cell CL0005012

CSI 1.7

rCSI 1.7%

PRS 42.4%
retinal cone cell CL0000573

CSI 1.8

rCSI 2.9%

PRS 38.9%
adipocyte CL0000136

CSI 1.8

rCSI 2.3%

PRS 43.4%
dopaminergic neuron CL0000700

CSI 1.8

rCSI 10.2%

PRS 34.6%
cerebral cortex endothelial cell CL1001602

CSI 1.8

rCSI 3.2%

PRS 39.0%
alveolar adventitial fibroblast CL4028006

CSI 1.8

rCSI 2.9%

PRS 49.6%
myeloid leukocyte CL0000766

CSI 1.9

rCSI 1.7%

PRS 49.1%
choroid plexus epithelial cell CL0000706

CSI 1.9

rCSI 3.1%

PRS 38.8%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.9

rCSI 2.4%

PRS 46.4%
chondrocyte CL0000138

CSI 1.9

rCSI 3.0%

PRS 41.2%
type B pancreatic cell CL0000169

CSI 1.9

rCSI 4.3%

PRS 45.9%
respiratory basal cell CL0002633

CSI 1.9

rCSI 2.0%

PRS 54.3%
naive T cell CL0000898

CSI 2.0

rCSI 1.4%

PRS 61.6%
centrilobular region hepatocyte CL0019029

CSI 2.0

rCSI 5.2%

PRS 55.9%
CD14-positive, CD16-positive monocyte CL0002397

CSI 2.0

rCSI 2.6%

PRS 61.8%
myoepithelial cell CL0000185

CSI 2.0

rCSI 5.1%

PRS 56.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its expression specificity (CSI Z-Score), [CDC16](/details-gene/8881) is a core component of the anaphase-promoting complex (APC/C) essential for cell cycle progression. The expression data suggests it is not a specific marker for any single cell type but rather exhibits a broad, ubiquitous expression pattern consistent with its fundamental role in cell division across diverse tissues. Its primary function involves mediating the degradation of key mitotic proteins, thereby ensuring the orderly transition from metaphase to anaphase. ## Cellular Roles and Expression Landscape The expression profile of [CDC16](/details-gene/8881), when analyzed for cell-type specificity, reveals its role as a housekeeping gene rather than a distinguishing cellular marker. In the **Overall** context, the CSI (Z-SCORE) is consistently 0.00 with non-significant p-values (p > 0.3) across a wide array of phenotypically distinct cells, including [parietal epithelial cell](/details-cell/CL1000452), [mesenchymal cell](/details-cell/CL0008019), [group 3 innate lymphoid cell](/details-cell/CL0001071), and [cardiac neuron](/details-cell/CL0010022). This lack of specificity is further underscored by mediocre percentile rank scores (PRS: 40-60%), indicating its expression is not selectively enriched in any particular cell population. This pattern is entirely consistent with the gene's established function. As an integral subunit of the anaphase-promoting complex, [CDC16](/details-gene/8881) is required for mitosis, a fundamental process in all proliferating cells. Research confirms its localization to the centrosome and mitotic spindle and its essential role in the metaphase-to-anaphase transition ([PubMed: 7736578](https://pubmed.ncbi.nlm.nih.gov/7736578)). The gene's broad expression across epithelial, hematopoietic, neuronal, and stromal lineages likely reflects the basal requirement for cell cycle machinery in tissue maintenance, repair, and development. ## Pathways and Molecular Function The functional annotations for [CDC16](/details-gene/8881) strongly reinforce the ubiquitous expression pattern observed. It is a central player in pathways governing cell division and protein degradation. Gene Ontology (GO) terms place it within the '[Anaphase-promoting complex](/details-go/GO:0005680)' where it contributes to '[Anaphase-promoting complex-dependent catabolic process](/details-go/GO:0031145)' and '[Positive regulation of mitotic metaphase/anaphase transition](/details-go/GO:0045842)'. Its molecular function involves various forms of protein ubiquitination, including '[Protein k11-linked ubiquitination](/details-go/GO:0070979)' and '[Protein k48-linked ubiquitination](/details-go/GO:0070936)', which are critical for targeting proteins for proteasomal degradation. Reactome pathways further detail its role in the core mechanics of the cell cycle. [CDC16](/details-gene/8881) is implicated in dozens of related processes, most notably '[Cell cycle, mitotic](/details-pathway/R-HSA-69278)', '[Separation of sister chromatids](/details-pathway/R-HSA-2467813)', and '[Apc/c-mediated degradation of cell cycle proteins](/details-pathway/R-HSA-174143)'. The breadth of these annotations, from DNA replication pre-initiation to late mitosis, explains why its expression is not restricted to a specific cell type but is instead a general requirement for cellular proliferation. Its regulation by phosphorylation is also a key theme in the literature, suggesting that its activity, rather than its transcript abundance, is the critical control point during the cell cycle ([PubMed: 14657031](https://pubmed.ncbi.nlm.nih.gov/14657031)). ## Research Directions The ubiquitous expression profile of [CDC16](/details-gene/8881) highlights its fundamental importance but also presents challenges for therapeutic targeting. Its non-specific nature suggests its role is conserved across most, if not all, dividing cells. Future research should focus on the post-translational regulation that governs its context-specific activity and its role in pathologies characterized by uncontrolled cell division, such as cancer. **Testable Hypotheses:** 1. **Hypothesis:** The rate of [CDC16](/details-gene/8881)-mediated protein turnover is significantly elevated in rapidly proliferating cancer cells compared to healthy proliferating cells, making the APC/C complex it belongs to a point of vulnerability. * **Experimental Approach:** Utilize quantitative mass spectrometry to compare the ubiquitination rates of known APC/C substrates (e.g., Cyclin B, Securin) in synchronized cancer cell lines versus non-transformed primary cells (e.g., fibroblasts). This would test if the catalytic activity of the APC/C, involving [CDC16](/details-gene/8881), is hyperactive in malignant states. 2. **Hypothesis:** While broadly expressed, the functional necessity of [CDC16](/details-gene/8881) is highest during the rapid clonal expansion of immune cells, and its transient inhibition could selectively dampen adaptive immune responses. * **Experimental Approach:** Employ a conditional knockout mouse model to delete [CDC16](/details-gene/8881) specifically in lymphocytes. Following immunization or infection, assess the capacity for T and B cell clonal expansion, germinal center formation, and antibody production using flow cytometry and ELISA. 3. **Hypothesis:** The phosphorylation status of [CDC16](/details-gene/8881), rather than its overall expression level, dictates its functional activity and integration into the APC/C, with distinct phosphorylation patterns defining different stages of mitosis and potentially different cell lineages. * **Experimental Approach:** Perform phosphoproteomic analysis on [CDC16](/details-gene/8881) immunoprecipitated from various cell types (e.g., [hematopoietic stem cell](/details-cell/CL0000037), [fibroblast of lung](/details-cell/CL0002553)) that have been synchronized at different points in the cell cycle. This could reveal cell-type-specific regulatory mechanisms. **Therapeutic Potential:** Given its central role in mitosis, the APC/C complex, including [CDC16](/details-gene/8881), represents a promising target for anti-cancer therapeutics. Small molecule inhibitors that disrupt APC/C function could induce mitotic arrest and apoptosis in rapidly dividing cancer cells. However, the ubiquitous expression pattern of [CDC16](/details-gene/8881) implies that such a therapeutic would have a narrow therapeutic window, likely causing significant toxicity to other proliferative tissues, such as the bone marrow and gastrointestinal epithelium. Future strategies may require developing agents that target cancer-specific vulnerabilities in APC/C regulation rather than inhibiting the complex directly.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1359269138

Symbol: CDC16_HUMAN

Name: Cell division cycle protein 16 homolog

UniProtKB Accession Codes:

Q13042 A2A365 Q5T8C8 Q7Z651 Q96AE6 Q9Y564

Database IDs:

Citations:

PubMed ID: 7736578

Title: CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition.

PubMed ID: 7736578

DOI: 10.1016/0092-8674(95)90336-4

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9405394

Title: The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex.

PubMed ID: 9405394

DOI: 10.1074/jbc.272.51.32011

PubMed ID: 9628895

Title: Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events.

PubMed ID: 9628895

DOI: 10.1083/jcb.141.6.1393

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 34595750

Title: A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

PubMed ID: 34595750

DOI: 10.1111/cge.14069

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 19668213

Title: Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.

PubMed ID: 19668213

DOI: 10.1038/nsmb.1645

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

Sequence Information:

Length: 620
Mass: 71656
Checksum: A9C4F24615DF17EB
Sequence:

MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREEPQDI YWLAQCLYLT AQYHRAAHAL 
RSRKLDKLYE ACRYLAARCH YAAKEHQQAL DVLDMEEPIN KRLFEKYLKD ESGFKDPSSD 
WEMSQSSIKS SICLLRGKIY DALDNRTLAT YSYKEALKLD VYCFEAFDLL TSHHMLTAQE 
EKELLESLPL SKLCNEEQEL LRFLFENKLK KYNKPSETVI PESVDGLQEN LDVVVSLAER 
HYYNCDFKMC YKLTSVVMEK DPFHASCLPV HIGTLVELNK ANELFYLSHK LVDLYPSNPV 
SWFAVGCYYL MVGHKNEHAR RYLSKATTLE KTYGPAWIAY GHSFAVESEH DQAMAAYFTA 
AQLMKGCHLP MLYIGLEYGL TNNSKLAERF FSQALSIAPE DPFVMHEVGV VAFQNGEWKT 
AEKWFLDALE KIKAIGNEVT VDKWEPLLNN LGHVCRKLKK YAEALDYHRQ ALVLIPQNAS 
TYSAIGYIHS LMGNFENAVD YFHTALGLRR DDTFSVTMLG HCIEMYIGDS EAYIGADIKD 
KLKCYDFDVH TMKTLKNIIS PPWDFREFEV EKQTAEETGL TPLETSRKTP DSRPSLEETF 
EIEMNESDMM LETSMSDHST

Genular Protein ID: 3098832011

Symbol: A0A3B3ISD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3ISD2

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 539
Mass: 62309
Checksum: 33DBE0FA6E889571
Sequence:

MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREEPQDI YWLAQCLYLT AQYHRAAHAL 
RSRKLDKLYE ACRYLAARCH YAAKEHQQAL DVLDMEEPIN KRLFEKYLKD ESGFKDPSSD 
WEMSQSSIKS SICLLRGKIY DALDNRTLAT YSYKEALKLD VYCFEAFDLL TSHHMLTAQE 
EKELLESLPL SKLCNEEQEL LRFLFENKLK KYNKPSETVI PESVDGLQEN LDVVVSLAER 
HYYNCDFKMC YKLTSVVMEK DPFHASCLPV HIGTLVELNK ANELFYLSHK LVDLYPSNPV 
SWFAVGCYYL MVGHKNEHAR RYLSKATTLE KTYGPAWIAY GHSFAVESEH DQAMAAYFTA 
AQLMKGCHLP MLYIGLEYGL TNNSKLAERF FSQALSIAPE DPFVMHEVGV VAFQNGEWKT 
AEKWFLDALE KIKAIGNEVT VDKWEPLLNN LGHVCRKLKK YAEALDYHRQ ALVLIPQNAS 
TYSAIGYIHS LMGNFENAVD YFHTALGLRR DDTFSVTMLG HCIEMYIGDS EAYIAPNWK

Genular Protein ID: 990275531

Symbol: B2RCW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RCW0

Database IDs:

Sequence Information:

Length: 619
Mass: 71454
Checksum: 76B6354F21C34D5B
Sequence:

MNLERLRKRV RQYLDQQQYQ SALFWADKVA SLSREPQDIY WLAQCLYLTA QYHRAAHALR 
SRKLDKLYEA CRYLAARCHY AAKEHQQALD VLDMEEPINK RLFEKYLKDE SGFKDPSSDW 
EMSQSSIKSS ICLLRGKIYD ALDNRTLATY SYKEALKLDV YCFEAFDLLT SHHMLTAQEE 
KELLESLPLS KLCNEEQELL RFLFENKLKK YNKPSETVIP ESVDGLQENL DVVVSLAERH 
YYNCDFKMCY KLTSVVMEKD PFHASCLPVH IGTLVELNKA NELFYLSHKL VDLYPSNPVS 
WFAVGCYYLM VGHKNEHARR YLSKATTLEK TYGPAWIAYG HSFAVESEHD QAMAAYFTAA 
QLMKGCHLPM LYIGLEYGLT NNSKLAERFF SQALSIAPED PFVMHEVGVV AFQNGEWKTA 
EKWFLDALEK IKAIGNGVTV DKWEPLLNNL GHVCRKLKKY AEALDYHRQA LVLIPQNAST 
YSAIGYIHSL MGNFENAVDY FHTALGLRRD DTFSVTMLGH CIEMYIGDSE AYIGADIKDK 
LKCYDFDVHT MKTLKNIISP PWDFREFEVE KQTAEETGLT PLETSRKTPD SRPSLEETFE 
IEMNESDMML ETSMSDHST

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: CDC16

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. PubMed ID: 7736578

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex. PubMed ID: 9405394

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. PubMed ID: 9628895

Mitotic regulation of the human anaphase-promoting complex by phosphorylation. PubMed ID: 14657031

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. PubMed ID: 34595750

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. PubMed ID: 19668213

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Initial characterization of the human central proteome. PubMed ID: 21269460

PubMed ID: 7736578

PubMed ID: 15057823

PubMed ID: 15489334

PubMed ID: 9405394

PubMed ID: 9628895

PubMed ID: 14657031

PubMed ID: 16964243

PubMed ID: 18485873

PubMed ID: 18691976

PubMed ID: 18669648

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 29033132

PubMed ID: 34595750

PubMed ID: 16364912

PubMed ID: 19668213

PubMed ID: 25043029

PubMed ID: 26083744

PubMed ID: 11237011

PubMed ID: 15057823

PubMed ID: 15496913

PubMed ID: 21269460