LATS1 | ENSG00000131023 | NCBI 9113

Details for: LATS1

Gene ID: 9113

Symbol: LATS1

Ensembl ID: ENSG00000131023

Description: large tumor suppressor kinase 1

Associated with

Signaling by hippo
(R-HSA-2028269)
Signal transduction
(R-HSA-162582)
Atp binding
(GO:0005524)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Cytoplasmic sequestering of protein
(GO:0051220)
Cytosol
(GO:0005829)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Hippo signaling
(GO:0035329)
Hormone-mediated signaling pathway
(GO:0009755)
Inner cell mass cell fate commitment
(GO:0001827)
Inner cell mass cellular morphogenesis
(GO:0001828)
Keratinocyte differentiation
(GO:0030216)
Magnesium ion binding
(GO:0000287)
Mammary gland epithelial cell differentiation
(GO:0060644)
Midbody
(GO:0030496)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045736)
Negative regulation of protein localization to nucleus
(GO:1900181)
Nuclear estrogen receptor binding
(GO:0030331)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of actin filament polymerization
(GO:0030833)
Regulation of intracellular estrogen receptor signaling pathway
(GO:0033146)
Regulation of organ growth
(GO:0046620)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of transforming growth factor beta receptor signaling pathway
(GO:0017015)
Regulation of ubiquitin-dependent protein catabolic process
(GO:2000058)
Sister chromatid segregation
(GO:0000819)
Spindle pole
(GO:0000922)

Other Information

Proteins

Serine/threonine-protein kinase LATS1

Genular Protein ID: 713877307

Symbol: LATS1_HUMAN

Name: Serine/threonine-protein kinase LATS1

UniProtKB Accession Codes:

O95835 Q6PKD0

Database IDs:

Citations:

PubMed ID: 9988268

Title: Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.

PubMed ID: 9988268

DOI: 10.1038/5960

PubMed ID: 10518011

Title: A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis.

PubMed ID: 10518011

DOI: 10.1016/s0014-5793(99)01224-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10831611

Title: Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.

PubMed ID: 10831611

DOI: 10.1083/jcb.149.5.1073

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15122335

Title: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function.

PubMed ID: 15122335

DOI: 10.1038/sj.onc.1207623

PubMed ID: 15220930

Title: LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.

PubMed ID: 15220930

DOI: 10.1038/ncb1140

PubMed ID: 15688006

Title: The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.

PubMed ID: 15688006

DOI: 10.1038/sj.onc.1208445

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18158288

Title: Tumor suppressor LATS1 is a negative regulator of oncogene YAP.

PubMed ID: 18158288

DOI: 10.1074/jbc.m709037200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20303269

Title: Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.

PubMed ID: 20303269

DOI: 10.1016/j.cub.2010.02.035

PubMed ID: 19739119

Title: Molecular characterization of human homologs of yeast MOB1.

PubMed ID: 19739119

DOI: 10.1002/ijc.24878

PubMed ID: 19927127

Title: Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

PubMed ID: 19927127

DOI: 10.1038/emboj.2009.342

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24682284

Title: Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling.

PubMed ID: 24682284

DOI: 10.1093/molbev/msu115

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

PubMed ID: 28068668

Title: The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha.

PubMed ID: 28068668

DOI: 10.1038/nature20829

PubMed ID: 28169360

Title: Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.

PubMed ID: 28169360

DOI: 10.1038/srep42125

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1130
Mass: 126870
Checksum: 11CFBCD8FD87DCD8
Sequence:

MKRSEKPEGY RQMRPKTFPA SNYTVSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMSTE 
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETNSSRSTSE VNPQMLQDLQ AAGFDEDMVI 
QALQKTNNRS IEAAIEFISK MSYQDPRREQ MAAAAARPIN ASMKPGNVQQ SVNRKQSWKG 
SKESLVPQRH GPPLGESVAY HSESPNSQTD VGRPLSGSGI SAFVQAHPSN GQRVNPPPPP 
QVRSVTPPPP PRGQTPPPRG TTPPPPSWEP NSQTKRYSGN MEYVISRISP VPPGAWQEGY 
PPPPLNTSPM NPPNQGQRGI SSVPVGRQPI IMQSSSKFNF PSGRPGMQNG TGQTDFMIHQ 
NVVPAGTVNR QPPPPYPLTA ANGQSPSALQ TGGSAAPSSY TNGSIPQSMM VPNRNSHNME 
LYNISVPGLQ TNWPQSSSAP AQSSPSSGHE IPTWQPNIPV RSNSFNNPLG NRASHSANSQ 
PSATTVTAIT PAPIQQPVKS MRVLKPELQT ALAPTHPSWI PQPIQTVQPS PFPEGTASNV 
TVMPPVAEAP NYQGPPPPYP KHLLHQNPSV PPYESISKPS KEDQPSLPKE DESEKSYENV 
DSGDKEKKQI TTSPITVRKN KKDEERRESR IQSYSPQAFK FFMEQHVENV LKSHQQRLHR 
KKQLENEMMR VGLSQDAQDQ MRKMLCQKES NYIRLKRAKM DKSMFVKIKT LGIGAFGEVC 
LARKVDTKAL YATKTLRKKD VLLRNQVAHV KAERDILAEA DNEWVVRLYY SFQDKDNLYF 
VMDYIPGGDM MSLLIRMGIF PESLARFYIA ELTCAVESVH KMGFIHRDIK PDNILIDRDG 
HIKLTDFGLC TGFRWTHDSK YYQSGDHPRQ DSMDFSNEWG DPSSCRCGDR LKPLERRAAR 
QHQRCLAHSL VGTPNYIAPE VLLRTGYTQL CDWWSVGVIL FEMLVGQPPF LAQTPLETQM 
KVINWQTSLH IPPQAKLSPE ASDLIIKLCR GPEDRLGKNG ADEIKAHPFF KTIDFSSDLR 
QQSASYIPKI THPTDTSNFD PVDPDKLWSD DNEEENVNDT LNGWYKNGKH PEHAFYEFTF 
RRFFDDNGYP YNYPKPIEYE YINSQGSEQQ SDEDDQNTGS EIKNRDLVYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LATS1

Associated with

Other Information

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. PubMed ID: 9988268

A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis. PubMed ID: 10518011

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. PubMed ID: 10831611

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function. PubMed ID: 15122335

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. PubMed ID: 15220930

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. PubMed ID: 15688006

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Tumor suppressor LATS1 is a negative regulator of oncogene YAP. PubMed ID: 18158288

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. PubMed ID: 20303269

Molecular characterization of human homologs of yeast MOB1. PubMed ID: 19739119

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. PubMed ID: 19927127

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. PubMed ID: 24682284

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. PubMed ID: 28087714

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. PubMed ID: 28068668

Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. PubMed ID: 28169360

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846