Details for: QARS1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 30.86rCSI 37.39%PRS 43.91
-
CSI 24.67rCSI 33.62%PRS 26.85
-
CSI 18.97rCSI 30.16%PRS 45.16
-
CSI 17.97rCSI 11.95%PRS 56.32
-
CSI 17.17rCSI 40.83%PRS 63.23
-
CSI 17.14rCSI 17.91%PRS 51.56
-
CSI 15.03rCSI 26.5%PRS 60.88
-
CSI 14.26rCSI 12.34%PRS 57.25
-
CSI 13.77rCSI 19.47%PRS 59.8
-
CSI 13.61rCSI 30.52%PRS 36.32
-
CSI 13.14rCSI 16.25%PRS 48.52
-
CSI 13.06rCSI 10.56%PRS 53.8
-
CSI 12.74rCSI 11.5%PRS 49.41
-
CSI 12.39rCSI 19.14%PRS 50.55
-
CSI 10.12rCSI 14.59%PRS 64.87
-
CSI 9.54rCSI 21.31%PRS 59.93
-
CSI 9.46rCSI 13.41%PRS 49.04
-
CSI 8.45rCSI 7.8%PRS 53.75
-
CSI 7.17rCSI 10.82%PRS 55.62
-
CSI 7.09rCSI 7.98%PRS 69.23
-
CSI 7.03rCSI 5.26%PRS 68.06
-
CSI 6.81rCSI 9.26%PRS 64.96
-
CSI 6.54rCSI 37.47%PRS 63.49
-
CSI 6.48rCSI 14.27%PRS 56.66
-
CSI 5.74rCSI 7.84%PRS 55
-
CSI 5.53rCSI 3.85%PRS 62.74
-
CSI 5.44rCSI 6.93%PRS 58.78
-
CSI 5.35rCSI 35.12%PRS 81.72
-
CSI 5.12rCSI 6.23%PRS 60.49
-
CSI 4.94rCSI 3.95%PRS 74.18
-
CSI 4.89rCSI 4.55%PRS 52.37
-
CSI 4.84rCSI 7.39%PRS 62.13
-
CSI 4.83rCSI 7.39%PRS 68.01
-
CSI 4.71rCSI 6.41%PRS 78.91
-
CSI 4.66rCSI 8.05%PRS 42.88
-
CSI 4.62rCSI 14.99%PRS 54.46
-
CSI 4.6rCSI 7.02%PRS 53.17
-
CSI 4.59rCSI 13.28%PRS 54.67
-
CSI 4.43rCSI 3.18%PRS 66.61
-
CSI 4.34rCSI 27.13%PRS 44.65
-
CSI 4.28rCSI 32.18%PRS 70.85
-
CSI 4.26rCSI 6.9%PRS 50.2
-
CSI 4.21rCSI 6.74%PRS 78.1
-
CSI 4.15rCSI 4.75%PRS 74.1
-
CSI 4.09rCSI 3.87%PRS 52.85
-
CSI 4.08rCSI 17.91%PRS 69.65
-
CSI 4.04rCSI 9.21%PRS 50.07
-
CSI 3.96rCSI 3.07%PRS 53.53
-
CSI 3.91rCSI 5.23%PRS 75.08
-
CSI 3.84rCSI 3.23%PRS 70.53
-
CSI 3.79rCSI 3.37%PRS 51.08
-
CSI 3.76rCSI 3.62%PRS 52.98
-
CSI 3.62rCSI 3.77%PRS 52.97
-
CSI 3.57rCSI 3.66%PRS 69.5
-
CSI 3.54rCSI 4.45%PRS 62.9
-
CSI 3.53rCSI 2.78%PRS 59.34
-
CSI 3.44rCSI 5.08%PRS 69.67
-
CSI 3.43rCSI 2.87%PRS 57.44
-
CSI 3.36rCSI 4.92%PRS 64.2
-
CSI 3.3rCSI 4.53%PRS 72.96
-
CSI 3.29rCSI 3.36%PRS 66.27
-
CSI 3.29rCSI 9.7%PRS 56.52
-
CSI 3.29rCSI 5.3%PRS 58.85
-
CSI 3.23rCSI 8%PRS 50.55
-
CSI 3.17rCSI 3.26%PRS 70.66
-
CSI 3.17rCSI 3.28%PRS 58.43
-
CSI 3.14rCSI 2.75%PRS 62.72
-
CSI 3.13rCSI 2.18%PRS 66.92
-
CSI 3.1rCSI 16.02%PRS 75.87
-
CSI 3.08rCSI 2.44%PRS 39.8
-
CSI 3.07rCSI 4.89%PRS 45.93
-
CSI 3.05rCSI 4.05%PRS 58.23
-
CSI 2.98rCSI 1.76%PRS 69.44
-
CSI 2.87rCSI 4.41%PRS 60.68
-
CSI 2.86rCSI 4.09%PRS 58.31
-
CSI 2.82rCSI 3.92%PRS 51.85
-
CSI 2.78rCSI 2.31%PRS 51.41
-
CSI 2.76rCSI 4.35%PRS 54.01
-
CSI 2.68rCSI 2.31%PRS 59.65
-
CSI 2.68rCSI 2.35%PRS 58.02
-
CSI 2.67rCSI 2.45%PRS 61.07
-
CSI 2.63rCSI 5.27%PRS 41.96
-
CSI 2.59rCSI 2.16%PRS 68.91
-
CSI 2.58rCSI 1.74%PRS 64.73
-
CSI 2.57rCSI 4.39%PRS 78
-
CSI 2.53rCSI 27.68%PRS 67.2
-
CSI 2.53rCSI 3.03%PRS 50.67
-
CSI 2.52rCSI 2.09%PRS 54.21
-
CSI 2.5rCSI 2.89%PRS 46.5
-
CSI 2.48rCSI 3.18%PRS 50.36
-
CSI 2.46rCSI 2.42%PRS 68.7
-
CSI 2.46rCSI 24.17%PRS 75.57
-
CSI 2.45rCSI 4.37%PRS 67.43
-
CSI 2.32rCSI 4.5%PRS 55.08
-
CSI 2.26rCSI 1.58%PRS 55.11
-
CSI 2.21rCSI 5.6%PRS 47.81
-
CSI 2.18rCSI 3.11%PRS 55.2
-
CSI 2.17rCSI 2.28%PRS 49.54
-
CSI 2.17rCSI 2.78%PRS 57.48
-
CSI 2.08rCSI 2.61%PRS 65.59
-
CSI 0.3rCSI 6.7%PRS 74.3%
-
CSI 0.3rCSI 3.2%PRS 70.4%
-
CSI 0.3rCSI 1.2%PRS 67.4%
-
CSI 0.5rCSI 2.6%PRS 63.2%
-
CSI 0.5rCSI 1.6%PRS 59.4%
-
CSI 0.5rCSI 3.0%PRS 84.2%
-
CSI 0.6rCSI 3.6%PRS 82.2%
-
CSI 0.6rCSI 7.5%PRS 82.8%
-
CSI 0.6rCSI 6.2%PRS 74.0%
-
CSI 0.7rCSI 2.1%PRS 59.1%
-
CSI 0.7rCSI 1.1%PRS 42.8%
-
CSI 0.7rCSI 3.4%PRS 74.2%
-
CSI 0.8rCSI 1.2%PRS 27.3%
-
CSI 0.8rCSI 3.0%PRS 71.7%
-
CSI 0.8rCSI 2.2%PRS 66.3%
-
CSI 0.8rCSI 3.3%PRS 67.5%
-
CSI 0.9rCSI 2.4%PRS 60.7%
-
CSI 0.9rCSI 5.1%PRS 62.8%
-
CSI 0.9rCSI 1.4%PRS 49.1%
-
CSI 0.9rCSI 4.2%PRS 73.2%
-
CSI 0.9rCSI 2.5%PRS 65.6%
-
CSI 1.0rCSI 2.4%PRS 80.5%
-
CSI 1.0rCSI 1.2%PRS 61.0%
-
CSI 1.0rCSI 0.9%PRS 63.2%
-
CSI 1.1rCSI 2.4%PRS 57.9%
-
CSI 1.1rCSI 3.1%PRS 68.4%
-
CSI 1.1rCSI 4.2%PRS 73.3%
-
CSI 1.1rCSI 2.7%PRS 71.3%
-
CSI 1.2rCSI 2.5%PRS 66.0%
-
CSI 1.2rCSI 1.4%PRS 42.6%
-
CSI 1.2rCSI 3.4%PRS 65.9%
-
CSI 1.2rCSI 2.1%PRS 62.3%
-
CSI 1.3rCSI 1.8%PRS 42.9%
-
CSI 1.3rCSI 4.5%PRS 85.3%
-
CSI 1.3rCSI 2.4%PRS 74.6%
-
CSI 1.3rCSI 3.4%PRS 61.0%
-
CSI 1.3rCSI 3.5%PRS 56.9%
-
CSI 1.4rCSI 1.9%PRS 45.3%
-
CSI 1.4rCSI 7.3%PRS 64.9%
-
CSI 1.5rCSI 3.0%PRS 56.5%
-
CSI 1.5rCSI 1.6%PRS 51.0%
-
CSI 1.5rCSI 2.2%PRS 62.5%
-
CSI 1.5rCSI 1.5%PRS 76.0%
-
CSI 1.5rCSI 9.7%PRS 72.8%
-
CSI 1.5rCSI 3.1%PRS 73.0%
-
CSI 1.5rCSI 1.2%PRS 57.1%
-
CSI 1.6rCSI 3.0%PRS 63.1%
-
CSI 1.6rCSI 1.4%PRS 41.1%
-
CSI 1.8rCSI 2.2%PRS 54.8%
-
CSI 1.8rCSI 4.3%PRS 57.5%
-
CSI 1.8rCSI 3.2%PRS 31.0%
-
CSI 1.8rCSI 8.1%PRS 51.7%
-
CSI 1.8rCSI 1.8%PRS 46.4%
-
CSI 1.9rCSI 4.0%PRS 69.7%
-
CSI 1.9rCSI 2.8%PRS 56.2%
-
CSI 1.9rCSI 3.0%PRS 63.8%
-
CSI 2.0rCSI 2.9%PRS 50.4%
-
CSI 2.0rCSI 3.3%PRS 58.1%
-
CSI 2.0rCSI 1.5%PRS 52.0%
-
CSI 2.0rCSI 10.8%PRS 66.7%
-
CSI 2.0rCSI 2.4%PRS 61.8%
-
CSI 2.1rCSI 2.8%PRS 61.4%
-
CSI 2.1rCSI 2.6%PRS 65.6%
-
CSI 2.2rCSI 2.8%PRS 57.5%
-
CSI 2.2rCSI 2.3%PRS 49.5%
-
CSI 2.2rCSI 3.1%PRS 55.2%
-
CSI 2.2rCSI 5.6%PRS 47.8%
-
CSI 2.3rCSI 1.6%PRS 55.1%
-
CSI 2.3rCSI 4.5%PRS 55.1%
-
CSI 2.5rCSI 4.4%PRS 67.4%
-
CSI 2.5rCSI 24.2%PRS 75.6%
-
CSI 2.5rCSI 2.4%PRS 68.7%
-
CSI 2.5rCSI 3.2%PRS 50.4%
-
CSI 2.5rCSI 2.9%PRS 46.5%
-
CSI 2.5rCSI 2.1%PRS 54.2%
-
CSI 2.5rCSI 3.0%PRS 50.7%
-
CSI 2.5rCSI 27.7%PRS 67.2%
-
CSI 2.6rCSI 4.4%PRS 78.0%
-
CSI 2.6rCSI 1.7%PRS 64.7%
-
CSI 2.6rCSI 2.2%PRS 68.9%
-
CSI 2.6rCSI 5.3%PRS 42.0%
-
CSI 2.7rCSI 2.5%PRS 61.1%
-
CSI 2.7rCSI 2.4%PRS 58.0%
-
CSI 2.7rCSI 2.3%PRS 59.7%
-
CSI 2.8rCSI 4.4%PRS 54.0%
-
CSI 2.8rCSI 2.3%PRS 51.4%
-
CSI 2.8rCSI 3.9%PRS 51.9%
-
CSI 2.9rCSI 4.1%PRS 58.3%
-
CSI 2.9rCSI 4.4%PRS 60.7%
-
CSI 3.0rCSI 1.8%PRS 69.4%
-
CSI 3.1rCSI 4.1%PRS 58.2%
-
CSI 3.1rCSI 4.9%PRS 45.9%
-
CSI 3.1rCSI 2.4%PRS 39.8%
-
CSI 3.1rCSI 16.0%PRS 75.9%
-
CSI 3.1rCSI 2.2%PRS 66.9%
-
CSI 3.1rCSI 2.8%PRS 62.7%
-
CSI 3.2rCSI 3.3%PRS 58.4%
-
CSI 3.2rCSI 3.3%PRS 70.7%
-
CSI 3.2rCSI 8.0%PRS 50.6%
-
CSI 3.3rCSI 5.3%PRS 58.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2757325089
Symbol: SYQ_HUMAN
Name: Glutamine--tRNA ligase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8078941
Title: Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer.
PubMed ID: 8078941
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10791971
Title: Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis.
PubMed ID: 10791971
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19131329
Title: Dissection of the structural organization of the aminoacyl-tRNA synthetase complex.
PubMed ID: 19131329
PubMed ID: 19289464
Title: Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.
PubMed ID: 19289464
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24656866
Title: Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
PubMed ID: 24656866
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25288775
Title: Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation.
PubMed ID: 25288775
PubMed ID: 26869582
Title: The crystal structure of human GlnRS provides basis for the development of neurological disorders.
PubMed ID: 26869582
DOI: 10.1093/nar/gkw082
Sequence Information:
- Length: 775
- Mass: 87799
- Checksum: ADDE23E6C442FF73
- Sequence:
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK ATGILLYGLA SRLRDTRRLS FLVSYIASKK IHTEPQLSAA LEYVRSHPLD PIDTVDFERE CGVGVIVTPE QIEEAVEAAI NRHRPQLLVE RYHFNMGLLM GEARAVLKWA DGKMIKNEVD MQVLHLLGPK LEADLEKKFK VAKARLEETD RRTAKDVVEN GETADQTLSL MEQLRGEALK FHKPGENYKT PGYVVTPHTM NLLKQHLEIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL RFDDTNPEKE EAKFFTAICD MVAWLGYTPY KVTYASDYFD QLYAWAVELI RRGLAYVCHQ RGEELKGHNT LPSPWRDRPM EESLLLFEAM RKGKFSEGEA TLRMKLVMED GKMDPVAYRV KYTPHHRTGD KWCIYPTYDY THCLCDSIEH ITHSLCTKEF QARRSSYFWL CNALDVYCPV QWEYGRLNLH YAVVSKRKIL QLVATGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG VTVAQTTMEP HLLEACVRDV LNDTAPRAMA VLESLRVIIT NFPAAKSLDI QVPNFPADET KGFHQVPFAP IVFIERTDFK EEPEPGFKRL AWGQPVGLRH TGYVIELQHV VKGPSGCVES LEVTCRRADA GEKPKAFIHW VSQPLMCEVR LYERLFQHKN PEDPTEVPGG FLSDLNLASL HVVDAALVDC SVALAKPFDK FQFERLGYFS VDPDSHQGKL VFNRTVTLKE DPGKV
Genular Protein ID: 2461466816
Symbol: B7Z840_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 282
- Mass: 31571
- Checksum: 5D10DAF0D8582767
- Sequence:
MPTCRLGPKF LLVSGVSAMA ALDSLSLFTS LGLSEQKARE TLKNSALSAQ LREAATQAQQ TLGSTIDKAT GILLYGLASR LRDTRRLSFL VSYIASKKIH TEPQLSAALE YVRSHPLDPI DTVDFERECG VGVIVTPEQI EEAVEAAINR HRPQLLVERY HFNMGLLMGE ARAVLKWADG KMIKNEVDMQ VLHLLGPKLE ADLEKKFKVA KARLEETDRR TAKDVVENGE TADQTLSLME QLRGEALKFH KPGTYPVPAR TQWNPAYWTC QSHQFQLWLC QV