KLF2 | ENSG00000127528 | NCBI 10365

Details for: KLF2

Gene ID: 10365

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: KLF2

Ensembl ID: ENSG00000127528

Description: KLF transcription factor 2

Cell Significance Landscape

Display Count:

Associated with

Cell morphogenesis
(GO:0000902)
Cellular response to cycloheximide
(GO:0071409)
Cellular response to fluid shear stress
(GO:0071498)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to laminar fluid shear stress
(GO:0071499)
Cellular response to peptide
(GO:1901653)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular stress response to acid chemical
(GO:0097533)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Epigenetic regulation of gene expression
(GO:0040029)
Erythrocyte maturation
(GO:0043249)
In utero embryonic development
(GO:0001701)
Metal ion binding
(GO:0046872)
Multicellular organism growth
(GO:0035264)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of sprouting angiogenesis
(GO:1903671)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of retinoic acid receptor signaling pathway
(GO:0048386)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Type i pneumocyte differentiation
(GO:0060509)
Vasodilation
(GO:0042311)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

central memory CD4-positive, alpha-beta T cell CL0000904

CSI 85.54

rCSI 50.52%

PRS 46.38
CD4-positive helper T cell CL0000492

CSI 84.94

rCSI 64.25%

PRS 44.61
CD14-low, CD16-positive monocyte CL0002396

CSI 82.43

rCSI 63.51%

PRS 32.13
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 66.46

rCSI 44.29%

PRS 61.5
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 65.99

rCSI 49.48%

PRS 68.6
memory B cell CL0000787

CSI 64.8

rCSI 63.99%

PRS 73.01
naive B cell CL0000788

CSI 62.27

rCSI 53.41%

PRS 44.45
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 55.5

rCSI 38.98%

PRS 59.46
class switched memory B cell CL0000972

CSI 48.21

rCSI 35.99%

PRS 51.54
activated type II NK T cell CL0000931

CSI 40.93

rCSI 46.07%

PRS 49.04
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 40.48

rCSI 50.87%

PRS 77.61
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 39.42

rCSI 47.76%

PRS 34.41
endothelial cell of artery CL1000413

CSI 38.57

rCSI 56.52%

PRS 73.39
double negative thymocyte CL0002489

CSI 38.21

rCSI 26.56%

PRS 40.53
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 36.21

rCSI 49.75%

PRS 54.51
activated CD4-positive, alpha-beta T cell CL0000896

CSI 33.15

rCSI 30.65%

PRS 53.59
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 32.94

rCSI 44.87%

PRS 62.4
pulmonary artery endothelial cell CL1001568

CSI 31.09

rCSI 42.3%

PRS 46.28
goblet cell CL0000160

CSI 29.78

rCSI 28.14%

PRS 34.87
T-helper 1 cell CL0000545

CSI 29.59

rCSI 53.42%

PRS 62.46
T follicular helper cell CL0002038

CSI 26.96

rCSI 20.18%

PRS 47.76
mucosal invariant T cell CL0000940

CSI 26.88

rCSI 21.72%

PRS 45.43
plasma cell CL0000786

CSI 25.68

rCSI 33.66%

PRS 75.27
foveolar cell of stomach CL0002179

CSI 25.49

rCSI 54.25%

PRS 48.58
plasmablast CL0000980

CSI 23.92

rCSI 18.82%

PRS 39.45
ionocyte CL0005006

CSI 23.86

rCSI 25.57%

PRS 31.64
squamous epithelial cell CL0000076

CSI 23.51

rCSI 55.81%

PRS 39.38
blood vessel endothelial cell CL0000071

CSI 23.47

rCSI 48.71%

PRS 32.83
CD8-positive, alpha-beta memory T cell CL0000909

CSI 23.47

rCSI 24.51%

PRS 67.36
Kupffer cell CL0000091

CSI 22.99

rCSI 52.57%

PRS 33.26
capillary endothelial cell CL0002144

CSI 22.52

rCSI 41.28%

PRS 63.41
mature T cell CL0002419

CSI 22.05

rCSI 17.15%

PRS 48.39
mature NK T cell CL0000814

CSI 21.92

rCSI 28.04%

PRS 72.07
gamma-delta T cell CL0000798

CSI 20.69

rCSI 24.3%

PRS 80.44
non-classical monocyte CL0000875

CSI 20.68

rCSI 33.15%

PRS 64.72
mononuclear phagocyte CL0000113

CSI 20.13

rCSI 44.3%

PRS 37.51
effector CD8-positive, alpha-beta T cell CL0001050

CSI 19.15

rCSI 14.56%

PRS 43.34
lung ciliated cell CL1000271

CSI 19.14

rCSI 22.13%

PRS 25.66
naive T cell CL0000898

CSI 19.02

rCSI 13.23%

PRS 45.24
mature B cell CL0000785

CSI 18.49

rCSI 16.07%

PRS 41.69
B cell CL0000236

CSI 18.45

rCSI 24.69%

PRS 69.72
myofibroblast cell CL0000186

CSI 17.88

rCSI 24.76%

PRS 40.48
interstitial cell of Cajal CL0002088

CSI 17.83

rCSI 22.7%

PRS 38.31
cerebral cortex endothelial cell CL1001602

CSI 17.59

rCSI 30.43%

PRS 26.3
bronchus fibroblast of lung CL2000093

CSI 17.54

rCSI 14.25%

PRS 34.64
regulatory T cell CL0000815

CSI 16.7

rCSI 19.36%

PRS 61.32
IgA plasma cell CL0000987

CSI 15.71

rCSI 16.08%

PRS 52.51
CD4-positive, alpha-beta memory T cell CL0000897

CSI 15.61

rCSI 11.21%

PRS 44.9
skin fibroblast CL0002620

CSI 15.5

rCSI 13.36%

PRS 43.87
tracheobronchial smooth muscle cell CL0019019

CSI 15.3

rCSI 26.98%

PRS 41.93
retinal blood vessel endothelial cell CL0002585

CSI 15.21

rCSI 24.29%

PRS 36.66
respiratory basal cell CL0002633

CSI 15.18

rCSI 15.73%

PRS 39.1
precursor B cell CL0000817

CSI 14.93

rCSI 13.08%

PRS 42.89
lung interstitial macrophage CL4033043

CSI 14.63

rCSI 32.84%

PRS 55.52
endothelial cell of lymphatic vessel CL0002138

CSI 14.23

rCSI 28.2%

PRS 62.04
CD14-positive monocyte CL0001054

CSI 14.07

rCSI 17.52%

PRS 44.59
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 13.96

rCSI 16.67%

PRS 52.7
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 13.29

rCSI 12.11%

PRS 48.1
fibroblast of lung CL0002553

CSI 13.28

rCSI 12.36%

PRS 33.55
vein endothelial cell CL0002543

CSI 13.26

rCSI 36.2%

PRS 69.06
CD14-positive, CD16-positive monocyte CL0002397

CSI 13.17

rCSI 17.26%

PRS 45.82
basal cell CL0000646

CSI 12.86

rCSI 17.2%

PRS 35.58
immature B cell CL0000816

CSI 12.8

rCSI 9.51%

PRS 46.08
platelet CL0000233

CSI 12.79

rCSI 53.08%

PRS 46.13
vein endothelial cell of respiratory system CL4033008

CSI 12.58

rCSI 86.36%

PRS 54.16
mesodermal cell CL0000222

CSI 12.54

rCSI 15.05%

PRS 32.43
enteric smooth muscle cell CL0002504

CSI 12.49

rCSI 17.83%

PRS 36.33
intestine goblet cell CL0019031

CSI 12.27

rCSI 10.9%

PRS 33.33
group 3 innate lymphoid cell CL0001071

CSI 12.14

rCSI 9.12%

PRS 36.28
plasmacytoid dendritic cell, human CL0001058

CSI 12.05

rCSI 8.41%

PRS 35.41
conventional dendritic cell CL0000990

CSI 12.04

rCSI 10.05%

PRS 59.65
pulmonary capillary endothelial cell CL4028001

CSI 11.98

rCSI 22.85%

PRS 49.88
T cell CL0000084

CSI 11.92

rCSI 23.3%

PRS 86.98
early lymphoid progenitor CL0000936

CSI 11.9

rCSI 10.46%

PRS 38.3
myeloid leukocyte CL0000766

CSI 11.79

rCSI 10.87%

PRS 34.89
luminal epithelial cell of mammary gland CL0002326

CSI 11.77

rCSI 21.38%

PRS 48.93
stem cell CL0000034

CSI 11.73

rCSI 11.31%

PRS 26.01
smooth muscle cell CL0000192

CSI 11.54

rCSI 27.53%

PRS 56.19
T-helper 17 cell CL0000899

CSI 11.29

rCSI 8.96%

PRS 54.49
epithelial cell of lower respiratory tract CL0002632

CSI 11.08

rCSI 8.59%

PRS 33.36
microcirculation associated smooth muscle cell CL0008035

CSI 10.92

rCSI 31.63%

PRS 36.61
epithelial cell of lung CL0000082

CSI 10.92

rCSI 9.05%

PRS 32.23
monocyte CL0000576

CSI 10.91

rCSI 19.71%

PRS 60.06
mast cell CL0000097

CSI 10.88

rCSI 23.49%

PRS 70.75
respiratory suprabasal cell CL4033048

CSI 10.62

rCSI 13.62%

PRS 38.21
intermediate monocyte CL0002393

CSI 10.59

rCSI 15.98%

PRS 34.89
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 10.49

rCSI 63.48%

PRS 60.46
vascular associated smooth muscle cell CL0000359

CSI 10.49

rCSI 34.02%

PRS 37.62
mesenchymal cell CL0008019

CSI 10.41

rCSI 26.43%

PRS 31.65
renal interstitial pericyte CL1001318

CSI 10.1

rCSI 27.82%

PRS 31.7
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 10.09

rCSI 23.01%

PRS 33.33
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 9.98

rCSI 50.09%

PRS 43.18
elicited macrophage CL0000861

CSI 9.97

rCSI 9.15%

PRS 39.72
perivascular cell CL4033054

CSI 9.94

rCSI 13.58%

PRS 37.69
macrophage CL0000235

CSI 9.92

rCSI 18.05%

PRS 68.39
innate lymphoid cell CL0001065

CSI 9.63

rCSI 19.88%

PRS 42.65
nasal mucosa goblet cell CL0002480

CSI 9.52

rCSI 11.04%

PRS 44.46
cardiac endothelial cell CL0010008

CSI 9.49

rCSI 38.28%

PRS 32.68
ciliated epithelial cell CL0000067

CSI 9.28

rCSI 8.16%

PRS 25.1
lung pericyte CL0009089

CSI 9.26

rCSI 24.45%

PRS 39.86

mesenchymal stem cell CL0000134

CSI 0.2

rCSI 1.9%

PRS 51.1%
IgM plasma cell CL0000986

CSI 0.2

rCSI 0.9%

PRS 80.3%
double negative T regulatory cell CL0011024

CSI 0.2

rCSI 3.8%

PRS 82.2%
B-1 B cell CL0000819

CSI 0.2

rCSI 5.9%

PRS 80.2%
peptic cell CL0000155

CSI 0.3

rCSI 2.8%

PRS 63.4%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 2.3%

PRS 59.2%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.5

rCSI 2.4%

PRS 57.3%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.5

rCSI 5.4%

PRS 70.5%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 2.1%

PRS 52.7%
enteroglial cell CL4040002

CSI 0.7

rCSI 3.4%

PRS 44.8%
kidney interstitial cell CL1000500

CSI 0.7

rCSI 11.0%

PRS 68.9%
bronchiolar smooth muscle cell CL4033017

CSI 0.7

rCSI 10.9%

PRS 63.0%
tracheal goblet cell CL1000329

CSI 0.8

rCSI 1.7%

PRS 54.6%
pancreatic stellate cell CL0002410

CSI 0.8

rCSI 4.8%

PRS 45.2%
acinar cell of salivary gland CL0002623

CSI 0.9

rCSI 21.9%

PRS 56.5%
group 2 innate lymphoid cell CL0001069

CSI 1.0

rCSI 5.2%

PRS 72.9%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.0

rCSI 1.8%

PRS 54.8%
smooth muscle cell of the pulmonary artery CL0002591

CSI 1.1

rCSI 8.0%

PRS 58.2%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.1

rCSI 11.4%

PRS 37.6%
mammary gland epithelial cell CL0002327

CSI 1.1

rCSI 4.0%

PRS 50.2%
bronchial goblet cell CL1000312

CSI 1.2

rCSI 4.7%

PRS 56.6%
Hofbauer cell CL3000001

CSI 1.2

rCSI 2.2%

PRS 42.4%
hepatic pit cell CL2000054

CSI 1.2

rCSI 17.0%

PRS 78.8%
tracheobronchial serous cell CL0019001

CSI 1.4

rCSI 5.9%

PRS 51.4%
glandular epithelial cell CL0000150

CSI 1.4

rCSI 3.7%

PRS 56.9%
mucus secreting cell CL0000319

CSI 1.4

rCSI 2.3%

PRS 42.9%
promyelocyte CL0000836

CSI 1.4

rCSI 2.1%

PRS 43.5%
BEST4+ enteroycte CL4030026

CSI 1.5

rCSI 1.8%

PRS 36.1%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 1.5

rCSI 3.8%

PRS 66.4%
myeloid dendritic cell CL0000782

CSI 1.5

rCSI 2.2%

PRS 48.5%
colon goblet cell CL0009039

CSI 1.5

rCSI 3.7%

PRS 46.1%
common dendritic progenitor CL0001029

CSI 1.6

rCSI 2.0%

PRS 42.3%
deuterosomal cell CL4033044

CSI 1.6

rCSI 5.4%

PRS 45.3%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.6

rCSI 4.2%

PRS 31.0%
placental villous trophoblast CL2000060

CSI 1.6

rCSI 2.5%

PRS 32.0%
common lymphoid progenitor CL0000051

CSI 1.8

rCSI 2.3%

PRS 55.9%
immature alpha-beta T cell CL0000790

CSI 1.8

rCSI 25.7%

PRS 92.5%
prostate gland microvascular endothelial cell CL2000059

CSI 1.9

rCSI 45.0%

PRS 65.7%
large pre-B-II cell CL0000957

CSI 1.9

rCSI 5.5%

PRS 49.1%
myelocyte CL0002193

CSI 1.9

rCSI 12.7%

PRS 70.4%
type EC enteroendocrine cell CL0000577

CSI 2.1

rCSI 7.6%

PRS 47.9%
cytotoxic T cell CL0000910

CSI 2.1

rCSI 12.2%

PRS 45.9%
eosinophil CL0000771

CSI 2.2

rCSI 14.2%

PRS 66.2%
megakaryocyte CL0000556

CSI 2.2

rCSI 9.7%

PRS 50.4%
basophil CL0000767

CSI 2.3

rCSI 4.8%

PRS 55.9%
lung endothelial cell CL1001567

CSI 2.3

rCSI 5.3%

PRS 61.6%
small pre-B-II cell CL0000954

CSI 2.3

rCSI 2.2%

PRS 58.1%
collagen secreting cell CL0000667

CSI 2.3

rCSI 13.2%

PRS 66.0%
blood vessel smooth muscle cell CL0019018

CSI 2.4

rCSI 19.3%

PRS 30.6%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.4

rCSI 1.6%

PRS 41.9%
fibroblast of breast CL4006000

CSI 2.5

rCSI 10.5%

PRS 60.5%
contractile cell CL0000183

CSI 2.5

rCSI 7.4%

PRS 32.7%
extravillous trophoblast CL0008036

CSI 2.7

rCSI 3.3%

PRS 30.2%
keratocyte CL0002363

CSI 2.7

rCSI 6.6%

PRS 44.9%
mesenchymal stem cell of adipose tissue CL0002570

CSI 2.8

rCSI 15.4%

PRS 57.3%
intestinal epithelial cell CL0002563

CSI 2.8

rCSI 2.9%

PRS 34.1%
intrahepatic cholangiocyte CL0002538

CSI 3.1

rCSI 7.4%

PRS 51.4%
tissue-resident macrophage CL0000864

CSI 3.3

rCSI 15.5%

PRS 54.7%
basal-myoepithelial cell of mammary gland CL0002324

CSI 3.4

rCSI 6.3%

PRS 58.3%
myoepithelial cell CL0000185

CSI 3.5

rCSI 8.9%

PRS 41.0%
muscle cell CL0000187

CSI 3.6

rCSI 7.3%

PRS 56.8%
acinar cell CL0000622

CSI 3.6

rCSI 5.3%

PRS 43.3%
dendritic cell, human CL0001056

CSI 3.6

rCSI 5.5%

PRS 39.6%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 3.8

rCSI 17.3%

PRS 56.8%
common myeloid progenitor CL0000049

CSI 3.8

rCSI 3.1%

PRS 34.0%
antibody secreting cell CL0000946

CSI 4.1

rCSI 18.1%

PRS 80.0%
skeletal muscle satellite stem cell CL0008011

CSI 4.1

rCSI 18.1%

PRS 61.0%
duct epithelial cell CL0000068

CSI 4.2

rCSI 6.2%

PRS 36.0%
pancreatic ductal cell CL0002079

CSI 4.3

rCSI 8.4%

PRS 35.1%
colon epithelial cell CL0011108

CSI 4.5

rCSI 4.7%

PRS 31.5%
multi-ciliated epithelial cell CL0005012

CSI 4.8

rCSI 4.8%

PRS 29.0%
kidney interstitial alternatively activated macrophage CL1000695

CSI 4.8

rCSI 12.6%

PRS 32.9%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 4.9

rCSI 15.0%

PRS 45.9%
endocardial cell CL0002350

CSI 5.1

rCSI 24.4%

PRS 37.3%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 5.2

rCSI 14.8%

PRS 49.0%
airway submucosal gland duct basal cell CL4033024

CSI 5.2

rCSI 33.3%

PRS 56.4%
endothelial cell of vascular tree CL0002139

CSI 5.2

rCSI 28.5%

PRS 40.8%
promonocyte CL0000559

CSI 5.2

rCSI 9.0%

PRS 42.8%
hematopoietic stem cell CL0000037

CSI 5.8

rCSI 3.8%

PRS 38.1%
lung macrophage CL1001603

CSI 5.9

rCSI 13.1%

PRS 39.2%
enteroendocrine cell CL0000164

CSI 5.9

rCSI 8.1%

PRS 36.4%
neutrophil CL0000775

CSI 6.0

rCSI 33.4%

PRS 48.6%
alternatively activated macrophage CL0000890

CSI 6.1

rCSI 7.6%

PRS 46.8%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 6.1

rCSI 70.4%

PRS 75.5%
stromal cell CL0000499

CSI 6.1

rCSI 17.2%

PRS 37.0%
fraction A pre-pro B cell CL0002045

CSI 6.1

rCSI 7.0%

PRS 56.9%
follicular B cell CL0000843

CSI 6.5

rCSI 23.5%

PRS 71.6%
endothelial cell of arteriole CL1000412

CSI 6.5

rCSI 36.0%

PRS 60.6%
granulocyte CL0000094

CSI 6.5

rCSI 9.9%

PRS 42.1%
microglial cell CL0000129

CSI 6.5

rCSI 26.3%

PRS 48.4%
vasa recta descending limb cell CL1001285

CSI 6.7

rCSI 53.6%

PRS 71.2%
colon macrophage CL0009038

CSI 6.8

rCSI 31.3%

PRS 57.2%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 6.9

rCSI 6.8%

PRS 48.0%
alveolar adventitial fibroblast CL4028006

CSI 7.2

rCSI 11.4%

PRS 34.4%
alpha-beta T cell CL0000789

CSI 7.3

rCSI 8.6%

PRS 46.8%
adventitial cell CL0002503

CSI 7.3

rCSI 17.5%

PRS 45.5%
endothelial cell of venule CL1000414

CSI 7.4

rCSI 65.9%

PRS 70.3%
inflammatory macrophage CL0000863

CSI 7.5

rCSI 12.8%

PRS 59.9%
mucous neck cell CL0000651

CSI 7.5

rCSI 10.8%

PRS 47.5%
CD1c-positive myeloid dendritic cell CL0002399

CSI 7.6

rCSI 9.2%

PRS 40.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [KLF2](/details-gene/10365) (Krueppel-like factor 2) is a protein-coding gene located on chromosome 19p13.11 that encodes a zinc-finger transcription factor. Functionally, [KLF2](/details-gene/10365) is a crucial regulator of gene expression involved in a wide array of biological processes, including lymphocyte development, endothelial cell function, and inflammatory responses. Its expression profile indicates it is a highly significant gene in multiple immune cell lineages, particularly in [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [CD4-positive helper T cell](/details-cell/CL0000492), and [CD14-low, CD16-positive monocyte](/details-cell/CL0002396). Its role as a DNA-binding transcription factor ([GO:0003700](https://www.ebi.ac.uk/QuickGO/term/GO:0003700)) positions it as a master regulator of cellular identity and response to environmental stimuli in these cell types. ## Cellular Roles and Expression Landscape The **Overall** expression landscape of [KLF2](/details-gene/10365) highlights its profound importance within the immune system. It demonstrates exceptionally high significance in key lymphocyte populations, establishing it as a defining marker for both the adaptive and innate immune compartments. * **T Cell Lineages:** [KLF2](/details-gene/10365) shows its highest significance in T lymphocytes, particularly [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904) (CSI: 85.54) and [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 84.94). Its notable presence in both naive ([naive thymus-derived CD8-positive, alpha-beta T cell](/details-cell/CL0000900), [naive thymus-derived CD4-positive, alpha-beta T cell](/details-cell/CL0000895)) and memory T cell subsets suggests a continuous role in T cell homeostasis, survival, and recirculation. * **Monocytes and Natural Killer Cells:** The gene is a highly significant marker for [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 82.43), also known as non-classical monocytes, pointing to a specialized role in this patrolling and anti-inflammatory subset. Furthermore, its high significance in both [CD16-positive, CD56-dim natural killer cell, human](/details-cell/CL0000939) and [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938) underscores its importance in NK cell biology. * **B Cell Lineages:** [KLF2](/details-gene/10365) is also prominently expressed in B cells, including [memory B cell](/details-cell/CL0000787) and [naive B cell](/details-cell/CL0000788), indicating a role in B cell development and the maintenance of immunological memory. * **Endothelial Cells:** Beyond the immune system, [KLF2](/details-gene/10365) is significantly expressed in [endothelial cell of artery](/details-cell/CL1000413). This is consistent with its well-documented role in vascular biology and response to hemodynamic forces. ## Pathways and Molecular Function As a DNA-binding transcription factor located in the nucleus ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)), [KLF2](/details-gene/10365) regulates the expression of target genes by binding to specific DNA sequences ([GO:0000978](https://www.ebi.ac.uk/QuickGO/term/GO:0000978)). Its functional annotations are well-aligned with its cellular expression profile. The gene's involvement in the cellular response to fluid shear stress ([GO:0071498](https://www.ebi.ac.uk/QuickGO/term/GO:0071498)) and vasodilation ([GO:0042311](https://www.ebi.ac.uk/QuickGO/term/GO:0042311)) directly corresponds to its significance in [endothelial cell of artery](/details-cell/CL1000413), where it acts as a key transducer of mechanical forces into biochemical signals. In the context of immunity, its role in responding to inflammatory cytokines such as tumor necrosis factor ([GO:0071356](https://www.ebi.ac.uk/QuickGO/term/GO:0071356)) and interleukin-1 ([GO:0071347](https://www.ebi.ac.uk/QuickGO/term/GO:0071347)) is consistent with its high expression in lymphocytes and monocytes. Notably, it is implicated in the negative regulation of interleukin-6 production ([GO:0032715](https://www.ebi.ac.uk/QuickGO/term/GO:0032715)), suggesting an anti-inflammatory function. Furthermore, its participation in erythrocyte maturation ([GO:0043249](https://www.ebi.ac.uk/QuickGO/term/GO:0043249)) points to broader roles in hematopoiesis. Several studies have contributed to the characterization of its structure and regulation ([Link](https://doi.org/10.1016/s0014-5793(99)00348-8), [Link](https://doi.org/10.1006/geno.1999.5888), [Link](https://doi.org/10.1074/jbc.m103670200)). ## Research Directions The specific and high-level expression of [KLF2](/details-gene/10365) across distinct immune cell subsets suggests it orchestrates cell-type-specific transcriptional programs critical for immune homeostasis and response. ### Testable Hypotheses: 1. Given its high significance in both naive and central memory T cells, **[KLF2](/details-gene/10365) likely functions as a gatekeeper of T cell quiescence and is essential for establishing long-term immunological memory by regulating genes involved in lymphocyte trafficking and survival.** 2. Based on its high significance in non-classical monocytes ([CD14-low, CD16-positive monocyte](/details-cell/CL0002396)) and its annotated role in negatively regulating IL-6 production, **[KLF2](/details-gene/10365) may be a critical factor in maintaining the anti-inflammatory and patrolling phenotype of non-classical monocytes, and its downregulation could contribute to chronic inflammatory conditions.** ### Proposed Experiment: To test the second hypothesis regarding the role of [KLF2](/details-gene/10365) in non-classical monocytes, one could perform loss-of-function studies. Primary human monocytes could be isolated and transfected with siRNA targeting [KLF2](/details-gene/10365) or a non-targeting control. Following knockdown, the cells could be stimulated with an inflammatory agonist like LPS. The functional consequences would be assessed by measuring the secretion of pro-inflammatory cytokines (e.g., IL-6, TNF-alpha) via ELISA and analyzing changes in the expression of key monocyte surface markers by flow cytometry. This would clarify the direct impact of [KLF2](/details-gene/10365) on the inflammatory capacity of these cells. ### Therapeutic Potential: As an intracellular transcription factor, [KLF2](/details-gene/10365) presents a challenging direct target for conventional small molecule therapeutics. However, its apparent role in promoting vascular health and suppressing inflammation suggests that strategies to enhance its expression or activity could be beneficial. Therapeutic approaches might focus on upstream pathways that regulate [KLF2](/details-gene/10365) transcription or stability. Therefore, **activation** or restoration of [KLF2](/details-gene/10365) function, rather than inhibition, would likely be the therapeutic goal for treating cardiovascular and chronic inflammatory diseases.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Krueppel-like factor 2

Genular Protein ID: 4106924368

Symbol: KLF2_HUMAN

Name: Krueppel-like factor 2

UniProtKB Accession Codes:

Q9Y5W3 Q6IPC4 Q9UJS5 Q9UKR6

Database IDs:

Citations:

PubMed ID: 10217429

Title: Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus.

PubMed ID: 10217429

DOI: 10.1016/s0014-5793(99)00348-8

PubMed ID: 10458913

Title: cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor.

PubMed ID: 10458913

DOI: 10.1006/geno.1999.5888

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375995

Title: Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.

PubMed ID: 11375995

DOI: 10.1074/jbc.m103670200

PubMed ID: 21063504

Title: A novel role of CCN3 in regulating endothelial inflammation.

PubMed ID: 21063504

DOI: 10.1007/s12079-010-0095-x

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

Length: 355
Mass: 37420
Checksum: D5849C831D676AE1
Sequence:

MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS MGLDGLGAEA 
APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL DAPLGPALHG RFLLAPPGRL 
VKAEPPEADG GGGYGCAPGL TRGPRGLKRE GAPGPAASCM RGPGGRPPPP PDTPPLSPDG 
PARLPAPGPR ASFPPPFGGP GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR 
GLLTPPASPL ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK 
PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH MKRHM

Details for: KLF2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. PubMed ID: 10217429

cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor. PubMed ID: 10458913

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. PubMed ID: 11375995

A novel role of CCN3 in regulating endothelial inflammation. PubMed ID: 21063504

MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. PubMed ID: 28167758