Details for: KLF2

Gene ID: 10365

Symbol: KLF2

Ensembl ID: ENSG00000127528

Description: KLF transcription factor 2

Associated with

  • Cell morphogenesis
    (GO:0000902)
  • Cellular response to cycloheximide
    (GO:0071409)
  • Cellular response to fluid shear stress
    (GO:0071498)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to laminar fluid shear stress
    (GO:0071499)
  • Cellular response to peptide
    (GO:1901653)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular stress response to acid chemical
    (GO:0097533)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Epigenetic regulation of gene expression
    (GO:0040029)
  • Erythrocyte maturation
    (GO:0043249)
  • In utero embryonic development
    (GO:0001701)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism growth
    (GO:0035264)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of sprouting angiogenesis
    (GO:1903671)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of retinoic acid receptor signaling pathway
    (GO:0048386)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Type i pneumocyte differentiation
    (GO:0060509)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 4106924368

Symbol: KLF2_HUMAN

Name: Krueppel-like factor 2

UniProtKB Accession Codes:

Q9Y5W3 Q6IPC4 Q9UJS5 Q9UKR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10217429

Title: Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus.

PubMed ID: 10217429

DOI: 10.1016/s0014-5793(99)00348-8

PubMed ID: 10458913

Title: cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor.

PubMed ID: 10458913

DOI: 10.1006/geno.1999.5888

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11375995

Title: Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.

PubMed ID: 11375995

DOI: 10.1074/jbc.m103670200

PubMed ID: 21063504

Title: A novel role of CCN3 in regulating endothelial inflammation.

PubMed ID: 21063504

DOI: 10.1007/s12079-010-0095-x

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

Sequence Information:

  • Length: 355
  • Mass: 37420
  • Checksum: D5849C831D676AE1
  • Sequence:
    • MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS MGLDGLGAEA 
APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL DAPLGPALHG RFLLAPPGRL 
VKAEPPEADG GGGYGCAPGL TRGPRGLKRE GAPGPAASCM RGPGGRPPPP PDTPPLSPDG 
PARLPAPGPR ASFPPPFGGP GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR 
GLLTPPASPL ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK 
PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH MKRHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.