Details for: LRRC59
Gene ID: 55379
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: LRRC59
Ensembl ID: ENSG00000108829
Description: leucine rich repeat containing 59
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 42.98rCSI 33.81%PRS 64.65
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CSI 22.91rCSI 28.35%PRS 54.29
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CSI 21.13rCSI 20.37%PRS 48.61
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CSI 17.54rCSI 23.32%PRS 64.3
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CSI 17.45rCSI 14.11%PRS 59.33
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CSI 17.28rCSI 20.29%PRS 60.56
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CSI 16.45rCSI 12.75%PRS 59.6
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CSI 15.95rCSI 25.2%PRS 60.01
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CSI 15.84rCSI 30.81%PRS 60.76
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CSI 12.94rCSI 16.96%PRS 71.59
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CSI 11.89rCSI 10.55%PRS 56.04
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CSI 11.69rCSI 24.89%PRS 70.19
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CSI 10.94rCSI 16.91%PRS 56.07
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CSI 10.72rCSI 25.49%PRS 67.89
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CSI 10.65rCSI 10.25%PRS 58.35
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CSI 9.61rCSI 31.18%PRS 58.98
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CSI 9.58rCSI 13.81%PRS 69.43
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CSI 8.11rCSI 47.18%PRS 67.65
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CSI 7.49rCSI 8.99%PRS 56.1
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CSI 7.2rCSI 6.5%PRS 54.8
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CSI 6.82rCSI 7.15%PRS 54.53
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CSI 6.75rCSI 14.78%PRS 66.73
-
CSI 6.75rCSI 15.07%PRS 65.7
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CSI 6.67rCSI 6.56%PRS 80.35
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CSI 6.48rCSI 8.5%PRS 84.8
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CSI 6.11rCSI 21.42%PRS 71.23
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CSI 5.99rCSI 5.04%PRS 75.33
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CSI 5.84rCSI 15.19%PRS 75.19
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CSI 5.83rCSI 9.44%PRS 55.02
-
CSI 5.75rCSI 5.89%PRS 73.48
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CSI 5.61rCSI 5.3%PRS 57.76
-
CSI 5.55rCSI 6.97%PRS 70.33
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CSI 5.42rCSI 10.33%PRS 73.49
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CSI 5.39rCSI 35.4%PRS 84.84
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CSI 5.32rCSI 9.66%PRS 74.13
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CSI 5.15rCSI 4.27%PRS 59.79
-
CSI 4.85rCSI 27.83%PRS 67.68
-
CSI 4.48rCSI 4.14%PRS 77.75
-
CSI 4.42rCSI 2.94%PRS 61.27
-
CSI 4.29rCSI 5.86%PRS 59.9
-
CSI 4.19rCSI 5.97%PRS 60.52
-
CSI 4.13rCSI 44.89%PRS 74.17
-
CSI 4.04rCSI 5.15%PRS 64.37
-
CSI 3.97rCSI 5.49%PRS 59.85
-
CSI 3.96rCSI 4.13%PRS 58.29
-
CSI 3.95rCSI 6.04%PRS 71.99
-
CSI 3.94rCSI 21.26%PRS 71.09
-
CSI 3.85rCSI 4.62%PRS 75.63
-
CSI 3.85rCSI 6.6%PRS 67.04
-
CSI 3.81rCSI 2.9%PRS 70.87
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CSI 3.8rCSI 5.84%PRS 55.25
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CSI 3.78rCSI 6%PRS 69.34
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CSI 3.77rCSI 3.7%PRS 73.83
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CSI 3.76rCSI 9.56%PRS 52.53
-
CSI 3.75rCSI 4.29%PRS 77.56
-
CSI 3.68rCSI 3.08%PRS 62.82
-
CSI 3.65rCSI 15.78%PRS 71.17
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CSI 3.56rCSI 4.85%PRS 69.98
-
CSI 3.5rCSI 3.83%PRS 62.08
-
CSI 3.49rCSI 2.83%PRS 58.66
-
CSI 3.43rCSI 3.38%PRS 60.71
-
CSI 3.43rCSI 9.78%PRS 70.28
-
CSI 3.4rCSI 4.9%PRS 67.66
-
CSI 3.31rCSI 2.87%PRS 62.88
-
CSI 3.3rCSI 3.72%PRS 74.39
-
CSI 3.29rCSI 2.89%PRS 63.29
-
CSI 3.27rCSI 9.45%PRS 71.47
-
CSI 3.24rCSI 2.45%PRS 71.73
-
CSI 3.18rCSI 9.4%PRS 61.29
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CSI 3.15rCSI 2.19%PRS 73.03
-
CSI 3.12rCSI 15.67%PRS 70.49
-
CSI 3.08rCSI 5.82%PRS 77.52
-
CSI 3.04rCSI 3.03%PRS 51.45
-
CSI 3rCSI 8.65%PRS 72.47
-
CSI 2.99rCSI 7.01%PRS 64.16
-
CSI 2.92rCSI 2.31%PRS 45.01
-
CSI 2.91rCSI 2.69%PRS 59.18
-
CSI 2.9rCSI 2.7%PRS 58.23
-
CSI 2.77rCSI 1.94%PRS 60.74
-
CSI 2.74rCSI 26.96%PRS 78.61
-
CSI 2.69rCSI 3.12%PRS 66.22
-
CSI 2.61rCSI 2.73%PRS 56.27
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CSI 2.59rCSI 3.79%PRS 62.24
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CSI 2.56rCSI 4.12%PRS 62.54
-
CSI 2.55rCSI 2.67%PRS 61.51
-
CSI 2.5rCSI 4.5%PRS 51.15
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CSI 2.48rCSI 3.95%PRS 51
-
CSI 2.42rCSI 3.36%PRS 57.02
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CSI 2.34rCSI 1.94%PRS 57.03
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CSI 2.31rCSI 2.96%PRS 62.98
-
CSI 2.28rCSI 3.35%PRS 54.67
-
CSI 2.26rCSI 7.08%PRS 41.76
-
CSI 2.26rCSI 1.69%PRS 73.01
-
CSI 2.25rCSI 2.6%PRS 51.48
-
CSI 2.21rCSI 1.65%PRS 71.53
-
CSI 2.18rCSI 1.92%PRS 46.07
-
CSI 2.17rCSI 5.38%PRS 56.46
-
CSI 2.15rCSI 3.18%PRS 74.35
-
CSI 2.15rCSI 1.87%PRS 68.55
-
CSI 2.09rCSI 2.86%PRS 63.82
-
CSI 0.2rCSI 5.2%PRS 77.3%
-
CSI 0.3rCSI 4.1%PRS 76.9%
-
CSI 0.3rCSI 3.0%PRS 71.3%
-
CSI 0.3rCSI 2.4%PRS 51.3%
-
CSI 0.3rCSI 5.4%PRS 87.4%
-
CSI 0.4rCSI 5.4%PRS 85.4%
-
CSI 0.5rCSI 2.8%PRS 86.5%
-
CSI 0.5rCSI 14.7%PRS 78.5%
-
CSI 0.5rCSI 2.7%PRS 69.4%
-
CSI 0.6rCSI 5.8%PRS 77.0%
-
CSI 0.7rCSI 16.3%PRS 78.4%
-
CSI 0.7rCSI 3.1%PRS 57.3%
-
CSI 0.7rCSI 3.7%PRS 79.9%
-
CSI 0.7rCSI 0.9%PRS 60.0%
-
CSI 0.7rCSI 3.3%PRS 89.2%
-
CSI 0.7rCSI 2.1%PRS 70.3%
-
CSI 0.7rCSI 1.2%PRS 50.5%
-
CSI 0.8rCSI 19.6%PRS 87.9%
-
CSI 0.9rCSI 3.6%PRS 75.3%
-
CSI 0.9rCSI 4.8%PRS 71.0%
-
CSI 0.9rCSI 6.9%PRS 75.2%
-
CSI 1.0rCSI 2.8%PRS 76.9%
-
CSI 1.0rCSI 1.5%PRS 47.8%
-
CSI 1.0rCSI 1.5%PRS 54.4%
-
CSI 1.0rCSI 7.1%PRS 71.9%
-
CSI 1.0rCSI 2.3%PRS 56.0%
-
CSI 1.1rCSI 1.6%PRS 58.7%
-
CSI 1.1rCSI 1.6%PRS 61.7%
-
CSI 1.1rCSI 3.0%PRS 66.0%
-
CSI 1.1rCSI 2.9%PRS 62.9%
-
CSI 1.1rCSI 4.8%PRS 72.6%
-
CSI 1.1rCSI 1.8%PRS 73.9%
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CSI 1.2rCSI 29.0%PRS 76.7%
-
CSI 1.2rCSI 1.6%PRS 50.2%
-
CSI 1.2rCSI 1.6%PRS 68.4%
-
CSI 1.2rCSI 6.6%PRS 88.9%
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CSI 1.3rCSI 1.7%PRS 79.5%
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CSI 1.3rCSI 2.3%PRS 39.3%
-
CSI 1.3rCSI 1.5%PRS 48.1%
-
CSI 1.3rCSI 2.9%PRS 73.0%
-
CSI 1.4rCSI 1.9%PRS 58.6%
-
CSI 1.5rCSI 5.3%PRS 77.5%
-
CSI 1.5rCSI 4.9%PRS 63.1%
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CSI 1.5rCSI 3.9%PRS 66.9%
-
CSI 1.6rCSI 2.2%PRS 62.5%
-
CSI 1.6rCSI 4.2%PRS 77.5%
-
CSI 1.6rCSI 1.3%PRS 79.6%
-
CSI 1.7rCSI 3.1%PRS 68.7%
-
CSI 1.7rCSI 2.9%PRS 71.9%
-
CSI 1.7rCSI 2.5%PRS 66.7%
-
CSI 1.7rCSI 1.3%PRS 58.1%
-
CSI 1.7rCSI 1.5%PRS 66.8%
-
CSI 1.8rCSI 4.5%PRS 66.5%
-
CSI 1.8rCSI 5.2%PRS 59.6%
-
CSI 1.8rCSI 1.4%PRS 75.2%
-
CSI 1.9rCSI 2.0%PRS 69.2%
-
CSI 1.9rCSI 1.6%PRS 64.2%
-
CSI 1.9rCSI 8.3%PRS 71.3%
-
CSI 1.9rCSI 2.8%PRS 69.7%
-
CSI 1.9rCSI 3.0%PRS 67.4%
-
CSI 2.0rCSI 4.1%PRS 55.4%
-
CSI 2.0rCSI 2.1%PRS 57.1%
-
CSI 2.0rCSI 4.5%PRS 62.4%
-
CSI 2.0rCSI 1.5%PRS 63.1%
-
CSI 2.0rCSI 4.8%PRS 67.2%
-
CSI 2.0rCSI 2.6%PRS 55.5%
-
CSI 2.0rCSI 3.0%PRS 59.8%
-
CSI 2.1rCSI 2.5%PRS 65.8%
-
CSI 2.1rCSI 1.4%PRS 71.0%
-
CSI 2.1rCSI 2.9%PRS 63.8%
-
CSI 2.2rCSI 1.9%PRS 68.6%
-
CSI 2.2rCSI 3.2%PRS 74.4%
-
CSI 2.2rCSI 5.4%PRS 56.5%
-
CSI 2.2rCSI 1.9%PRS 46.1%
-
CSI 2.2rCSI 1.7%PRS 71.5%
-
CSI 2.3rCSI 2.6%PRS 51.5%
-
CSI 2.3rCSI 1.7%PRS 73.0%
-
CSI 2.3rCSI 7.1%PRS 41.8%
-
CSI 2.3rCSI 3.4%PRS 54.7%
-
CSI 2.3rCSI 3.0%PRS 63.0%
-
CSI 2.3rCSI 1.9%PRS 57.0%
-
CSI 2.4rCSI 3.4%PRS 57.0%
-
CSI 2.5rCSI 4.0%PRS 51.0%
-
CSI 2.5rCSI 4.5%PRS 51.2%
-
CSI 2.6rCSI 2.7%PRS 61.5%
-
CSI 2.6rCSI 4.1%PRS 62.5%
-
CSI 2.6rCSI 3.8%PRS 62.2%
-
CSI 2.6rCSI 2.7%PRS 56.3%
-
CSI 2.7rCSI 3.1%PRS 66.2%
-
CSI 2.7rCSI 27.0%PRS 78.6%
-
CSI 2.8rCSI 1.9%PRS 60.7%
-
CSI 2.9rCSI 2.7%PRS 58.2%
-
CSI 2.9rCSI 2.7%PRS 59.2%
-
CSI 2.9rCSI 2.3%PRS 45.0%
-
CSI 3.0rCSI 7.0%PRS 64.2%
-
CSI 3.0rCSI 8.7%PRS 72.5%
-
CSI 3.0rCSI 3.0%PRS 51.5%
-
CSI 3.1rCSI 5.8%PRS 77.5%
-
CSI 3.1rCSI 15.7%PRS 70.5%
-
CSI 3.2rCSI 2.2%PRS 73.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3530589428
Symbol: LRC59_HUMAN
Name: Leucine-rich repeat-containing protein 59
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11964394
Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.
PubMed ID: 11964394
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541025
Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
PubMed ID: 16541025
DOI: 10.1038/nature04663
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 22321063
Title: Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1.
PubMed ID: 22321063
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25489052
Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
PubMed ID: 25489052
DOI: 10.1093/hmg/ddu611
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 307
- Mass: 34930
- Checksum: E39C33C72C60448D
- Sequence:
MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV LQTDSQQ