NANS | ENSG00000095380 | NCBI 54187

Details for: NANS

Gene ID: 54187

Symbol: NANS

Ensembl ID: ENSG00000095380

Description: N-acetylneuraminate synthase

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Biosynthesis of the n-glycan precursor (dolichol lipid-linked oligosaccharide, llo) and transfer to a nascent protein
(R-HSA-446193)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Sialic acid metabolism
(R-HSA-4085001)
Synthesis of substrates in n-glycan biosythesis
(R-HSA-446219)
Carbohydrate biosynthetic process
(GO:0016051)
Cmp-n-acetylneuraminate biosynthetic process
(GO:0006055)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Glycosylation
(GO:0070085)
N-acetylneuraminate synthase activity
(GO:0050462)
N-acylneuraminate-9-phosphate synthase activity
(GO:0047444)
N-acylneuraminate cytidylyltransferase activity
(GO:0008781)

Other Information

Proteins

Sialic acid synthase

Genular Protein ID: 3812073743

Symbol: SIAS_HUMAN

Name: Sialic acid synthase

UniProtKB Accession Codes:

Q9NR45 B2RE98 Q8WUV9 Q9BWS6 Q9NVD4

Database IDs:

Citations:

PubMed ID: 10749855

Title: Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability.

PubMed ID: 10749855

DOI: 10.1074/jbc.m000217200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27213289

Title: NANS-mediated synthesis of sialic acid is required for brain and skeletal development.

PubMed ID: 27213289

DOI: 10.1038/ng.3578

PubMed ID: 16597820

Title: Solution structure of the antifreeze-like domain of human sialic acid synthase.

PubMed ID: 16597820

DOI: 10.1110/ps.051700406

Sequence Information:

Length: 359
Mass: 40308
Checksum: 2E02D47F4F98592F
Sequence:

MPLELELCPG RWVGGQHPCF IIAEIGQNHQ GDLDVAKRMI RMAKECGADC AKFQKSELEF 
KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYRELQR YAEEVGIFFT ASGMDEMAVE 
FLHELNVPFF KVGSGDTNNF PYLEKTAKKG RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC 
FLQCTSAYPL QPEDVNLRVI SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT 
LDKTWKGSDH SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK 
IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV DNHGKKIKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NANS

Associated with

Other Information

Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability. PubMed ID: 10749855

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

NANS-mediated synthesis of sialic acid is required for brain and skeletal development. PubMed ID: 27213289

Solution structure of the antifreeze-like domain of human sialic acid synthase. PubMed ID: 16597820