Details for: NANS
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 42.28rCSI 49.66%PRS 72.73
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CSI 40.34rCSI 35.8%PRS 68.43
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CSI 37.68rCSI 54.31%PRS 79.49
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CSI 29.79rCSI 29.73%PRS 64.03
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CSI 27.16rCSI 26.19%PRS 62.28
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CSI 26.75rCSI 21.04%PRS 77.16
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CSI 25.42rCSI 82.46%PRS 69.81
-
CSI 23.29rCSI 55.36%PRS 78.21
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CSI 22.35rCSI 25.84%PRS 61.56
-
CSI 19.81rCSI 31.47%PRS 80.62
-
CSI 19.64rCSI 41.82%PRS 79.5
-
CSI 14.6rCSI 13.8%PRS 69.85
-
CSI 14.44rCSI 15.07%PRS 70.58
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CSI 13.47rCSI 19.76%PRS 81.62
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CSI 12.99rCSI 16.07%PRS 67.62
-
CSI 12.38rCSI 12.97%PRS 67.52
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CSI 12.1rCSI 21.65%PRS 70.15
-
CSI 11.99rCSI 40.55%PRS 71.32
-
CSI 11.87rCSI 11.05%PRS 71.32
-
CSI 11.86rCSI 27.03%PRS 65.68
-
CSI 11.63rCSI 46.48%PRS 82.68
-
CSI 11.14rCSI 58.52%PRS 78.32
-
CSI 10.98rCSI 32.75%PRS 84.09
-
CSI 10.8rCSI 8.37%PRS 73.81
-
CSI 10.46rCSI 22.83%PRS 80.78
-
CSI 10.16rCSI 43.88%PRS 80.8
-
CSI 9.85rCSI 8.53%PRS 75.28
-
CSI 9.26rCSI 14.92%PRS 71.98
-
CSI 9.08rCSI 21.54%PRS 72.72
-
CSI 8.9rCSI 9.11%PRS 81.91
-
CSI 8.11rCSI 12.4%PRS 81.93
-
CSI 8.07rCSI 60.64%PRS 83.93
-
CSI 7.6rCSI 9.75%PRS 67.02
-
CSI 7.55rCSI 12.9%PRS 89.74
-
CSI 7.26rCSI 15.06%PRS 67.63
-
CSI 7.16rCSI 7.5%PRS 74.1
-
CSI 6.9rCSI 5.11%PRS 63.38
-
CSI 6.76rCSI 19.38%PRS 88.64
-
CSI 6.69rCSI 9.79%PRS 65.4
-
CSI 6.6rCSI 16.77%PRS 64.21
-
CSI 6.54rCSI 5.29%PRS 72.49
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CSI 6.1rCSI 13.84%PRS 72.75
-
CSI 6.05rCSI 7.93%PRS 89.57
-
CSI 6rCSI 5.9%PRS 73.14
-
CSI 5.9rCSI 6.16%PRS 87.96
-
CSI 5.9rCSI 16.1%PRS 83.58
-
CSI 5.89rCSI 57.89%PRS 85.17
-
CSI 5.79rCSI 62.99%PRS 82.39
-
CSI 5.64rCSI 5.09%PRS 67.94
-
CSI 5.4rCSI 9.25%PRS 78.38
-
CSI 5.32rCSI 4.92%PRS 87.57
-
CSI 5.28rCSI 8.47%PRS 86.63
-
CSI 5.18rCSI 6.21%PRS 84.63
-
CSI 5.1rCSI 6.54%PRS 74.77
-
CSI 4.9rCSI 5.2%PRS 78.29
-
CSI 4.71rCSI 6.44%PRS 76.13
-
CSI 4.7rCSI 7.22%PRS 63.04
-
CSI 4.6rCSI 4.8%PRS 68.3
-
CSI 4.59rCSI 6.01%PRS 83.12
-
CSI 4.58rCSI 5.58%PRS 77.74
-
CSI 4.57rCSI 21.42%PRS 83.78
-
CSI 4.55rCSI 3.18%PRS 73.54
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CSI 4.42rCSI 3.54%PRS 87.57
-
CSI 4.32rCSI 9.46%PRS 77.32
-
CSI 4.25rCSI 5.41%PRS 76.45
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CSI 4.25rCSI 3.52%PRS 73.04
-
CSI 4.21rCSI 9.45%PRS 85.32
-
CSI 4.19rCSI 3.87%PRS 72.31
-
CSI 4.08rCSI 8.14%PRS 85.23
-
CSI 3.8rCSI 5.05%PRS 76.92
-
CSI 3.66rCSI 2.91%PRS 89.48
-
CSI 3.61rCSI 5.86%PRS 66.14
-
CSI 3.61rCSI 5.57%PRS 69.35
-
CSI 3.6rCSI 4.32%PRS 68.76
-
CSI 3.59rCSI 8.2%PRS 71.28
-
CSI 3.52rCSI 4.08%PRS 76.63
-
CSI 3.5rCSI 3.21%PRS 79.58
-
CSI 3.37rCSI 2.96%PRS 58.53
-
CSI 3.28rCSI 4.8%PRS 75.44
-
CSI 3.28rCSI 2.88%PRS 75.98
-
CSI 3.27rCSI 36.51%PRS 85.63
-
CSI 3.1rCSI 2.59%PRS 76.28
-
CSI 3.01rCSI 4.34%PRS 78.57
-
CSI 2.94rCSI 28.91%PRS 83.75
-
CSI 2.93rCSI 16.82%PRS 78.25
-
CSI 2.93rCSI 4.47%PRS 75
-
CSI 2.92rCSI 2.19%PRS 76.47
-
CSI 2.88rCSI 3.85%PRS 70.31
-
CSI 2.85rCSI 3.55%PRS 49.83
-
CSI 2.85rCSI 2.8%PRS 85.17
-
CSI 2.84rCSI 66.2%PRS 86.21
-
CSI 2.81rCSI 2.33%PRS 70.62
-
CSI 2.77rCSI 3.85%PRS 68.96
-
CSI 2.76rCSI 4.36%PRS 72.65
-
CSI 2.75rCSI 4.54%PRS 75.81
-
CSI 2.72rCSI 3.18%PRS 85.59
-
CSI 2.65rCSI 3.8%PRS 72.88
-
CSI 2.63rCSI 2.2%PRS 73.94
-
CSI 2.62rCSI 5.8%PRS 56.41
-
CSI 2.61rCSI 5.75%PRS 74.79
-
CSI 0.2rCSI 4.7%PRS 85.9%
-
CSI 0.2rCSI 2.3%PRS 91.5%
-
CSI 0.3rCSI 1.4%PRS 82.1%
-
CSI 0.3rCSI 8.0%PRS 82.7%
-
CSI 0.4rCSI 1.2%PRS 53.5%
-
CSI 0.4rCSI 6.1%PRS 83.1%
-
CSI 0.4rCSI 2.7%PRS 91.7%
-
CSI 0.6rCSI 2.1%PRS 49.9%
-
CSI 0.6rCSI 2.1%PRS 77.3%
-
CSI 0.6rCSI 4.2%PRS 80.1%
-
CSI 0.6rCSI 3.3%PRS 80.0%
-
CSI 0.6rCSI 2.8%PRS 93.9%
-
CSI 0.6rCSI 3.3%PRS 89.0%
-
CSI 0.7rCSI 3.7%PRS 80.4%
-
CSI 0.7rCSI 3.3%PRS 86.3%
-
CSI 0.8rCSI 5.0%PRS 91.5%
-
CSI 1.0rCSI 1.9%PRS 87.1%
-
CSI 1.0rCSI 1.5%PRS 63.2%
-
CSI 1.0rCSI 7.1%PRS 83.3%
-
CSI 1.0rCSI 1.5%PRS 83.9%
-
CSI 1.0rCSI 4.6%PRS 92.4%
-
CSI 1.1rCSI 2.9%PRS 77.0%
-
CSI 1.1rCSI 1.7%PRS 59.9%
-
CSI 1.1rCSI 1.8%PRS 59.6%
-
CSI 1.1rCSI 2.2%PRS 80.5%
-
CSI 1.2rCSI 1.7%PRS 73.0%
-
CSI 1.3rCSI 2.3%PRS 50.8%
-
CSI 1.3rCSI 2.0%PRS 66.8%
-
CSI 1.4rCSI 9.4%PRS 81.0%
-
CSI 1.4rCSI 2.1%PRS 75.7%
-
CSI 1.4rCSI 2.6%PRS 82.0%
-
CSI 1.4rCSI 2.6%PRS 83.8%
-
CSI 1.5rCSI 4.3%PRS 80.8%
-
CSI 1.5rCSI 1.7%PRS 73.7%
-
CSI 1.6rCSI 2.0%PRS 53.1%
-
CSI 1.6rCSI 3.0%PRS 91.7%
-
CSI 1.6rCSI 1.9%PRS 51.6%
-
CSI 1.6rCSI 2.0%PRS 80.6%
-
CSI 1.6rCSI 4.3%PRS 85.7%
-
CSI 1.6rCSI 3.4%PRS 85.0%
-
CSI 1.7rCSI 2.5%PRS 84.6%
-
CSI 1.7rCSI 8.2%PRS 80.8%
-
CSI 1.7rCSI 3.3%PRS 74.0%
-
CSI 1.7rCSI 1.3%PRS 83.7%
-
CSI 1.8rCSI 10.8%PRS 83.6%
-
CSI 1.8rCSI 4.9%PRS 80.2%
-
CSI 1.8rCSI 2.8%PRS 71.3%
-
CSI 1.8rCSI 4.0%PRS 69.2%
-
CSI 1.8rCSI 3.2%PRS 82.1%
-
CSI 1.8rCSI 1.4%PRS 57.8%
-
CSI 1.8rCSI 1.9%PRS 76.0%
-
CSI 1.9rCSI 2.8%PRS 80.0%
-
CSI 1.9rCSI 1.5%PRS 72.4%
-
CSI 1.9rCSI 3.1%PRS 74.8%
-
CSI 2.0rCSI 3.1%PRS 79.6%
-
CSI 2.0rCSI 48.6%PRS 83.8%
-
CSI 2.0rCSI 2.5%PRS 79.7%
-
CSI 2.0rCSI 7.2%PRS 80.9%
-
CSI 2.1rCSI 2.7%PRS 88.2%
-
CSI 2.1rCSI 2.6%PRS 72.4%
-
CSI 2.1rCSI 6.2%PRS 79.8%
-
CSI 2.2rCSI 4.8%PRS 78.6%
-
CSI 2.2rCSI 1.8%PRS 70.8%
-
CSI 2.2rCSI 13.0%PRS 77.3%
-
CSI 2.3rCSI 3.2%PRS 72.4%
-
CSI 2.3rCSI 5.7%PRS 69.4%
-
CSI 2.3rCSI 2.5%PRS 71.0%
-
CSI 2.3rCSI 4.3%PRS 58.3%
-
CSI 2.3rCSI 3.4%PRS 85.3%
-
CSI 2.3rCSI 3.2%PRS 71.5%
-
CSI 2.4rCSI 1.6%PRS 73.4%
-
CSI 2.4rCSI 2.3%PRS 70.2%
-
CSI 2.4rCSI 12.0%PRS 89.3%
-
CSI 2.4rCSI 2.1%PRS 74.0%
-
CSI 2.5rCSI 5.1%PRS 59.8%
-
CSI 2.6rCSI 3.2%PRS 81.7%
-
CSI 2.6rCSI 5.8%PRS 74.8%
-
CSI 2.6rCSI 5.8%PRS 56.4%
-
CSI 2.6rCSI 2.2%PRS 73.9%
-
CSI 2.7rCSI 3.8%PRS 72.9%
-
CSI 2.7rCSI 3.2%PRS 85.6%
-
CSI 2.8rCSI 4.5%PRS 75.8%
-
CSI 2.8rCSI 4.4%PRS 72.7%
-
CSI 2.8rCSI 3.9%PRS 69.0%
-
CSI 2.8rCSI 2.3%PRS 70.6%
-
CSI 2.8rCSI 66.2%PRS 86.2%
-
CSI 2.9rCSI 2.8%PRS 85.2%
-
CSI 2.9rCSI 3.6%PRS 49.8%
-
CSI 2.9rCSI 3.9%PRS 70.3%
-
CSI 2.9rCSI 2.2%PRS 76.5%
-
CSI 2.9rCSI 4.5%PRS 75.0%
-
CSI 2.9rCSI 16.8%PRS 78.3%
-
CSI 2.9rCSI 28.9%PRS 83.8%
-
CSI 3.0rCSI 4.3%PRS 78.6%
-
CSI 3.1rCSI 2.6%PRS 76.3%
-
CSI 3.3rCSI 36.5%PRS 85.6%
-
CSI 3.3rCSI 2.9%PRS 76.0%
-
CSI 3.3rCSI 4.8%PRS 75.4%
-
CSI 3.4rCSI 3.0%PRS 58.5%
-
CSI 3.5rCSI 3.2%PRS 79.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3812073743
Symbol: SIAS_HUMAN
Name: Sialic acid synthase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10749855
Title: Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid biosynthetic ability.
PubMed ID: 10749855
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27213289
Title: NANS-mediated synthesis of sialic acid is required for brain and skeletal development.
PubMed ID: 27213289
DOI: 10.1038/ng.3578
PubMed ID: 16597820
Title: Solution structure of the antifreeze-like domain of human sialic acid synthase.
PubMed ID: 16597820
DOI: 10.1110/ps.051700406
Sequence Information:
- Length: 359
- Mass: 40308
- Checksum: 2E02D47F4F98592F
- Sequence:
MPLELELCPG RWVGGQHPCF IIAEIGQNHQ GDLDVAKRMI RMAKECGADC AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYRELQR YAEEVGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDVNLRVI SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK IPEGTILTMD MLTVKVGEPK GYPPEDIFNL VGKKVLVTVE EDDTIMEELV DNHGKKIKS