Details for: SASH1
Gene ID: 23328
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SASH1
Ensembl ID: ENSG00000111961
Description: SAM and SH3 domain containing 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 35.15rCSI 78.8%PRS 46.65
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CSI 32.07rCSI 68.32%PRS 36
-
CSI 31.27rCSI 54.83%PRS 56.53
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CSI 26.85rCSI 46.44%PRS 54.6
-
CSI 22.52rCSI 28.01%PRS 44.14
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CSI 20.79rCSI 26.8%PRS 47.23
-
CSI 17.08rCSI 39.07%PRS 64.53
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CSI 16.94rCSI 13.05%PRS 65.26
-
CSI 16.8rCSI 33.35%PRS 61.8
-
CSI 15.97rCSI 22.64%PRS 60.88
-
CSI 15.9rCSI 60.09%PRS 46.64
-
CSI 15.77rCSI 49.33%PRS 50.04
-
CSI 15.3rCSI 18.92%PRS 61.21
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CSI 15.07rCSI 14.51%PRS 64.42
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CSI 15rCSI 23.86%PRS 56.94
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CSI 13.61rCSI 19.95%PRS 76.1
-
CSI 13.27rCSI 18.16%PRS 57.63
-
CSI 13.16rCSI 15.19%PRS 57.41
-
CSI 12.56rCSI 32.48%PRS 59.5
-
CSI 12.54rCSI 20.01%PRS 56.87
-
CSI 11.36rCSI 15.79%PRS 63.02
-
CSI 11.14rCSI 35.64%PRS 61.58
-
CSI 11.11rCSI 27.13%PRS 57.65
-
CSI 10.97rCSI 54.07%PRS 75.3
-
CSI 10.26rCSI 23.69%PRS 53.15
-
CSI 10.04rCSI 7.94%PRS 51.37
-
CSI 9.99rCSI 24.01%PRS 71.67
-
CSI 9.98rCSI 8.77%PRS 52.44
-
CSI 9.49rCSI 25.35%PRS 55.49
-
CSI 9.33rCSI 23.98%PRS 63.51
-
CSI 9.2rCSI 13.53%PRS 57.79
-
CSI 9.06rCSI 16.28%PRS 57.73
-
CSI 9rCSI 33.7%PRS 56.43
-
CSI 8.52rCSI 17.67%PRS 61.65
-
CSI 8.35rCSI 13.34%PRS 68.74
-
CSI 8.32rCSI 15.86%PRS 78.8
-
CSI 8rCSI 10.27%PRS 56.78
-
CSI 7.94rCSI 20.94%PRS 73.19
-
CSI 7.59rCSI 8.77%PRS 54.89
-
CSI 7.25rCSI 24.57%PRS 58.42
-
CSI 7.17rCSI 22.11%PRS 72.4
-
CSI 7.16rCSI 17.73%PRS 63.06
-
CSI 7.11rCSI 41.99%PRS 58.95
-
CSI 6.93rCSI 16.17%PRS 81.42
-
CSI 6.92rCSI 18.04%PRS 64.24
-
CSI 6.78rCSI 18.28%PRS 71.46
-
CSI 6.66rCSI 12.21%PRS 74.68
-
CSI 6.58rCSI 6.86%PRS 64.83
-
CSI 6.47rCSI 45.74%PRS 56.36
-
CSI 6.45rCSI 11.72%PRS 56.22
-
CSI 6.41rCSI 9.53%PRS 65.89
-
CSI 6.31rCSI 13.89%PRS 47.1
-
CSI 6.22rCSI 5.05%PRS 64.84
-
CSI 6.17rCSI 29.54%PRS 64.5
-
CSI 6.08rCSI 30.61%PRS 64.47
-
CSI 6.07rCSI 5.6%PRS 66.05
-
CSI 5.98rCSI 24.12%PRS 63.43
-
CSI 5.95rCSI 51.27%PRS 51.56
-
CSI 5.94rCSI 8.11%PRS 70.39
-
CSI 5.93rCSI 5.52%PRS 65.15
-
CSI 5.92rCSI 7.21%PRS 71.99
-
CSI 5.71rCSI 32.93%PRS 62.9
-
CSI 5.69rCSI 58.86%PRS 58.25
-
CSI 5.55rCSI 12.23%PRS 68.51
-
CSI 5.47rCSI 11.09%PRS 43.49
-
CSI 5.37rCSI 6.41%PRS 45.77
-
CSI 5.36rCSI 30.3%PRS 49.6
-
CSI 5.19rCSI 4.48%PRS 69.4
-
CSI 5.09rCSI 17.07%PRS 49.36
-
CSI 4.94rCSI 14.6%PRS 54.22
-
CSI 4.86rCSI 11.08%PRS 60.64
-
CSI 4.67rCSI 10.43%PRS 72.43
-
CSI 4.52rCSI 7.98%PRS 72.59
-
CSI 4.49rCSI 24.55%PRS 62.67
-
CSI 4.48rCSI 10.89%PRS 44.44
-
CSI 4.39rCSI 31.38%PRS 64.35
-
CSI 4.35rCSI 6.99%PRS 47.89
-
CSI 4.29rCSI 13.91%PRS 64.32
-
CSI 4.25rCSI 5.35%PRS 76.45
-
CSI 4.15rCSI 17.63%PRS 57.58
-
CSI 4.12rCSI 15.71%PRS 55.13
-
CSI 4.12rCSI 21.11%PRS 69.43
-
CSI 4.1rCSI 6.19%PRS 68.99
-
CSI 4.01rCSI 9.52%PRS 67.81
-
CSI 3.98rCSI 11.54%PRS 54.03
-
CSI 3.93rCSI 4.07%PRS 70.34
-
CSI 3.85rCSI 4.13%PRS 64.35
-
CSI 3.84rCSI 4.2%PRS 68.22
-
CSI 3.77rCSI 4.7%PRS 75.1
-
CSI 3.66rCSI 10.4%PRS 62.43
-
CSI 3.65rCSI 10.06%PRS 59.85
-
CSI 3.62rCSI 4.2%PRS 71.95
-
CSI 3.6rCSI 19.96%PRS 79.08
-
CSI 3.45rCSI 2.56%PRS 57.05
-
CSI 3.34rCSI 9.12%PRS 80.75
-
CSI 3.29rCSI 6.77%PRS 54.33
-
CSI 3.24rCSI 4.75%PRS 60.14
-
CSI 3.23rCSI 3.88%PRS 62.61
-
CSI 3.21rCSI 5.39%PRS 45.96
-
CSI 3.07rCSI 2.38%PRS 66.96
-
CSI 0.3rCSI 2.8%PRS 76.0%
-
CSI 0.4rCSI 2.6%PRS 56.2%
-
CSI 0.4rCSI 8.3%PRS 78.7%
-
CSI 0.4rCSI 2.5%PRS 72.9%
-
CSI 0.5rCSI 1.9%PRS 76.3%
-
CSI 0.5rCSI 1.8%PRS 72.5%
-
CSI 0.5rCSI 5.6%PRS 62.6%
-
CSI 0.6rCSI 3.3%PRS 47.1%
-
CSI 0.6rCSI 3.5%PRS 77.6%
-
CSI 0.6rCSI 5.4%PRS 79.6%
-
CSI 0.7rCSI 4.9%PRS 79.8%
-
CSI 0.7rCSI 2.4%PRS 53.0%
-
CSI 0.7rCSI 3.3%PRS 80.0%
-
CSI 0.8rCSI 3.5%PRS 79.8%
-
CSI 0.8rCSI 2.1%PRS 58.6%
-
CSI 0.9rCSI 2.5%PRS 77.0%
-
CSI 0.9rCSI 2.1%PRS 51.6%
-
CSI 0.9rCSI 7.1%PRS 57.8%
-
CSI 0.9rCSI 1.6%PRS 45.1%
-
CSI 0.9rCSI 3.8%PRS 76.3%
-
CSI 1.0rCSI 6.4%PRS 65.4%
-
CSI 1.0rCSI 4.6%PRS 74.7%
-
CSI 1.0rCSI 1.6%PRS 67.0%
-
CSI 1.1rCSI 3.8%PRS 44.3%
-
CSI 1.2rCSI 2.2%PRS 75.0%
-
CSI 1.2rCSI 3.9%PRS 62.4%
-
CSI 1.2rCSI 3.2%PRS 81.8%
-
CSI 1.2rCSI 9.0%PRS 51.0%
-
CSI 1.2rCSI 3.2%PRS 67.9%
-
CSI 1.3rCSI 6.7%PRS 69.1%
-
CSI 1.3rCSI 3.7%PRS 75.8%
-
CSI 1.3rCSI 6.1%PRS 82.2%
-
CSI 1.3rCSI 2.0%PRS 63.0%
-
CSI 1.3rCSI 3.9%PRS 65.8%
-
CSI 1.4rCSI 2.0%PRS 66.6%
-
CSI 1.5rCSI 8.1%PRS 72.9%
-
CSI 1.5rCSI 1.9%PRS 69.3%
-
CSI 1.5rCSI 1.5%PRS 57.9%
-
CSI 1.6rCSI 7.0%PRS 60.9%
-
CSI 1.6rCSI 10.3%PRS 81.0%
-
CSI 1.7rCSI 14.4%PRS 61.2%
-
CSI 1.7rCSI 15.5%PRS 73.6%
-
CSI 1.9rCSI 4.9%PRS 61.5%
-
CSI 1.9rCSI 4.1%PRS 76.5%
-
CSI 2.0rCSI 9.0%PRS 54.7%
-
CSI 2.1rCSI 1.9%PRS 73.5%
-
CSI 2.1rCSI 2.0%PRS 67.2%
-
CSI 2.1rCSI 14.2%PRS 76.6%
-
CSI 2.1rCSI 3.4%PRS 69.8%
-
CSI 2.1rCSI 5.0%PRS 65.1%
-
CSI 2.1rCSI 1.8%PRS 68.6%
-
CSI 2.2rCSI 5.5%PRS 72.2%
-
CSI 2.2rCSI 5.3%PRS 72.7%
-
CSI 2.2rCSI 5.0%PRS 80.8%
-
CSI 2.3rCSI 3.3%PRS 69.6%
-
CSI 2.4rCSI 9.6%PRS 58.3%
-
CSI 2.4rCSI 4.7%PRS 77.3%
-
CSI 2.5rCSI 12.0%PRS 62.7%
-
CSI 2.5rCSI 3.6%PRS 54.1%
-
CSI 2.6rCSI 4.6%PRS 63.7%
-
CSI 2.6rCSI 11.7%PRS 64.4%
-
CSI 2.6rCSI 3.3%PRS 66.2%
-
CSI 2.7rCSI 2.8%PRS 68.0%
-
CSI 2.7rCSI 11.9%PRS 48.6%
-
CSI 2.7rCSI 64.6%PRS 45.8%
-
CSI 2.7rCSI 7.9%PRS 63.3%
-
CSI 2.7rCSI 5.0%PRS 52.7%
-
CSI 2.7rCSI 6.8%PRS 53.9%
-
CSI 2.7rCSI 64.7%PRS 45.0%
-
CSI 2.7rCSI 4.2%PRS 65.2%
-
CSI 2.7rCSI 5.5%PRS 53.5%
-
CSI 2.8rCSI 4.4%PRS 75.4%
-
CSI 2.8rCSI 3.7%PRS 64.8%
-
CSI 2.9rCSI 11.5%PRS 41.6%
-
CSI 2.9rCSI 4.8%PRS 53.6%
-
CSI 3.0rCSI 6.7%PRS 56.1%
-
CSI 3.0rCSI 4.0%PRS 75.8%
-
CSI 3.0rCSI 5.1%PRS 86.0%
-
CSI 3.1rCSI 4.8%PRS 71.6%
-
CSI 3.1rCSI 2.4%PRS 67.0%
-
CSI 3.2rCSI 5.4%PRS 46.0%
-
CSI 3.2rCSI 3.9%PRS 62.6%
-
CSI 3.2rCSI 4.8%PRS 60.1%
-
CSI 3.3rCSI 6.8%PRS 54.3%
-
CSI 3.3rCSI 9.1%PRS 80.8%
-
CSI 3.5rCSI 2.6%PRS 57.1%
-
CSI 3.6rCSI 20.0%PRS 79.1%
-
CSI 3.6rCSI 4.2%PRS 72.0%
-
CSI 3.7rCSI 10.1%PRS 59.9%
-
CSI 3.7rCSI 10.4%PRS 62.4%
-
CSI 3.8rCSI 4.7%PRS 75.1%
-
CSI 3.8rCSI 4.2%PRS 68.2%
-
CSI 3.9rCSI 4.1%PRS 64.4%
-
CSI 3.9rCSI 4.1%PRS 70.3%
-
CSI 4.0rCSI 11.5%PRS 54.0%
-
CSI 4.0rCSI 9.5%PRS 67.8%
-
CSI 4.1rCSI 6.2%PRS 69.0%
-
CSI 4.1rCSI 21.1%PRS 69.4%
-
CSI 4.1rCSI 15.7%PRS 55.1%
-
CSI 4.2rCSI 17.6%PRS 57.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1647165273
Symbol: SASH1_HUMAN
Name: SAM and SH3 domain-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12771949
Title: SASH1 - a candidate tumour suppressor gene on chromosome 6q24.3 is downregulated in breast cancer.
PubMed ID: 12771949
PubMed ID: 9872452
Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 9872452
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23333244
Title: SASH1 regulates melanocyte transepithelial migration through a novel Galphas-SASH1-IQGAP1-E-cadherin dependent pathway.
PubMed ID: 23333244
PubMed ID: 23776175
Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.
PubMed ID: 23776175
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25315659
Title: Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma.
PubMed ID: 25315659
PubMed ID: 26203640
Title: SASH1 is involved in an autosomal dominant lentiginous phenotype.
PubMed ID: 26203640
DOI: 10.1038/jid.2015.292
PubMed ID: 27659786
Title: Lentiginous phenotypes caused by diverse pathogenic genes (SASH1 and PTPN11): clinical and molecular discrimination.
PubMed ID: 27659786
DOI: 10.1111/cge.12728
PubMed ID: 27840890
Title: A novel de novo mutation of the SASH1 gene in a chinese family with multiple lentigines.
PubMed ID: 27840890
PubMed ID: 27885802
Title: A novel P53/POMC/Galphas/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation.
PubMed ID: 27885802
DOI: 10.1111/jcmm.13022
PubMed ID: 29956681
Title: Novel mutations in SASH1 associated with dyschromatosis universalis hereditaria.
PubMed ID: 29956681
Sequence Information:
- Length: 1247
- Mass: 136653
- Checksum: 48A806B3AE32E563
- Sequence:
MEDAGAAGPG PEPEPEPEPE PEPAPEPEPE PKPGAGTSEA FSRLWTDVMG ILDGSLGNID DLAQQYADYY NTCFSDVCER MEELRKRRVS QDLEVEKPDA SPTSLQLRSQ IEESLGFCSA VSTPEVERKN PLHKSNSEDS SVGKGDWKKK NKYFWQNFRK NQKGIMRQTS KGEDVGYVAS EITMSDEERI QLMMMVKEKM ITIEEALARL KEYEAQHRQS AALDPADWPD GSYPTFDGSS NCNSREQSDD ETEESVKFKR LHKLVNSTRR VRKKLIRVEE MKKPSTEGGE EHVFENSPVL DERSALYSGV HKKPLFFDGS PEKPPEDDSD SLTTSPSSSS LDTWGAGRKL VKTFSKGESR GLIKPPKKMG TFFSYPEEEK AQKVSRSLTE GEMKKGLGSL SHGRTCSFGG FDLTNRSLHV GSNNSDPMGK EGDFVYKEVI KSPTASRISL GKKVKSVKET MRKRMSKKYS SSVSEQDSGL DGMPGSPPPS QPDPEHLDKP KLKAGGSVES LRSSLSGQSS MSGQTVSTTD SSTSNRESVK SEDGDDEEPP YRGPFCGRAR VHTDFTPSPY DTDSLKLKKG DIIDIISKPP MGTWMGLLNN KVGTFKFIYV DVLSEDEEKP KRPTRRRRKG RPPQPKSVED LLDRINLKEH MPTFLFNGYE DLDTFKLLEE EDLDELNIRD PEHRAVLLTA VELLQEYDSN SDQSGSQEKL LVDSQGLSGC SPRDSGCYES SENLENGKTR KASLLSAKSS TEPSLKSFSR NQLGNYPTLP LMKSGDALKQ GQEEGRLGGG LAPDTSKSCD PPGVTGLNKN RRSLPVSICR SCETLEGPQT VDTWPRSHSL DDLQVEPGAE QDVPTEVTEP PPQIVPEVPQ KTTASSTKAQ PLEQDSAVDN ALLLTQSKRF SEPQKLTTKK LEGSIAASGR GLSPPQCLPR NYDAQPPGAK HGLARTPLEG HRKGHEFEGT HHPLGTKEGV DAEQRMQPKI PSQPPPVPAK KSRERLANGL HPVPMGPSGA LPSPDAPCLP VKRGSPASPT SPSDCPPALA PRPLSGQAPG SPPSTRPPPW LSELPENTSL QEHGVKLGPA LTRKVSCARG VDLETLTENK LHAEGIDLTE EPYSDKHGRC GIPEALVQRY AEDLDQPERD VAANMDQIRV KQLRKQHRMA IPSGGLTEIC RKPVSPGCIS SVSDWLISIG LPMYAGTLST AGFSTLSQVP SLSHTCLQEA GITEERHIRK LLSAARLFKL PPGPEAM