Details for: UBALD2

Gene ID: 283991

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: UBALD2

Ensembl ID: ENSG00000185262

Description: UBA like domain containing 2

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmablast CL0000980
    CSI 27.64
    rCSI 21.75%
    PRS 33.44
  • acinar cell CL0000622
    CSI 18.15
    rCSI 26.62%
    PRS 36.48
  • mature B cell CL0000785
    CSI 16.81
    rCSI 14.61%
    PRS 34.85
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 12.5
    rCSI 11.29%
    PRS 25.59
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 10.65
    rCSI 13.95%
    PRS 39.06
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 10.49
    rCSI 12.67%
    PRS 33.57
  • colon epithelial cell CL0011108
    CSI 10.32
    rCSI 10.81%
    PRS 26.14
  • enteroendocrine cell CL0000164
    CSI 9.91
    rCSI 13.54%
    PRS 30.76
  • common dendritic progenitor CL0001029
    CSI 9.46
    rCSI 11.87%
    PRS 35.86
  • dendritic cell, human CL0001056
    CSI 9.34
    rCSI 14.35%
    PRS 33.3
  • memory T cell CL0000813
    CSI 9.19
    rCSI 17.71%
    PRS 57.39
  • ciliated cell CL0000064
    CSI 8.62
    rCSI 13.96%
    PRS 27.84
  • ciliated epithelial cell CL0000067
    CSI 8.19
    rCSI 7.2%
    PRS 20.6
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 7.32
    rCSI 4.93%
    PRS 34.83
  • extravillous trophoblast CL0008036
    CSI 7.3
    rCSI 9.04%
    PRS 24.78
  • transit amplifying cell of colon CL0009011
    CSI 7.11
    rCSI 8.35%
    PRS 31.81
  • fallopian tube secretory epithelial cell CL4030006
    CSI 7.07
    rCSI 6.8%
    PRS 28.92
  • IgG plasma cell CL0000985
    CSI 6.8
    rCSI 8.15%
    PRS 45.8
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 6.66
    rCSI 25.91%
    PRS 44.85
  • granulocyte monocyte progenitor cell CL0000557
    CSI 6.63
    rCSI 5.74%
    PRS 31.2
  • endothelial cell of lymphatic vessel CL0002138
    CSI 6.41
    rCSI 12.7%
    PRS 58.87
  • melanocyte CL0000148
    CSI 6.39
    rCSI 4.73%
    PRS 24.14
  • retinal cone cell CL0000573
    CSI 6.32
    rCSI 10.18%
    PRS 21.63
  • neutrophil CL0000775
    CSI 6.02
    rCSI 33.66%
    PRS 43.82
  • chondrocyte CL0000138
    CSI 5.67
    rCSI 9.02%
    PRS 23.65
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 5.36
    rCSI 6.73%
    PRS 75.59
  • common myeloid progenitor CL0000049
    CSI 5.35
    rCSI 4.33%
    PRS 28.21
  • bronchus fibroblast of lung CL2000093
    CSI 5.28
    rCSI 4.29%
    PRS 29.08
  • early lymphoid progenitor CL0000936
    CSI 5.19
    rCSI 4.56%
    PRS 31.94
  • stromal cell CL0000499
    CSI 5.17
    rCSI 14.54%
    PRS 33.17
  • common lymphoid progenitor CL0000051
    CSI 4.91
    rCSI 6.56%
    PRS 49.21
  • innate lymphoid cell CL0001065
    CSI 4.88
    rCSI 10.07%
    PRS 38.17
  • plasma cell CL0000786
    CSI 4.83
    rCSI 6.33%
    PRS 72.93
  • regulatory T cell CL0000815
    CSI 4.71
    rCSI 5.46%
    PRS 59.07
  • blood vessel endothelial cell CL0000071
    CSI 4.68
    rCSI 9.71%
    PRS 27.56
  • precursor B cell CL0000817
    CSI 4.18
    rCSI 3.66%
    PRS 36.23
  • transit amplifying cell of small intestine CL0009012
    CSI 3.87
    rCSI 16.97%
    PRS 47.61
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 3.81
    rCSI 2.86%
    PRS 64.3
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 3.65
    rCSI 2.57%
    PRS 55.62
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 3.56
    rCSI 4.31%
    PRS 31.33
  • vascular associated smooth muscle cell CL0000359
    CSI 3.49
    rCSI 11.32%
    PRS 32.49
  • CD4-positive helper T cell CL0000492
    CSI 3.39
    rCSI 2.56%
    PRS 37.65
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.14
    rCSI 2.52%
    PRS 47.31
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 3.14
    rCSI 8.45%
    PRS 35.89
  • double negative thymocyte CL0002489
    CSI 3.09
    rCSI 2.15%
    PRS 33.8
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 3.05
    rCSI 4.16%
    PRS 56.66
  • mature NK T cell CL0000814
    CSI 2.94
    rCSI 3.77%
    PRS 70.45
  • pro-B cell CL0000826
    CSI 2.92
    rCSI 2.41%
    PRS 28.43
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 2.86
    rCSI 1.91%
    PRS 56.84
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 2.84
    rCSI 8.14%
    PRS 41.29
  • mature alpha-beta T cell CL0000791
    CSI 2.8
    rCSI 10.12%
    PRS 45.18
  • group 3 innate lymphoid cell CL0001071
    CSI 2.79
    rCSI 2.1%
    PRS 29.98
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.77
    rCSI 2.11%
    PRS 36.68
  • ionocyte CL0005006
    CSI 2.71
    rCSI 2.9%
    PRS 25.97
  • unswitched memory B cell CL0000970
    CSI 2.69
    rCSI 2.27%
    PRS 42.73
  • memory B cell CL0000787
    CSI 2.62
    rCSI 2.58%
    PRS 70.74
  • epithelial cell CL0000066
    CSI 2.6
    rCSI 4%
    PRS 34.62
  • inflammatory macrophage CL0000863
    CSI 2.59
    rCSI 4.43%
    PRS 52.97
  • club cell CL0000158
    CSI 2.56
    rCSI 3.76%
    PRS 30.66
  • stem cell CL0000034
    CSI 2.56
    rCSI 2.46%
    PRS 21.02
  • secretory cell CL0000151
    CSI 2.5
    rCSI 2.61%
    PRS 28.71
  • immature B cell CL0000816
    CSI 2.45
    rCSI 1.82%
    PRS 39.66
  • enterocyte CL0000584
    CSI 2.4
    rCSI 3.87%
    PRS 39.4
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.39
    rCSI 1.85%
    PRS 27.43
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.38
    rCSI 1.41%
    PRS 39.02
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 2.37
    rCSI 3.04%
    PRS 26.77
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.33
    rCSI 4.44%
    PRS 43
  • pancreatic A cell CL0000171
    CSI 2.33
    rCSI 2.44%
    PRS 29.78
  • class switched memory B cell CL0000972
    CSI 2.27
    rCSI 1.7%
    PRS 44.76
  • naive T cell CL0000898
    CSI 2.25
    rCSI 1.57%
    PRS 38.62
  • intestine goblet cell CL0019031
    CSI 2.18
    rCSI 1.94%
    PRS 27.97
  • mature T cell CL0002419
    CSI 2.17
    rCSI 1.69%
    PRS 40.68
  • fraction A pre-pro B cell CL0002045
    CSI 2.15
    rCSI 2.46%
    PRS 50.97
  • T follicular helper cell CL0002038
    CSI 2.11
    rCSI 1.58%
    PRS 41.86
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 2.08
    rCSI 10.42%
    PRS 36.59
  • CD14-positive monocyte CL0001054
    CSI 2.05
    rCSI 2.55%
    PRS 37.9
  • granulocyte CL0000094
    CSI 2.04
    rCSI 3.12%
    PRS 35.57
  • monocyte CL0000576
    CSI 2.04
    rCSI 3.69%
    PRS 57.06
  • goblet cell CL0000160
    CSI 2
    rCSI 1.89%
    PRS 29.23
  • plasmacytoid dendritic cell, human CL0001058
    CSI 1.98
    rCSI 1.38%
    PRS 29.62
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 1.98
    rCSI 2.28%
    PRS 24.25
  • alpha-beta T cell CL0000789
    CSI 1.97
    rCSI 2.31%
    PRS 39.23
  • neural crest cell CL0011012
    CSI 1.97
    rCSI 1.56%
    PRS 19.46
  • alternatively activated macrophage CL0000890
    CSI 1.96
    rCSI 2.46%
    PRS 40.64
  • perivascular cell CL4033054
    CSI 1.95
    rCSI 2.67%
    PRS 31.55
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.93
    rCSI 5.4%
    PRS 41.99
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 1.91
    rCSI 1.77%
    PRS 47.26
  • intestinal tuft cell CL0019032
    CSI 1.88
    rCSI 2.88%
    PRS 31.88
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 1.84
    rCSI 5.42%
    PRS 32.51
  • activated type II NK T cell CL0000931
    CSI 1.83
    rCSI 2.06%
    PRS 42.79
  • erythrocyte CL0000232
    CSI 1.82
    rCSI 4.13%
    PRS 35
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.8
    rCSI 2.88%
    PRS 30.68
  • IgA plasma cell CL0000987
    CSI 1.79
    rCSI 1.84%
    PRS 46.96
  • syncytiotrophoblast cell CL0000525
    CSI 1.79
    rCSI 5.15%
    PRS 46.67
  • lung macrophage CL1001603
    CSI 1.78
    rCSI 3.97%
    PRS 32.74
  • multi-ciliated epithelial cell CL0005012
    CSI 1.77
    rCSI 1.77%
    PRS 24.01
  • brush cell CL0002204
    CSI 1.76
    rCSI 3.49%
    PRS 57.71
  • Kupffer cell CL0000091
    CSI 1.75
    rCSI 4.01%
    PRS 27.46
  • lung ciliated cell CL1000271
    CSI 1.71
    rCSI 1.98%
    PRS 20.92
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 1.71
    rCSI 1.67%
    PRS 41.68
  • eosinophil CL0000771
    CSI 0.1
    rCSI 0.6%
    PRS 60.9%
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 1.0%
    PRS 39.7%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.3
    rCSI 1.8%
    PRS 50.6%
  • respiratory goblet cell CL0002370
    CSI 0.4
    rCSI 3.9%
    PRS 49.0%
  • tracheobronchial serous cell CL0019001
    CSI 0.4
    rCSI 1.8%
    PRS 46.2%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.4
    rCSI 1.3%
    PRS 18.1%
  • epithelial cell of urethra CL1000296
    CSI 0.4
    rCSI 10.9%
    PRS 60.6%
  • endothelial cell of placenta CL0009092
    CSI 0.5
    rCSI 2.2%
    PRS 37.3%
  • transit amplifying cell CL0009010
    CSI 0.5
    rCSI 0.7%
    PRS 43.3%
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.5
    rCSI 5.4%
    PRS 67.8%
  • hepatic pit cell CL2000054
    CSI 0.5
    rCSI 6.9%
    PRS 76.9%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.5
    rCSI 2.7%
    PRS 44.2%
  • germinal center B cell CL0000844
    CSI 0.5
    rCSI 1.5%
    PRS 54.0%
  • myeloid dendritic cell CL0000782
    CSI 0.5
    rCSI 0.8%
    PRS 41.5%
  • small intestine goblet cell CL1000495
    CSI 0.5
    rCSI 1.1%
    PRS 36.8%
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 0.6
    rCSI 3.3%
    PRS 66.1%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.6
    rCSI 1.7%
    PRS 31.1%
  • Hofbauer cell CL3000001
    CSI 0.6
    rCSI 1.1%
    PRS 35.4%
  • transitional stage B cell CL0000818
    CSI 0.6
    rCSI 2.0%
    PRS 62.5%
  • neural progenitor cell CL0011020
    CSI 0.6
    rCSI 2.8%
    PRS 25.0%
  • deuterosomal cell CL4033044
    CSI 0.6
    rCSI 2.2%
    PRS 40.6%
  • bronchial goblet cell CL1000312
    CSI 0.6
    rCSI 2.6%
    PRS 51.7%
  • activated CD4-positive, alpha-beta T cell, human CL0001043
    CSI 0.7
    rCSI 1.6%
    PRS 80.6%
  • type L enteroendocrine cell CL0002279
    CSI 0.7
    rCSI 1.2%
    PRS 49.5%
  • podocyte CL0000653
    CSI 0.7
    rCSI 3.1%
    PRS 27.1%
  • large pre-B-II cell CL0000957
    CSI 0.7
    rCSI 2.0%
    PRS 43.3%
  • helper T cell CL0000912
    CSI 0.8
    rCSI 1.1%
    PRS 37.7%
  • pancreatic ductal cell CL0002079
    CSI 0.8
    rCSI 1.5%
    PRS 29.0%
  • erythroblast CL0000765
    CSI 0.8
    rCSI 2.1%
    PRS 40.8%
  • type EC enteroendocrine cell CL0000577
    CSI 0.8
    rCSI 2.8%
    PRS 42.5%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 1.0
    rCSI 5.8%
    PRS 54.9%
  • intermediate monocyte CL0002393
    CSI 1.0
    rCSI 1.5%
    PRS 28.8%
  • basophil CL0000767
    CSI 1.0
    rCSI 2.0%
    PRS 50.5%
  • respiratory basal cell CL0002633
    CSI 1.0
    rCSI 1.0%
    PRS 32.9%
  • T-helper 17 cell CL0000899
    CSI 1.0
    rCSI 0.8%
    PRS 47.4%
  • BEST4+ enteroycte CL4030026
    CSI 1.0
    rCSI 1.3%
    PRS 30.0%
  • hematopoietic stem cell CL0000037
    CSI 1.1
    rCSI 0.7%
    PRS 32.5%
  • lung pericyte CL0009089
    CSI 1.1
    rCSI 2.9%
    PRS 33.4%
  • pancreatic acinar cell CL0002064
    CSI 1.1
    rCSI 1.5%
    PRS 30.9%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.1
    rCSI 2.0%
    PRS 24.2%
  • colon goblet cell CL0009039
    CSI 1.2
    rCSI 2.8%
    PRS 39.8%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.2
    rCSI 2.7%
    PRS 28.2%
  • intraepithelial lymphocyte CL0002496
    CSI 1.2
    rCSI 3.2%
    PRS 73.2%
  • enteroendocrine cell of small intestine CL0009006
    CSI 1.2
    rCSI 2.6%
    PRS 41.0%
  • intestinal epithelial cell CL0002563
    CSI 1.2
    rCSI 1.3%
    PRS 28.7%
  • M cell of gut CL0000682
    CSI 1.3
    rCSI 1.3%
    PRS 44.2%
  • tuft cell of colon CL0009041
    CSI 1.3
    rCSI 3.0%
    PRS 49.0%
  • keratinocyte CL0000312
    CSI 1.3
    rCSI 1.1%
    PRS 32.6%
  • pancreatic stellate cell CL0002410
    CSI 1.3
    rCSI 7.5%
    PRS 39.6%
  • cerebral cortex endothelial cell CL1001602
    CSI 1.3
    rCSI 2.3%
    PRS 21.6%
  • promonocyte CL0000559
    CSI 1.3
    rCSI 2.2%
    PRS 36.8%
  • luminal cell of prostate epithelium CL0002340
    CSI 1.3
    rCSI 7.2%
    PRS 44.7%
  • respiratory suprabasal cell CL4033048
    CSI 1.3
    rCSI 1.7%
    PRS 32.2%
  • conjunctival epithelial cell CL1000432
    CSI 1.3
    rCSI 2.0%
    PRS 28.3%
  • mononuclear phagocyte CL0000113
    CSI 1.3
    rCSI 3.0%
    PRS 31.6%
  • natural T-regulatory cell CL0000903
    CSI 1.4
    rCSI 2.6%
    PRS 64.0%
  • basal cell CL0000646
    CSI 1.4
    rCSI 1.8%
    PRS 30.2%
  • ependymal cell CL0000065
    CSI 1.4
    rCSI 2.8%
    PRS 15.8%
  • squamous epithelial cell CL0000076
    CSI 1.4
    rCSI 3.3%
    PRS 33.6%
  • intrahepatic cholangiocyte CL0002538
    CSI 1.4
    rCSI 3.3%
    PRS 45.5%
  • pulmonary artery endothelial cell CL1001568
    CSI 1.4
    rCSI 1.9%
    PRS 40.2%
  • peripheral nervous system neuron CL2000032
    CSI 1.4
    rCSI 1.9%
    PRS 24.4%
  • platelet CL0000233
    CSI 1.4
    rCSI 5.9%
    PRS 41.7%
  • T-helper 1 cell CL0000545
    CSI 1.5
    rCSI 2.6%
    PRS 57.7%
  • epithelial cell of lung CL0000082
    CSI 1.5
    rCSI 1.2%
    PRS 26.7%
  • mucous neck cell CL0000651
    CSI 1.5
    rCSI 2.2%
    PRS 41.8%
  • placental villous trophoblast CL2000060
    CSI 1.5
    rCSI 2.3%
    PRS 26.4%
  • colonocyte CL1000347
    CSI 1.5
    rCSI 2.2%
    PRS 36.2%
  • pulmonary ionocyte CL0017000
    CSI 1.5
    rCSI 1.9%
    PRS 34.4%
  • centrilobular region hepatocyte CL0019029
    CSI 1.5
    rCSI 4.0%
    PRS 39.3%
  • elicited macrophage CL0000861
    CSI 1.5
    rCSI 1.4%
    PRS 33.3%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.6
    rCSI 2.8%
    PRS 16.8%
  • foveolar cell of stomach CL0002179
    CSI 1.6
    rCSI 3.4%
    PRS 42.1%
  • acinar cell of salivary gland CL0002623
    CSI 1.6
    rCSI 37.2%
    PRS 49.3%
  • lung microvascular endothelial cell CL2000016
    CSI 1.6
    rCSI 30.8%
    PRS 60.0%
  • myoepithelial cell CL0000185
    CSI 1.6
    rCSI 4.1%
    PRS 34.3%
  • glandular epithelial cell CL0000150
    CSI 1.6
    rCSI 4.3%
    PRS 50.2%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.6
    rCSI 1.3%
    PRS 26.4%
  • promyelocyte CL0000836
    CSI 1.6
    rCSI 2.4%
    PRS 37.4%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 1.7
    rCSI 1.7%
    PRS 41.7%
  • lung ciliated cell CL1000271
    CSI 1.7
    rCSI 2.0%
    PRS 20.9%
  • Kupffer cell CL0000091
    CSI 1.8
    rCSI 4.0%
    PRS 27.5%
  • brush cell CL0002204
    CSI 1.8
    rCSI 3.5%
    PRS 57.7%
  • multi-ciliated epithelial cell CL0005012
    CSI 1.8
    rCSI 1.8%
    PRS 24.0%
  • lung macrophage CL1001603
    CSI 1.8
    rCSI 4.0%
    PRS 32.7%
  • syncytiotrophoblast cell CL0000525
    CSI 1.8
    rCSI 5.2%
    PRS 46.7%
  • IgA plasma cell CL0000987
    CSI 1.8
    rCSI 1.8%
    PRS 47.0%
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.8
    rCSI 2.9%
    PRS 30.7%
  • erythrocyte CL0000232
    CSI 1.8
    rCSI 4.1%
    PRS 35.0%
  • activated type II NK T cell CL0000931
    CSI 1.8
    rCSI 2.1%
    PRS 42.8%
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 1.8
    rCSI 5.4%
    PRS 32.5%
  • intestinal tuft cell CL0019032
    CSI 1.9
    rCSI 2.9%
    PRS 31.9%
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 1.9
    rCSI 1.8%
    PRS 47.3%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.9
    rCSI 5.4%
    PRS 42.0%
  • perivascular cell CL4033054
    CSI 2.0
    rCSI 2.7%
    PRS 31.6%
  • alternatively activated macrophage CL0000890
    CSI 2.0
    rCSI 2.5%
    PRS 40.6%
  • neural crest cell CL0011012
    CSI 2.0
    rCSI 1.6%
    PRS 19.5%
  • alpha-beta T cell CL0000789
    CSI 2.0
    rCSI 2.3%
    PRS 39.2%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.0
    rCSI 2.3%
    PRS 24.3%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.0
    rCSI 1.4%
    PRS 29.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [UBALD2](/details-gene/283991) (UBA like domain containing 2) is a protein-coding gene located on chromosome 17q25.1. While its function is not extensively characterized, its name suggests a role in ubiquitin-related signaling pathways due to the presence of a UBA-like domain. **Overall**, expression data reveals that [UBALD2](/details-gene/283991) is a highly significant marker for specific, functionally active cell populations. Its expression is exceptionally prominent in [plasmablasts](/details-cell/CL0000980), indicating a potential key role in antibody-secreting cells. It is also highly expressed in other secretory cell types such as [acinar cells](/details-cell/CL0000622), as well as in various immune cells of both myeloid and lymphoid lineages, including [mature B cells](/details-cell/CL0000785) and dendritic cells. ## Cellular Roles and Expression Landscape The expression profile of [UBALD2](/details-gene/283991) points towards a specialized function in highly metabolic and secretory cells, particularly within the immune system and glandular tissues. The most significant expression is observed in [plasmablasts](/details-cell/CL0000980) (CSI: 27.64), which are terminally differentiated B cells responsible for massive antibody production. This suggests [UBALD2](/details-gene/283991) may be integral to the cellular machinery supporting high-level protein synthesis and secretion. This notion is further supported by its high significance in [acinar cells](/details-cell/CL0000622) (CSI: 18.15) and [enteroendocrine cells](/details-cell/CL0000164) (CSI: 9.91), which are also professional secretory cells. Beyond its role in terminal differentiation, [UBALD2](/details-gene/283991) appears broadly important across the hematopoietic system. It is significantly expressed in [mature B cells](/details-cell/CL0000785) (CSI: 16.81) and earlier hematopoietic progenitors like [megakaryocyte-erythroid progenitor cells](/details-cell/CL0000050) (CSI: 12.50). Furthermore, its expression is notable in professional antigen-presenting cells of the myeloid lineage, including [CD14-positive, CD16-positive monocytes](/details-cell/CL0002397) (CSI: 10.65), [CD1c-positive myeloid dendritic cells](/details-cell/CL0002399) (CSI: 10.49), and [common dendritic progenitors](/details-cell/CL0001029) (CSI: 9.46). A role in the adaptive immune response is also suggested by its expression in [memory T cells](/details-cell/CL0000813) (CSI: 9.19). This widespread, yet specific, expression pattern suggests a fundamental role in the function of mature immune effector cells. ## Pathways and Molecular Function Detailed functional annotations for [UBALD2](/details-gene/283991) are limited. The presence of a UBA (ubiquitin-associated) like domain strongly suggests its involvement in pathways that are regulated by protein ubiquitination. UBA domains are known to bind to ubiquitin, often mediating protein-protein interactions within processes such as protein degradation via the proteasome, DNA repair, and cell signaling. One study involving N-terminal acetylome analysis identified this protein, hinting at a potential connection to N-terminal protein modification, a process crucial for protein stability and function ([Link](https://doi.org/10.1073/pnas.1210303109)). This is consistent with its high expression in cells with high protein turnover and secretion, where protein quality control is paramount. The gene was also included in the Mammalian Gene Collection (MGC) project, which aimed to create a complete catalog of full-length human cDNAs ([Link](https://doi.org/10.1101/gr.2596504)). ## Research Directions The specific expression pattern of [UBALD2](/details-gene/283991) in highly secretory cells presents clear avenues for future investigation. ### Proposed Hypotheses: 1. **Role in Plasma Cell Function:** The exceptionally high and specific expression in [plasmablasts](/details-cell/CL0000980) suggests that [UBALD2](/details-gene/283991) is a critical component of the endoplasmic reticulum-associated degradation (ERAD) or unfolded protein response (UPR) pathways, which are essential for managing the massive protein load during immunoglobulin synthesis. Its loss may lead to ER stress and apoptosis in these cells. 2. **Function in Myeloid Cell Activation:** The consistent expression across dendritic cell subtypes and monocytes suggests [UBALD2](/details-gene/283991) could be involved in regulating antigen presentation or inflammatory signaling. It may mediate the ubiquitination and subsequent turnover of key signaling proteins downstream of pattern recognition receptors. ### Experimental Approach: To test the first hypothesis regarding its role in [plasmablast](/details-cell/CL0000980) function, a conditional knockout of [UBALD2](/details-gene/283991) in B-lineage cells could be generated in a mouse model. Following immunization to induce a T-cell dependent immune response, the differentiation of B cells into [plasmablasts](/details-cell/CL0000980) and long-lived plasma cells could be quantified using flow cytometry. The functional consequence of [UBALD2](/details-gene/283991) loss could be assessed by measuring serum antibody titers using ELISA and evaluating the cellular stress response through immunoblotting for UPR markers like BiP and CHOP in isolated plasma cells. ### Therapeutic Potential: Given its high expression in [plasmablasts](/details-cell/CL0000980), [UBALD2](/details-gene/283991) could represent a novel therapeutic target for plasma cell-driven diseases, such as multiple myeloma or certain autoimmune disorders. If [UBALD2](/details-gene/283991) is essential for the survival of malignant plasma cells, a strategy of **inhibition** could be therapeutically beneficial. Its potential expression in other healthy secretory tissues, like [acinar cells](/details-cell/CL0000622), would need to be carefully evaluated to predict and mitigate potential on-target, off-tumor toxicities.

Genular Protein ID: 174546853

Symbol: UBAD2_HUMAN

Name: UBA-like domain-containing protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 164
  • Mass: 17877
  • Checksum: 3FF451ADFECBD558
  • Sequence:
  • MSVNMDELRH QVMINQFVLA AGCAADQAKQ LLQAAHWQFE TALSTFFQET NIPNSHHHHQ 
    MMCTPSNTPA TPPNFPDALA MFSKLRASEG LQSSNSPMTA AACSPPANFS PFWASSPPSH 
    QAPWIPPSSP TTFHHLHRPQ PTWPPGAQQG GAQQKAMAAM DGQR