Details for: DOCK8
Gene ID: 81704
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DOCK8
Ensembl ID: ENSG00000107099
Description: dedicator of cytokinesis 8
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 55.02rCSI 90.11%PRS 30.06
-
CSI 52.32rCSI 40.31%PRS 36.53
-
CSI 24.72rCSI 81.92%PRS 39.94
-
CSI 24.61rCSI 67.83%PRS 35.41
-
CSI 23.32rCSI 33.78%PRS 53.53
-
CSI 20.97rCSI 84.42%PRS 51.02
-
CSI 18.22rCSI 27.49%PRS 39.53
-
CSI 18rCSI 74.81%PRS 40.35
-
CSI 16.71rCSI 20.78%PRS 40.47
-
CSI 15.39rCSI 24.77%PRS 30.01
-
CSI 13.06rCSI 24.66%PRS 47.29
-
CSI 11.65rCSI 9.99%PRS 47.84
-
CSI 10.83rCSI 14.47%PRS 60.49
-
CSI 10.63rCSI 9.34%PRS 42.78
-
CSI 10.02rCSI 8.03%PRS 59.12
-
CSI 9.67rCSI 12.93%PRS 45.89
-
CSI 9.1rCSI 22.23%PRS 35.1
-
CSI 8.11rCSI 28.83%PRS 75.71
-
CSI 8.07rCSI 5.62%PRS 50.12
-
CSI 8.06rCSI 6.1%PRS 49.51
-
CSI 7.22rCSI 18.82%PRS 37.13
-
CSI 6.95rCSI 17.62%PRS 29.96
-
CSI 6.64rCSI 40.2%PRS 63.77
-
CSI 6.63rCSI 4.76%PRS 49.95
-
CSI 6.23rCSI 12.37%PRS 37.95
-
CSI 6.02rCSI 4.73%PRS 44.03
-
CSI 5.93rCSI 24.42%PRS 59.81
-
CSI 5.91rCSI 13.27%PRS 58.94
-
CSI 5.5rCSI 5.2%PRS 39.13
-
CSI 5.41rCSI 3.76%PRS 45.65
-
CSI 5.39rCSI 4.36%PRS 49.3
-
CSI 5.24rCSI 5.14%PRS 52.81
-
CSI 5.22rCSI 4.57%PRS 47.41
-
CSI 5.01rCSI 3.52%PRS 62.25
-
CSI 5rCSI 10.94%PRS 47.75
-
CSI 4.95rCSI 11.28%PRS 37.12
-
CSI 4.69rCSI 5.5%PRS 52.34
-
CSI 4.63rCSI 6.68%PRS 48.02
-
CSI 4.61rCSI 3.45%PRS 71.6
-
CSI 4.46rCSI 29.58%PRS 37.34
-
CSI 4.41rCSI 2.93%PRS 42.16
-
CSI 4.36rCSI 3.23%PRS 32.64
-
CSI 4.35rCSI 7.68%PRS 23.69
-
CSI 4.31rCSI 5.77%PRS 70.64
-
CSI 4.23rCSI 5.41%PRS 73.3
-
CSI 4.21rCSI 3.21%PRS 48.33
-
CSI 4.16rCSI 3.09%PRS 50.63
-
CSI 4.11rCSI 2.74%PRS 64.74
-
CSI 4.11rCSI 2.87%PRS 39.8
-
CSI 4.06rCSI 7.39%PRS 69.92
-
CSI 3.98rCSI 4.77%PRS 56.78
-
CSI 3.94rCSI 5.57%PRS 47.61
-
CSI 3.89rCSI 3.6%PRS 58.24
-
CSI 3.83rCSI 19.21%PRS 48.29
-
CSI 3.75rCSI 2.81%PRS 40.93
-
CSI 3.73rCSI 8.34%PRS 43.99
-
CSI 3.63rCSI 5.82%PRS 67.97
-
CSI 3.62rCSI 8.62%PRS 40.77
-
CSI 3.61rCSI 7.63%PRS 59.57
-
CSI 3.56rCSI 3.51%PRS 74.78
-
CSI 3.51rCSI 6%PRS 64.3
-
CSI 3.5rCSI 3.44%PRS 67.25
-
CSI 3.42rCSI 15.99%PRS 58.58
-
CSI 3.41rCSI 2.82%PRS 38.85
-
CSI 3.39rCSI 35.91%PRS 40.63
-
CSI 3.28rCSI 5.01%PRS 46.71
-
CSI 3.21rCSI 3.31%PRS 55.14
-
CSI 3.11rCSI 3.99%PRS 34.8
-
CSI 3.09rCSI 2.4%PRS 53.53
-
CSI 3.07rCSI 2.57%PRS 61.72
-
CSI 3.04rCSI 4.75%PRS 65.18
-
CSI 3.03rCSI 2.04%PRS 47.14
-
CSI 3.03rCSI 3.78%PRS 49.13
-
CSI 3.02rCSI 2.77%PRS 44.68
-
CSI 2.99rCSI 2.65%PRS 37.43
-
CSI 2.97rCSI 2.22%PRS 56.28
-
CSI 2.9rCSI 3.52%PRS 36.67
-
CSI 2.88rCSI 3.01%PRS 69.77
-
CSI 2.86rCSI 3.21%PRS 53.84
-
CSI 2.81rCSI 2.1%PRS 52.27
-
CSI 2.8rCSI 3.97%PRS 35.54
-
CSI 2.8rCSI 2.85%PRS 50.23
-
CSI 2.8rCSI 4.27%PRS 38.42
-
CSI 2.77rCSI 6.11%PRS 41.86
-
CSI 2.7rCSI 8.84%PRS 71.15
-
CSI 2.69rCSI 2.43%PRS 35
-
CSI 2.69rCSI 4.65%PRS 29.94
-
CSI 2.69rCSI 10.06%PRS 32.37
-
CSI 2.64rCSI 3.03%PRS 61.05
-
CSI 2.61rCSI 2.38%PRS 52.58
-
CSI 2.48rCSI 2.38%PRS 62.12
-
CSI 2.47rCSI 4.23%PRS 59.05
-
CSI 2.47rCSI 3.1%PRS 51.2
-
CSI 2.39rCSI 4.85%PRS 23.04
-
CSI 2.39rCSI 2.85%PRS 57.66
-
CSI 2.37rCSI 3.67%PRS 36.22
-
CSI 2.32rCSI 5.31%PRS 37.51
-
CSI 2.32rCSI 4.81%PRS 36.6
-
CSI 2.3rCSI 1.99%PRS 41.78
-
CSI 2.29rCSI 3.64%PRS 32.26
-
CSI 0.2rCSI 0.8%PRS 57.5%
-
CSI 0.3rCSI 4.1%PRS 72.4%
-
CSI 0.4rCSI 2.0%PRS 50.3%
-
CSI 0.4rCSI 2.1%PRS 62.1%
-
CSI 0.4rCSI 7.3%PRS 73.8%
-
CSI 0.4rCSI 4.8%PRS 72.1%
-
CSI 0.5rCSI 2.4%PRS 81.8%
-
CSI 0.5rCSI 3.6%PRS 70.0%
-
CSI 0.6rCSI 3.6%PRS 73.1%
-
CSI 0.6rCSI 7.7%PRS 79.5%
-
CSI 0.8rCSI 3.4%PRS 82.4%
-
CSI 0.8rCSI 2.8%PRS 56.6%
-
CSI 0.9rCSI 4.8%PRS 71.8%
-
CSI 0.9rCSI 2.5%PRS 40.1%
-
CSI 0.9rCSI 21.8%PRS 24.0%
-
CSI 1.0rCSI 2.3%PRS 55.0%
-
CSI 1.0rCSI 2.8%PRS 53.1%
-
CSI 1.0rCSI 5.6%PRS 49.0%
-
CSI 1.0rCSI 8.0%PRS 33.9%
-
CSI 1.0rCSI 2.1%PRS 46.0%
-
CSI 1.0rCSI 2.8%PRS 32.2%
-
CSI 1.1rCSI 2.0%PRS 36.9%
-
CSI 1.1rCSI 2.8%PRS 36.2%
-
CSI 1.2rCSI 1.4%PRS 48.9%
-
CSI 1.3rCSI 2.4%PRS 72.8%
-
CSI 1.3rCSI 3.6%PRS 78.5%
-
CSI 1.3rCSI 3.2%PRS 55.0%
-
CSI 1.3rCSI 2.4%PRS 65.7%
-
CSI 1.3rCSI 7.1%PRS 75.2%
-
CSI 1.3rCSI 3.4%PRS 69.8%
-
CSI 1.3rCSI 3.1%PRS 57.4%
-
CSI 1.3rCSI 1.6%PRS 44.7%
-
CSI 1.4rCSI 1.7%PRS 34.2%
-
CSI 1.4rCSI 2.3%PRS 43.0%
-
CSI 1.4rCSI 3.2%PRS 52.6%
-
CSI 1.5rCSI 3.8%PRS 51.4%
-
CSI 1.5rCSI 1.9%PRS 50.9%
-
CSI 1.5rCSI 3.0%PRS 55.8%
-
CSI 1.5rCSI 4.3%PRS 40.7%
-
CSI 1.5rCSI 10.8%PRS 45.5%
-
CSI 1.6rCSI 2.7%PRS 47.3%
-
CSI 1.6rCSI 2.0%PRS 47.1%
-
CSI 1.7rCSI 4.9%PRS 36.6%
-
CSI 1.7rCSI 2.3%PRS 58.6%
-
CSI 1.7rCSI 2.3%PRS 66.4%
-
CSI 1.7rCSI 5.0%PRS 54.3%
-
CSI 1.8rCSI 2.7%PRS 42.4%
-
CSI 1.8rCSI 2.8%PRS 48.3%
-
CSI 1.8rCSI 6.3%PRS 71.7%
-
CSI 1.8rCSI 10.2%PRS 52.0%
-
CSI 1.9rCSI 31.5%PRS 72.9%
-
CSI 1.9rCSI 2.9%PRS 55.6%
-
CSI 1.9rCSI 2.5%PRS 39.8%
-
CSI 1.9rCSI 3.7%PRS 67.9%
-
CSI 1.9rCSI 3.4%PRS 36.4%
-
CSI 2.0rCSI 1.2%PRS 51.6%
-
CSI 2.0rCSI 6.5%PRS 40.7%
-
CSI 2.0rCSI 3.1%PRS 44.3%
-
CSI 2.0rCSI 3.7%PRS 62.3%
-
CSI 2.1rCSI 1.7%PRS 38.5%
-
CSI 2.1rCSI 9.2%PRS 36.7%
-
CSI 2.1rCSI 1.7%PRS 59.4%
-
CSI 2.1rCSI 2.5%PRS 63.0%
-
CSI 2.1rCSI 9.4%PRS 35.5%
-
CSI 2.2rCSI 5.0%PRS 44.0%
-
CSI 2.2rCSI 3.5%PRS 41.2%
-
CSI 2.2rCSI 2.7%PRS 64.9%
-
CSI 2.2rCSI 6.7%PRS 61.8%
-
CSI 2.2rCSI 10.3%PRS 61.5%
-
CSI 2.3rCSI 2.1%PRS 39.1%
-
CSI 2.3rCSI 2.0%PRS 46.5%
-
CSI 2.3rCSI 4.3%PRS 29.2%
-
CSI 2.3rCSI 3.6%PRS 32.3%
-
CSI 2.3rCSI 2.0%PRS 41.8%
-
CSI 2.3rCSI 4.8%PRS 36.6%
-
CSI 2.3rCSI 5.3%PRS 37.5%
-
CSI 2.4rCSI 3.7%PRS 36.2%
-
CSI 2.4rCSI 2.9%PRS 57.7%
-
CSI 2.4rCSI 4.9%PRS 23.0%
-
CSI 2.5rCSI 3.1%PRS 51.2%
-
CSI 2.5rCSI 4.2%PRS 59.1%
-
CSI 2.5rCSI 2.4%PRS 62.1%
-
CSI 2.6rCSI 2.4%PRS 52.6%
-
CSI 2.6rCSI 3.0%PRS 61.1%
-
CSI 2.7rCSI 10.1%PRS 32.4%
-
CSI 2.7rCSI 4.7%PRS 29.9%
-
CSI 2.7rCSI 2.4%PRS 35.0%
-
CSI 2.7rCSI 8.8%PRS 71.2%
-
CSI 2.8rCSI 6.1%PRS 41.9%
-
CSI 2.8rCSI 4.3%PRS 38.4%
-
CSI 2.8rCSI 2.9%PRS 50.2%
-
CSI 2.8rCSI 4.0%PRS 35.5%
-
CSI 2.8rCSI 2.1%PRS 52.3%
-
CSI 2.9rCSI 3.2%PRS 53.8%
-
CSI 2.9rCSI 3.0%PRS 69.8%
-
CSI 2.9rCSI 3.5%PRS 36.7%
-
CSI 3.0rCSI 2.2%PRS 56.3%
-
CSI 3.0rCSI 2.7%PRS 37.4%
-
CSI 3.0rCSI 2.8%PRS 44.7%
-
CSI 3.0rCSI 3.8%PRS 49.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 716367964
Symbol: DOCK8_HUMAN
Name: Dedicator of cytokinesis protein 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12693554
Title: Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.
PubMed ID: 12693554
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10729223
Title: The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex-related domain.
PubMed ID: 10729223
PubMed ID: 12432077
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
PubMed ID: 12432077
DOI: 10.1242/jcs.00219
PubMed ID: 18060736
Title: Dedicator of cytokinesis 8 is disrupted in two patients with mental retardation and developmental disabilities.
PubMed ID: 18060736
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22461490
Title: DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
PubMed ID: 22461490
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25762780
Title: HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.
PubMed ID: 25762780
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28028151
Title: LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
PubMed ID: 28028151
DOI: 10.1084/jem.20160068
PubMed ID: 19776401
Title: Combined immunodeficiency associated with DOCK8 mutations.
PubMed ID: 19776401
PubMed ID: 24169519
Title: 20 ans apres: a second mutation in MAOA identified by targeted high-throughput sequencing in a family with altered behavior and cognition.
PubMed ID: 24169519
Sequence Information:
- Length: 2099
- Mass: 238529
- Checksum: AF651C26E2D8E73E
- Sequence:
MATLPSAERR AFALKINRYS SAEIRKQFTL PPNLGQYHRQ SISTSGFPSL QLPQFYDPVE PVDFEGLLMT HLNSLDVQLA QELGDFTDDD LDVVFTPKEC RTLQPSLPEE GVELDPHVRD CVQTYIREWL IVNRKNQGSP EICGFKKTGS RKDFHKTLPK QTFESETLEC SEPAAQAGPR HLNVLCDVSG KGPVTACDFD LRSLQPDKRL ENLLQQVSAE DFEKQNEEAR RTNRQAELFA LYPSVDEEDA VEIRPVPECP KEHLGNRILV KLLTLKFEIE IEPLFASIAL YDVKERKKIS ENFHCDLNSD QFKGFLRAHT PSVAASSQAR SAVFSVTYPS SDIYLVVKIE KVLQQGEIGD CAEPYTVIKE SDGGKSKEKI EKLKLQAESF CQRLGKYRMP FAWAPISLSS FFNVSTLERE VTDVDSVVGR SSVGERRTLA QSRRLSERAL SLEENGVGSN FKTSTLSVSS FFKQEGDRLS DEDLFKFLAD YKRSSSLQRR VKSIPGLLRL EISTAPEIIN CCLTPEMLPV KPFPENRTRP HKEILEFPTR EVYVPHTVYR NLLYVYPQRL NFVNKLASAR NITIKIQFMC GEDASNAMPV IFGKSSGPEF LQEVYTAVTY HNKSPDFYEE VKIKLPAKLT VNHHLLFTFY HISCQQKQGA SVETLLGYSW LPILLNERLQ TGSYCLPVAL EKLPPNYSMH SAEKVPLQNP PIKWAEGHKG VFNIEVQAVS SVHTQDNHLE KFFTLCHSLE SQVTFPIRVL DQKISEMALE HELKLSIICL NSSRLEPLVL FLHLVLDKLF QLSVQPMVIA GQTANFSQFA FESVVAIANS LHNSKDLSKD QHGRNCLLAS YVHYVFRLPE VQRDVPKSGA PTALLDPRSY HTYGRTSAAA VSSKLLQARV MSSSNPDLAG THSAADEEVK NIMSSKIADR NCSRMSYYCS GSSDAPSSPA APRPASKKHF HEELALQMVV STGMVRETVF KYAWFFFELL VKSMAQHVHN MDKRDSFRRT RFSDRFMDDI TTIVNVVTSE IAALLVKPQK ENEQAEKMNI SLAFFLYDLL SLMDRGFVFN LIRHYCSQLS AKLSNLPTLI SMRLEFLRIL CSHEHYLNLN LFFMNADTAP TSPCPSISSQ NSSSCSSFQD QKIASMFDLT SEYRQQHFLT GLLFTELAAA LDAEGEGISK VQRKAVSAIH SLLSSHDLDP RCVKPEVKVK IAALYLPLVG IILDALPQLC DFTVADTRRY RTSGSDEEQE GAGAINQNVA LAIAGNNFNL KTSGIVLSSL PYKQYNMLNA DTTRNLMICF LWIMKNADQS LIRKWIADLP STQLNRILDL LFICVLCFEY KGKQSSDKVS TQVLQKSRDV KARLEEALLR GEGARGEMMR RRAPGNDRFP GLNENLRWKK EQTHWRQANE KLDKTKAELD QEALISGNLA TEAHLIILDM QENIIQASSA LDCKDSLLGG VLRVLVNSLN CDQSTTYLTH CFATLRALIA KFGDLLFEEE VEQCFDLCHQ VLHHCSSSMD VTRSQACATL YLLMRFSFGA TSNFARVKMQ VTMSLASLVG RAPDFNEEHL RRSLRTILAY SEEDTAMQMT PFPTQVEELL CNLNSILYDT VKMREFQEDP EMLMDLMYRI AKSYQASPDL RLTWLQNMAE KHTKKKCYTE AAMCLVHAAA LVAEYLSMLE DHSYLPVGSV SFQNISSNVL EESVVSEDTL SPDEDGVCAG QYFTESGLVG LLEQAAELFS TGGLYETVNE VYKLVIPILE AHREFRKLTL THSKLQRAFD SIVNKDHKRM FGTYFRVGFF GSKFGDLDEQ EFVYKEPAIT KLPEISHRLE AFYGQCFGAE FVEVIKDSTP VDKTKLDPNK AYIQITFVEP YFDEYEMKDR VTYFEKNFNL RRFMYTTPFT LEGRPRGELH EQYRRNTVLT TMHAFPYIKT RISVIQKEEF VLTPIEVAIE DMKKKTLQLA VAINQEPPDA KMLQMVLQGS VGATVNQGPL EVAQVFLAEI PADPKLYRHH NKLRLCFKEF IMRCGEAVEK NKRLITADQR EYQQELKKNY NKLKENLRPM IERKIPELYK PIFRVESQKR DSFHRSSFRK CETQLSQGS
Genular Protein ID: 3395048009
Symbol: E2J6M5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 113
- Mass: 12839
- Checksum: B4891CB74DE49FA2
- Sequence:
MTHLNSLDVQ LAQELGDFTD DDLDVVFTPK ECRTLQPSLP EEGVELDPHV RDCVQTYIRE WLIVNRKNQG SPEICGFKKT GSRKDFHKTL PKQTFESETL ECSEPAAQAG PRH
Genular Protein ID: 423102159
Symbol: E2J6M6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 19776401
Title: Combined immunodeficiency associated with DOCK8 mutations.
PubMed ID: 19776401
Sequence Information:
- Length: 922
- Mass: 104006
- Checksum: 61E6A8873887319B
- Sequence:
MTHLNSLDVQ LAQELGDFTD DDLDVVFTPK ECRTLQPSLP EEGVELDPHV RDCVQTYIRE WLIVNRKNQG SPEICGFKKT GSRKDFHKTL PKQTFESETL ECSEPAAQAG PRHLNVLCDV SGKGPVTACD FDLRSLQPDK RLENLLQQVS AEDFEKQNEE ARRTNRQAEL FALYPSVDEE DAVEIRPVPE CPKEHLGNRI LVKLLTLKFE IEIEPLFASI ALYDVKERKK ISENFHCDLN SDQFKGFLRA HTPSVAASSQ ARSAVFSVTY PSSDIYLVVK IEKVLQQGEI GDCAEPYTVI KESDGGKSKE KIEKLKLQAE SFCQRLGKYR MPFAWAPISL SSFFSVSTLE REVTDVDSVV GRSSVGERRT LAQSRRLSER ALSLEENGVG SNFKTSTLSV SSFFKQEGDR LSDEDLFKFL ADYKRSSSLQ RRVKSIPGLL RLEISTAPEI INCCLTPEML PVKPFPENRT RPHKEILEFP TREVYVPHTV YRSLLYVYPQ RLNFVNKLAS ARNITIKIQF MCGEDASNAM PVIFGKSSGP EFLQEVYTAV TYHNKSPDFY EEVKIKLPAK LTVNHHLLFT FYHISCQQKQ GASVETLLGY SWLPILLNER LQTGSYRLPV ALEKLPPNYS MHSAEKVPLQ NPPIKWAEGH KGVFNIEVQA VSSVHTQDNH LKKFFTLCHS LESQVTFPIR VLDQKISEMA LEHELKLSII CLNSSRLEPL VLFLHLVLDK LFQLSVQPMV IAGQTANFSQ FAFESVVAIA NSLHNSKDLS KDQHGRNCLL ASYVHYVFRL PEVQRDVPKS GAPTALLDPR SYHTYGRTSA AAVSSKLLQA RVMSSSNPDL AGTHSAADEE VKNIMSSKIA DRNCSRMSYY CSGSSDAPSS PAAPRPASKK HFHKELALQM VVSTGMVRET VFKYAWFFFE LL