Details for: MYO1E
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.08rCSI 62.42%PRS 57.14
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CSI 18.81rCSI 20.16%PRS 59.12
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CSI 17.89rCSI 49.31%PRS 55.73
-
CSI 17.84rCSI 28.45%PRS 52.7
-
CSI 17.64rCSI 28.18%PRS 63.91
-
CSI 16.64rCSI 43.24%PRS 63.52
-
CSI 15.6rCSI 23.82%PRS 60.55
-
CSI 15.17rCSI 20.74%PRS 65.87
-
CSI 15.12rCSI 28.84%PRS 75.29
-
CSI 14.92rCSI 18.56%PRS 61.78
-
CSI 13.42rCSI 29.55%PRS 72.89
-
CSI 13.35rCSI 23.09%PRS 50.07
-
CSI 13.28rCSI 26.95%PRS 39.54
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CSI 13.01rCSI 20.97%PRS 63.92
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CSI 12.9rCSI 16.22%PRS 71.94
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CSI 12.89rCSI 24.33%PRS 70.44
-
CSI 12.32rCSI 10.33%PRS 64.4
-
CSI 12.23rCSI 54.35%PRS 59.27
-
CSI 11.74rCSI 29.78%PRS 49.36
-
CSI 11.55rCSI 32.84%PRS 58.25
-
CSI 11.29rCSI 22.41%PRS 57.73
-
CSI 10.39rCSI 54.61%PRS 65.66
-
CSI 9.7rCSI 13.48%PRS 58.69
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CSI 9.12rCSI 29.18%PRS 57.54
-
CSI 9.03rCSI 25.82%PRS 73.04
-
CSI 8.79rCSI 8.11%PRS 61.39
-
CSI 8.7rCSI 19.44%PRS 67.65
-
CSI 8.5rCSI 9.82%PRS 53.17
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CSI 8.44rCSI 6.27%PRS 73.17
-
CSI 8.36rCSI 19.11%PRS 59.72
-
CSI 8.11rCSI 7.82%PRS 50.44
-
CSI 7.38rCSI 19.91%PRS 67.53
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CSI 7.25rCSI 20.32%PRS 71.65
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CSI 7.23rCSI 8.95%PRS 56.26
-
CSI 7.04rCSI 7.02%PRS 53.13
-
CSI 6.92rCSI 10.17%PRS 53.78
-
CSI 6.73rCSI 19.88%PRS 49.23
-
CSI 6.62rCSI 21.95%PRS 64.03
-
CSI 6.46rCSI 12.97%PRS 49.06
-
CSI 6.32rCSI 13.85%PRS 68.35
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CSI 6.16rCSI 10.8%PRS 51.95
-
CSI 5.92rCSI 6.18%PRS 60.17
-
CSI 5.47rCSI 7.31%PRS 68.81
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CSI 5.46rCSI 29.84%PRS 59.08
-
CSI 5.42rCSI 7.5%PRS 61.19
-
CSI 5.08rCSI 24.32%PRS 58.89
-
CSI 5.08rCSI 4.13%PRS 60.42
-
CSI 5.05rCSI 6.87%PRS 71.78
-
CSI 4.78rCSI 5.95%PRS 39.91
-
CSI 4.71rCSI 3.72%PRS 46.79
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CSI 4.7rCSI 10.72%PRS 51.79
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CSI 4.57rCSI 11.82%PRS 54.86
-
CSI 4.57rCSI 7.27%PRS 52.25
-
CSI 4.56rCSI 4.3%PRS 59.42
-
CSI 4.55rCSI 10.19%PRS 42.61
-
CSI 4.5rCSI 7.3%PRS 56.53
-
CSI 4.5rCSI 3.34%PRS 52.51
-
CSI 4.37rCSI 6.4%PRS 64.28
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CSI 4.34rCSI 17.67%PRS 71.87
-
CSI 4.29rCSI 6.59%PRS 56.38
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CSI 4.26rCSI 3.7%PRS 70.58
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CSI 4.11rCSI 15.39%PRS 52.06
-
CSI 4.07rCSI 6.22%PRS 64.18
-
CSI 4.06rCSI 9.7%PRS 68.76
-
CSI 3.98rCSI 20.04%PRS 61.12
-
CSI 3.98rCSI 8.76%PRS 64.15
-
CSI 3.98rCSI 22.92%PRS 58.79
-
CSI 3.81rCSI 9.94%PRS 59.73
-
CSI 3.81rCSI 30.95%PRS 53.21
-
CSI 3.8rCSI 6.26%PRS 65.3
-
CSI 3.74rCSI 5.91%PRS 61.98
-
CSI 3.73rCSI 2.93%PRS 66.52
-
CSI 3.68rCSI 9.7%PRS 68.8
-
CSI 3.67rCSI 5.91%PRS 49.57
-
CSI 3.66rCSI 5.25%PRS 64.08
-
CSI 3.57rCSI 17.09%PRS 60.09
-
CSI 3.55rCSI 5.03%PRS 56.12
-
CSI 3.51rCSI 5.89%PRS 41.83
-
CSI 3.5rCSI 8.54%PRS 53.7
-
CSI 3.41rCSI 8.1%PRS 63.79
-
CSI 3.26rCSI 7.77%PRS 61.06
-
CSI 3.21rCSI 2.95%PRS 68.72
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CSI 3.21rCSI 4.12%PRS 52.87
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CSI 3.14rCSI 9.09%PRS 72.8
-
CSI 3.06rCSI 12.31%PRS 65.31
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CSI 3.03rCSI 5.41%PRS 73.43
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CSI 3.01rCSI 4.02%PRS 60.32
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CSI 2.97rCSI 21.02%PRS 51.98
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CSI 2.96rCSI 6.94%PRS 65.22
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CSI 2.93rCSI 4.2%PRS 49.83
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CSI 2.91rCSI 6%PRS 62.02
-
CSI 2.88rCSI 7.28%PRS 67.97
-
CSI 2.82rCSI 2.95%PRS 56.35
-
CSI 2.77rCSI 7.41%PRS 51.09
-
CSI 2.76rCSI 3.02%PRS 63.76
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CSI 2.72rCSI 4.88%PRS 59.03
-
CSI 2.6rCSI 6.44%PRS 58.28
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CSI 2.58rCSI 6.26%PRS 40.47
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CSI 2.49rCSI 7.39%PRS 69.94
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CSI 2.48rCSI 6.97%PRS 56.68
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CSI 0.2rCSI 1.7%PRS 76.4%
-
CSI 0.3rCSI 4.3%PRS 77.8%
-
CSI 0.4rCSI 4.9%PRS 51.3%
-
CSI 0.4rCSI 2.2%PRS 69.2%
-
CSI 0.4rCSI 1.5%PRS 64.3%
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CSI 0.5rCSI 2.1%PRS 74.9%
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CSI 0.6rCSI 2.5%PRS 73.6%
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CSI 0.6rCSI 2.2%PRS 69.1%
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CSI 0.8rCSI 8.2%PRS 58.4%
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CSI 0.8rCSI 3.7%PRS 78.8%
-
CSI 0.9rCSI 2.0%PRS 46.2%
-
CSI 1.0rCSI 1.7%PRS 75.4%
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CSI 1.0rCSI 1.9%PRS 62.7%
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CSI 1.0rCSI 1.6%PRS 71.0%
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CSI 1.0rCSI 8.9%PRS 57.5%
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CSI 1.1rCSI 5.9%PRS 75.5%
-
CSI 1.2rCSI 5.7%PRS 71.2%
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CSI 1.2rCSI 4.9%PRS 58.8%
-
CSI 1.2rCSI 4.0%PRS 58.4%
-
CSI 1.3rCSI 3.0%PRS 67.8%
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CSI 1.4rCSI 3.2%PRS 56.4%
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CSI 1.4rCSI 6.7%PRS 76.7%
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CSI 1.4rCSI 2.2%PRS 57.9%
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CSI 1.5rCSI 1.8%PRS 49.9%
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CSI 1.5rCSI 1.6%PRS 65.3%
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CSI 1.6rCSI 1.9%PRS 70.8%
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CSI 1.6rCSI 2.5%PRS 49.2%
-
CSI 1.6rCSI 8.5%PRS 70.1%
-
CSI 1.6rCSI 2.0%PRS 68.7%
-
CSI 1.6rCSI 3.9%PRS 70.9%
-
CSI 1.7rCSI 5.9%PRS 40.3%
-
CSI 1.7rCSI 3.9%PRS 72.6%
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CSI 1.7rCSI 2.6%PRS 75.6%
-
CSI 1.7rCSI 2.2%PRS 66.3%
-
CSI 1.7rCSI 2.6%PRS 63.9%
-
CSI 1.7rCSI 2.5%PRS 76.0%
-
CSI 1.7rCSI 2.2%PRS 64.6%
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CSI 1.8rCSI 1.5%PRS 47.8%
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CSI 1.8rCSI 2.1%PRS 62.2%
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CSI 1.8rCSI 9.7%PRS 72.3%
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CSI 1.9rCSI 2.8%PRS 73.5%
-
CSI 1.9rCSI 2.3%PRS 67.4%
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CSI 1.9rCSI 8.5%PRS 77.8%
-
CSI 1.9rCSI 5.0%PRS 64.3%
-
CSI 2.0rCSI 5.7%PRS 61.4%
-
CSI 2.0rCSI 7.5%PRS 50.9%
-
CSI 2.0rCSI 1.4%PRS 62.6%
-
CSI 2.0rCSI 4.0%PRS 77.3%
-
CSI 2.1rCSI 3.6%PRS 68.2%
-
CSI 2.1rCSI 13.1%PRS 51.9%
-
CSI 2.1rCSI 6.3%PRS 77.8%
-
CSI 2.1rCSI 3.2%PRS 68.8%
-
CSI 2.1rCSI 1.7%PRS 61.5%
-
CSI 2.2rCSI 1.7%PRS 60.3%
-
CSI 2.2rCSI 6.5%PRS 58.7%
-
CSI 2.2rCSI 4.7%PRS 78.2%
-
CSI 2.2rCSI 5.8%PRS 59.7%
-
CSI 2.3rCSI 9.9%PRS 50.6%
-
CSI 2.3rCSI 4.5%PRS 77.5%
-
CSI 2.3rCSI 2.1%PRS 57.9%
-
CSI 2.3rCSI 16.7%PRS 60.3%
-
CSI 2.4rCSI 5.6%PRS 78.7%
-
CSI 2.4rCSI 2.8%PRS 67.7%
-
CSI 2.5rCSI 6.5%PRS 78.7%
-
CSI 2.5rCSI 3.8%PRS 67.6%
-
CSI 2.5rCSI 7.0%PRS 56.7%
-
CSI 2.5rCSI 7.4%PRS 69.9%
-
CSI 2.6rCSI 6.3%PRS 40.5%
-
CSI 2.6rCSI 6.4%PRS 58.3%
-
CSI 2.7rCSI 4.9%PRS 59.0%
-
CSI 2.8rCSI 3.0%PRS 63.8%
-
CSI 2.8rCSI 7.4%PRS 51.1%
-
CSI 2.8rCSI 3.0%PRS 56.4%
-
CSI 2.9rCSI 7.3%PRS 68.0%
-
CSI 2.9rCSI 6.0%PRS 62.0%
-
CSI 2.9rCSI 4.2%PRS 49.8%
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CSI 3.0rCSI 6.9%PRS 65.2%
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CSI 3.0rCSI 21.0%PRS 52.0%
-
CSI 3.0rCSI 4.0%PRS 60.3%
-
CSI 3.0rCSI 5.4%PRS 73.4%
-
CSI 3.1rCSI 12.3%PRS 65.3%
-
CSI 3.1rCSI 9.1%PRS 72.8%
-
CSI 3.2rCSI 4.1%PRS 52.9%
-
CSI 3.2rCSI 3.0%PRS 68.7%
-
CSI 3.3rCSI 7.8%PRS 61.1%
-
CSI 3.4rCSI 8.1%PRS 63.8%
-
CSI 3.5rCSI 8.5%PRS 53.7%
-
CSI 3.5rCSI 5.9%PRS 41.8%
-
CSI 3.6rCSI 5.0%PRS 56.1%
-
CSI 3.6rCSI 17.1%PRS 60.1%
-
CSI 3.7rCSI 5.3%PRS 64.1%
-
CSI 3.7rCSI 5.9%PRS 49.6%
-
CSI 3.7rCSI 9.7%PRS 68.8%
-
CSI 3.7rCSI 2.9%PRS 66.5%
-
CSI 3.7rCSI 5.9%PRS 62.0%
-
CSI 3.8rCSI 6.3%PRS 65.3%
-
CSI 3.8rCSI 31.0%PRS 53.2%
-
CSI 3.8rCSI 9.9%PRS 59.7%
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CSI 4.0rCSI 22.9%PRS 58.8%
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CSI 4.0rCSI 8.8%PRS 64.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2097023535
Symbol: MYO1E_HUMAN
Name: Unconventional myosin-Ie
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7932763
Title: Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain.
PubMed ID: 7932763
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 8022818
Title: Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.
PubMed ID: 8022818
PubMed ID: 7972138
PubMed ID: 11940582
Title: The kinetic mechanism of Myo1e (human myosin-IC).
PubMed ID: 11940582
PubMed ID: 17257598
Title: Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.
PubMed ID: 17257598
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19846667
Title: Distinct roles for CARMIL isoforms in cell migration.
PubMed ID: 19846667
PubMed ID: 20860408
Title: Myo1e binds anionic phospholipids with high affinity.
PubMed ID: 20860408
DOI: 10.1021/bi1012657
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21458045
Title: A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation.
PubMed ID: 21458045
PubMed ID: 21756023
Title: MYO1E mutations and childhood familial focal segmental glomerulosclerosis.
PubMed ID: 21756023
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 21697813
Title: Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome.
PubMed ID: 21697813
DOI: 10.1038/ki.2011.148
PubMed ID: 23595123
Title: A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families.
PubMed ID: 23595123
DOI: 10.1038/jhg.2013.27
PubMed ID: 25349199
Title: A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome.
PubMed ID: 25349199
PubMed ID: 28837161
Title: Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay.
PubMed ID: 28837161
DOI: 10.1038/gim.2017.113
PubMed ID: 36316095
Title: Steroid-Resistant Nephrotic Syndrome-Associated MYO1E Mutations Have Differential Effects on Myosin 1e Localization, Dynamics, and Activity.
PubMed ID: 36316095
Sequence Information:
- Length: 1108
- Mass: 127062
- Checksum: 3073050B9BB4DDC6
- Sequence:
MGSKGVYQYH WQSHNVKHSG VDDMVLLSKI TENSIVENLK KRYMDDYIFT YIGSVLISVN PFKQMPYFGE KEIEMYQGAA QYENPPHIYA LADNMYRNMI IDRENQCVII SGESGAGKTV AAKYIMSYIS RVSGGGTKVQ HVKDIILQSN PLLEAFGNAK TVRNNNSSRF GKYFEIQFSP GGEPDGGKIS NFLLEKSRVV MRNPGERSFH IFYQLIEGAS AEQKHSLGIT SMDYYYYLSL SGSYKVDDID DRREFQETLH AMNVIGIFAE EQTLVLQIVA GILHLGNISF KEVGNYAAVE SEEFLAFPAY LLGINQDRLK EKLTSRQMDS KWGGKSESIH VTLNVEQACY TRDALAKALH ARVFDFLVDS INKAMEKDHE EYNIGVLDIY GFEIFQKNGF EQFCINFVNE KLQQIFIELT LKAEQEEYVQ EGIRWTPIEY FNNKIVCDLI ENKVNPPGIM SILDDVCATM HAVGEGADQT LLQKLQMQIG SHEHFNSWNQ GFIIHHYAGK VSYDMDGFCE RNRDVLFMDL IELMQSSELP FIKSLFPENL QADKKGRPTT AGSKIKKQAN DLVSTLMKCT PHYIRCIKPN ETKKPRDWEE SRVKHQVEYL GLKENIRVRR AGYAYRRIFQ KFLQRYAILT KATWPSWQGE EKQGVLHLLQ SVNMDSDQFQ LGRSKVFIKA PESLFLLEEM RERKYDGYAR VIQKSWRKFV ARKKYVQMRE EASDLLLNKK ERRRNSINRN FIGDYIGMEE HPELQQFVGK REKIDFADTV TKYDRRFKGV KRDLLLTPKC LYLIGREKVK QGPDKGLVKE VLKRKIEIER ILSVSLSTMQ DDIFILHEQE YDSLLESVFK TEFLSLLAKR YEEKTQKQLP LKFSNTLELK LKKENWGPWS AGGSRQVQFH QGFGDLAVLK PSNKVLQVSI GPGLPKNSRP TRRNTTQNTG YSSGTQNANY PVRAAPPPPG YHQNGVIRNQ YVPYPHAPGS QRSNQKSLYT SMARPPLPRQ QSTSSDRVSQ TPESLDFLKV PDQGAAGVRR QTTSRPPPAG GRPKPQPKPK PQVPQCKALY AYDAQDTDEL SFNANDIIDI IKEDPSGWWT GRLRGKQGLF PNNYVTKI