Details for: NAE1
Gene ID: 8883
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NAE1
Ensembl ID: ENSG00000159593
Description: NEDD8 activating enzyme E1 subunit 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 14.97rCSI 10.45%PRS 35.23
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CSI 13.25rCSI 22.24%PRS 21.31
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CSI 12.41rCSI 19.71%PRS 42.7
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CSI 9.83rCSI 11.35%PRS 29.4
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CSI 8.52rCSI 8.51%PRS 28.89
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CSI 7.71rCSI 13.6%PRS 41.75
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CSI 6.79rCSI 21.23%PRS 24.13
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CSI 6.45rCSI 10.37%PRS 23.14
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CSI 5.98rCSI 8.18%PRS 32.07
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CSI 5.83rCSI 7.25%PRS 35.9
-
CSI 5.65rCSI 35.31%PRS 27.72
-
CSI 5.58rCSI 15.87%PRS 35.02
-
CSI 5.41rCSI 13.72%PRS 26.28
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CSI 5.37rCSI 19.45%PRS 51.65
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CSI 5.15rCSI 6.03%PRS 46.64
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CSI 4.99rCSI 7.61%PRS 31.16
-
CSI 4.89rCSI 7.55%PRS 31.84
-
CSI 4.54rCSI 3.64%PRS 54.02
-
CSI 4.39rCSI 16.61%PRS 22.16
-
CSI 4.28rCSI 4.36%PRS 45.39
-
CSI 4.2rCSI 4.04%PRS 34.41
-
CSI 4.18rCSI 18.4%PRS 29.13
-
CSI 4.05rCSI 23.21%PRS 44.78
-
CSI 3.98rCSI 3.03%PRS 43.18
-
CSI 3.81rCSI 6.18%PRS 32.92
-
CSI 3.7rCSI 5.08%PRS 54.29
-
CSI 3.46rCSI 2.67%PRS 32
-
CSI 3.37rCSI 8.56%PRS 31.48
-
CSI 3.31rCSI 8.39%PRS 40.74
-
CSI 3.23rCSI 7.24%PRS 21.89
-
CSI 3.15rCSI 4.62%PRS 35.17
-
CSI 3.12rCSI 9.22%PRS 38.14
-
CSI 3.06rCSI 2.28%PRS 51.37
-
CSI 3.05rCSI 4.17%PRS 37.5
-
CSI 2.89rCSI 2.24%PRS 48.17
-
CSI 2.86rCSI 3.69%PRS 22.04
-
CSI 2.81rCSI 1.96%PRS 45.07
-
CSI 2.8rCSI 2.59%PRS 34.74
-
CSI 2.79rCSI 3.55%PRS 38.17
-
CSI 2.76rCSI 4.97%PRS 28.34
-
CSI 2.65rCSI 13.3%PRS 42.96
-
CSI 2.59rCSI 2.45%PRS 34.68
-
CSI 2.58rCSI 1.8%PRS 40.34
-
CSI 2.54rCSI 2.19%PRS 43.71
-
CSI 2.54rCSI 5.78%PRS 33.18
-
CSI 2.52rCSI 3.5%PRS 33.74
-
CSI 2.52rCSI 1.95%PRS 33.18
-
CSI 2.5rCSI 1.8%PRS 44.72
-
CSI 2.36rCSI 2.43%PRS 50.09
-
CSI 2.33rCSI 1.73%PRS 45.89
-
CSI 2.32rCSI 1.72%PRS 28.9
-
CSI 2.31rCSI 1.73%PRS 47.62
-
CSI 2.3rCSI 1.94%PRS 49.57
-
CSI 2.3rCSI 2.46%PRS 31.44
-
CSI 2.28rCSI 1.89%PRS 32.05
-
CSI 2.27rCSI 1.53%PRS 41.76
-
CSI 2.27rCSI 1.72%PRS 44.41
-
CSI 2.26rCSI 1.34%PRS 46.22
-
CSI 2.19rCSI 1.92%PRS 38.12
-
CSI 2.19rCSI 2.33%PRS 49.41
-
CSI 2.18rCSI 5.21%PRS 25.33
-
CSI 2.17rCSI 1.93%PRS 33.17
-
CSI 2.15rCSI 2.08%PRS 25.88
-
CSI 2.1rCSI 2.06%PRS 35.72
-
CSI 2.1rCSI 3.63%PRS 26.16
-
CSI 2.1rCSI 1.84%PRS 42.71
-
CSI 2.08rCSI 2.79%PRS 41.08
-
CSI 2.01rCSI 4.03%PRS 25.47
-
CSI 1.98rCSI 2.16%PRS 37.17
-
CSI 1.97rCSI 2.07%PRS 31.37
-
CSI 1.91rCSI 1.58%PRS 34.14
-
CSI 1.91rCSI 1.27%PRS 37.9
-
CSI 1.9rCSI 7.39%PRS 52.54
-
CSI 1.9rCSI 2.82%PRS 36.9
-
CSI 1.89rCSI 1.54%PRS 34.49
-
CSI 1.87rCSI 55.95%PRS 58.87
-
CSI 1.86rCSI 2.25%PRS 39.97
-
CSI 1.86rCSI 2.38%PRS 38
-
CSI 1.85rCSI 1.39%PRS 36.1
-
CSI 1.85rCSI 4.26%PRS 27.77
-
CSI 1.84rCSI 2.72%PRS 37.79
-
CSI 1.82rCSI 1.64%PRS 30.88
-
CSI 1.79rCSI 42.97%PRS 20.72
-
CSI 1.78rCSI 1.66%PRS 33.37
-
CSI 1.78rCSI 1.4%PRS 23.71
-
CSI 1.77rCSI 2.11%PRS 21.21
-
CSI 1.76rCSI 2.8%PRS 28.41
-
CSI 1.74rCSI 5.59%PRS 42.22
-
CSI 1.73rCSI 1.81%PRS 33.87
-
CSI 1.73rCSI 2.65%PRS 39.37
-
CSI 1.72rCSI 3.93%PRS 28.97
-
CSI 1.71rCSI 3.1%PRS 29.19
-
CSI 1.69rCSI 1.56%PRS 53.43
-
CSI 1.69rCSI 2.96%PRS 27.15
-
CSI 1.68rCSI 6.04%PRS 20.31
-
CSI 1.62rCSI 2.21%PRS 36.24
-
CSI 1.61rCSI 2.07%PRS 32.08
-
CSI 1.61rCSI 1.27%PRS 39.29
-
CSI 1.59rCSI 1.38%PRS 41.47
-
CSI 1.57rCSI 1.95%PRS 29.96
-
CSI 0.1rCSI 0.8%PRS 45.8%
-
CSI 0.3rCSI 2.1%PRS 23.7%
-
CSI 0.3rCSI 2.8%PRS 22.8%
-
CSI 0.4rCSI 3.6%PRS 62.5%
-
CSI 0.4rCSI 5.3%PRS 28.2%
-
CSI 0.4rCSI 0.7%PRS 26.2%
-
CSI 0.4rCSI 0.5%PRS 38.9%
-
CSI 0.4rCSI 4.2%PRS 78.2%
-
CSI 0.5rCSI 1.8%PRS 49.6%
-
CSI 0.5rCSI 2.5%PRS 58.6%
-
CSI 0.6rCSI 3.2%PRS 45.0%
-
CSI 0.6rCSI 1.7%PRS 36.4%
-
CSI 0.6rCSI 1.5%PRS 31.8%
-
CSI 0.6rCSI 1.8%PRS 27.0%
-
CSI 0.6rCSI 2.7%PRS 53.6%
-
CSI 0.6rCSI 2.7%PRS 32.3%
-
CSI 0.7rCSI 2.5%PRS 29.9%
-
CSI 0.7rCSI 1.2%PRS 20.6%
-
CSI 0.7rCSI 4.6%PRS 56.7%
-
CSI 0.7rCSI 4.3%PRS 22.4%
-
CSI 0.7rCSI 3.9%PRS 48.7%
-
CSI 0.7rCSI 5.8%PRS 52.9%
-
CSI 0.8rCSI 2.6%PRS 28.4%
-
CSI 0.8rCSI 2.2%PRS 49.0%
-
CSI 0.8rCSI 1.7%PRS 24.5%
-
CSI 0.8rCSI 1.7%PRS 41.2%
-
CSI 0.8rCSI 2.2%PRS 42.1%
-
CSI 0.8rCSI 1.8%PRS 31.1%
-
CSI 0.8rCSI 1.3%PRS 34.2%
-
CSI 0.8rCSI 1.8%PRS 47.6%
-
CSI 0.8rCSI 4.3%PRS 57.0%
-
CSI 0.8rCSI 1.6%PRS 25.5%
-
CSI 0.9rCSI 2.1%PRS 20.7%
-
CSI 0.9rCSI 2.7%PRS 22.3%
-
CSI 0.9rCSI 2.1%PRS 49.8%
-
CSI 0.9rCSI 1.0%PRS 25.5%
-
CSI 0.9rCSI 1.3%PRS 35.7%
-
CSI 1.0rCSI 1.3%PRS 44.9%
-
CSI 1.0rCSI 1.5%PRS 37.8%
-
CSI 1.0rCSI 1.6%PRS 36.5%
-
CSI 1.0rCSI 10.8%PRS 50.9%
-
CSI 1.0rCSI 1.2%PRS 37.2%
-
CSI 1.0rCSI 2.9%PRS 48.8%
-
CSI 1.0rCSI 21.2%PRS 29.7%
-
CSI 1.1rCSI 1.8%PRS 26.4%
-
CSI 1.1rCSI 1.4%PRS 32.3%
-
CSI 1.1rCSI 1.8%PRS 28.8%
-
CSI 1.1rCSI 1.5%PRS 37.1%
-
CSI 1.1rCSI 1.7%PRS 49.5%
-
CSI 1.2rCSI 2.1%PRS 32.8%
-
CSI 1.2rCSI 1.6%PRS 35.4%
-
CSI 1.2rCSI 1.8%PRS 34.7%
-
CSI 1.2rCSI 1.5%PRS 20.1%
-
CSI 1.2rCSI 1.8%PRS 43.1%
-
CSI 1.3rCSI 1.6%PRS 42.1%
-
CSI 1.3rCSI 1.0%PRS 54.3%
-
CSI 1.3rCSI 1.8%PRS 31.4%
-
CSI 1.3rCSI 31.1%PRS 21.5%
-
CSI 1.3rCSI 1.5%PRS 56.8%
-
CSI 1.3rCSI 1.9%PRS 31.2%
-
CSI 1.3rCSI 4.5%PRS 25.2%
-
CSI 1.3rCSI 1.8%PRS 62.2%
-
CSI 1.3rCSI 1.1%PRS 38.4%
-
CSI 1.4rCSI 2.6%PRS 34.9%
-
CSI 1.4rCSI 1.2%PRS 37.0%
-
CSI 1.4rCSI 1.1%PRS 33.8%
-
CSI 1.4rCSI 1.3%PRS 24.9%
-
CSI 1.5rCSI 2.2%PRS 33.9%
-
CSI 1.5rCSI 2.0%PRS 28.9%
-
CSI 1.5rCSI 3.0%PRS 20.0%
-
CSI 1.5rCSI 2.7%PRS 49.5%
-
CSI 1.5rCSI 3.9%PRS 33.9%
-
CSI 1.5rCSI 2.3%PRS 49.7%
-
CSI 1.5rCSI 5.7%PRS 28.6%
-
CSI 1.5rCSI 1.6%PRS 35.5%
-
CSI 1.5rCSI 31.4%PRS 28.6%
-
CSI 1.6rCSI 3.2%PRS 31.0%
-
CSI 1.6rCSI 2.0%PRS 30.0%
-
CSI 1.6rCSI 1.4%PRS 41.5%
-
CSI 1.6rCSI 1.3%PRS 39.3%
-
CSI 1.6rCSI 2.1%PRS 32.1%
-
CSI 1.6rCSI 2.2%PRS 36.2%
-
CSI 1.7rCSI 6.0%PRS 20.3%
-
CSI 1.7rCSI 3.0%PRS 27.2%
-
CSI 1.7rCSI 1.6%PRS 53.4%
-
CSI 1.7rCSI 3.1%PRS 29.2%
-
CSI 1.7rCSI 3.9%PRS 29.0%
-
CSI 1.7rCSI 2.7%PRS 39.4%
-
CSI 1.7rCSI 1.8%PRS 33.9%
-
CSI 1.7rCSI 5.6%PRS 42.2%
-
CSI 1.8rCSI 2.8%PRS 28.4%
-
CSI 1.8rCSI 2.1%PRS 21.2%
-
CSI 1.8rCSI 1.4%PRS 23.7%
-
CSI 1.8rCSI 1.7%PRS 33.4%
-
CSI 1.8rCSI 43.0%PRS 20.7%
-
CSI 1.8rCSI 1.6%PRS 30.9%
-
CSI 1.8rCSI 2.7%PRS 37.8%
-
CSI 1.9rCSI 4.3%PRS 27.8%
-
CSI 1.9rCSI 1.4%PRS 36.1%
-
CSI 1.9rCSI 2.4%PRS 38.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2570762664
Symbol: ULA1_HUMAN
Name: NEDD8-activating enzyme E1 regulatory subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8626687
Title: APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.
PubMed ID: 8626687
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10493829
Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
PubMed ID: 10493829
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10207026
Title: Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.
PubMed ID: 10207026
PubMed ID: 10722740
Title: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.
PubMed ID: 10722740
PubMed ID: 12740388
Title: Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
PubMed ID: 12740388
PubMed ID: 14557245
Title: APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
PubMed ID: 14557245
PubMed ID: 12694406
Title: ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.
PubMed ID: 12694406
PubMed ID: 18627766
Title: TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.
PubMed ID: 18627766
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 36608681
Title: Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration.
PubMed ID: 36608681
PubMed ID: 14690597
Title: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
PubMed ID: 14690597
PubMed ID: 12646924
Title: Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
PubMed ID: 12646924
DOI: 10.1038/nature01456
PubMed ID: 15361859
Title: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
PubMed ID: 15361859
DOI: 10.1038/nsmb826
Sequence Information:
- Length: 534
- Mass: 60246
- Checksum: 5EC8D3ACE6374F21
- Sequence:
MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL