NAE1 | ENSG00000159593 | NCBI 8883

Details for: NAE1

Gene ID: 8883

Symbol: NAE1

Ensembl ID: ENSG00000159593

Description: NEDD8 activating enzyme E1 subunit 1

Associated with

Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Mitotic dna replication checkpoint signaling
(GO:0033314)
Nedd8 activating enzyme activity
(GO:0019781)
Neuron apoptotic process
(GO:0051402)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein neddylation
(GO:0045116)
Protein ubiquitination
(GO:0016567)
Regulation of apoptotic process
(GO:0042981)
Regulation of neuron apoptotic process
(GO:0043523)
Signal transduction
(GO:0007165)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin activating enzyme activity
(GO:0004839)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

NEDD8-activating enzyme E1 regulatory subunit

Genular Protein ID: 2570762664

Symbol: ULA1_HUMAN

Name: NEDD8-activating enzyme E1 regulatory subunit

UniProtKB Accession Codes:

Q13564 A6NCK0 A6NFN4 A8MU28 B2R700 B3KUP9

Database IDs:

Citations:

PubMed ID: 8626687

Title: APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.

PubMed ID: 8626687

DOI: 10.1074/jbc.271.19.11339

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207026

Title: Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.

PubMed ID: 10207026

DOI: 10.1074/jbc.274.17.12036

PubMed ID: 10722740

Title: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.

PubMed ID: 10722740

DOI: 10.1074/jbc.275.12.8929

PubMed ID: 12740388

Title: Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.

PubMed ID: 12740388

DOI: 10.1074/jbc.m303177200

PubMed ID: 14557245

Title: APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.

PubMed ID: 14557245

DOI: 10.1083/jcb.200304003

PubMed ID: 12694406

Title: ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.

PubMed ID: 12694406

DOI: 10.1046/j.1471-4159.2003.01727.x

PubMed ID: 18627766

Title: TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.

PubMed ID: 18627766

DOI: 10.1016/j.bbrc.2008.07.019

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 36608681

Title: Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration.

PubMed ID: 36608681

DOI: 10.1016/j.ajhg.2022.12.003

PubMed ID: 14690597

Title: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

PubMed ID: 14690597

DOI: 10.1016/s1097-2765(03)00452-0

PubMed ID: 12646924

Title: Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

PubMed ID: 12646924

DOI: 10.1038/nature01456

PubMed ID: 15361859

Title: A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

PubMed ID: 15361859

DOI: 10.1038/nsmb826

Sequence Information:

Length: 534
Mass: 60246
Checksum: 5EC8D3ACE6374F21
Sequence:

MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 
DGNQVSGEDA GNNFFLQRSS IGKNRAEAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF 
CRFTVVVATQ LPESTSLRLA DVLWNSQIPL LICRTYGLVG YMRIIIKEHP VIESHPDNAL 
EDLRLDKPFP ELREHFQSYD LDHMEKKDHS HTPWIVIIAK YLAQWYSETN GRIPKTYKEK 
EDFRDLIRQG ILKNENGAPE DEENFEEAIK NVNTALNTTQ IPSSIEDIFN DDRCINITKQ 
TPSFWILARA LKEFVAKEGQ GNLPVRGTIP DMIADSGKYI KLQNVYREKA KKDAAAVGNH 
VAKLLQSIGQ APESISEKEL KLLCSNSAFL RVVRCRSLAE EYGLDTINKD EIISSMDNPD 
NEIVLYLMLR AVDRFHKQQG RYPGVSNYQV EEDIGKLKSC LTGFLQEYGL SVMVKDDYVH 
EFCRYGAAEP HTIAAFLGGA AAQEVIKIIT KQFVIFNNTY IYSGMSQTSA TFQL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NAE1

Associated with

Other Information

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. PubMed ID: 8626687

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. PubMed ID: 10207026

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. PubMed ID: 10722740

Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. PubMed ID: 12740388

APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. PubMed ID: 14557245

ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. PubMed ID: 12694406

TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. PubMed ID: 18627766

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration. PubMed ID: 36608681

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. PubMed ID: 14690597

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. PubMed ID: 12646924

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. PubMed ID: 15361859