Details for: RNF145

Gene ID: 153830

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RNF145

Ensembl ID: ENSG00000145860

Description: ring finger protein 145

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • epithelial cell of lower respiratory tract CL0002632
    CSI 77.12
    rCSI 59.78%
    PRS 28.48
  • club cell CL0000158
    CSI 29.76
    rCSI 43.59%
    PRS 31.54
  • pulmonary alveolar type 2 cell CL0002063
    CSI 29.13
    rCSI 45.18%
    PRS 40.27
  • respiratory suprabasal cell CL4033048
    CSI 28.48
    rCSI 36.53%
    PRS 33.35
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 27.03
    rCSI 24.62%
    PRS 42.45
  • conjunctival epithelial cell CL1000432
    CSI 25.94
    rCSI 39.62%
    PRS 29.31
  • tracheal goblet cell CL1000329
    CSI 23.24
    rCSI 50.73%
    PRS 50.31
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 20.24
    rCSI 49.19%
    PRS 17.59
  • goblet cell CL0000160
    CSI 19
    rCSI 17.96%
    PRS 30.24
  • duct epithelial cell CL0000068
    CSI 18.32
    rCSI 26.81%
    PRS 30.94
  • L6b glutamatergic cortical neuron CL4023038
    CSI 18.14
    rCSI 56.7%
    PRS 18.89
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 16.41
    rCSI 59.05%
    PRS 17.12
  • bronchial goblet cell CL1000312
    CSI 15.37
    rCSI 61.43%
    PRS 52.84
  • dendritic cell, human CL0001056
    CSI 14.31
    rCSI 21.98%
    PRS 34.33
  • fallopian tube secretory epithelial cell CL4030006
    CSI 14.28
    rCSI 13.74%
    PRS 29.95
  • kidney connecting tubule epithelial cell CL1000768
    CSI 13.8
    rCSI 34.99%
    PRS 22.47
  • secretory cell CL0000151
    CSI 13.17
    rCSI 13.75%
    PRS 29.75
  • parietal epithelial cell CL1000452
    CSI 12.38
    rCSI 33.1%
    PRS 24.41
  • nasal mucosa goblet cell CL0002480
    CSI 11.71
    rCSI 13.58%
    PRS 39.8
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 11.63
    rCSI 43.97%
    PRS 18.78
  • deuterosomal cell CL4033044
    CSI 11.32
    rCSI 38.28%
    PRS 41.44
  • corneal epithelial cell CL0000575
    CSI 11.26
    rCSI 32.22%
    PRS 46.88
  • endothelial cell of placenta CL0009092
    CSI 11.14
    rCSI 54.93%
    PRS 38.45
  • respiratory basal cell CL0002633
    CSI 11.04
    rCSI 11.44%
    PRS 33.99
  • lung ciliated cell CL1000271
    CSI 11.01
    rCSI 12.74%
    PRS 21.73
  • astrocyte of the cerebral cortex CL0002605
    CSI 10.06
    rCSI 22.55%
    PRS 18.63
  • tracheobronchial serous cell CL0019001
    CSI 9.87
    rCSI 42.66%
    PRS 47.33
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 9.8
    rCSI 16.44%
    PRS 18.01
  • multi-ciliated epithelial cell CL0005012
    CSI 9.52
    rCSI 9.5%
    PRS 24.85
  • renal beta-intercalated cell CL0002201
    CSI 9.41
    rCSI 22.43%
    PRS 32
  • OFF-bipolar cell CL0000750
    CSI 9
    rCSI 12.31%
    PRS 40.95
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 9
    rCSI 53.01%
    PRS 18.99
  • dopaminergic neuron CL0000700
    CSI 9
    rCSI 50.87%
    PRS 18.65
  • Hofbauer cell CL3000001
    CSI 8.78
    rCSI 16.58%
    PRS 36.63
  • lung secretory cell CL1000272
    CSI 8.46
    rCSI 20.93%
    PRS 27.25
  • colonocyte CL1000347
    CSI 8.43
    rCSI 12.08%
    PRS 37.34
  • naive B cell CL0000788
    CSI 8.15
    rCSI 6.99%
    PRS 40.79
  • intestine goblet cell CL0019031
    CSI 8.13
    rCSI 7.22%
    PRS 28.95
  • type B pancreatic cell CL0000169
    CSI 7.08
    rCSI 15.67%
    PRS 26.82
  • melanocyte CL0000148
    CSI 6.86
    rCSI 5.08%
    PRS 25
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 6.7
    rCSI 6.83%
    PRS 40.31
  • VIP GABAergic cortical interneuron CL4023016
    CSI 6.29
    rCSI 7.51%
    PRS 17.81
  • pulmonary capillary endothelial cell CL4028001
    CSI 6.09
    rCSI 11.61%
    PRS 44.28
  • luminal cell of prostate epithelium CL0002340
    CSI 6.04
    rCSI 32.5%
    PRS 45.93
  • mesenchymal cell CL0008019
    CSI 5.76
    rCSI 14.63%
    PRS 28
  • lung goblet cell CL1000143
    CSI 5.7
    rCSI 63.7%
    PRS 69.13
  • perivascular cell CL4033054
    CSI 5.69
    rCSI 7.78%
    PRS 32.73
  • Mueller cell CL0000636
    CSI 5.55
    rCSI 12.66%
    PRS 24.91
  • vascular leptomeningeal cell CL4023051
    CSI 5.42
    rCSI 9.5%
    PRS 23.02
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 5.41
    rCSI 15.51%
    PRS 42.78
  • mature T cell CL0002419
    CSI 5.28
    rCSI 4.1%
    PRS 42.1
  • ON-bipolar cell CL0000749
    CSI 5.26
    rCSI 7.82%
    PRS 32.56
  • GABAergic amacrine cell CL4030027
    CSI 5.05
    rCSI 17.3%
    PRS 24.71
  • group 3 innate lymphoid cell CL0001071
    CSI 5
    rCSI 3.75%
    PRS 31.09
  • enteroendocrine cell CL0000164
    CSI 4.99
    rCSI 6.82%
    PRS 31.82
  • stem cell CL0000034
    CSI 4.97
    rCSI 4.79%
    PRS 21.89
  • airway submucosal gland duct basal cell CL4033024
    CSI 4.93
    rCSI 31.55%
    PRS 54.4
  • Kupffer cell CL0000091
    CSI 4.91
    rCSI 11.24%
    PRS 28.5
  • respiratory goblet cell CL0002370
    CSI 4.91
    rCSI 53.42%
    PRS 50.32
  • fibroblast of cardiac tissue CL0002548
    CSI 4.9
    rCSI 23.46%
    PRS 26.08
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 4.88
    rCSI 4.51%
    PRS 48.66
  • precursor B cell CL0000817
    CSI 4.83
    rCSI 4.23%
    PRS 37.44
  • cardiac neuron CL0010022
    CSI 4.77
    rCSI 15.26%
    PRS 25.47
  • pro-B cell CL0000826
    CSI 4.76
    rCSI 3.94%
    PRS 29.51
  • myoepithelial cell CL0000185
    CSI 4.75
    rCSI 12.02%
    PRS 35.52
  • endocardial cell CL0002350
    CSI 4.73
    rCSI 22.67%
    PRS 33.26
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 4.7
    rCSI 5.84%
    PRS 16.93
  • inflammatory macrophage CL0000863
    CSI 4.62
    rCSI 7.9%
    PRS 54.17
  • central nervous system neuron CL2000029
    CSI 4.48
    rCSI 32.92%
    PRS 19.42
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 4.47
    rCSI 8.91%
    PRS 45.99
  • hepatic stellate cell CL0000632
    CSI 4.44
    rCSI 16.65%
    PRS 24.53
  • retinal ganglion cell CL0000740
    CSI 4.27
    rCSI 9.44%
    PRS 21
  • early lymphoid progenitor CL0000936
    CSI 4.25
    rCSI 3.73%
    PRS 33.03
  • cardiac endothelial cell CL0010008
    CSI 4.24
    rCSI 17.12%
    PRS 27.58
  • neural crest cell CL0011012
    CSI 4.24
    rCSI 3.35%
    PRS 20.23
  • pulmonary ionocyte CL0017000
    CSI 4.22
    rCSI 5.14%
    PRS 35.59
  • inhibitory interneuron CL0000498
    CSI 4.19
    rCSI 9.66%
    PRS 23.8
  • myofibroblast cell CL0000186
    CSI 4.16
    rCSI 5.75%
    PRS 36.71
  • epithelial cell of lung CL0000082
    CSI 4.11
    rCSI 3.41%
    PRS 27.71
  • H2 horizontal cell CL0004218
    CSI 4.11
    rCSI 20.44%
    PRS 30.55
  • double negative thymocyte CL0002489
    CSI 4.04
    rCSI 2.81%
    PRS 35.04
  • retinal bipolar neuron CL0000748
    CSI 3.9
    rCSI 7.3%
    PRS 21.61
  • serous secreting cell of bronchus submucosal gland CL4033005
    CSI 3.88
    rCSI 22.06%
    PRS 66.67
  • cerebral cortex neuron CL0010012
    CSI 3.83
    rCSI 15.6%
    PRS 29.33
  • unswitched memory B cell CL0000970
    CSI 3.83
    rCSI 3.22%
    PRS 44.15
  • renal interstitial pericyte CL1001318
    CSI 3.77
    rCSI 10.38%
    PRS 27.16
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 3.74
    rCSI 5.09%
    PRS 57.9
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.68
    rCSI 2.64%
    PRS 39.31
  • pancreatic D cell CL0000173
    CSI 3.59
    rCSI 3.53%
    PRS 31.08
  • CD14-positive monocyte CL0001054
    CSI 3.57
    rCSI 4.45%
    PRS 38.97
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.56
    rCSI 9.21%
    PRS 26.8
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.55
    rCSI 10.54%
    PRS 38.86
  • stratified epithelial cell CL0000079
    CSI 3.53
    rCSI 21.77%
    PRS 67.05
  • colon macrophage CL0009038
    CSI 3.49
    rCSI 16.13%
    PRS 52.42
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 3.49
    rCSI 6.16%
    PRS 17.51
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.48
    rCSI 2.79%
    PRS 48.52
  • radial glial cell CL0000681
    CSI 3.41
    rCSI 4.74%
    PRS 29.2
  • fibroblast of lung CL0002553
    CSI 3.4
    rCSI 3.17%
    PRS 29.04
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 3.36
    rCSI 2.56%
    PRS 37.93
  • mucosal invariant T cell CL0000940
    CSI 3.32
    rCSI 2.69%
    PRS 40.83
  • tracheobronchial goblet cell CL0019003
    CSI 0.1
    rCSI 2.2%
    PRS 83.1%
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 0.9%
    PRS 41.0%
  • medium spiny neuron CL1001474
    CSI 0.2
    rCSI 1.7%
    PRS 18.3%
  • enteric neuron CL0007011
    CSI 0.3
    rCSI 3.6%
    PRS 56.2%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 0.3
    rCSI 6.0%
    PRS 63.5%
  • pancreatic PP cell CL0002275
    CSI 0.3
    rCSI 1.1%
    PRS 45.3%
  • glandular epithelial cell CL0000150
    CSI 0.3
    rCSI 0.8%
    PRS 51.6%
  • paneth cell of colon CL0009009
    CSI 0.3
    rCSI 3.0%
    PRS 59.3%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.3
    rCSI 1.6%
    PRS 37.8%
  • respiratory epithelial cell CL0002368
    CSI 0.3
    rCSI 2.0%
    PRS 68.5%
  • pancreatic stellate cell CL0002410
    CSI 0.4
    rCSI 2.3%
    PRS 40.5%
  • S cone cell CL0003050
    CSI 0.4
    rCSI 1.8%
    PRS 27.3%
  • eye photoreceptor cell CL0000287
    CSI 0.4
    rCSI 4.8%
    PRS 58.3%
  • IgG plasma cell CL0000985
    CSI 0.4
    rCSI 0.5%
    PRS 47.0%
  • primitive red blood cell CL0002355
    CSI 0.4
    rCSI 2.4%
    PRS 44.6%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 0.5
    rCSI 0.8%
    PRS 36.6%
  • type EC enteroendocrine cell CL0000577
    CSI 0.5
    rCSI 1.6%
    PRS 43.7%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 0.5
    rCSI 1.1%
    PRS 21.0%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.5
    rCSI 2.4%
    PRS 45.2%
  • diffuse bipolar 1 cell CL4033027
    CSI 0.5
    rCSI 3.7%
    PRS 28.9%
  • neuroendocrine cell CL0000165
    CSI 0.5
    rCSI 1.9%
    PRS 49.7%
  • erythroblast CL0000765
    CSI 0.5
    rCSI 1.3%
    PRS 42.0%
  • pancreatic ductal cell CL0002079
    CSI 0.5
    rCSI 1.0%
    PRS 30.0%
  • starburst amacrine cell CL0004232
    CSI 0.5
    rCSI 4.5%
    PRS 29.4%
  • serous secreting cell CL0000313
    CSI 0.6
    rCSI 2.8%
    PRS 72.2%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.6
    rCSI 1.9%
    PRS 29.9%
  • invaginating midget bipolar cell CL4033034
    CSI 0.6
    rCSI 3.6%
    PRS 29.7%
  • diffuse bipolar 2 cell CL4033028
    CSI 0.6
    rCSI 4.9%
    PRS 29.8%
  • basophil CL0000767
    CSI 0.7
    rCSI 1.4%
    PRS 51.4%
  • Langerhans cell CL0000453
    CSI 0.7
    rCSI 1.0%
    PRS 46.8%
  • endothelial cell of uterus CL0009095
    CSI 0.7
    rCSI 5.0%
    PRS 61.3%
  • flat midget bipolar cell CL4033033
    CSI 0.7
    rCSI 5.1%
    PRS 28.3%
  • enteroglial cell CL4040002
    CSI 0.7
    rCSI 3.8%
    PRS 41.5%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.8
    rCSI 2.2%
    PRS 32.1%
  • hepatocyte CL0000182
    CSI 0.8
    rCSI 1.4%
    PRS 27.2%
  • diffuse bipolar 3b cell CL4033030
    CSI 0.8
    rCSI 5.1%
    PRS 29.6%
  • hematopoietic stem cell CL0000037
    CSI 0.8
    rCSI 0.5%
    PRS 33.5%
  • interstitial cell of Cajal CL0002088
    CSI 0.8
    rCSI 1.0%
    PRS 33.3%
  • OFFx cell CL4033036
    CSI 0.8
    rCSI 3.8%
    PRS 29.7%
  • adventitial cell CL0002503
    CSI 0.8
    rCSI 1.9%
    PRS 40.8%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 0.8
    rCSI 1.5%
    PRS 53.9%
  • glycinergic amacrine cell CL4030028
    CSI 0.8
    rCSI 2.1%
    PRS 29.2%
  • H1 horizontal cell CL0004217
    CSI 0.8
    rCSI 3.2%
    PRS 34.9%
  • pancreatic acinar cell CL0002064
    CSI 0.8
    rCSI 1.1%
    PRS 31.9%
  • foveolar cell of stomach CL0002179
    CSI 0.9
    rCSI 1.8%
    PRS 43.4%
  • mature alpha-beta T cell CL0000791
    CSI 0.9
    rCSI 3.3%
    PRS 46.4%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.9
    rCSI 6.3%
    PRS 50.2%
  • vasa recta ascending limb cell CL1001131
    CSI 0.9
    rCSI 4.2%
    PRS 65.0%
  • erythroid progenitor cell CL0000038
    CSI 0.9
    rCSI 5.4%
    PRS 40.2%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.0
    rCSI 0.7%
    PRS 27.4%
  • intestinal tuft cell CL0019032
    CSI 1.0
    rCSI 1.5%
    PRS 32.9%
  • transitional stage B cell CL0000818
    CSI 1.0
    rCSI 3.2%
    PRS 63.5%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.0
    rCSI 1.8%
    PRS 43.2%
  • diffuse bipolar 3a cell CL4033029
    CSI 1.0
    rCSI 6.8%
    PRS 29.2%
  • intrahepatic cholangiocyte CL0002538
    CSI 1.0
    rCSI 2.4%
    PRS 46.7%
  • promyelocyte CL0000836
    CSI 1.0
    rCSI 1.5%
    PRS 38.5%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.0
    rCSI 8.5%
    PRS 27.0%
  • glial cell CL0000125
    CSI 1.1
    rCSI 4.1%
    PRS 26.5%
  • stromal cell of ovary CL0002132
    CSI 1.1
    rCSI 3.0%
    PRS 44.7%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.1
    rCSI 1.3%
    PRS 47.4%
  • tendon cell CL0000388
    CSI 1.1
    rCSI 2.9%
    PRS 58.4%
  • helper T cell CL0000912
    CSI 1.1
    rCSI 1.6%
    PRS 38.8%
  • retinal pigment epithelial cell CL0002586
    CSI 1.1
    rCSI 2.2%
    PRS 29.8%
  • tissue-resident macrophage CL0000864
    CSI 1.2
    rCSI 5.5%
    PRS 49.9%
  • epithelial cell of urethra CL1000296
    CSI 1.2
    rCSI 29.5%
    PRS 61.2%
  • mucus secreting cell CL0000319
    CSI 1.2
    rCSI 1.9%
    PRS 37.2%
  • extravillous trophoblast CL0008036
    CSI 1.2
    rCSI 1.5%
    PRS 25.7%
  • intermediate monocyte CL0002393
    CSI 1.2
    rCSI 1.8%
    PRS 29.8%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.2
    rCSI 3.9%
    PRS 20.5%
  • common myeloid progenitor CL0000049
    CSI 1.2
    rCSI 1.0%
    PRS 29.2%
  • natural T-regulatory cell CL0000903
    CSI 1.2
    rCSI 2.4%
    PRS 65.2%
  • GABAergic neuron CL0000617
    CSI 1.3
    rCSI 4.2%
    PRS 21.4%
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 1.3
    rCSI 0.8%
    PRS 40.4%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.3
    rCSI 2.4%
    PRS 25.1%
  • glutamatergic neuron CL0000679
    CSI 1.3
    rCSI 2.7%
    PRS 27.3%
  • choroid plexus epithelial cell CL0000706
    CSI 1.3
    rCSI 2.2%
    PRS 22.7%
  • immature B cell CL0000816
    CSI 1.3
    rCSI 1.0%
    PRS 40.8%
  • ON parasol ganglion cell CL4033052
    CSI 1.3
    rCSI 18.7%
    PRS 24.0%
  • macroglial cell CL0000126
    CSI 1.3
    rCSI 3.4%
    PRS 34.5%
  • BEST4+ enteroycte CL4030026
    CSI 1.3
    rCSI 1.7%
    PRS 31.1%
  • acinar cell of salivary gland CL0002623
    CSI 1.3
    rCSI 31.3%
    PRS 50.6%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 1.4
    rCSI 3.5%
    PRS 27.7%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 1.4
    rCSI 0.9%
    PRS 36.2%
  • T-helper 17 cell CL0000899
    CSI 1.4
    rCSI 1.1%
    PRS 48.9%
  • retinal cone cell CL0000573
    CSI 1.4
    rCSI 2.2%
    PRS 22.5%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.4
    rCSI 1.8%
    PRS 40.2%
  • ionocyte CL0005006
    CSI 1.4
    rCSI 1.5%
    PRS 27.0%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.4
    rCSI 3.1%
    PRS 22.2%
  • Schwann cell CL0002573
    CSI 1.5
    rCSI 4.1%
    PRS 30.9%
  • small intestine goblet cell CL1000495
    CSI 1.5
    rCSI 3.2%
    PRS 38.0%
  • retina horizontal cell CL0000745
    CSI 1.5
    rCSI 2.3%
    PRS 26.9%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.5
    rCSI 2.1%
    PRS 50.0%
  • transit amplifying cell of colon CL0009011
    CSI 1.5
    rCSI 1.8%
    PRS 32.9%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.5
    rCSI 1.8%
    PRS 34.7%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 1.5
    rCSI 2.4%
    PRS 56.8%
  • basal cell of prostate epithelium CL0002341
    CSI 1.5
    rCSI 4.4%
    PRS 51.6%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.5
    rCSI 5.0%
    PRS 20.9%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.5
    rCSI 8.8%
    PRS 33.7%
  • intestinal epithelial cell CL0002563
    CSI 1.5
    rCSI 1.6%
    PRS 29.7%
  • placental villous trophoblast CL2000060
    CSI 1.5
    rCSI 2.4%
    PRS 27.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [RNF145](/details-gene/153830) (Ring Finger Protein 145) is a protein-coding gene located on chromosome 5q33.3 that encodes an E3 ubiquitin-protein ligase. Functional annotations indicate its localization to the endoplasmic reticulum membrane, where it participates in the [proteasome-mediated ubiquitin-dependent protein catabolic process](/details-go/GO:0043161). The gene's existence and sequence were confirmed through large-scale cDNA and genome sequencing projects ([Link](https://doi.org/10.1038/ng1285), [Link](https://doi.org/10.1038/nature02919), [Link](https://doi.org/10.1101/gr.2596504)). **Overall**, its expression profile is dominated by high significance in various epithelial lineages, particularly those of the respiratory tract, such as [epithelial cell of lower respiratory tract](/details-cell/CL0002632) and [club cell](/details-cell/CL0000158). This suggests a primary role for [RNF145](/details-gene/153830) in maintaining protein homeostasis and quality control within secretory and barrier tissues. ## Cellular Roles and Expression Landscape The expression landscape of [RNF145](/details-gene/153830) strongly points to a specialized function in epithelial cell biology. **Overall**, the gene exhibits its highest significance in the [epithelial cell of lower respiratory tract](/details-cell/CL0002632) (CSI: 77.12), a finding reinforced by its high scores in other key respiratory cells, including secretory [club cell](/details-cell/CL0000158)s (CSI: 29.76), surfactant-producing [pulmonary alveolar type 2 cell](/details-cell/CL0002063)s (CSI: 29.13), and mucus-secreting [goblet cell](/details-cell/CL0000160)s (CSI: 19.00). This pattern of high expression in secretory epithelial cells is not confined to the lungs, as evidenced by its significance in [conjunctival epithelial cell](/details-cell/CL1000432)s and [fallopian tube secretory epithelial cell](/details-cell/CL4030006)s. Beyond its primary epithelial association, [RNF145](/details-gene/153830) also shows moderate but notable significance in distinct, non-epithelial cell types. These include subsets of the immune system, such as the [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: 27.03) and [dendritic cell, human](/details-cell/CL0001056) (CSI: 14.31), as well as specific neuronal populations like the [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 20.24). This expression pattern suggests that while the predominant role of [RNF145](/details-gene/153830) relates to epithelial function, it may also fulfill more specialized roles in long-term immune memory and neuronal protein regulation. ## Pathways and Molecular Function Functionally, [RNF145](/details-gene/153830) is annotated as an enzyme with [ubiquitin protein ligase activity](/details-go/GO:0061630), a key component of the ubiquitin-proteasome system. Its specific localization to the [endoplasmic reticulum membrane](/details-go/GO:0005789) strongly suggests its involvement in ER-associated degradation (ERAD). This pathway is critical for identifying and targeting misfolded or unfolded proteins within the ER for destruction, thereby preventing cellular stress. This molecular function is highly consistent with the gene's cellular expression profile. The high significance of [RNF145](/details-gene/153830) in professional secretory cells like [goblet cell](/details-cell/CL0000160)s, [club cell](/details-cell/CL0000158)s, and [pulmonary alveolar type 2 cell](/details-cell/CL0002063)s, which experience a high protein synthesis load, underscores its likely role in managing ER protein quality control. In immune cells like [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913)s, its activity may be directed towards regulating the turnover of membrane receptors or signaling components crucial for their long-term survival and function. ## Research Directions The specific role of [RNF145](/details-gene/153830) as an ER-resident E3 ligase with high expression in secretory epithelial cells presents several avenues for future research, particularly in the context of respiratory diseases. ### Proposed Hypotheses 1. **Role in Respiratory Epithelial Homeostasis:** Given its function and expression, [RNF145](/details-gene/153830) may be a critical regulator of the unfolded protein response (UPR) and ERAD pathway in respiratory epithelial cells. Its dysregulation could impair the ability of these cells to cope with the high demand for mucus and surfactant protein synthesis, potentially contributing to the pathology of diseases characterized by ER stress, such as chronic obstructive pulmonary disease (COPD) or cystic fibrosis. 2. **Regulation of T-cell Memory:** The specific expression of [RNF145](/details-gene/153830) in [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913)s suggests a role in maintaining this long-lived cell population. It may regulate the stability of key survival factors or cell surface receptors, thereby controlling the persistence and reactivation potential of the memory T-cell pool. ### Key Experiment To test the first hypothesis, the function of [RNF145](/details-gene/153830) in respiratory epithelium could be investigated using an air-liquid interface (ALI) culture system with primary human bronchial epithelial cells. `RNF145` expression could be ablated using CRISPR-Cas9, and the cultures would then be challenged with an ER stress-inducing agent like tunicamycin. The consequences would be measured by quantifying key UPR signaling markers (e.g., spliced XBP1, ATF4, CHOP) via qRT-PCR and Western blot, assessing cell differentiation and mucus production via immunofluorescence, and analyzing the global ubiquitylome by mass spectrometry to identify specific protein substrates of RNF145. ### Therapeutic Potential As an enzyme, [RNF145](/details-gene/153830) is a potentially druggable target. Its high expression in respiratory epithelial cells suggests that modulating its activity could be a therapeutic strategy for certain lung diseases. If its over-activity leads to the inappropriate degradation of a critical protein, targeted **inhibition** could be beneficial. Conversely, in diseases caused by the aggregation of misfolded proteins due to ERAD insufficiency, small-molecule **activators** of [RNF145](/details-gene/153830) could help clear toxic aggregates. The gene's relatively specific expression pattern raises the possibility of developing therapies with a favorable therapeutic window and limited systemic side effects.

Genular Protein ID: 3164237981

Symbol: RN145_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 663
  • Mass: 75617
  • Checksum: EAE984696500ABD3
  • Sequence:
  • MAAKEKLEAV LNVALRVPSI MLLDVLYRWD VSSFFQQIQR SSLSNNPLFQ YKYLALNMHY 
    VGYILSVVLL TLPRQHLVQL YLYFLTALLL YAGHQISRDY VRSELEFAYE GPMYLEPLSM 
    NRFTTALIGQ LVVCTLCSCV MKTKQIWLFS AHMLPLLARL CLVPLETIVI INKFAMIFTG 
    LEVLYFLGSN LLVPYNLAKS AYRELVQVVE VYGLLALGMS LWNQLVVPVL FMVFWLVLFA 
    LQIYSYFSTR DQPASRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ 
    GYRAFMNDPA MNRGMTEGVT LLILAVQTGL IELQVVHRAF LLSIILFIVV ASILQSMLEI 
    ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPAYMAYMI CQFFHMDFWL LIIISSSILT 
    SLQVLGTLFI YVLFMVEEFR KEPVENMDDV IYYVNGTYRL LEFLVALCVV AYGVSETIFG 
    EWTVMGSMII FIHSYYNVWL RAQLGWKSFL LRRDAVNKIK SLPIATKEQL EKHNDICAIC 
    YQDMKSAVIT PCSHFFHAGC LKKWLYVQET CPLCHCHLKN SSQLPGLGTE PVLQPHAGAE 
    QNVMFQEGTE PPGQEHTPGT RIQEGSRDNN EYIARRPDNQ EGAFDPKEYP HSAKDEAHPV 
    ESA

Genular Protein ID: 2982352687

Symbol: Q8NDT8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 121
  • Mass: 13434
  • Checksum: B0D856621E835B8D
  • Sequence:
  • DMKSAVITPC SHFFHAGCLK KWLYVQETCP LCHCHLKNSS QLPGLGTEPV LQPHAGAEQN 
    VMFQEGTEPP GQEHTPGTRI QEGSRDNNEY IARRPDNQEG AFDPKEYPHS AKDEAHPVES 
    A

Genular Protein ID: 623231052

Symbol: A8K9Y9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 663
  • Mass: 75587
  • Checksum: EB9FA1F9A4E64ED3
  • Sequence:
  • MAAKEKLEAV LNVALRVPSI MLLDVLYRRD VSSFFQQIQR SSLSNNPLFQ YKYLALNMHY 
    VGYILSVVLL TLPRQHLVQL YLYFLTALLL YAGHQISRDY VRSELEFAYE GPMYLEPLSM 
    NRFTTALIGQ LVVCTLCSCV MKTKQIWLFS AHMLPLLARL CLVPLETIVI INKFAMIFTG 
    LEVLYFLGSN LLVPYNLAKS AYRELVQVVE VYGLLALGMS LWNQLVVPVL FMVFWLVLFA 
    LQIYSYFSTR DQPASRERLL FLFLTSIAEC CSTPYSLLGL VFTVSFVALG VLTLCKFYLQ 
    GYRAFMNDPA MNRGMTEGVT LLILAVQTGL IELQVVHRAF LLSIILFIVV ASILQSMLEI 
    ADPIVLALGA SRDKSLWKHF RAVSLCLFLL VFPAYMAYMI CQFFHMDFWL LIIISSSILT 
    SLQVLGTLFI YVLFMVEEFR KEPVENMDDV IYYVNGTYRL LEFLVALCVV AYGVSETIFG 
    EWTVMGSMII FIHSYYNVWL RAQLGWKSFL LRRDAVNKIK SLPIATKEQL EKHNDICAIC 
    YQDMKSAVIT PCSHFFHAGC LKKWLYVQET CPLCHCHLKN SSQLPGLGTE PVLQPHAGAE 
    QNVMFQEGTE PPGQEHTPGT RIQEGSRDNN EYIARRPDNQ EGAFDPKEYP HSAKDEAHPV 
    ESA