Details for: RTF1
Gene ID: 23168
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: RTF1
Ensembl ID: ENSG00000137815
Description: RTF1 homolog, Paf1/RNA polymerase II complex component
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 27.45rCSI 24.79%PRS 18.03
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CSI 25.32rCSI 31.77%PRS 25.93
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CSI 23.04rCSI 18.63%PRS 20.07
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CSI 21.86rCSI 29.79%PRS 17.76
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CSI 21.05rCSI 20.27%PRS 20.76
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CSI 20.48rCSI 56.27%PRS 32.83
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CSI 19.03rCSI 29.4%PRS 18.8
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CSI 18.14rCSI 21.3%PRS 23.16
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CSI 17.38rCSI 14.57%PRS 23.85
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CSI 15.82rCSI 21.64%PRS 31.25
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CSI 15.43rCSI 16.12%PRS 20.93
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CSI 15.41rCSI 52.8%PRS 17.47
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CSI 15.38rCSI 79.39%PRS 38.83
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CSI 15.14rCSI 43.82%PRS 22.68
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CSI 15.12rCSI 35.95%PRS 29.9
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CSI 14.04rCSI 16.85%PRS 19.61
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CSI 13.63rCSI 11.8%PRS 22.56
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CSI 13.35rCSI 8.87%PRS 24
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CSI 13.01rCSI 41.73%PRS 28.6
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CSI 12.81rCSI 37.12%PRS 15.4
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CSI 11.77rCSI 13.48%PRS 40.19
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CSI 10.52rCSI 15.53%PRS 31.33
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CSI 9.28rCSI 36.12%PRS 32.83
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CSI 9.09rCSI 26.83%PRS 24.15
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CSI 8.63rCSI 16.78%PRS 20.51
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CSI 7.84rCSI 17.32%PRS 14.37
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CSI 7.51rCSI 11.01%PRS 26.29
-
CSI 7.25rCSI 6.99%PRS 14.48
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CSI 6.91rCSI 44.27%PRS 30.93
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CSI 6.17rCSI 4.87%PRS 13.78
-
CSI 5.89rCSI 29.04%PRS 27.15
-
CSI 5.84rCSI 25.64%PRS 36.78
-
CSI 5.84rCSI 6.09%PRS 53.67
-
CSI 5.43rCSI 42.58%PRS 39.74
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CSI 5.28rCSI 6.53%PRS 17.58
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CSI 5.01rCSI 13.52%PRS 25.97
-
CSI 4.82rCSI 71.25%PRS 47.27
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CSI 4.74rCSI 27.57%PRS 29.71
-
CSI 4.67rCSI 11.36%PRS 11.63
-
CSI 4.66rCSI 5.99%PRS 19.37
-
CSI 4.66rCSI 6.65%PRS 22.58
-
CSI 4.63rCSI 15.16%PRS 51.52
-
CSI 4.58rCSI 9.41%PRS 19.92
-
CSI 4.47rCSI 6.82%PRS 18.66
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CSI 4.42rCSI 8.52%PRS 44.48
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CSI 4.33rCSI 5.91%PRS 22.71
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CSI 4.27rCSI 4.8%PRS 31.86
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CSI 3.86rCSI 7.75%PRS 14.85
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CSI 3.8rCSI 3.2%PRS 31.71
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CSI 3.56rCSI 85.12%PRS 10.23
-
CSI 3.54rCSI 85.52%PRS 11.19
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CSI 3.45rCSI 5.89%PRS 40.16
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CSI 3.45rCSI 10.77%PRS 12.65
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CSI 3.35rCSI 4.83%PRS 28
-
CSI 3.33rCSI 19.58%PRS 12.4
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CSI 3.21rCSI 2.43%PRS 27.48
-
CSI 3.21rCSI 11.55%PRS 11.14
-
CSI 3.19rCSI 7.42%PRS 39.51
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CSI 3.09rCSI 8.83%PRS 33.71
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CSI 2.96rCSI 3.69%PRS 21.35
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CSI 2.94rCSI 22.07%PRS 36.47
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CSI 2.88rCSI 18.94%PRS 57.18
-
CSI 2.88rCSI 3.5%PRS 25.14
-
CSI 2.78rCSI 4.25%PRS 22.89
-
CSI 2.76rCSI 7.96%PRS 37.08
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CSI 2.68rCSI 3.1%PRS 17.55
-
CSI 2.67rCSI 54.28%PRS 16.16
-
CSI 2.59rCSI 77.78%PRS 43.52
-
CSI 2.57rCSI 47.07%PRS 54.84
-
CSI 2.54rCSI 8.49%PRS 14.29
-
CSI 2.39rCSI 1.94%PRS 21.16
-
CSI 2.32rCSI 47.27%PRS 17.22
-
CSI 2.26rCSI 5.37%PRS 24.78
-
CSI 2.21rCSI 1.64%PRS 17.47
-
CSI 2.18rCSI 1.92%PRS 14.59
-
CSI 2.15rCSI 9.56%PRS 68.17
-
CSI 2.12rCSI 30.11%PRS 15.31
-
CSI 2.1rCSI 48.93%PRS 37.21
-
CSI 2.09rCSI 3.93%PRS 38.95
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CSI 2.08rCSI 19.77%PRS 68.37
-
CSI 2.07rCSI 1.72%PRS 20.32
-
CSI 1.96rCSI 15.91%PRS 20.16
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CSI 1.9rCSI 2.91%PRS 23.92
-
CSI 1.87rCSI 1.47%PRS 24.18
-
CSI 1.83rCSI 20.01%PRS 35.54
-
CSI 1.82rCSI 10.45%PRS 30.08
-
CSI 1.73rCSI 6.17%PRS 58.01
-
CSI 1.61rCSI 6.58%PRS 20.51
-
CSI 1.6rCSI 11.8%PRS 11.8
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CSI 1.57rCSI 2.33%PRS 23.89
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CSI 1.53rCSI 8.25%PRS 34.89
-
CSI 1.53rCSI 3.67%PRS 35.63
-
CSI 1.51rCSI 5.67%PRS 16.92
-
CSI 1.5rCSI 1.16%PRS 19.22
-
CSI 1.5rCSI 1.04%PRS 21.3
-
CSI 1.48rCSI 1.37%PRS 20.75
-
CSI 1.47rCSI 3.72%PRS 24.8
-
CSI 1.46rCSI 1.1%PRS 53.35
-
CSI 1.42rCSI 3.97%PRS 31
-
CSI 1.4rCSI 1.91%PRS 22.25
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CSI -2.5rCSI -7.0%PRS 18.7%
-
CSI -1.9rCSI -2.2%PRS 27.4%
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CSI -1.5rCSI -4.0%PRS 16.7%
-
CSI -1.5rCSI -3.3%PRS 12.4%
-
CSI -1.4rCSI -3.5%PRS 53.1%
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CSI -1.0rCSI -2.1%PRS 21.1%
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CSI -0.9rCSI -4.5%PRS 15.7%
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CSI -0.8rCSI -0.7%PRS 23.4%
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CSI -0.7rCSI -3.8%PRS 11.1%
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CSI -0.6rCSI -0.9%PRS 22.9%
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CSI -0.5rCSI -1.2%PRS 28.9%
-
CSI -0.4rCSI -2.4%PRS 57.5%
-
CSI -0.4rCSI -0.4%PRS 30.5%
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CSI -0.3rCSI -0.6%PRS 14.1%
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CSI -0.3rCSI -1.6%PRS 51.1%
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CSI -0.1rCSI -0.1%PRS 29.6%
-
CSI -0.1rCSI -0.1%PRS 34.6%
-
CSI 0.0rCSI -0.2%PRS 15.6%
-
CSI 0.0rCSI -0.1%PRS 18.6%
-
CSI 0.0rCSI 0.1%PRS 10.2%
-
CSI 0.0rCSI 0.1%PRS 20.1%
-
CSI 0.0rCSI 0.2%PRS 29.3%
-
CSI 0.1rCSI 0.1%PRS 30.1%
-
CSI 0.1rCSI 0.3%PRS 60.9%
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CSI 0.1rCSI 1.7%PRS 72.1%
-
CSI 0.1rCSI 1.9%PRS 69.6%
-
CSI 0.1rCSI 0.1%PRS 28.5%
-
CSI 0.1rCSI 0.6%PRS 21.6%
-
CSI 0.1rCSI 0.7%PRS 71.6%
-
CSI 0.1rCSI 0.6%PRS 21.1%
-
CSI 0.1rCSI 0.4%PRS 34.7%
-
CSI 0.1rCSI 2.1%PRS 79.1%
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CSI 0.1rCSI 2.5%PRS 53.5%
-
CSI 0.1rCSI 1.1%PRS 38.0%
-
CSI 0.1rCSI 0.6%PRS 60.9%
-
CSI 0.1rCSI 2.5%PRS 67.2%
-
CSI 0.1rCSI 0.2%PRS 11.8%
-
CSI 0.1rCSI 1.3%PRS 65.3%
-
CSI 0.1rCSI 0.3%PRS 38.8%
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CSI 0.1rCSI 0.4%PRS 24.4%
-
CSI 0.1rCSI 0.6%PRS 18.8%
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CSI 0.1rCSI 0.9%PRS 38.6%
-
CSI 0.1rCSI 1.4%PRS 57.4%
-
CSI 0.1rCSI 1.4%PRS 50.8%
-
CSI 0.2rCSI 0.7%PRS 73.8%
-
CSI 0.2rCSI 0.2%PRS 24.7%
-
CSI 0.2rCSI 3.0%PRS 54.1%
-
CSI 0.2rCSI 0.6%PRS 39.1%
-
CSI 0.2rCSI 1.1%PRS 53.7%
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CSI 0.2rCSI 0.8%PRS 21.9%
-
CSI 0.2rCSI 0.8%PRS 49.2%
-
CSI 0.2rCSI 0.8%PRS 18.0%
-
CSI 0.2rCSI 0.7%PRS 34.2%
-
CSI 0.2rCSI 0.4%PRS 39.7%
-
CSI 0.2rCSI 0.2%PRS 35.8%
-
CSI 0.2rCSI 0.7%PRS 34.2%
-
CSI 0.2rCSI 0.5%PRS 13.0%
-
CSI 0.2rCSI 0.8%PRS 41.7%
-
CSI 0.2rCSI 3.2%PRS 54.0%
-
CSI 0.2rCSI 2.1%PRS 51.3%
-
CSI 0.2rCSI 0.3%PRS 20.2%
-
CSI 0.2rCSI 2.0%PRS 50.8%
-
CSI 0.2rCSI 0.7%PRS 13.6%
-
CSI 0.2rCSI 0.3%PRS 12.4%
-
CSI 0.2rCSI 0.9%PRS 19.5%
-
CSI 0.2rCSI 2.6%PRS 72.9%
-
CSI 0.2rCSI 0.6%PRS 23.1%
-
CSI 0.3rCSI 2.9%PRS 47.1%
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CSI 0.3rCSI 0.9%PRS 31.8%
-
CSI 0.3rCSI 0.2%PRS 27.5%
-
CSI 0.3rCSI 1.0%PRS 27.3%
-
CSI 0.3rCSI 1.2%PRS 41.2%
-
CSI 0.3rCSI 0.7%PRS 26.0%
-
CSI 0.3rCSI 0.9%PRS 64.9%
-
CSI 0.3rCSI 0.7%PRS 18.5%
-
CSI 0.3rCSI 0.6%PRS 23.2%
-
CSI 0.3rCSI 0.8%PRS 45.2%
-
CSI 0.3rCSI 0.5%PRS 26.3%
-
CSI 0.3rCSI 7.0%PRS 86.2%
-
CSI 0.3rCSI 0.9%PRS 26.9%
-
CSI 0.3rCSI 4.1%PRS 58.5%
-
CSI 0.3rCSI 0.3%PRS 36.8%
-
CSI 0.3rCSI 0.5%PRS 25.8%
-
CSI 0.3rCSI 0.7%PRS 29.6%
-
CSI 0.3rCSI 0.6%PRS 30.5%
-
CSI 0.3rCSI 1.8%PRS 35.3%
-
CSI 0.3rCSI 0.9%PRS 25.9%
-
CSI 0.3rCSI 3.1%PRS 63.1%
-
CSI 0.3rCSI 0.6%PRS 15.5%
-
CSI 0.4rCSI 1.7%PRS 24.8%
-
CSI 0.4rCSI 0.5%PRS 46.0%
-
CSI 0.4rCSI 0.8%PRS 20.7%
-
CSI 0.4rCSI 0.3%PRS 18.6%
-
CSI 0.4rCSI 0.8%PRS 42.9%
-
CSI 0.4rCSI 1.2%PRS 16.0%
-
CSI 0.4rCSI 1.6%PRS 36.6%
-
CSI 0.4rCSI 0.4%PRS 40.4%
-
CSI 0.4rCSI 0.5%PRS 30.7%
-
CSI 0.4rCSI 0.8%PRS 47.7%
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CSI 0.4rCSI 1.6%PRS 47.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1629085102
Symbol: RTF1_HUMAN
Name: RNA polymerase-associated protein RTF1 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19345177
Title: A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
PubMed ID: 19345177
PubMed ID: 20178742
Title: The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.
PubMed ID: 20178742
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 18184592
Title: Structure and DNA binding of the human Rtf1 Plus3 domain.
PubMed ID: 18184592
Sequence Information:
- Length: 710
- Mass: 80313
- Checksum: 54CC014655AA22B8
- Sequence:
MRGRLCVGRA AAAAAAVAVP LAGGQEGSPG GGRRGSRGTT MVKKRKGRVV IDSDTEDSGS DENLDQELLS LAKRKRSDSE EKEPPVSQPA ASSDSETSDS DDEWTFGSNK NKKKGKARKI EKKGTMKKQA NKTASSGSSD KDSSAESSAP EEGEVSDSDS NSSSSSSDSD SSSEDEEFHD GYGEDLMGDE EDRARLEQMT EKEREQELFN RIEKREVLKR RFEIKKKLKT AKKKEKKEKK KKQEEEQEKK KLTQIQESQV TSHNKERRSK RDEKLDKKSQ AMEELKAERE KRKNRTAELL AKKQPLKTSE VYSDDEEEEE DDKSSEKSDR SSRTSSSDEE EEKEEIPPKS QPVSLPEELN RVRLSRHKLE RWCHMPFFAK TVTGCFVRIG IGNHNSKPVY RVAEITGVVE TAKVYQLGGT RTNKGLQLRH GNDQRVFRLE FVSNQEFTES EFMKWKEAMF SAGMQLPTLD EINKKELSIK EALNYKFNDQ DIEEIVKEKE RFRKAPPNYA MKKTQLLKEK AMAEDLGDQD KAKQIQDQLN ELEERAEALD RQRTKNISAI SYINQRNREW NIVESEKALV AESHNMKNQQ MDPFTRRQCK PTIVSNSRDP AVQAAILAQL NAKYGSGVLP DAPKEMSKGQ GKDKDLNSKS ASDLSEDLFK VHDFDVKIDL QVPSSESKAL AITSKAPPAK DGAPRRSLNL EDYKKRRGLI