PDE7A | ENSG00000205268 | NCBI 5150

Details for: PDE7A

Associated with

G alpha (s) signalling events
(R-HSA-418555)
Gpcr downstream signalling
(R-HSA-388396)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
3',5'-cyclic-amp phosphodiesterase activity
(GO:0004115)
3',5'-cyclic-gmp phosphodiesterase activity
(GO:0047555)
Camp-mediated signaling
(GO:0019933)
Camp catabolic process
(GO:0006198)
Cytosol
(GO:0005829)
Metal ion binding
(GO:0046872)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

cardiac muscle cell CL0000746

CSI 52.85

rCSI 75.83%

PRS 21.13
lamp5 GABAergic cortical interneuron CL4023011

CSI 22.84

rCSI 38.33%

PRS 16.43
regular atrial cardiac myocyte CL0002129

CSI 17.66

rCSI 56.84%

PRS 27.69
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 17.23

rCSI 41.88%

PRS 16.08
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 15.9

rCSI 57.22%

PRS 15.59
double negative thymocyte CL0002489

CSI 15.7

rCSI 10.92%

PRS 32.41
near-projecting glutamatergic cortical neuron CL4023012

CSI 15.68

rCSI 59.25%

PRS 17.11
glioblast CL0000030

CSI 12.21

rCSI 19.47%

PRS 22.97
L6b glutamatergic cortical neuron CL4023038

CSI 11.79

rCSI 36.85%

PRS 17.28
precursor B cell CL0000817

CSI 11.78

rCSI 10.32%

PRS 34.98
epithelial cell of lower respiratory tract CL0002632

CSI 11.14

rCSI 8.63%

PRS 26.19
chondrocyte CL0000138

CSI 11

rCSI 17.5%

PRS 22.64
alveolar adventitial fibroblast CL4028006

CSI 10.87

rCSI 17.17%

PRS 27.11
pvalb GABAergic cortical interneuron CL4023018

CSI 10.27

rCSI 12.78%

PRS 15.45
regular ventricular cardiac myocyte CL0002131

CSI 10.13

rCSI 63.3%

PRS 21.55
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 9.73

rCSI 7.3%

PRS 63.4
CD1c-positive myeloid dendritic cell CL0002399

CSI 9.53

rCSI 11.51%

PRS 32.2
hematopoietic precursor cell CL0008001

CSI 9.4

rCSI 9.67%

PRS 41.78
erythroblast CL0000765

CSI 9.27

rCSI 24.6%

PRS 39.49
respiratory basal cell CL0002633

CSI 8.86

rCSI 9.18%

PRS 31.62
S cone cell CL0003050

CSI 8.8

rCSI 38.67%

PRS 25.38
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 8.37

rCSI 26.19%

PRS 18.76
airway submucosal gland duct basal cell CL4033024

CSI 8.23

rCSI 52.62%

PRS 53
hematopoietic stem cell CL0000037

CSI 7.9

rCSI 5.25%

PRS 31.36
group 3 innate lymphoid cell CL0001071

CSI 7.35

rCSI 5.52%

PRS 28.78
GABAergic amacrine cell CL4030027

CSI 7.19

rCSI 24.64%

PRS 22.95
ciliated epithelial cell CL0000067

CSI 7.14

rCSI 6.28%

PRS 19.7
rod bipolar cell CL0000751

CSI 7.02

rCSI 12.62%

PRS 22.37
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 6.74

rCSI 7.78%

PRS 23.26
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 6.73

rCSI 39.64%

PRS 17.27
retinal bipolar neuron CL0000748

CSI 6.53

rCSI 12.22%

PRS 19.8
intestinal crypt stem cell of small intestine CL0009017

CSI 6.44

rCSI 17.36%

PRS 34.51
radial glial cell CL0000681

CSI 6.43

rCSI 8.93%

PRS 27.07
naive B cell CL0000788

CSI 6.14

rCSI 5.26%

PRS 38.9
mesothelial cell CL0000077

CSI 6.1

rCSI 23.85%

PRS 10.16
common dendritic progenitor CL0001029

CSI 6.04

rCSI 7.58%

PRS 34.45
elicited macrophage CL0000861

CSI 5.62

rCSI 5.16%

PRS 31.93
intestinal tuft cell CL0019032

CSI 5.57

rCSI 8.52%

PRS 30.6
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 5.46

rCSI 14.14%

PRS 59.93
lung macrophage CL1001603

CSI 5.24

rCSI 11.71%

PRS 31.38
retinal rod cell CL0000604

CSI 5.22

rCSI 9.21%

PRS 26.13
CD4-positive, alpha-beta memory T cell CL0000897

CSI 5.15

rCSI 3.7%

PRS 36.57
myeloid dendritic cell CL0000782

CSI 5

rCSI 7.24%

PRS 39.96
CD14-positive monocyte CL0001054

CSI 4.93

rCSI 6.14%

PRS 36.45
Bergmann glial cell CL0000644

CSI 4.92

rCSI 6.73%

PRS 26.14
epithelial cell of proximal tubule CL0002306

CSI 4.82

rCSI 11.76%

PRS 25.74
brush cell of tracheobronchial tree CL0002075

CSI 4.81

rCSI 14.28%

PRS 36.42
CD4-positive, alpha-beta thymocyte CL0000810

CSI 4.8

rCSI 3.85%

PRS 45.76
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 4.78

rCSI 3.36%

PRS 54.66
cardiac endothelial cell CL0010008

CSI 4.75

rCSI 19.18%

PRS 25.17
conjunctival epithelial cell CL1000432

CSI 4.53

rCSI 6.92%

PRS 27.06
neuroblast (sensu Vertebrata) CL0000031

CSI 4.47

rCSI 5.74%

PRS 25.66
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 4.42

rCSI 2.98%

PRS 33.37
mononuclear phagocyte CL0000113

CSI 4.33

rCSI 9.54%

PRS 30.44
naive T cell CL0000898

CSI 4.31

rCSI 3%

PRS 37.19
fallopian tube secretory epithelial cell CL4030006

CSI 4.3

rCSI 4.13%

PRS 27.73
double-positive, alpha-beta thymocyte CL0000809

CSI 4.29

rCSI 4.38%

PRS 37.64
unswitched memory B cell CL0000970

CSI 4.13

rCSI 3.48%

PRS 41.22
cerebral cortex endothelial cell CL1001602

CSI 4.04

rCSI 7%

PRS 20.64
mucosal invariant T cell CL0000940

CSI 3.96

rCSI 3.2%

PRS 38.57
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 3.84

rCSI 3.77%

PRS 40.44
interneuron CL0000099

CSI 3.77

rCSI 7.58%

PRS 20.01
activated CD8-positive, alpha-beta T cell CL0000906

CSI 3.77

rCSI 3.71%

PRS 60.55
alveolar type 1 fibroblast cell CL4028004

CSI 3.76

rCSI 4.12%

PRS 29.95
inhibitory interneuron CL0000498

CSI 3.74

rCSI 8.64%

PRS 21.85
parietal epithelial cell CL1000452

CSI 3.71

rCSI 9.92%

PRS 22.46
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.58

rCSI 3.26%

PRS 39.78
ciliated cell CL0000064

CSI 3.56

rCSI 5.76%

PRS 26.73
plasmacytoid dendritic cell, human CL0001058

CSI 3.53

rCSI 2.46%

PRS 28.4
alpha-beta T cell CL0000789

CSI 3.52

rCSI 4.13%

PRS 37.65
sncg GABAergic cortical interneuron CL4023015

CSI 3.44

rCSI 5.53%

PRS 17.9
neural crest cell CL0011012

CSI 3.35

rCSI 2.65%

PRS 18.58
sst GABAergic cortical interneuron CL4023017

CSI 3.35

rCSI 4.32%

PRS 17.05
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.3

rCSI 5.84%

PRS 16.06
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 3.29

rCSI 7.49%

PRS 27.09
mature T cell CL0002419

CSI 3.28

rCSI 2.55%

PRS 39.15
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.22

rCSI 8.39%

PRS 25.5
neural cell CL0002319

CSI 3.18

rCSI 12.01%

PRS 30.09
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.16

rCSI 1.87%

PRS 37.57
Mueller cell CL0000636

CSI 3.14

rCSI 7.17%

PRS 23.04
basal cell CL0000646

CSI 3.13

rCSI 4.18%

PRS 29.03
CD8-positive, alpha-beta memory T cell CL0000909

CSI 3.06

rCSI 3.2%

PRS 62.49
astrocyte of the cerebral cortex CL0002605

CSI 3.04

rCSI 6.82%

PRS 17.07
early lymphoid progenitor CL0000936

CSI 3.03

rCSI 2.66%

PRS 30.7
cerebral cortex GABAergic interneuron CL0010011

CSI 3.02

rCSI 8.93%

PRS 31.19
vascular leptomeningeal cell CL4023051

CSI 3.01

rCSI 5.28%

PRS 21.03
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 2.97

rCSI 3.54%

PRS 44.71
adventitial cell CL0002503

CSI 2.95

rCSI 7.05%

PRS 38.47
VIP GABAergic cortical interneuron CL4023016

CSI 2.93

rCSI 3.5%

PRS 16.26
cardiac neuron CL0010022

CSI 2.91

rCSI 9.32%

PRS 23.11
melanocyte CL0000148

CSI 2.84

rCSI 2.1%

PRS 23.04
direct pathway medium spiny neuron CL4023026

CSI 2.83

rCSI 67.76%

PRS 15.32
indirect pathway medium spiny neuron CL4023029

CSI 2.75

rCSI 66.36%

PRS 16.21
ependymal cell CL0000065

CSI 2.74

rCSI 5.55%

PRS 14.95
mature B cell CL0000785

CSI 2.71

rCSI 2.35%

PRS 33.51
CD4-positive helper T cell CL0000492

CSI 2.65

rCSI 2.01%

PRS 36.33
epicardial adipocyte CL1000309

CSI 2.61

rCSI 8.5%

PRS 31.33
class switched memory B cell CL0000972

CSI 2.61

rCSI 1.95%

PRS 43.27
retinal cone cell CL0000573

CSI 2.6

rCSI 4.19%

PRS 20.69
kidney connecting tubule epithelial cell CL1000768

CSI 2.59

rCSI 6.58%

PRS 20.63

lymphoid lineage restricted progenitor cell CL0000838

CSI 0.1

rCSI 0.5%

PRS 43.2%
B-1 B cell CL0000819

CSI 0.1

rCSI 3.7%

PRS 77.6%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 0.9%

PRS 38.5%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.3

rCSI 3.1%

PRS 32.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 0.4

rCSI 3.3%

PRS 35.4%
stromal cell CL0000499

CSI 0.4

rCSI 1.2%

PRS 32.3%
ON parasol ganglion cell CL4033052

CSI 0.5

rCSI 6.9%

PRS 21.8%
lung secretory cell CL1000272

CSI 0.5

rCSI 1.2%

PRS 25.1%
thymocyte CL0000893

CSI 0.5

rCSI 1.8%

PRS 67.0%
flat midget bipolar cell CL4033033

CSI 0.5

rCSI 3.7%

PRS 26.7%
podocyte CL0000653

CSI 0.5

rCSI 2.4%

PRS 26.0%
hepatic pit cell CL2000054

CSI 0.5

rCSI 7.4%

PRS 76.4%
exhausted T cell CL0011025

CSI 0.6

rCSI 9.9%

PRS 68.0%
invaginating midget bipolar cell CL4033034

CSI 0.6

rCSI 3.7%

PRS 27.9%
neural progenitor cell CL0011020

CSI 0.7

rCSI 2.9%

PRS 24.0%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.7

rCSI 1.6%

PRS 19.1%
colon macrophage CL0009038

CSI 0.7

rCSI 3.1%

PRS 50.3%
diffuse bipolar 1 cell CL4033027

CSI 0.7

rCSI 5.1%

PRS 27.2%
diffuse bipolar 2 cell CL4033028

CSI 0.7

rCSI 5.2%

PRS 28.1%
GABAergic interneuron CL0011005

CSI 0.8

rCSI 12.0%

PRS 26.8%
H2 horizontal cell CL0004218

CSI 0.8

rCSI 4.0%

PRS 28.4%
GABAergic neuron CL0000617

CSI 0.9

rCSI 2.9%

PRS 19.6%
amacrine cell CL0000561

CSI 0.9

rCSI 2.5%

PRS 21.2%
transit amplifying cell CL0009010

CSI 0.9

rCSI 1.3%

PRS 42.0%
OFFx cell CL4033036

CSI 0.9

rCSI 4.1%

PRS 27.9%
germinal center B cell CL0000844

CSI 0.9

rCSI 2.6%

PRS 53.3%
diffuse bipolar 3b cell CL4033030

CSI 0.9

rCSI 5.9%

PRS 27.9%
diffuse bipolar 6 cell CL4033032

CSI 0.9

rCSI 4.7%

PRS 29.7%
OFF midget ganglion cell CL4033047

CSI 0.9

rCSI 18.4%

PRS 23.7%
glutamatergic neuron CL0000679

CSI 0.9

rCSI 1.9%

PRS 25.5%
tissue-resident macrophage CL0000864

CSI 0.9

rCSI 4.4%

PRS 48.2%
medium spiny neuron CL1001474

CSI 1.0

rCSI 8.2%

PRS 16.1%
T follicular helper cell CL0002038

CSI 1.0

rCSI 0.7%

PRS 40.6%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.0

rCSI 3.3%

PRS 18.8%
Hofbauer cell CL3000001

CSI 1.0

rCSI 2.0%

PRS 34.1%
retina horizontal cell CL0000745

CSI 1.0

rCSI 1.6%

PRS 24.8%
blood vessel smooth muscle cell CL0019018

CSI 1.1

rCSI 8.9%

PRS 25.3%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.1

rCSI 1.9%

PRS 47.8%
tracheobronchial smooth muscle cell CL0019019

CSI 1.1

rCSI 2.0%

PRS 34.2%
lung ciliated cell CL1000271

CSI 1.1

rCSI 1.3%

PRS 20.0%
transitional stage B cell CL0000818

CSI 1.1

rCSI 3.7%

PRS 61.3%
pancreatic ductal cell CL0002079

CSI 1.1

rCSI 2.2%

PRS 27.7%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.1

rCSI 2.2%

PRS 43.1%
keratocyte CL0002363

CSI 1.2

rCSI 2.8%

PRS 37.9%
retinal pigment epithelial cell CL0002586

CSI 1.2

rCSI 2.4%

PRS 27.8%
helper T cell CL0000912

CSI 1.2

rCSI 1.7%

PRS 36.5%
memory T cell CL0000813

CSI 1.2

rCSI 2.4%

PRS 56.1%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.2

rCSI 1.7%

PRS 55.5%
small intestine goblet cell CL1000495

CSI 1.4

rCSI 3.0%

PRS 35.3%
pulmonary alveolar type 1 cell CL0002062

CSI 1.4

rCSI 8.0%

PRS 32.0%
IgG plasma cell CL0000985

CSI 1.4

rCSI 1.7%

PRS 44.5%
fast muscle cell CL0000190

CSI 1.4

rCSI 5.4%

PRS 47.0%
diffuse bipolar 3a cell CL4033029

CSI 1.4

rCSI 9.5%

PRS 27.3%
T-helper 17 cell CL0000899

CSI 1.4

rCSI 1.1%

PRS 46.0%
fraction A pre-pro B cell CL0002045

CSI 1.5

rCSI 1.7%

PRS 49.8%
tuft cell of colon CL0009041

CSI 1.5

rCSI 3.4%

PRS 47.7%
dopaminergic neuron CL0000700

CSI 1.5

rCSI 8.3%

PRS 16.7%
cerebral cortex pyramidal neuron CL4023111

CSI 1.5

rCSI 9.1%

PRS 55.4%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.5

rCSI 4.3%

PRS 39.8%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.5

rCSI 1.2%

PRS 25.3%
alveolar macrophage CL0000583

CSI 1.5

rCSI 2.5%

PRS 31.4%
common lymphoid progenitor CL0000051

CSI 1.5

rCSI 2.0%

PRS 47.7%
glial cell CL0000125

CSI 1.5

rCSI 5.7%

PRS 24.8%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 1.5

rCSI 3.3%

PRS 20.2%
follicular B cell CL0000843

CSI 1.5

rCSI 5.5%

PRS 67.6%
respiratory hillock cell CL4030023

CSI 1.6

rCSI 2.8%

PRS 42.1%
pulmonary alveolar type 2 cell CL0002063

CSI 1.6

rCSI 2.5%

PRS 37.9%
renal principal cell CL0005009

CSI 1.6

rCSI 4.1%

PRS 32.9%
innate lymphoid cell CL0001065

CSI 1.6

rCSI 3.4%

PRS 37.1%
basal-myoepithelial cell of mammary gland CL0002324

CSI 1.7

rCSI 3.1%

PRS 51.9%
BEST4+ enteroycte CL4030026

CSI 1.7

rCSI 2.1%

PRS 28.7%
granulocyte monocyte progenitor cell CL0000557

CSI 1.7

rCSI 1.4%

PRS 30.0%
central nervous system neuron CL2000029

CSI 1.7

rCSI 12.3%

PRS 17.4%
neuroplacodal cell CL0000032

CSI 1.7

rCSI 15.5%

PRS 54.6%
starburst amacrine cell CL0004232

CSI 1.7

rCSI 14.3%

PRS 27.8%
Schwann cell CL0002573

CSI 1.7

rCSI 4.9%

PRS 29.1%
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.7

rCSI 9.6%

PRS 54.4%
fibroblast of cardiac tissue CL0002548

CSI 1.8

rCSI 8.4%

PRS 23.5%
hepatocyte CL0000182

CSI 1.8

rCSI 3.2%

PRS 25.1%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.8

rCSI 1.7%

PRS 24.5%
promyelocyte CL0000836

CSI 1.9

rCSI 2.7%

PRS 36.3%
OFF-bipolar cell CL0000750

CSI 1.9

rCSI 2.5%

PRS 38.6%
multi-ciliated epithelial cell CL0005012

CSI 1.9

rCSI 1.9%

PRS 23.0%
peripheral nervous system neuron CL2000032

CSI 1.9

rCSI 2.6%

PRS 23.4%
natural T-regulatory cell CL0000903

CSI 1.9

rCSI 3.6%

PRS 62.9%
choroid plexus epithelial cell CL0000706

CSI 1.9

rCSI 3.2%

PRS 20.8%
intermediate monocyte CL0002393

CSI 2.0

rCSI 3.0%

PRS 27.5%
epithelial cell of lung CL0000082

CSI 2.0

rCSI 1.6%

PRS 25.6%
IgA plasma cell CL0000987

CSI 2.0

rCSI 2.0%

PRS 45.8%
duct epithelial cell CL0000068

CSI 2.0

rCSI 2.9%

PRS 28.6%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.0

rCSI 2.9%

PRS 25.0%
cerebellar granule cell CL0001031

CSI 2.1

rCSI 3.0%

PRS 24.8%
neuron CL0000540

CSI 2.1

rCSI 5.5%

PRS 23.2%
stem cell CL0000034

CSI 2.1

rCSI 2.0%

PRS 20.0%
midbrain dopaminergic neuron CL2000097

CSI 2.1

rCSI 13.3%

PRS 37.5%
renal interstitial pericyte CL1001318

CSI 2.1

rCSI 5.8%

PRS 25.2%
fibroblast of lung CL0002553

CSI 2.1

rCSI 2.0%

PRS 26.9%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.2

rCSI 5.6%

PRS 24.8%
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 2.2

rCSI 2.8%

PRS 75.1%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.2

rCSI 3.4%

PRS 54.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its specificity (CSI Z-Score), phosphodiesterase 7A ([PDE7A](/details-gene/5150)) does not emerge as a defining marker for any single cell type. Instead, the data suggests it is a broadly expressed gene with a fundamental role in regulating intracellular signaling. Its low, non-significant specificity scores across diverse cell lineages, including neuronal, cardiac, and immune cells, are consistent with its function as a phosphodiesterase that hydrolyzes the ubiquitous second messenger, cyclic AMP (cAMP). This broad expression pattern points to a role as a general modulator of core cellular processes rather than a driver of cell-specific identity. ## Cellular Roles and Expression Landscape The expression profile of [PDE7A](/details-gene/5150), when assessed by its cell-type specificity (**CSI Z-SCORE**), indicates a lack of enrichment in any particular cell population. Across the **Overall** context, the gene exhibits statistically non-significant specificity scores (CSI Z-SCORE: 0.00, p-values > 0.05) and low percentile rankings (PRS: <35%) in all top-listed cells. This suggests that its expression level within these cells is not significantly elevated above the average expression across all cell types, precluding its use as a specific biomarker. Despite the lack of specificity, [PDE7A](/details-gene/5150) is expressed in a wide array of functionally distinct cells. These include cells from the cardiovascular system, such as [cardiac muscle cell](/details-cell/CL0000746), [regular atrial cardiac myocyte](/details-cell/CL0002129), and [regular ventricular cardiac myocyte](/details-cell/CL0002131). Its presence in the nervous system is also notable, with expression detected in multiple neuronal subtypes like [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011). Furthermore, its expression in immune progenitors, including [double negative thymocyte](/details-cell/CL0002489) and [precursor B cell](/details-cell/CL0000817), aligns with previous research highlighting its role in lymphocyte function (Li, et al., *PNAS*, 2001; [PubMed: 11371644](https://pubmed.ncbi.nlm.nih.gov/11371644/)). This widespread but non-specific expression pattern is consistent with a housekeeping or fundamental regulatory role in signal transduction common to many cell types. ## Pathways and Molecular Function The functional annotations for [PDE7A](/details-gene/5150) strongly corroborate its observed broad expression pattern. As an enzyme with `3',5'-cyclic-amp phosphodiesterase activity` ([GO:0004115](https://www.ebi.ac.uk/QuickGO/term/GO:0004115)), its primary role is the `cAMP catabolic process` ([GO:0006198](https://www.ebi.ac.uk/QuickGO/term/GO:0006198)), which serves to terminate cAMP-mediated signaling. This function is integral to numerous ubiquitous signaling cascades. Consistent with this role, [PDE7A](/details-gene/5150) is a component of major Reactome pathways, including `G alpha (s) signalling events` ([R-HSA-418555](https://reactome.org/content/detail/R-HSA-418555)) and `Gpcr downstream signalling` ([R-HSA-388396](https://reactome.org/content/detail/R-HSA-388396)). These pathways are fundamental to how cells respond to a vast range of extracellular stimuli, from hormones to neurotransmitters. By controlling intracellular cAMP levels, [PDE7A](/details-gene/5150) acts as a critical negative regulator, helping to shape the duration and amplitude of cellular responses. Its localization to the `cytosol` ([GO:0005829](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)) and `nucleus` ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)) suggests it can modulate signaling in multiple subcellular compartments, further reinforcing its importance as a general cellular regulator. ## Research Directions The broad expression of [PDE7A](/details-gene/5150) across immune, neuronal, and cardiac cells, combined with its role in regulating a critical second messenger, suggests that its activity must be precisely controlled in a cell- and context-dependent manner. This offers several avenues for future research. ### Testable Hypotheses: 1. **Hypothesis:** In early lymphocyte development, [PDE7A](/details-gene/5150) acts as a key homeostatic regulator in [double negative thymocyte](/details-cell/CL0002489) and [precursor B cell](/details-cell/CL0000817) to maintain low basal cAMP levels, thereby preventing ligand-independent signaling and ensuring proper progression through developmental checkpoints. * **Experimental Approach:** Utilize a conditional knockout mouse model to delete `Pde7a` specifically in hematopoietic progenitors. Analyze thymic and bone marrow populations using flow cytometry to identify developmental blocks or abnormal cell numbers in the T and B cell lineages. Measure intracellular cAMP levels in sorted progenitor populations to confirm dysregulation. 2. **Hypothesis:** The various neuronal subtypes listed, such as [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041) and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), express distinct splice variants of [PDE7A](/details-gene/5150) that are differentially localized to subcellular compartments (e.g., dendrites vs. axon terminals), enabling fine-tuned, location-specific control over cAMP pools that govern synaptic plasticity and excitability. * **Experimental Approach:** Perform single-cell RNA sequencing combined with long-read sequencing on sorted neuronal populations from the mouse cortex to identify and quantify cell-type-specific `Pde7a` isoforms. Subsequently, use spatial transcriptomics or high-resolution *in situ* hybridization (e.g., RNA-scope) to map the subcellular localization of these specific splice variants within different neuronal types. 3. **Hypothesis:** In the heart, differential expression of [PDE7A](/details-gene/5150) isoforms, as previously reported (Bloom and Beavo, *JBC*, 1997; [PubMed: 9195912](https://pubmed.ncbi.nlm.nih.gov/9195912/)), contributes to the distinct electrophysiological and contractile responses of [atrial](/details-cell/CL0002129) versus [ventricular myocytes](/details-cell/CL0002131) to beta-adrenergic stimulation. * **Experimental Approach:** Isolate primary atrial and ventricular cardiomyocytes from a relevant animal model (e.g., rabbit or pig). Use isoform-specific qPCR to quantify [PDE7A](/details-gene/5150) splice variant expression. Functionally, treat isolated myocytes with a selective PDE7 inhibitor followed by an adrenergic agonist (e.g., isoproterenol) and measure changes in calcium transients and contraction dynamics using live-cell imaging and edge-detection software. ### Therapeutic Potential: The role of [PDE7A](/details-gene/5150) in T cell activation makes it a potential target for inflammatory and autoimmune diseases. PDE7-selective inhibitors could be developed to increase intracellular cAMP, which generally has an immunosuppressive effect. However, its broad expression profile, particularly in the central nervous system and heart, poses a significant risk for off-target effects. Future therapeutic strategies may require the development of inhibitors targeting specific splice isoforms or drug delivery systems that can achieve tissue or cell-type selectivity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TM22

Genular Protein ID: 3109751218

Symbol: PDE7A_HUMAN

Name: TM22

UniProtKB Accession Codes:

Q13946 A0AVH6 A8K436 A8K9G5 O15380 Q96T72

Database IDs:

Citations:

PubMed ID: 8389765

Title: Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae.

PubMed ID: 8389765

DOI: 10.1016/s0021-9258(18)31474-1

PubMed ID: 9195912

Title: Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.

PubMed ID: 9195912

DOI: 10.1074/jbc.272.26.16152

PubMed ID: 11371644

Title: T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.

PubMed ID: 11371644

DOI: 10.1073/pnas.101131098

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15470020

Title: A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines.

PubMed ID: 15470020

DOI: 10.4049/jimmunol.173.8.4806

PubMed ID: 15994308

Title: Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

PubMed ID: 15994308

DOI: 10.1074/jbc.m504398200

PubMed ID: 19350606

Title: Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors.

PubMed ID: 19350606

DOI: 10.1002/cmdc.200900043

Sequence Information:

Length: 482
Mass: 55505
Checksum: 3B3C8F6E9154F88C
Sequence:

MEVCYQLPVL PLDRPVPQHV LSRRGAISFS SSSALFGCPN PRQLSQRRGA ISYDSSDQTA 
LYIRMLGDVR VRSRAGFESE RRGSHPYIDF RIFHSQSEIE VSVSARNIRR LLSFQRYLRS 
SRFFRGTAVS NSLNILDDDY NGQAKCMLEK VGNWNFDIFL FDRLTNGNSL VSLTFHLFSL 
HGLIEYFHLD MMKLRRFLVM IQEDYHSQNP YHNAVHAADV TQAMHCYLKE PKLANSVTPW 
DILLSLIAAA THDLDHPGVN QPFLIKTNHY LATLYKNTSV LENHHWRSAV GLLRESGLFS 
HLPLESRQQM ETQIGALILA TDISRQNEYL SLFRSHLDRG DLCLEDTRHR HLVLQMALKC 
ADICNPCRTW ELSKQWSEKV TEEFFHQGDI EKKYHLGVSP LCDRHTESIA NIQIGFMTYL 
VEPLFTEWAR FSNTRLSQTM LGHVGLNKAS WKGLQREQSS SEDTDAAFEL NSQLLPQENR 
LS

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sclera UBERON0001773
	\|— Sclera Healthy UBERON0001773_PATO0000461
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: PDE7A

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. PubMed ID: 8389765

Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. PubMed ID: 9195912

T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. PubMed ID: 11371644

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. PubMed ID: 15470020

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. PubMed ID: 15994308

Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. PubMed ID: 19350606