H2AJ | ENSG00000246705 | NCBI 55766

Details for: H2AJ

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Biological_process
(GO:0008150)
Cellular response to gamma radiation
(GO:0071480)
Cellular senescence
(GO:0090398)
Cerebral cortex development
(GO:0021987)
Extracellular exosome
(GO:0070062)
Heterochromatin formation
(GO:0031507)
Molecular_function
(GO:0003674)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Protein heterodimerization activity
(GO:0046982)
Spermatogenesis
(GO:0007283)
Structural constituent of chromatin
(GO:0030527)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

multi-ciliated epithelial cell CL0005012

CSI 85.68

rCSI 85.51%

PRS 13.42
ciliated epithelial cell CL0000067

CSI 75.75

rCSI 66.62%

PRS 11.4
pancreatic A cell CL0000171

CSI 71.98

rCSI 75.41%

PRS 16.79
colon epithelial cell CL0011108

CSI 59.27

rCSI 62.09%

PRS 14.61
lung ciliated cell CL1000271

CSI 55.77

rCSI 64.49%

PRS 11.5
intestinal epithelial cell CL0002563

CSI 47.46

rCSI 49.6%

PRS 16.44
fallopian tube secretory epithelial cell CL4030006

CSI 46.4

rCSI 44.67%

PRS 16.27
promonocyte CL0000559

CSI 46.06

rCSI 78.9%

PRS 21.24
luminal epithelial cell of mammary gland CL0002326

CSI 41.56

rCSI 75.52%

PRS 24.03
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 35.09

rCSI 79.99%

PRS 16.27
enterocyte CL0000584

CSI 34.62

rCSI 55.83%

PRS 24.76
intestine goblet cell CL0019031

CSI 34.21

rCSI 30.37%

PRS 15.72
granulocyte monocyte progenitor cell CL0000557

CSI 32.97

rCSI 28.55%

PRS 17.64
foveolar cell of stomach CL0002179

CSI 32.73

rCSI 69.68%

PRS 25.21
pancreatic D cell CL0000173

CSI 32.37

rCSI 31.83%

PRS 17.08
mucous neck cell CL0000651

CSI 30.68

rCSI 44.22%

PRS 25.07
tracheal goblet cell CL1000329

CSI 29.21

rCSI 63.77%

PRS 31.22
colonocyte CL1000347

CSI 28.42

rCSI 40.74%

PRS 21.53
duct epithelial cell CL0000068

CSI 27.19

rCSI 39.77%

PRS 16.62
pancreatic acinar cell CL0002064

CSI 26.96

rCSI 35.83%

PRS 17.2
melanocyte CL0000148

CSI 26.85

rCSI 19.89%

PRS 13.83
Hofbauer cell CL3000001

CSI 26.73

rCSI 50.46%

PRS 19.66
deuterosomal cell CL4033044

CSI 25.78

rCSI 87.14%

PRS 25.71
nasal mucosa goblet cell CL0002480

CSI 25.43

rCSI 29.5%

PRS 23.12
microcirculation associated smooth muscle cell CL0008035

CSI 24.27

rCSI 70.26%

PRS 17.81
respiratory suprabasal cell CL4033048

CSI 23.73

rCSI 30.44%

PRS 18.15
club cell CL0000158

CSI 23.71

rCSI 34.73%

PRS 18.26
perivascular cell CL4033054

CSI 23.27

rCSI 31.81%

PRS 17.83
pancreatic ductal cell CL0002079

CSI 22.07

rCSI 42.93%

PRS 16.09
pulmonary ionocyte CL0017000

CSI 20.97

rCSI 25.53%

PRS 19.79
squamous epithelial cell CL0000076

CSI 20.8

rCSI 49.36%

PRS 19.62
ciliated cell CL0000064

CSI 19.32

rCSI 31.3%

PRS 15.97
colon goblet cell CL0009039

CSI 19.08

rCSI 45.36%

PRS 23.54
promyelocyte CL0000836

CSI 17.91

rCSI 25.84%

PRS 21.91
intestinal tuft cell CL0019032

CSI 17.75

rCSI 27.13%

PRS 17.99
ionocyte CL0005006

CSI 16.19

rCSI 17.36%

PRS 14.46
pancreatic epsilon cell CL0005019

CSI 15.87

rCSI 73.99%

PRS 36.21
epithelial cell CL0000066

CSI 15.63

rCSI 24.01%

PRS 22.05
acinar cell CL0000622

CSI 15.57

rCSI 22.83%

PRS 20.65
luminal cell of prostate epithelium CL0002340

CSI 15.38

rCSI 82.74%

PRS 28.03
placental villous trophoblast CL2000060

CSI 15.33

rCSI 23.69%

PRS 14.68
keratocyte CL0002363

CSI 14.46

rCSI 34.76%

PRS 23.41
transit amplifying cell CL0009010

CSI 14.32

rCSI 21.9%

PRS 25.51
fibroblast of lung CL0002553

CSI 13.73

rCSI 12.77%

PRS 15.73
pancreatic PP cell CL0002275

CSI 12.24

rCSI 48.71%

PRS 27.37
common dendritic progenitor CL0001029

CSI 12.06

rCSI 15.14%

PRS 20.21
enterocyte of epithelium of large intestine CL0002071

CSI 11.79

rCSI 61.9%

PRS 27.41
conjunctival epithelial cell CL1000432

CSI 11.72

rCSI 17.89%

PRS 15.77
myofibroblast cell CL0000186

CSI 11.44

rCSI 15.84%

PRS 22.4
keratinocyte CL0000312

CSI 11.41

rCSI 9.57%

PRS 18.79
kidney epithelial cell CL0002518

CSI 11.22

rCSI 21.43%

PRS 35.63
type B pancreatic cell CL0000169

CSI 10.98

rCSI 24.32%

PRS 14.6
tracheobronchial serous cell CL0019001

CSI 10.92

rCSI 47.16%

PRS 29.41
bronchial goblet cell CL1000312

CSI 10.77

rCSI 43.05%

PRS 33.66
P/D1 enteroendocrine cell CL0002268

CSI 10.61

rCSI 57.76%

PRS 37.79
BEST4+ enteroycte CL4030026

CSI 10.02

rCSI 12.46%

PRS 16.62
pancreatic stellate cell CL0002410

CSI 9.98

rCSI 58.09%

PRS 23.56
mammary gland epithelial cell CL0002327

CSI 9.96

rCSI 34.96%

PRS 28.07
secretory cell CL0000151

CSI 9.88

rCSI 10.31%

PRS 16.1
rod bipolar cell CL0000751

CSI 9.85

rCSI 17.7%

PRS 13
large pre-B-II cell CL0000957

CSI 9.6

rCSI 27.41%

PRS 26.94
enteroendocrine cell CL0000164

CSI 9.44

rCSI 12.9%

PRS 17.41
podocyte CL0000653

CSI 9.22

rCSI 40.96%

PRS 15.41
primitive red blood cell CL0002355

CSI 9.13

rCSI 49.27%

PRS 28.74
epithelial cell of lung CL0000082

CSI 9.02

rCSI 7.48%

PRS 14.81
intestinal crypt stem cell of small intestine CL0009017

CSI 8.9

rCSI 23.98%

PRS 20.29
tuft cell of colon CL0009041

CSI 8.59

rCSI 20.01%

PRS 32.05
enteroendocrine cell of colon CL0009042

CSI 8.48

rCSI 39.75%

PRS 40.31
intestinal crypt stem cell of colon CL0009043

CSI 8.44

rCSI 63.38%

PRS 28.53
smooth muscle cell CL0000192

CSI 8.39

rCSI 20.01%

PRS 43.22
epithelial cell of lower respiratory tract CL0002632

CSI 8.21

rCSI 6.37%

PRS 14.98
plasmacytoid dendritic cell, human CL0001058

CSI 8.15

rCSI 5.69%

PRS 16.6
transit amplifying cell of small intestine CL0009012

CSI 8.11

rCSI 35.61%

PRS 29.23
enteric smooth muscle cell CL0002504

CSI 7.63

rCSI 10.89%

PRS 17.71
adventitial cell CL0002503

CSI 7.37

rCSI 17.6%

PRS 24.17
glandular epithelial cell CL0000150

CSI 7.24

rCSI 19.06%

PRS 30.59
goblet cell CL0000160

CSI 7.1

rCSI 6.71%

PRS 16.42
mesenchymal stem cell of adipose tissue CL0002570

CSI 7.02

rCSI 39.14%

PRS 42.49
smooth muscle cell of the pulmonary artery CL0002591

CSI 6.71

rCSI 51.4%

PRS 49.47
pulmonary capillary endothelial cell CL4028001

CSI 6.67

rCSI 12.71%

PRS 25.03
activated type II NK T cell CL0000931

CSI 6.28

rCSI 7.06%

PRS 25.22
cardiac muscle cell CL0000746

CSI 6.18

rCSI 8.86%

PRS 12.16
fraction A pre-pro B cell CL0002045

CSI 6.08

rCSI 6.96%

PRS 31.98
elicited macrophage CL0000861

CSI 5.78

rCSI 5.3%

PRS 18.16
hepatocyte CL0000182

CSI 5.72

rCSI 10.25%

PRS 14.55
double negative thymocyte CL0002489

CSI 5.66

rCSI 3.94%

PRS 18.57
respiratory goblet cell CL0002370

CSI 5.63

rCSI 61.27%

PRS 30.05
epithelial cell of esophagus CL0002252

CSI 5.57

rCSI 55.01%

PRS 50.8
lung pericyte CL0009089

CSI 5.46

rCSI 14.42%

PRS 18.79
pro-B cell CL0000826

CSI 5.42

rCSI 4.49%

PRS 15.81
alveolar type 1 fibroblast cell CL4028004

CSI 5.38

rCSI 5.89%

PRS 17.9
common myeloid progenitor CL0000049

CSI 5.28

rCSI 4.27%

PRS 15.64
tracheobronchial smooth muscle cell CL0019019

CSI 5.19

rCSI 9.16%

PRS 20.75
myeloid leukocyte CL0000766

CSI 5.18

rCSI 4.78%

PRS 16.07
IgA plasma cell CL0000987

CSI 5.1

rCSI 5.23%

PRS 29.12
respiratory hillock cell CL4030023

CSI 4.99

rCSI 8.9%

PRS 26.51
paneth cell of colon CL0009009

CSI 4.92

rCSI 48.33%

PRS 42.6
lung interstitial macrophage CL4033043

CSI 4.9

rCSI 11%

PRS 32.03
respiratory epithelial cell CL0002368

CSI 4.85

rCSI 29.96%

PRS 48.79
bronchiolar smooth muscle cell CL4033017

CSI 4.8

rCSI 72.08%

PRS 46.27

midzonal region hepatocyte CL0019028

CSI -4.9

rCSI -11.5%

PRS 23.2%
thymocyte CL0000893

CSI -4.6

rCSI -16.4%

PRS 47.9%
lung neuroendocrine cell CL1000223

CSI -4.4

rCSI -6.6%

PRS 18.1%
basal-myoepithelial cell of mammary gland CL0002324

CSI -4.1

rCSI -7.8%

PRS 33.8%
blood vessel endothelial cell CL0000071

CSI -3.3

rCSI -6.8%

PRS 15.7%
CD4-positive, alpha-beta memory T cell CL0000897

CSI -3.0

rCSI -2.1%

PRS 21.5%
T follicular helper cell CL0002038

CSI -2.5

rCSI -1.9%

PRS 25.3%
cardiac neuron CL0010022

CSI -1.5

rCSI -4.8%

PRS 11.7%
Kupffer cell CL0000091

CSI -1.4

rCSI -3.2%

PRS 15.2%
mononuclear phagocyte CL0000113

CSI -1.3

rCSI -2.9%

PRS 17.5%
activated CD4-positive, alpha-beta T cell CL0000896

CSI -1.0

rCSI -0.9%

PRS 28.4%
retinal cone cell CL0000573

CSI -0.4

rCSI -0.6%

PRS 12.1%
vascular leptomeningeal cell CL4023051

CSI -0.1

rCSI -0.2%

PRS 11.7%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.4%

PRS 22.9%
pre-conventional dendritic cell CL0002010

CSI 0.1

rCSI 1.1%

PRS 48.3%
adipocyte CL0000136

CSI 0.1

rCSI 0.1%

PRS 15.4%
mature alpha-beta T cell CL0000791

CSI 0.1

rCSI 0.5%

PRS 26.9%
mesenchymal lymphangioblast CL0005021

CSI 0.2

rCSI 5.1%

PRS 62.3%
fibroblast of cardiac tissue CL0002548

CSI 0.2

rCSI 1.0%

PRS 11.1%
OFF-bipolar cell CL0000750

CSI 0.2

rCSI 0.3%

PRS 25.1%
tracheobronchial goblet cell CL0019003

CSI 0.2

rCSI 3.7%

PRS 80.0%
colon macrophage CL0009038

CSI 0.3

rCSI 1.1%

PRS 32.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.3

rCSI 0.6%

PRS 11.9%
basophil CL0000767

CSI 0.3

rCSI 0.6%

PRS 31.5%
kidney interstitial cell CL1000500

CSI 0.3

rCSI 4.6%

PRS 66.6%
retina horizontal cell CL0000745

CSI 0.3

rCSI 0.5%

PRS 14.6%
germinal center B cell CL0000844

CSI 0.3

rCSI 0.9%

PRS 37.7%
parietal epithelial cell CL1000452

CSI 0.3

rCSI 0.8%

PRS 13.0%
myeloid dendritic cell, human CL0001057

CSI 0.4

rCSI 2.0%

PRS 48.2%
endothelial cell of placenta CL0009092

CSI 0.4

rCSI 1.8%

PRS 21.3%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.4

rCSI 0.5%

PRS 20.2%
stratified epithelial cell CL0000079

CSI 0.5

rCSI 3.0%

PRS 54.6%
small intestine goblet cell CL1000495

CSI 0.5

rCSI 1.1%

PRS 21.0%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 2.0%

PRS 25.7%
vasa recta descending limb cell CL1001285

CSI 0.5

rCSI 4.2%

PRS 57.4%
helper T cell CL0000912

CSI 0.6

rCSI 0.8%

PRS 21.8%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 0.6

rCSI 0.6%

PRS 24.6%
parietal cell CL0000162

CSI 0.6

rCSI 5.0%

PRS 66.5%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.6

rCSI 0.9%

PRS 14.6%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.6

rCSI 0.7%

PRS 27.3%
paneth cell CL0000510

CSI 0.7

rCSI 1.0%

PRS 24.7%
eosinophil CL0000771

CSI 0.7

rCSI 4.3%

PRS 39.9%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.7

rCSI 7.3%

PRS 56.1%
epithelial cell of nephron CL1000449

CSI 0.7

rCSI 6.6%

PRS 59.0%
natural T-regulatory cell CL0000903

CSI 0.7

rCSI 1.4%

PRS 42.0%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.8

rCSI 3.9%

PRS 30.6%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.8

rCSI 4.7%

PRS 34.9%
intermediate monocyte CL0002393

CSI 0.8

rCSI 1.2%

PRS 15.7%
myoepithelial cell CL0000185

CSI 0.8

rCSI 2.0%

PRS 19.4%
neutrophil CL0000775

CSI 0.8

rCSI 4.5%

PRS 30.3%
mesodermal cell CL0000222

CSI 0.8

rCSI 1.0%

PRS 15.5%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.8

rCSI 2.0%

PRS 24.9%
vein endothelial cell of respiratory system CL4033008

CSI 0.9

rCSI 5.9%

PRS 30.6%
intraepithelial lymphocyte CL0002496

CSI 0.9

rCSI 2.4%

PRS 56.9%
myeloid dendritic cell CL0000782

CSI 0.9

rCSI 1.3%

PRS 23.4%
stromal cell of ovary CL0002132

CSI 0.9

rCSI 2.4%

PRS 25.9%
epicardial adipocyte CL1000309

CSI 0.9

rCSI 2.9%

PRS 18.9%
T-helper 1 cell CL0000545

CSI 0.9

rCSI 1.6%

PRS 40.2%
CD14-low, CD16-positive monocyte CL0002396

CSI 0.9

rCSI 0.7%

PRS 14.4%
fibroblast of breast CL4006000

CSI 1.0

rCSI 4.3%

PRS 39.1%
endothelial cell of lymphatic vessel CL0002138

CSI 1.1

rCSI 2.1%

PRS 44.5%
skin fibroblast CL0002620

CSI 1.1

rCSI 0.9%

PRS 25.1%
small pre-B-II cell CL0000954

CSI 1.1

rCSI 1.0%

PRS 32.1%
enteroglial cell CL4040002

CSI 1.1

rCSI 5.9%

PRS 27.5%
lung microvascular endothelial cell CL2000016

CSI 1.1

rCSI 22.0%

PRS 46.4%
erythroid progenitor cell CL0000038

CSI 1.3

rCSI 7.2%

PRS 24.1%
peripheral nervous system neuron CL2000032

CSI 1.3

rCSI 1.7%

PRS 14.0%
smooth muscle cell of prostate CL1000487

CSI 1.3

rCSI 7.6%

PRS 55.4%
vasa recta ascending limb cell CL1001131

CSI 1.3

rCSI 6.0%

PRS 51.8%
renal alpha-intercalated cell CL0005011

CSI 1.3

rCSI 1.8%

PRS 20.7%
innate lymphoid cell CL0001065

CSI 1.3

rCSI 2.8%

PRS 23.6%
cerebral cortex endothelial cell CL1001602

CSI 1.4

rCSI 2.3%

PRS 11.9%
enterocyte of epithelium of small intestine CL1000334

CSI 1.4

rCSI 21.3%

PRS 38.3%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 1.4

rCSI 6.3%

PRS 52.0%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.4

rCSI 1.9%

PRS 37.2%
T-helper 17 cell CL0000899

CSI 1.5

rCSI 1.2%

PRS 27.9%
paneth cell of epithelium of small intestine CL1000343

CSI 1.5

rCSI 4.2%

PRS 24.3%
basal cell of prostate epithelium CL0002341

CSI 1.6

rCSI 4.5%

PRS 34.2%
renal interstitial pericyte CL1001318

CSI 1.6

rCSI 4.5%

PRS 14.6%
Langerhans cell CL0000453

CSI 1.6

rCSI 2.5%

PRS 27.5%
erythroblast CL0000765

CSI 1.7

rCSI 4.4%

PRS 25.5%
retinal blood vessel endothelial cell CL0002585

CSI 1.7

rCSI 2.8%

PRS 17.2%
glial cell CL0000125

CSI 1.7

rCSI 6.6%

PRS 15.5%
mature B cell CL0000785

CSI 1.8

rCSI 1.5%

PRS 19.5%
epithelial cell of proximal tubule CL0002306

CSI 1.8

rCSI 4.3%

PRS 15.6%
tendon cell CL0000388

CSI 1.8

rCSI 4.7%

PRS 40.4%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.8

rCSI 4.8%

PRS 14.6%
memory T cell CL0000813

CSI 1.9

rCSI 3.7%

PRS 35.1%
mesenchymal cell CL0008019

CSI 2.0

rCSI 4.9%

PRS 15.9%
type L enteroendocrine cell CL0002279

CSI 2.1

rCSI 3.9%

PRS 30.7%
erythrocyte CL0000232

CSI 2.1

rCSI 4.7%

PRS 21.8%
double-positive, alpha-beta thymocyte CL0000809

CSI 2.1

rCSI 2.1%

PRS 22.4%
late pro-B cell CL0002048

CSI 2.1

rCSI 5.3%

PRS 43.9%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.2

rCSI 6.2%

PRS 23.0%
alpha-beta T cell CL0000789

CSI 2.2

rCSI 2.5%

PRS 21.0%
follicular dendritic cell CL0000442

CSI 2.2

rCSI 34.8%

PRS 64.9%
tissue-resident macrophage CL0000864

CSI 2.2

rCSI 10.5%

PRS 31.9%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.3

rCSI 1.3%

PRS 21.7%
pulmonary artery endothelial cell CL1001568

CSI 2.3

rCSI 3.1%

PRS 23.9%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.3

rCSI 1.6%

PRS 18.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Pathway Categories (for ONTOLOGY source):

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Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [H2AJ](/details-gene/55766) is a protein-coding gene located on chromosome 12p12.3 that encodes the histone variant H2A.J. As a structural component of chromatin, [H2AJ](/details-gene/55766) is fundamentally involved in nucleosome organization and epigenetic regulation. Its function is strongly linked to processes such as [cellular senescence](/details-term/GO:0090398), DNA repair, and the regulation of gene expression. Expression data indicates that [H2AJ](/details-gene/55766) is a significant marker for various types of epithelial cells, particularly [multi-ciliated epithelial cells](/details-cell/CL0005012) and secretory cells like [pancreatic A cells](/details-cell/CL0000171), suggesting a specialized role in maintaining the chromatin state of terminally differentiated tissues. The gene was characterized as part of the Mammalian Gene Collection (MGC) project [Link](https://doi.org/10.1101/gr.2596504). ## Cellular Roles and Expression Landscape The expression profile of [H2AJ](/details-gene/55766) highlights its prominent role in specialized epithelial cell populations. **Overall**, it shows the highest significance in cells involved in barrier and secretory functions. The most significant expression is observed in ciliated cell types, including [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 85.68), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 75.75), and [lung ciliated cell](/details-cell/CL1000271) (CSI: 55.77). This strong association suggests a key function in establishing or maintaining the unique chromatin architecture of these terminally differentiated cells. Beyond ciliated epithelia, [H2AJ](/details-gene/55766) is also highly significant in secretory and absorptive lineages such as [pancreatic A cells](/details-cell/CL0000171) (CSI: 71.98), [colon epithelial cells](/details-cell/CL0011108) (CSI: 59.27), and [enterocytes](/details-cell/CL0000584) (CSI: 34.62). Its presence in progenitor cells like [promonocytes](/details-cell/CL0000559) and [granulocyte monocyte progenitor cells](/details-cell/CL0000557) may indicate a role in lineage commitment or differentiation. Conversely, [H2AJ](/details-gene/55766) shows minimal or negative significance in various hematopoietic lineages, particularly lymphoid cells such as [thymocytes](/details-cell/CL0000893) and [CD4-positive, alpha-beta memory T cells](/details-cell/CL0000897). Its low significance in [blood vessel endothelial cells](/details-cell/CL0000071) and [cardiac neurons](/details-cell/CL0010022) further underscores its specialized role, suggesting it is not a universally expressed core histone but rather a variant deployed in specific cellular contexts, primarily outside of the immune, vascular, and nervous systems. ## Pathways and Molecular Function The functional annotations for [H2AJ](/details-gene/55766) confirm its identity as a histone variant integral to chromatin dynamics. At the molecular level, it functions as a '[structural constituent of chromatin](/details-term/GO:0030527)' and is a component of the '[nucleosome](/details-term/GO:0000786)'. This foundational role connects it to a vast array of high-level biological processes. A prominent theme is its involvement in [cellular senescence](/details-term/GO:0090398), a process of irreversible cell cycle arrest. This is supported by its participation in the Reactome pathways '[Cellular senescence](/details-pathway/R-HSA-2559583)', '[DNA damage/telomere stress induced senescence](/details-pathway/R-HSA-2559586)', and the '[Senescence-Associated Secretory Phenotype (SASP)](/details-pathway/R-HSA-2559582)'. This functional link is consistent with its high expression in long-lived, terminally differentiated cells like those found in epithelial linings. Furthermore, [H2AJ](/details-gene/55766) is implicated in fundamental nuclear processes including '[Chromatin organization](/details-pathway/R-HSA-4839726)', '[DNA repair](/details-pathway/R-HSA-73894)', and '[Gene expression (transcription)](/details-pathway/R-HSA-74160)'. Its involvement in numerous pathways related to epigenetic regulation, such as '[DNA methylation](/details-pathway/R-HSA-5334118)' and '[Chromatin modifying enzymes](/details-pathway/R-HSA-3247509)', suggests that its incorporation into nucleosomes can alter local chromatin structure to either permit or restrict access for transcriptional machinery, thereby shaping cellular identity and function. ## Research Directions The specific enrichment of [H2AJ](/details-gene/55766) in differentiated epithelial cells, coupled with its strong association with cellular senescence, provides a basis for several testable hypotheses. 1. **Hypothesis 1:** The accumulation of [H2AJ](/details-gene/55766) in the chromatin of terminally differentiated ciliated epithelial cells is a critical step for establishing a stable, non-proliferative state. Its deposition may contribute to the senescence-associated changes observed in respiratory tissues during aging or in response to chronic stress (e.g., pollutants). 2. **Hypothesis 2:** In secretory cells like pancreatic alpha cells, [H2AJ](/details-gene/55766) helps establish and maintain specific chromatin domains that are permissive for the high-level transcription of key functional genes, such as glucagon. Its presence may prevent epigenetic silencing of the cell’s core identity genes over its lifespan. To test the role of [H2AJ](/details-gene/55766) in ciliated cell differentiation and senescence (Hypothesis 1), a compelling experimental approach would be to use an *in vitro* air-liquid interface (ALI) culture system with primary human bronchial epithelial cells. One could perform a shRNA-mediated knockdown of [H2AJ](/details-gene/55766) prior to inducing differentiation and subsequently assess ciliogenesis via immunofluorescence and transcriptional maturation via RNA-seq. Furthermore, chromatin immunoprecipitation followed by sequencing (ChIP-seq) for [H2AJ](/details-gene/55766) could be performed on both young and senescent ALI cultures to map its genomic localization and determine if it accumulates at senescence-associated heterochromatin foci or regulates SASP-related genes. **Therapeutic Potential:** As a nuclear histone variant, [H2AJ](/details-gene/55766) is a challenging direct therapeutic target. Its fundamental role in chromatin structure suggests that systemic inhibition or activation could lead to significant off-target effects. However, given its strong link to cellular senescence and high expression in specific epithelial tissues, modulating its expression or the enzymes that deposit/remove it could hold indirect therapeutic potential. For instance, in age-related pulmonary diseases characterized by epithelial senescence, targeting the pathways that lead to [H2AJ](/details-gene/55766) accumulation might represent a novel strategy to mitigate tissue dysfunction. This would likely involve targeting upstream regulatory factors rather than the histone protein itself.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Histone H2A.J

Genular Protein ID: 469916474

Symbol: H2AJ_HUMAN

Name: Histone H2A.J

UniProtKB Accession Codes:

Q9BTM1 Q9NV63

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 129
Mass: 14019
Checksum: E35049617B456D45
Sequence:

MSGRGKQGGK VRAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT 
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK 
TESQKTKSK

	Overall overall
	Adrenal gland UBERON0002369
	Ascending colon UBERON0001156
	Axilla UBERON0009472
	\|— Axilla Breast cancer UBERON0009472_MONDO0007254
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	Heart right ventricle UBERON0002080
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Primary motor cortex UBERON0001384
	Rectum UBERON0001052
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	Right atrium auricular region UBERON0006631
	Sigmoid colon UBERON0001159
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952