Details for: PDLIM1
Gene ID: 9124
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PDLIM1
Ensembl ID: ENSG00000107438
Description: PDZ and LIM domain 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 67.52rCSI 70.57%PRS 22.54
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CSI 60.65rCSI 60.53%PRS 18.47
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CSI 59.18rCSI 61.99%PRS 20.19
-
CSI 58.68rCSI 56.58%PRS 15.75
-
CSI 57.69rCSI 61.3%PRS 36.65
-
CSI 55.84rCSI 49.1%PRS 15.72
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CSI 49.15rCSI 57.72%PRS 24.86
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CSI 44.12rCSI 45.71%PRS 25.49
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CSI 42.73rCSI 54.8%PRS 25.02
-
CSI 41.76rCSI 37.07%PRS 21.78
-
CSI 41.37rCSI 51.46%PRS 23.04
-
CSI 40.75rCSI 34.16%PRS 25.6
-
CSI 39.89rCSI 57.17%PRS 29.03
-
CSI 38.55rCSI 44.57%PRS 15.95
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CSI 36.93rCSI 50.25%PRS 32.61
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CSI 35.07rCSI 31.67%PRS 19.56
-
CSI 33.06rCSI 53.3%PRS 32.61
-
CSI 31.03rCSI 24.06%PRS 20.78
-
CSI 29.99rCSI 71.97%PRS 38.15
-
CSI 29.04rCSI 44.35%PRS 21.77
-
CSI 28.63rCSI 27.56%PRS 22.39
-
CSI 26.91rCSI 51.32%PRS 33.84
-
CSI 26.26rCSI 74.97%PRS 36.07
-
CSI 26.17rCSI 24.73%PRS 22.71
-
CSI 26.06rCSI 27.19%PRS 22.17
-
CSI 25.76rCSI 35.67%PRS 30.21
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CSI 25.68rCSI 34.36%PRS 65.04
-
CSI 25.66rCSI 37%PRS 30.34
-
CSI 25.64rCSI 21.26%PRS 20.51
-
CSI 25.47rCSI 60.55%PRS 32.01
-
CSI 24.18rCSI 35.38%PRS 22.91
-
CSI 24.08rCSI 23.78%PRS 66.76
-
CSI 24.03rCSI 52.64%PRS 28.82
-
CSI 23.6rCSI 37.69%PRS 23.66
-
CSI 23.59rCSI 18.56%PRS 26.15
-
CSI 23.3rCSI 27.02%PRS 31.08
-
CSI 23.27rCSI 54.26%PRS 48.39
-
CSI 22.71rCSI 33.28%PRS 71.03
-
CSI 22.65rCSI 34.65%PRS 34.79
-
CSI 22.58rCSI 43.92%PRS 22.18
-
CSI 22.58rCSI 19.78%PRS 28.79
-
CSI 21.95rCSI 59.18%PRS 28.01
-
CSI 21.5rCSI 46.94%PRS 41.36
-
CSI 21.39rCSI 61.94%PRS 24.35
-
CSI 20.83rCSI 95.57%PRS 48.75
-
CSI 20.77rCSI 29.93%PRS 33.92
-
CSI 20.73rCSI 56.56%PRS 65.09
-
CSI 20.64rCSI 30.23%PRS 24.58
-
CSI 20.51rCSI 19.09%PRS 21.68
-
CSI 20.27rCSI 42.05%PRS 21.5
-
CSI 19.96rCSI 30.67%PRS 29.24
-
CSI 19.72rCSI 36.14%PRS 60.63
-
CSI 19.45rCSI 34.69%PRS 35.63
-
CSI 19.16rCSI 64.76%PRS 33.94
-
CSI 19.04rCSI 55.09%PRS 44.64
-
CSI 18.9rCSI 14.04%PRS 31.78
-
CSI 18.67rCSI 13.04%PRS 23.06
-
CSI 18.53rCSI 30.03%PRS 21.79
-
CSI 18.13rCSI 24.24%PRS 23.66
-
CSI 18.07rCSI 24.7%PRS 24.4
-
CSI 18.01rCSI 26.41%PRS 28.33
-
CSI 17.83rCSI 40.65%PRS 22.21
-
CSI 17.36rCSI 14.97%PRS 33.29
-
CSI 17.27rCSI 53.23%PRS 32.05
-
CSI 16.98rCSI 16.33%PRS 43.13
-
CSI 16.58rCSI 12.61%PRS 28.58
-
CSI 16.56rCSI 18.14%PRS 24.31
-
CSI 16.23rCSI 14.11%PRS 27.2
-
CSI 16.21rCSI 16.68%PRS 34.86
-
CSI 16.21rCSI 32.12%PRS 55.06
-
CSI 15.91rCSI 59.6%PRS 18.2
-
CSI 15.89rCSI 24.55%PRS 20.18
-
CSI 15.76rCSI 24.88%PRS 21.68
-
CSI 15.75rCSI 24.43%PRS 31.95
-
CSI 15.58rCSI 67.59%PRS 37.22
-
CSI 15.44rCSI 20.53%PRS 23.7
-
CSI 15.43rCSI 12.78%PRS 21.97
-
CSI 15.38rCSI 25.33%PRS 25.52
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CSI 15.2rCSI 15.92%PRS 22.95
-
CSI 15.19rCSI 27.61%PRS 32.85
-
CSI 14.98rCSI 18.23%PRS 27
-
CSI 14.14rCSI 29.03%PRS 45.39
-
CSI 13.6rCSI 93.37%PRS 41.19
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CSI 13.27rCSI 11.17%PRS 34.05
-
CSI 13.22rCSI 13%PRS 23.29
-
CSI 12.83rCSI 10.43%PRS 22.72
-
CSI 12.26rCSI 64.4%PRS 36.58
-
CSI 12.06rCSI 9%PRS 36.18
-
CSI 11.94rCSI 12.8%PRS 19.88
-
CSI 11.93rCSI 18.23%PRS 24.67
-
CSI 11.88rCSI 30.06%PRS 26.58
-
CSI 11.41rCSI 26.57%PRS 41.83
-
CSI 11.31rCSI 29.85%PRS 25.78
-
CSI 11.2rCSI 81.89%PRS 54.56
-
CSI 9.75rCSI 16.86%PRS 16.52
-
CSI 9.66rCSI 31.33%PRS 25.91
-
CSI 9.54rCSI 13.04%PRS 24.07
-
CSI 9.49rCSI 20.9%PRS 24.65
-
CSI 9.45rCSI 37.77%PRS 44.43
-
CSI 9.14rCSI 25.61%PRS 33.34
-
CSI -2.0rCSI -1.8%PRS 25.4%
-
CSI -1.6rCSI -2.0%PRS 33.0%
-
CSI -0.6rCSI -1.0%PRS 16.6%
-
CSI 0.1rCSI 1.3%PRS 37.8%
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CSI 0.3rCSI 6.0%PRS 39.9%
-
CSI 0.3rCSI 1.2%PRS 74.4%
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CSI 0.3rCSI 1.3%PRS 35.4%
-
CSI 0.4rCSI 1.6%PRS 13.2%
-
CSI 0.5rCSI 2.9%PRS 61.6%
-
CSI 0.5rCSI 1.8%PRS 66.2%
-
CSI 0.6rCSI 7.6%PRS 63.8%
-
CSI 0.6rCSI 5.7%PRS 59.5%
-
CSI 0.8rCSI 12.1%PRS 56.1%
-
CSI 1.1rCSI 1.0%PRS 24.4%
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CSI 1.1rCSI 2.8%PRS 56.0%
-
CSI 1.1rCSI 3.0%PRS 20.1%
-
CSI 1.2rCSI 7.3%PRS 16.8%
-
CSI 1.2rCSI 5.9%PRS 28.5%
-
CSI 1.2rCSI 2.8%PRS 31.6%
-
CSI 1.2rCSI 10.0%PRS 21.5%
-
CSI 1.3rCSI 7.0%PRS 37.6%
-
CSI 1.3rCSI 7.7%PRS 59.7%
-
CSI 1.5rCSI 4.7%PRS 22.4%
-
CSI 1.5rCSI 1.3%PRS 24.9%
-
CSI 1.5rCSI 31.9%PRS 77.0%
-
CSI 1.5rCSI 46.0%PRS 45.9%
-
CSI 1.6rCSI 15.6%PRS 53.6%
-
CSI 1.7rCSI 7.9%PRS 46.1%
-
CSI 1.8rCSI 39.7%PRS 69.0%
-
CSI 1.8rCSI 13.6%PRS 53.9%
-
CSI 1.8rCSI 46.1%PRS 74.7%
-
CSI 1.8rCSI 7.6%PRS 50.6%
-
CSI 1.8rCSI 1.4%PRS 14.8%
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CSI 2.0rCSI 8.9%PRS 21.0%
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CSI 2.0rCSI 11.5%PRS 32.1%
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CSI 2.0rCSI 16.2%PRS 66.9%
-
CSI 2.1rCSI 10.0%PRS 17.3%
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CSI 2.2rCSI 4.8%PRS 25.2%
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CSI 2.2rCSI 3.4%PRS 28.0%
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CSI 2.2rCSI 9.8%PRS 71.2%
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CSI 2.2rCSI 14.5%PRS 52.6%
-
CSI 2.2rCSI 55.6%PRS 56.0%
-
CSI 2.3rCSI 1.8%PRS 21.7%
-
CSI 2.3rCSI 40.7%PRS 68.5%
-
CSI 2.5rCSI 3.4%PRS 40.7%
-
CSI 2.8rCSI 72.8%PRS 71.8%
-
CSI 2.9rCSI 7.0%PRS 21.2%
-
CSI 2.9rCSI 14.6%PRS 65.9%
-
CSI 2.9rCSI 46.5%PRS 73.8%
-
CSI 2.9rCSI 8.0%PRS 20.1%
-
CSI 3.1rCSI 9.0%PRS 39.2%
-
CSI 3.1rCSI 6.0%PRS 46.0%
-
CSI 3.2rCSI 6.7%PRS 32.1%
-
CSI 3.3rCSI 62.7%PRS 56.3%
-
CSI 3.3rCSI 79.1%PRS 59.7%
-
CSI 3.4rCSI 22.6%PRS 73.7%
-
CSI 3.5rCSI 16.3%PRS 51.9%
-
CSI 3.5rCSI 4.2%PRS 26.0%
-
CSI 3.5rCSI 54.3%PRS 50.5%
-
CSI 3.7rCSI 4.4%PRS 37.3%
-
CSI 3.7rCSI 23.5%PRS 51.0%
-
CSI 3.7rCSI 11.0%PRS 47.7%
-
CSI 3.7rCSI 21.8%PRS 62.6%
-
CSI 3.8rCSI 70.1%PRS 58.5%
-
CSI 3.8rCSI 13.9%PRS 63.6%
-
CSI 3.9rCSI 15.0%PRS 29.4%
-
CSI 3.9rCSI 4.8%PRS 18.9%
-
CSI 3.9rCSI 16.8%PRS 39.1%
-
CSI 3.9rCSI 5.6%PRS 24.3%
-
CSI 3.9rCSI 9.9%PRS 21.6%
-
CSI 4.1rCSI 8.7%PRS 34.2%
-
CSI 4.2rCSI 26.0%PRS 63.1%
-
CSI 4.3rCSI 4.9%PRS 43.2%
-
CSI 4.4rCSI 7.8%PRS 20.0%
-
CSI 4.8rCSI 11.8%PRS 20.0%
-
CSI 4.8rCSI 21.6%PRS 61.4%
-
CSI 5.0rCSI 8.0%PRS 16.5%
-
CSI 5.0rCSI 7.4%PRS 33.6%
-
CSI 5.1rCSI 28.1%PRS 53.8%
-
CSI 5.1rCSI 12.2%PRS 26.7%
-
CSI 5.1rCSI 20.7%PRS 19.7%
-
CSI 5.1rCSI 30.8%PRS 37.2%
-
CSI 5.2rCSI 28.3%PRS 33.1%
-
CSI 5.4rCSI 8.0%PRS 24.6%
-
CSI 5.7rCSI 12.5%PRS 32.6%
-
CSI 5.8rCSI 33.2%PRS 27.3%
-
CSI 6.0rCSI 13.2%PRS 20.0%
-
CSI 6.0rCSI 65.5%PRS 40.7%
-
CSI 6.1rCSI 17.4%PRS 37.7%
-
CSI 6.1rCSI 11.5%PRS 41.5%
-
CSI 6.1rCSI 68.6%PRS 62.0%
-
CSI 6.3rCSI 21.9%PRS 37.2%
-
CSI 6.3rCSI 11.1%PRS 17.2%
-
CSI 6.3rCSI 10.0%PRS 27.8%
-
CSI 6.4rCSI 4.2%PRS 25.8%
-
CSI 6.4rCSI 8.1%PRS 25.0%
-
CSI 6.5rCSI 37.8%PRS 31.9%
-
CSI 6.5rCSI 6.0%PRS 22.5%
-
CSI 6.5rCSI 23.2%PRS 34.9%
-
CSI 6.7rCSI 8.0%PRS 21.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2389130405
Symbol: PDLI1_HUMAN
Name: PDZ and LIM domain protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10022510
Title: Characterization of the human 36-kDa carboxyl terminal LIM domain protein (hCLIM1).
PubMed ID: 10022510
DOI: 10.1002/(sici)1097-4644(19990201)72:2<279::aid-jcb12>3.0.co;2-7
PubMed ID: 11110697
Title: Human CLP-36, a PDZ-domain and LIM-domain protein, binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.
PubMed ID: 11110697
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 10861853
Title: Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2.
PubMed ID: 10861853
DOI: 10.1002/1097-4644(20000915)78:4<558::aid-jcb5>3.0.co;2-i
PubMed ID: 10753915
Title: CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.
PubMed ID: 10753915
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18088087
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 329
- Mass: 36072
- Checksum: C85881A04D63D314
- Sequence:
MTTQQIDLQG PGPWGFRLVG GKDFEQPLAI SRVTPGSKAA LANLCIGDVI TAIDGENTSN MTHLEAQNRI KGCTDNLTLT VARSEHKVWS PLVTEEGKRH PYKMNLASEP QEVLHIGSAH NRSAMPFTAS PASSTTARVI TNQYNNPAGL YSSENISNFN NALESKTAAS GVEANSRPLD HAQPPSSLVI DKESEVYKML QEKQELNEPP KQSTSFLVLQ EILESEEKGD PNKPSGFRSV KAPVTKVAAS IGNAQKLPMC DKCGTGIVGV FVKLRDRHRH PECYVCTDCG TNLKQKGHFF VEDQIYCEKH ARERVTPPEG YEVVTVFPK