TMED10 | ENSG00000170348 | NCBI 10972

Details for: TMED10

Gene ID: 10972

Symbol: TMED10

Ensembl ID: ENSG00000170348

Description: transmembrane p24 trafficking protein 10

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Cargo receptor activity
(GO:0038024)
Cis-golgi network
(GO:0005801)
Copi-coated vesicle
(GO:0030137)
Copi-coated vesicle budding
(GO:0035964)
Copi coating of golgi vesicle
(GO:0048205)
Copii-coated er to golgi transport vesicle
(GO:0030134)
Copii vesicle coating
(GO:0048208)
Cytosol to ergic protein transport
(GO:0106273)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Er to golgi transport vesicle membrane
(GO:0012507)
Gamma-secretase complex
(GO:0070765)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Golgi organization
(GO:0007030)
Intracellular protein transport
(GO:0006886)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-1 production
(GO:0032732)
Positive regulation of protein secretion
(GO:0050714)
Protein binding
(GO:0005515)
Protein localization to ergic
(GO:0106272)
Protein transmembrane transport
(GO:0071806)
Protein transmembrane transporter activity
(GO:0008320)
Regulated exocytosis
(GO:0045055)
Regulation of amyloid-beta formation
(GO:1902003)
Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
(GO:0006890)
Secretory granule membrane
(GO:0030667)
Syntaxin binding
(GO:0019905)
Trans-golgi network transport vesicle
(GO:0030140)
Transport vesicle
(GO:0030133)
Vesicle cargo loading
(GO:0035459)
Vesicle targeting, to, from or within golgi
(GO:0048199)
Zymogen granule membrane
(GO:0042589)

Other Information

Proteins

Transmembrane emp24 domain-containing protein 10

Genular Protein ID: 3689515795

Symbol: TMEDA_HUMAN

Name: Transmembrane emp24 domain-containing protein 10

UniProtKB Accession Codes:

P49755 B2R605 Q15602 Q16536 Q86TC2 Q86TS5

Database IDs:

Citations:

PubMed ID: 8663407

Title: Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.

PubMed ID: 8663407

DOI: 10.1074/jbc.271.29.17183

PubMed ID: 7596406

Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

PubMed ID: 7596406

DOI: 10.1038/375754a0

PubMed ID: 10376215

Title: A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II.

PubMed ID: 10376215

DOI: 10.3109/10425179909008429

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 9382861

Title: Involvement of the transmembrane protein p23 in biosynthetic protein transport.

PubMed ID: 9382861

DOI: 10.1083/jcb.139.5.1119

PubMed ID: 9472029

Title: gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.

PubMed ID: 9472029

DOI: 10.1083/jcb.140.4.751

PubMed ID: 10052452

Title: Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors.

PubMed ID: 10052452

DOI: 10.1016/s0092-8674(00)80654-6

PubMed ID: 10359607

Title: Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members.

PubMed ID: 10359607

DOI: 10.1091/mbc.10.6.1939

PubMed ID: 10761932

Title: Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex.

PubMed ID: 10761932

DOI: 10.1016/s0092-8674(00)80703-5

PubMed ID: 11056392

Title: Identification and characterization of novel isoforms of COP I subunits.

PubMed ID: 11056392

DOI: 10.1093/oxfordjournals.jbchem.a022817

PubMed ID: 10852829

Title: Coupled transport of p24 family members.

PubMed ID: 10852829

DOI: 10.1242/jcs.113.13.2507

PubMed ID: 11726511

Title: Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23.

PubMed ID: 11726511

DOI: 10.1093/emboj/20.23.6751

PubMed ID: 12237308

Title: Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.

PubMed ID: 12237308

DOI: 10.1074/jbc.m206989200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16940185

Title: Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins.

PubMed ID: 16940185

DOI: 10.1128/mcb.01055-06

PubMed ID: 16641999

Title: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

PubMed ID: 16641999

DOI: 10.1038/nature04667

PubMed ID: 17288597

Title: Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.

PubMed ID: 17288597

DOI: 10.1186/1750-1326-2-4

PubMed ID: 18287528

Title: The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.

PubMed ID: 18287528

DOI: 10.1091/mbc.e07-10-0989

PubMed ID: 19837036

Title: GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.

PubMed ID: 19837036

DOI: 10.1016/j.cell.2009.08.040

PubMed ID: 19296914

Title: Arf GAP2 is positively regulated by coatomer and cargo.

PubMed ID: 19296914

DOI: 10.1016/j.cellsig.2009.03.006

PubMed ID: 20427317

Title: Selective export of human GPI-anchored proteins from the endoplasmic reticulum.

PubMed ID: 20427317

DOI: 10.1242/jcs.062950

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21545355

Title: Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.

PubMed ID: 21545355

DOI: 10.1042/bc20110006

PubMed ID: 21219331

Title: Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.

PubMed ID: 21219331

DOI: 10.1111/j.1471-4159.2011.07173.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27569046

Title: 3D structure and interaction of p24beta and p24delta golgi dynamics domains: implication for p24 complex formation and cargo transport.

PubMed ID: 27569046

DOI: 10.1016/j.jmb.2016.08.023

PubMed ID: 31455601

Title: RAB21 interacts with TMED10 and modulates its localization and abundance.

PubMed ID: 31455601

DOI: 10.1242/bio.045336

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

Sequence Information:

Length: 219
Mass: 24976
Checksum: 0A0486BE65C4DBBB
Sequence:

MSGLSGPPAR RGPFPLALLL LFLLGPRLVL AISFHLPINS RKCLREEIHK DLLVTGAYEI 
SDQSGGAGGL RSHLKITDSA GHILYSKEDA TKGKFAFTTE DYDMFEVCFE SKGTGRIPDQ 
LVILDMKHGV EAKNYEEIAK VEKLKPLEVE LRRLEDLSES IVNDFAYMKK REEEMRDTNE 
STNTRVLYFS IFSMFCLIGL ATWQVFYLRR FFKAKKLIE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TMED10

Associated with

Other Information

Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. PubMed ID: 8663407

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. PubMed ID: 7596406

A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II. PubMed ID: 10376215

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini. PubMed ID: 19892738

Involvement of the transmembrane protein p23 in biosynthetic protein transport. PubMed ID: 9382861

gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. PubMed ID: 9472029

Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors. PubMed ID: 10052452

Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. PubMed ID: 10359607

Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex. PubMed ID: 10761932

Identification and characterization of novel isoforms of COP I subunits. PubMed ID: 11056392

Coupled transport of p24 family members. PubMed ID: 10852829

Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23. PubMed ID: 11726511

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. PubMed ID: 12237308

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins. PubMed ID: 16940185

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. PubMed ID: 16641999

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. PubMed ID: 17288597

The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. PubMed ID: 18287528

GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi. PubMed ID: 19837036

Arf GAP2 is positively regulated by coatomer and cargo. PubMed ID: 19296914

Selective export of human GPI-anchored proteins from the endoplasmic reticulum. PubMed ID: 20427317

Initial characterization of the human central proteome. PubMed ID: 21269460

Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi. PubMed ID: 21545355

Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking. PubMed ID: 21219331

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

3D structure and interaction of p24beta and p24delta golgi dynamics domains: implication for p24 complex formation and cargo transport. PubMed ID: 27569046

RAB21 interacts with TMED10 and modulates its localization and abundance. PubMed ID: 31455601

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion. PubMed ID: 32272059