Details for: TMED10
Gene ID: 10972
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TMED10
Ensembl ID: ENSG00000170348
Description: transmembrane p24 trafficking protein 10
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 99.66rCSI 78.4%PRS 10.9
-
CSI 80.93rCSI 84.78%PRS 9.74
-
CSI 76.41rCSI 67.2%PRS 6.63
-
CSI 73.27rCSI 90.64%PRS 8.02
-
CSI 72.35rCSI 71.16%PRS 9.93
-
CSI 67.79rCSI 65.26%PRS 9.47
-
CSI 60.99rCSI 42.58%PRS 9.64
-
CSI 58.14rCSI 77.28%PRS 9.97
-
CSI 55.52rCSI 55.41%PRS 7.86
-
CSI 45.3rCSI 47.34%PRS 9.65
-
CSI 44.56rCSI 64.22%PRS 14.76
-
CSI 44.39rCSI 58.18%PRS 42.81
-
CSI 44.08rCSI 50.97%PRS 6.7
-
CSI 42.71rCSI 44.74%PRS 8.5
-
CSI 40.79rCSI 90.3%PRS 8.48
-
CSI 39.72rCSI 30.79%PRS 8.73
-
CSI 38.67rCSI 37.28%PRS 6
-
CSI 38.06rCSI 34.94%PRS 10.45
-
CSI 37.13rCSI 54.45%PRS 12.06
-
CSI 37.12rCSI 57.36%PRS 8.56
-
CSI 35.67rCSI 36.52%PRS 17.24
-
CSI 34.04rCSI 30.21%PRS 9.15
-
CSI 32.24rCSI 62.69%PRS 9.32
-
CSI 31.21rCSI 29.5%PRS 9.55
-
CSI 29.26rCSI 69.55%PRS 13.75
-
CSI 27.89rCSI 20.66%PRS 8.26
-
CSI 26.65rCSI 56.73%PRS 14.77
-
CSI 26.6rCSI 38.92%PRS 9.68
-
CSI 25.83rCSI 68.01%PRS 17.93
-
CSI 25.33rCSI 55.3%PRS 18.57
-
CSI 25rCSI 31.37%PRS 11.69
-
CSI 24.81rCSI 20.06%PRS 9.04
-
CSI 23.56rCSI 34.52%PRS 10.71
-
CSI 22.96rCSI 26.63%PRS 13.58
-
CSI 21.34rCSI 35.16%PRS 10.72
-
CSI 20.88rCSI 60.15%PRS 18.14
-
CSI 20.07rCSI 45.76%PRS 9.58
-
CSI 19.81rCSI 30.44%PRS 13.12
-
CSI 18.98rCSI 22.73%PRS 15.86
-
CSI 18.58rCSI 33.76%PRS 13.97
-
CSI 17.98rCSI 28.55%PRS 11.87
-
CSI 17.34rCSI 69.03%PRS 16.14
-
CSI 17.16rCSI 68.59%PRS 20.24
-
CSI 16.94rCSI 14.66%PRS 10.2
-
CSI 16.93rCSI 25.89%PRS 14.87
-
CSI 16.81rCSI 56.81%PRS 15.67
-
CSI 16.08rCSI 17.09%PRS 16.33
-
CSI 15.7rCSI 13.16%PRS 10.94
-
CSI 15.19rCSI 12.6%PRS 8.69
-
CSI 15.15rCSI 24.43%PRS 14.64
-
CSI 15.1rCSI 21.79%PRS 12.8
-
CSI 15.07rCSI 52.87%PRS 16.6
-
CSI 14.18rCSI 38.96%PRS 15.22
-
CSI 14.11rCSI 26.64%PRS 11.35
-
CSI 13.61rCSI 15.98%PRS 10.87
-
CSI 13.38rCSI 32.1%PRS 16.92
-
CSI 13.28rCSI 38.44%PRS 10.37
-
CSI 13.18rCSI 13.75%PRS 9.39
-
CSI 13.04rCSI 60.8%PRS 22.3
-
CSI 12.61rCSI 54.48%PRS 17.75
-
CSI 11.75rCSI 57.9%PRS 12.45
-
CSI 11.67rCSI 17.27%PRS 10.5
-
CSI 11.47rCSI 18.59%PRS 9.36
-
CSI 11.43rCSI 66.51%PRS 13.78
-
CSI 11.04rCSI 49.66%PRS 44.37
-
CSI 10.76rCSI 12.11%PRS 14.78
-
CSI 10.66rCSI 20.35%PRS 21.92
-
CSI 10.63rCSI 57.2%PRS 16.62
-
CSI 10.45rCSI 13.4%PRS 10.55
-
CSI 9.76rCSI 53.14%PRS 23.19
-
CSI 9.75rCSI 12.13%PRS 9.7
-
CSI 9.74rCSI 31.25%PRS 13.59
-
CSI 9.72rCSI 43.24%PRS 38.61
-
CSI 9.65rCSI 49.8%PRS 18.37
-
CSI 9.39rCSI 13.87%PRS 14.43
-
CSI 9.09rCSI 32.26%PRS 15.01
-
CSI 8.98rCSI 12.27%PRS 10.1
-
CSI 8.9rCSI 13.08%PRS 8.67
-
CSI 8.84rCSI 54.56%PRS 30
-
CSI 8.7rCSI 8.81%PRS 51.11
-
CSI 8.36rCSI 12.77%PRS 9.17
-
CSI 8.35rCSI 93.38%PRS 30.75
-
CSI 7.92rCSI 40.03%PRS 39.67
-
CSI 7.86rCSI 77.27%PRS 27.95
-
CSI 7.62rCSI 5.06%PRS 10.93
-
CSI 7.51rCSI 81.69%PRS 17.67
-
CSI 7.5rCSI 9.12%PRS 11.54
-
CSI 7.42rCSI 32.59%PRS 17.09
-
CSI 7.3rCSI 19.68%PRS 11.81
-
CSI 7.15rCSI 33.03%PRS 19.45
-
CSI 6.62rCSI 6.1%PRS 9.32
-
CSI 6.42rCSI 15.07%PRS 14.75
-
CSI 6.16rCSI 5.01%PRS 9.73
-
CSI 6.06rCSI 6.49%PRS 8.41
-
CSI 5.83rCSI 4.9%PRS 15.07
-
CSI 5.79rCSI 40.89%PRS 28.85
-
CSI 5.78rCSI 20.91%PRS 15.74
-
CSI 5.65rCSI 4.72%PRS 28.09
-
CSI 5.56rCSI 8.78%PRS 9.17
-
CSI 5.45rCSI 4.09%PRS 9.47
-
CSI -12.4rCSI -21.9%PRS 12.1%
-
CSI -9.7rCSI -20.2%PRS 9.1%
-
CSI -5.9rCSI -18.3%PRS 6.3%
-
CSI -3.7rCSI -13.2%PRS 5.0%
-
CSI -2.9rCSI -17.9%PRS 7.3%
-
CSI -2.7rCSI -3.2%PRS 13.0%
-
CSI -2.5rCSI -6.5%PRS 10.9%
-
CSI -1.5rCSI -7.3%PRS 5.7%
-
CSI -1.5rCSI -1.3%PRS 14.1%
-
CSI -1.2rCSI -2.6%PRS 6.6%
-
CSI -1.1rCSI -3.1%PRS 13.3%
-
CSI -1.0rCSI -18.3%PRS 30.4%
-
CSI -0.8rCSI -1.8%PRS 20.3%
-
CSI -0.8rCSI -5.7%PRS 4.4%
-
CSI -0.7rCSI -4.3%PRS 41.9%
-
CSI -0.7rCSI -3.8%PRS 12.6%
-
CSI -0.6rCSI -1.0%PRS 22.8%
-
CSI -0.6rCSI -3.2%PRS 36.2%
-
CSI -0.3rCSI -1.0%PRS 5.8%
-
CSI -0.3rCSI -0.7%PRS 7.1%
-
CSI -0.2rCSI -0.4%PRS 25.8%
-
CSI -0.2rCSI -0.5%PRS 5.7%
-
CSI -0.2rCSI -1.0%PRS 5.7%
-
CSI -0.1rCSI -0.7%PRS 78.4%
-
CSI 0.0rCSI 0.1%PRS 8.4%
-
CSI 0.0rCSI 0.3%PRS 2.2%
-
CSI 0.1rCSI 0.1%PRS 5.2%
-
CSI 0.1rCSI 0.3%PRS 7.4%
-
CSI 0.1rCSI 0.5%PRS 5.6%
-
CSI 0.1rCSI 2.4%PRS 26.3%
-
CSI 0.2rCSI 0.3%PRS 5.4%
-
CSI 0.2rCSI 1.2%PRS 18.0%
-
CSI 0.2rCSI 0.4%PRS 19.3%
-
CSI 0.2rCSI 0.9%PRS 33.5%
-
CSI 0.2rCSI 0.8%PRS 15.2%
-
CSI 0.2rCSI 0.2%PRS 11.3%
-
CSI 0.2rCSI 0.3%PRS 13.1%
-
CSI 0.2rCSI 0.6%PRS 11.9%
-
CSI 0.3rCSI 5.9%PRS 4.0%
-
CSI 0.3rCSI 6.4%PRS 4.8%
-
CSI 0.3rCSI 1.6%PRS 13.7%
-
CSI 0.3rCSI 0.9%PRS 16.1%
-
CSI 0.3rCSI 2.5%PRS 38.6%
-
CSI 0.3rCSI 1.5%PRS 12.8%
-
CSI 0.4rCSI 5.4%PRS 29.9%
-
CSI 0.4rCSI 9.6%PRS 45.1%
-
CSI 0.4rCSI 1.3%PRS 12.2%
-
CSI 0.4rCSI 0.5%PRS 18.9%
-
CSI 0.5rCSI 0.6%PRS 9.6%
-
CSI 0.5rCSI 7.6%PRS 49.8%
-
CSI 0.5rCSI 1.1%PRS 12.3%
-
CSI 0.5rCSI 3.3%PRS 30.3%
-
CSI 0.5rCSI 0.8%PRS 10.6%
-
CSI 0.5rCSI 0.9%PRS 9.2%
-
CSI 0.5rCSI 0.7%PRS 12.8%
-
CSI 0.5rCSI 1.7%PRS 27.1%
-
CSI 0.5rCSI 2.9%PRS 29.1%
-
CSI 0.5rCSI 9.2%PRS 37.3%
-
CSI 0.5rCSI 0.4%PRS 16.1%
-
CSI 0.5rCSI 13.3%PRS 64.2%
-
CSI 0.6rCSI 1.4%PRS 9.0%
-
CSI 0.6rCSI 4.4%PRS 20.7%
-
CSI 0.6rCSI 1.8%PRS 10.2%
-
CSI 0.6rCSI 2.0%PRS 37.9%
-
CSI 0.6rCSI 13.9%PRS 32.8%
-
CSI 0.6rCSI 0.9%PRS 7.3%
-
CSI 0.6rCSI 6.1%PRS 39.4%
-
CSI 0.6rCSI 0.9%PRS 15.3%
-
CSI 0.7rCSI 0.8%PRS 5.3%
-
CSI 0.7rCSI 1.0%PRS 8.6%
-
CSI 0.7rCSI 2.6%PRS 13.7%
-
CSI 0.7rCSI 1.8%PRS 15.4%
-
CSI 0.7rCSI 3.2%PRS 21.0%
-
CSI 0.7rCSI 3.7%PRS 34.0%
-
CSI 0.7rCSI 2.1%PRS 23.6%
-
CSI 0.7rCSI 3.7%PRS 16.9%
-
CSI 0.7rCSI 16.4%PRS 58.9%
-
CSI 0.7rCSI 0.9%PRS 5.0%
-
CSI 0.7rCSI 4.4%PRS 39.9%
-
CSI 0.7rCSI 5.9%PRS 9.6%
-
CSI 0.7rCSI 1.4%PRS 6.8%
-
CSI 0.7rCSI 1.7%PRS 11.3%
-
CSI 0.7rCSI 0.9%PRS 12.8%
-
CSI 0.8rCSI 1.0%PRS 5.7%
-
CSI 0.8rCSI 1.5%PRS 25.2%
-
CSI 0.8rCSI 3.8%PRS 53.7%
-
CSI 0.8rCSI 6.9%PRS 63.2%
-
CSI 0.8rCSI 3.5%PRS 28.8%
-
CSI 0.8rCSI 1.6%PRS 21.8%
-
CSI 0.8rCSI 1.9%PRS 14.6%
-
CSI 0.8rCSI 2.6%PRS 6.6%
-
CSI 0.8rCSI 0.6%PRS 15.4%
-
CSI 0.8rCSI 5.0%PRS 20.8%
-
CSI 0.8rCSI 3.6%PRS 16.7%
-
CSI 0.8rCSI 5.5%PRS 55.9%
-
CSI 0.9rCSI 4.3%PRS 12.0%
-
CSI 0.9rCSI 2.7%PRS 15.4%
-
CSI 0.9rCSI 4.7%PRS 31.4%
-
CSI 0.9rCSI 1.4%PRS 6.0%
-
CSI 0.9rCSI 2.5%PRS 9.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3689515795
Symbol: TMEDA_HUMAN
Name: Transmembrane emp24 domain-containing protein 10
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8663407
Title: Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.
PubMed ID: 8663407
PubMed ID: 7596406
Title: Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
PubMed ID: 7596406
DOI: 10.1038/375754a0
PubMed ID: 10376215
Title: A comparative study of rat and human Tmp21 (p23) reveals the pseudogene-like features of human Tmp21-II.
PubMed ID: 10376215
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19892738
Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.
PubMed ID: 19892738
PubMed ID: 9382861
Title: Involvement of the transmembrane protein p23 in biosynthetic protein transport.
PubMed ID: 9382861
PubMed ID: 9472029
Title: gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer.
PubMed ID: 9472029
PubMed ID: 10052452
Title: Coupling of coat assembly and vesicle budding to packaging of putative cargo receptors.
PubMed ID: 10052452
PubMed ID: 10359607
Title: Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members.
PubMed ID: 10359607
PubMed ID: 10761932
Title: Decoding of sorting signals by coatomer through a GTPase switch in the COPI coat complex.
PubMed ID: 10761932
PubMed ID: 11056392
Title: Identification and characterization of novel isoforms of COP I subunits.
PubMed ID: 11056392
PubMed ID: 10852829
PubMed ID: 11726511
Title: Recruitment to Golgi membranes of ADP-ribosylation factor 1 is mediated by the cytoplasmic domain of p23.
PubMed ID: 11726511
PubMed ID: 12237308
Title: Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway.
PubMed ID: 12237308
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 16940185
Title: Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins.
PubMed ID: 16940185
DOI: 10.1128/mcb.01055-06
PubMed ID: 16641999
Title: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
PubMed ID: 16641999
DOI: 10.1038/nature04667
PubMed ID: 17288597
Title: Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.
PubMed ID: 17288597
PubMed ID: 18287528
Title: The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.
PubMed ID: 18287528
PubMed ID: 19837036
Title: GPI glycan remodeling by PGAP5 regulates transport of GPI-anchored proteins from the ER to the Golgi.
PubMed ID: 19837036
PubMed ID: 19296914
Title: Arf GAP2 is positively regulated by coatomer and cargo.
PubMed ID: 19296914
PubMed ID: 20427317
Title: Selective export of human GPI-anchored proteins from the endoplasmic reticulum.
PubMed ID: 20427317
DOI: 10.1242/jcs.062950
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21545355
Title: Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.
PubMed ID: 21545355
DOI: 10.1042/bc20110006
PubMed ID: 21219331
Title: Proteinase-activated receptors, nucleotide P2Y receptors, and mu-opioid receptor-1B are under the control of the type I transmembrane proteins p23 and p24A in post-Golgi trafficking.
PubMed ID: 21219331
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27569046
Title: 3D structure and interaction of p24beta and p24delta golgi dynamics domains: implication for p24 complex formation and cargo transport.
PubMed ID: 27569046
PubMed ID: 31455601
Title: RAB21 interacts with TMED10 and modulates its localization and abundance.
PubMed ID: 31455601
DOI: 10.1242/bio.045336
PubMed ID: 32272059
Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.
PubMed ID: 32272059
Sequence Information:
- Length: 219
- Mass: 24976
- Checksum: 0A0486BE65C4DBBB
- Sequence:
MSGLSGPPAR RGPFPLALLL LFLLGPRLVL AISFHLPINS RKCLREEIHK DLLVTGAYEI SDQSGGAGGL RSHLKITDSA GHILYSKEDA TKGKFAFTTE DYDMFEVCFE SKGTGRIPDQ LVILDMKHGV EAKNYEEIAK VEKLKPLEVE LRRLEDLSES IVNDFAYMKK REEEMRDTNE STNTRVLYFS IFSMFCLIGL ATWQVFYLRR FFKAKKLIE