SYF2 | ENSG00000117614 | NCBI 25949

Details for: SYF2

Gene ID: 25949

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SYF2

Ensembl ID: ENSG00000117614

Description: SYF2 pre-mRNA splicing factor

Cell Significance Landscape

Display Count:

Associated with

Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Catalytic step 2 spliceosome
(GO:0071013)
Embryonic organ development
(GO:0048568)
Gastrulation
(GO:0007369)
In utero embryonic development
(GO:0001701)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mrna splicing, via spliceosome
(GO:0000398)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cell population proliferation
(GO:0008284)
Post-mrna release spliceosomal complex
(GO:0071014)
Protein binding
(GO:0005515)
Prp19 complex
(GO:0000974)
Rna binding
(GO:0003723)
U2-type catalytic step 2 spliceosome
(GO:0071007)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

hematopoietic stem cell CL0000037

CSI 53.57

rCSI 35.61%

PRS 7.7
fallopian tube secretory epithelial cell CL4030006

CSI 43.31

rCSI 41.69%

PRS 6.7
ciliated epithelial cell CL0000067

CSI 35.49

rCSI 31.21%

PRS 4.66
fraction A pre-pro B cell CL0002045

CSI 33.55

rCSI 38.41%

PRS 13.43
keratinocyte CL0000312

CSI 30.27

rCSI 25.38%

PRS 7.75
CD14-low, CD16-positive monocyte CL0002396

CSI 28.85

rCSI 22.23%

PRS 5.85
common dendritic progenitor CL0001029

CSI 28.58

rCSI 35.87%

PRS 8.22
intestinal epithelial cell CL0002563

CSI 26.31

rCSI 27.49%

PRS 6.79
stromal cell of ovary CL0002132

CSI 25.5

rCSI 70.08%

PRS 10.76
stem cell CL0000034

CSI 24.91

rCSI 24.02%

PRS 3.88
pancreatic acinar cell CL0002064

CSI 24.54

rCSI 32.62%

PRS 7.02
megakaryocyte-erythroid progenitor cell CL0000050

CSI 24.41

rCSI 22.05%

PRS 5.71
microcirculation associated smooth muscle cell CL0008035

CSI 23.66

rCSI 68.49%

PRS 7.35
granulocyte monocyte progenitor cell CL0000557

CSI 21.89

rCSI 18.95%

PRS 7.18
large pre-B-II cell CL0000957

CSI 21.14

rCSI 60.36%

PRS 11.5
common lymphoid progenitor CL0000051

CSI 20.34

rCSI 27.18%

PRS 12.4
transit amplifying cell of colon CL0009011

CSI 19.1

rCSI 22.43%

PRS 7.71
extravillous trophoblast CL0008036

CSI 17.44

rCSI 21.58%

PRS 5.66
colon goblet cell CL0009039

CSI 16.13

rCSI 38.35%

PRS 9.71
placental villous trophoblast CL2000060

CSI 15.92

rCSI 24.6%

PRS 6.06
mature B cell CL0000785

CSI 14.75

rCSI 12.83%

PRS 7.96
common myeloid progenitor CL0000049

CSI 14.59

rCSI 11.8%

PRS 6.35
transitional stage B cell CL0000818

CSI 13.75

rCSI 45.01%

PRS 19.63
enterocyte CL0000584

CSI 13.06

rCSI 21.07%

PRS 10.41
early lymphoid progenitor CL0000936

CSI 11.8

rCSI 10.36%

PRS 7.25
glandular epithelial cell CL0000150

CSI 11.51

rCSI 30.3%

PRS 12.66
peripheral nervous system neuron CL2000032

CSI 11.02

rCSI 15.02%

PRS 5.81
CD4-positive helper T cell CL0000492

CSI 10.84

rCSI 8.2%

PRS 8.98
myeloid lineage restricted progenitor cell CL0000839

CSI 10.56

rCSI 54.5%

PRS 12.97
promonocyte CL0000559

CSI 10.08

rCSI 17.27%

PRS 8.66
double-positive, alpha-beta thymocyte CL0000809

CSI 9.63

rCSI 9.81%

PRS 9.32
colon epithelial cell CL0011108

CSI 9.39

rCSI 9.83%

PRS 6
mucous neck cell CL0000651

CSI 9.18

rCSI 13.24%

PRS 10.47
pro-B cell CL0000826

CSI 9.09

rCSI 7.53%

PRS 6.47
endothelial cell of placenta CL0009092

CSI 9.01

rCSI 44.42%

PRS 8.77
naive T cell CL0000898

CSI 8.88

rCSI 6.18%

PRS 9.35
late pro-B cell CL0002048

CSI 8.77

rCSI 21.99%

PRS 21.11
pancreatic ductal cell CL0002079

CSI 8.61

rCSI 16.75%

PRS 6.58
cerebral cortex GABAergic interneuron CL0010011

CSI 8.5

rCSI 25.1%

PRS 8.14
intestinal crypt stem cell of small intestine CL0009017

CSI 8.49

rCSI 22.89%

PRS 8.34
colon macrophage CL0009038

CSI 8.17

rCSI 37.75%

PRS 14.1
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 7.96

rCSI 15.86%

PRS 11.09
activated type II NK T cell CL0000931

CSI 7.7

rCSI 8.66%

PRS 10.68
pancreatic stellate cell CL0002410

CSI 7.42

rCSI 43.17%

PRS 9.76
inflammatory macrophage CL0000863

CSI 7.05

rCSI 12.05%

PRS 13.42
thymocyte CL0000893

CSI 6.94

rCSI 24.65%

PRS 20.97
epithelial cell of lung CL0000082

CSI 6.9

rCSI 5.72%

PRS 6.16
forebrain radial glial cell CL0013000

CSI 6.79

rCSI 21.79%

PRS 9.71
kidney epithelial cell CL0002518

CSI 6.77

rCSI 12.92%

PRS 15.72
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 6.69

rCSI 9.48%

PRS 6.12
intestinal crypt stem cell of colon CL0009043

CSI 6.59

rCSI 49.49%

PRS 12.07
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 6.47

rCSI 39.17%

PRS 15.12
mucus secreting cell CL0000319

CSI 6.37

rCSI 10.12%

PRS 8.4
alveolar type 1 fibroblast cell CL4028004

CSI 6.34

rCSI 6.94%

PRS 7.47
naive B cell CL0000788

CSI 6.32

rCSI 5.42%

PRS 14.98
pancreatic D cell CL0000173

CSI 6.3

rCSI 6.2%

PRS 6.98
basophil CL0000767

CSI 6.2

rCSI 13.12%

PRS 14.13
tendon cell CL0000388

CSI 6.16

rCSI 16.02%

PRS 19.7
lymphoid lineage restricted progenitor cell CL0000838

CSI 6.02

rCSI 23.44%

PRS 10.71
double negative thymocyte CL0002489

CSI 6

rCSI 4.17%

PRS 7.56
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 5.98

rCSI 4.49%

PRS 19.2
precursor B cell CL0000817

CSI 5.8

rCSI 5.08%

PRS 8.72
secretory cell CL0000151

CSI 5.79

rCSI 6.04%

PRS 6.63
interstitial cell of Cajal CL0002088

CSI 5.61

rCSI 7.15%

PRS 7.5
acinar cell CL0000622

CSI 5.57

rCSI 8.16%

PRS 8.5
Mueller cell CL0000636

CSI 5.47

rCSI 12.48%

PRS 5.89
basal-myoepithelial cell of mammary gland CL0002324

CSI 5.38

rCSI 10.18%

PRS 14.41
unswitched memory B cell CL0000970

CSI 5.07

rCSI 4.26%

PRS 10.75
interneuron CL0000099

CSI 5.05

rCSI 10.14%

PRS 4.79
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 5.03

rCSI 4.94%

PRS 10.3
eosinophil CL0000771

CSI 4.99

rCSI 32.75%

PRS 17.15
small pre-B-II cell CL0000954

CSI 4.91

rCSI 4.72%

PRS 13.99
primitive red blood cell CL0002355

CSI 4.74

rCSI 25.59%

PRS 12.57
squamous epithelial cell CL0000076

CSI 4.74

rCSI 11.25%

PRS 8.64
neuroblast (sensu Vertebrata) CL0000031

CSI 4.63

rCSI 5.95%

PRS 6.35
conjunctival epithelial cell CL1000432

CSI 4.61

rCSI 7.03%

PRS 6.49
type B pancreatic cell CL0000169

CSI 4.55

rCSI 10.08%

PRS 5.99
T-helper 17 cell CL0000899

CSI 4.5

rCSI 3.57%

PRS 11.44
respiratory basal cell CL0002633

CSI 4.49

rCSI 4.65%

PRS 7.6
immature B cell CL0000816

CSI 4.49

rCSI 3.33%

PRS 9.69
epithelial cell CL0000066

CSI 4.38

rCSI 6.74%

PRS 9.31
CD4-positive, alpha-beta memory T cell CL0000897

CSI 4.29

rCSI 3.08%

PRS 8.8
melanocyte CL0000148

CSI 4.2

rCSI 3.11%

PRS 5.92
pulmonary capillary endothelial cell CL4028001

CSI 4.18

rCSI 7.97%

PRS 10.44
plasmacytoid dendritic cell, human CL0001058

CSI 4.18

rCSI 2.92%

PRS 6.8
cardiac muscle cell CL0000746

CSI 4.06

rCSI 5.83%

PRS 5.21
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.99

rCSI 3.2%

PRS 11.9
class switched memory B cell CL0000972

CSI 3.88

rCSI 2.9%

PRS 10.96
myeloid dendritic cell CL0000782

CSI 3.83

rCSI 5.56%

PRS 9.53
lung ciliated cell CL1000271

CSI 3.81

rCSI 4.41%

PRS 4.72
vein endothelial cell of respiratory system CL4033008

CSI 3.78

rCSI 25.95%

PRS 12.87
mature T cell CL0002419

CSI 3.77

rCSI 2.93%

PRS 9.27
T follicular helper cell CL0002038

CSI 3.75

rCSI 2.81%

PRS 10.57
multi-ciliated epithelial cell CL0005012

CSI 3.75

rCSI 3.74%

PRS 5.55
pancreatic PP cell CL0002275

CSI 3.71

rCSI 14.78%

PRS 11.45
transit amplifying cell of small intestine CL0009012

CSI 3.62

rCSI 15.89%

PRS 12.17
sst GABAergic cortical interneuron CL4023017

CSI 3.61

rCSI 4.65%

PRS 4.04
myofibroblast cell CL0000186

CSI 3.6

rCSI 4.99%

PRS 9.34
memory B cell CL0000787

CSI 3.59

rCSI 3.55%

PRS 27.57
deuterosomal cell CL4033044

CSI 3.58

rCSI 12.1%

PRS 11.07

lung neuroendocrine cell CL1000223

CSI -24.2

rCSI -35.8%

PRS 7.4%
alpha-beta T cell CL0000789

CSI -4.4

rCSI -5.2%

PRS 9.8%
astrocyte of the cerebral cortex CL0002605

CSI -2.6

rCSI -5.7%

PRS 4.0%
choroid plexus epithelial cell CL0000706

CSI -2.3

rCSI -3.7%

PRS 5.0%
lung pericyte CL0009089

CSI -1.4

rCSI -3.7%

PRS 7.8%
pulmonary alveolar type 2 cell CL0002063

CSI -0.4

rCSI -0.7%

PRS 10.2%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -0.1

rCSI -0.1%

PRS 10.1%
basal cell of epidermis CL0002187

CSI 0.0

rCSI 0.0%

PRS 8.1%
platelet CL0000233

CSI 0.1

rCSI 0.3%

PRS 17.5%
chondrocyte CL0000138

CSI 0.1

rCSI 0.2%

PRS 5.8%
small intestine goblet cell CL1000495

CSI 0.1

rCSI 0.3%

PRS 8.7%
kidney connecting tubule epithelial cell CL1000768

CSI 0.2

rCSI 0.4%

PRS 5.0%
prostate gland microvascular endothelial cell CL2000059

CSI 0.2

rCSI 4.3%

PRS 24.2%
Cajal-Retzius cell CL0000695

CSI 0.2

rCSI 1.4%

PRS 14.9%
pre-conventional dendritic cell CL0002010

CSI 0.2

rCSI 2.8%

PRS 22.7%
kidney loop of Henle epithelial cell CL1000909

CSI 0.2

rCSI 4.7%

PRS 48.9%
B-2 B cell CL0000822

CSI 0.2

rCSI 5.0%

PRS 38.7%
memory T cell CL0000813

CSI 0.3

rCSI 0.5%

PRS 14.8%
L6b glutamatergic cortical neuron CL4023038

CSI 0.3

rCSI 1.0%

PRS 4.1%
retinal bipolar neuron CL0000748

CSI 0.3

rCSI 0.6%

PRS 4.9%
epithelial cell of esophagus CL0002252

CSI 0.3

rCSI 3.4%

PRS 25.9%
myelocyte CL0002193

CSI 0.4

rCSI 2.3%

PRS 22.3%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.4%

PRS 3.5%
cytotoxic T cell CL0000910

CSI 0.4

rCSI 2.2%

PRS 9.9%
blood vessel smooth muscle cell CL0019018

CSI 0.4

rCSI 3.1%

PRS 6.9%
double negative T regulatory cell CL0011024

CSI 0.4

rCSI 7.9%

PRS 47.2%
IgG plasma cell CL0000985

CSI 0.4

rCSI 0.5%

PRS 11.3%
endothelial cell of arteriole CL1000412

CSI 0.4

rCSI 2.4%

PRS 26.3%
foveolar cell of stomach CL0002179

CSI 0.5

rCSI 1.0%

PRS 10.5%
mesenchymal lymphangioblast CL0005021

CSI 0.5

rCSI 11.7%

PRS 34.4%
helper T cell CL0000912

CSI 0.5

rCSI 0.6%

PRS 9.4%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.5

rCSI 2.3%

PRS 8.5%
type L enteroendocrine cell CL0002279

CSI 0.5

rCSI 0.9%

PRS 12.8%
retinal ganglion cell CL0000740

CSI 0.5

rCSI 1.1%

PRS 4.6%
bronchial goblet cell CL1000312

CSI 0.5

rCSI 2.0%

PRS 14.3%
Merkel cell CL0000242

CSI 0.5

rCSI 11.7%

PRS 45.2%
odontoblast CL0000060

CSI 0.5

rCSI 11.7%

PRS 34.7%
megakaryocyte CL0000556

CSI 0.5

rCSI 2.4%

PRS 12.0%
rod bipolar cell CL0000751

CSI 0.6

rCSI 1.0%

PRS 5.5%
tracheal goblet cell CL1000329

CSI 0.6

rCSI 1.3%

PRS 13.2%
vasa recta ascending limb cell CL1001131

CSI 0.6

rCSI 2.8%

PRS 28.4%
endothelial cell of venule CL1000414

CSI 0.6

rCSI 5.5%

PRS 35.2%
enteroendocrine cell of small intestine CL0009006

CSI 0.6

rCSI 1.4%

PRS 9.9%
paneth cell CL0000510

CSI 0.6

rCSI 0.9%

PRS 10.2%
vascular associated smooth muscle cell CL0000359

CSI 0.6

rCSI 2.1%

PRS 7.9%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.7

rCSI 1.1%

PRS 3.8%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.7

rCSI 7.6%

PRS 27.3%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 0.7

rCSI 0.9%

PRS 16.1%
IgA plasma cell CL0000987

CSI 0.7

rCSI 0.7%

PRS 12.3%
alternatively activated macrophage CL0000890

CSI 0.7

rCSI 0.9%

PRS 10.0%
erythroid progenitor cell CL0000038

CSI 0.7

rCSI 4.0%

PRS 10.2%
basophil mast progenitor cell CL0002028

CSI 0.7

rCSI 3.7%

PRS 23.4%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.7

rCSI 3.2%

PRS 24.2%
perivascular cell CL4033054

CSI 0.7

rCSI 1.0%

PRS 7.4%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.7

rCSI 0.9%

PRS 11.3%
fibroblast of breast CL4006000

CSI 0.7

rCSI 3.1%

PRS 17.8%
tracheobronchial serous cell CL0019001

CSI 0.8

rCSI 3.2%

PRS 12.6%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 1.9%

PRS 3.7%
intraepithelial lymphocyte CL0002496

CSI 0.8

rCSI 2.1%

PRS 30.0%
renal beta-intercalated cell CL0002201

CSI 0.8

rCSI 1.9%

PRS 8.1%
respiratory hillock cell CL4030023

CSI 0.8

rCSI 1.4%

PRS 11.2%
retina horizontal cell CL0000745

CSI 0.9

rCSI 1.3%

PRS 6.0%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 0.9

rCSI 1.2%

PRS 13.8%
myoepithelial cell CL0000185

CSI 0.9

rCSI 2.2%

PRS 8.1%
myeloid dendritic cell, human CL0001057

CSI 0.9

rCSI 5.1%

PRS 21.1%
neural progenitor cell CL0011020

CSI 0.9

rCSI 4.0%

PRS 6.5%
P/D1 enteroendocrine cell CL0002268

CSI 0.9

rCSI 5.0%

PRS 16.4%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.9

rCSI 2.4%

PRS 6.1%
transit amplifying cell CL0009010

CSI 0.9

rCSI 1.4%

PRS 10.6%
mammary gland epithelial cell CL0002327

CSI 0.9

rCSI 3.3%

PRS 11.8%
basal cell of prostate epithelium CL0002341

CSI 0.9

rCSI 2.7%

PRS 14.6%
germinal center B cell CL0000844

CSI 1.0

rCSI 2.9%

PRS 17.1%
mononuclear phagocyte CL0000113

CSI 1.0

rCSI 2.1%

PRS 7.1%
keratocyte CL0002363

CSI 1.0

rCSI 2.4%

PRS 10.0%
paneth cell of epithelium of small intestine CL1000343

CSI 1.0

rCSI 2.8%

PRS 10.1%
T-helper 1 cell CL0000545

CSI 1.0

rCSI 1.8%

PRS 19.1%
retinal rod cell CL0000604

CSI 1.1

rCSI 1.8%

PRS 6.7%
luminal epithelial cell of mammary gland CL0002326

CSI 1.1

rCSI 1.9%

PRS 9.9%
dendritic cell, human CL0001056

CSI 1.1

rCSI 1.6%

PRS 7.5%
erythroblast CL0000765

CSI 1.1

rCSI 2.9%

PRS 11.0%
cerebellar granule cell CL0001031

CSI 1.1

rCSI 1.6%

PRS 6.4%
mature alpha-beta T cell CL0000791

CSI 1.1

rCSI 4.1%

PRS 11.2%
Hofbauer cell CL3000001

CSI 1.1

rCSI 2.1%

PRS 8.1%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 1.1

rCSI 2.6%

PRS 6.7%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 1.1

rCSI 1.8%

PRS 16.5%
respiratory suprabasal cell CL4033048

CSI 1.2

rCSI 1.5%

PRS 7.5%
cerebral cortex endothelial cell CL1001602

CSI 1.2

rCSI 2.0%

PRS 4.9%
luminal cell of prostate epithelium CL0002340

CSI 1.2

rCSI 6.3%

PRS 11.8%
pluripotent stem cell CL0002248

CSI 1.2

rCSI 36.0%

PRS 15.7%
tuft cell of colon CL0009041

CSI 1.2

rCSI 2.9%

PRS 15.0%
corneal epithelial cell CL0000575

CSI 1.2

rCSI 3.5%

PRS 12.3%
BEST4+ enteroycte CL4030026

CSI 1.3

rCSI 1.6%

PRS 6.9%
ON-bipolar cell CL0000749

CSI 1.3

rCSI 1.9%

PRS 8.2%
lung macrophage CL1001603

CSI 1.3

rCSI 2.9%

PRS 7.3%
tracheobronchial smooth muscle cell CL0019019

CSI 1.3

rCSI 2.3%

PRS 8.6%
smooth muscle cell CL0000192

CSI 1.3

rCSI 3.2%

PRS 22.0%
muscle cell CL0000187

CSI 1.3

rCSI 2.7%

PRS 15.6%
alveolar adventitial fibroblast CL4028006

CSI 1.4

rCSI 2.1%

PRS 6.5%
glial cell CL0000125

CSI 1.4

rCSI 5.2%

PRS 6.9%
hematopoietic precursor cell CL0008001

CSI 1.4

rCSI 1.4%

PRS 10.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SYF2](/details-gene/25949), also known as SYF2 pre-mRNA splicing factor, is a protein-coding gene located on chromosome 1p36.11. As an integral component of the spliceosome, particularly the Prp19 and the catalytic step 2 complexes, its primary function is centered on pre-mRNA splicing, a fundamental process for eukaryotic gene expression ([Link](https://doi.org/10.1016/j.cell.2017.04.033)). Expression data reveals that [SYF2](/details-gene/25949) is a significant gene in highly proliferative and metabolically active cells, including [hematopoietic stem cell](/details-cell/CL0000037)s, various epithelial cell types such as [fallopian tube secretory epithelial cell](/details-cell/CL4030006)s, and progenitor cells of the immune system. This expression pattern underscores its essential role in development, cell division, and the maintenance of tissues with high turnover rates. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [SYF2](/details-gene/25949) highlights its importance in cells requiring robust and continuous gene expression regulation through RNA processing. The gene shows the highest significance in progenitor and stem cell populations, most notably in [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 53.57), [fraction A pre-pro B cell](/details-cell/CL0002045) (CSI: 33.55), and [common dendritic progenitor](/details-cell/CL0001029) (CSI: 28.58). This is consistent with its annotated roles in embryonic development and the positive regulation of cell proliferation, suggesting that hematopoietic and immune system development are highly dependent on its splicing activity. Beyond progenitor cells, [SYF2](/details-gene/25949) is also highly significant in specialized, active epithelial tissues. These include [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 43.31), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 35.49), and [keratinocyte](/details-cell/CL0000312) (CSI: 30.27). Such high expression suggests a crucial "workhorse" function in maintaining the complex transcriptional programs necessary for the function and turnover of these barrier and secretory tissues. Conversely, [SYF2](/details-gene/25949) shows low or negative significance in more terminally differentiated or specialized cell types. Its lowest significance score is observed in [lung neuroendocrine cell](/details-cell/CL1000223) (CSI: -24.17), with low scores also noted in certain mature lymphocyte populations like [alpha-beta T cell](/details-cell/CL0000789) (CSI: -4.40) and neural cells like [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: -2.56). This pattern suggests that while splicing is a ubiquitous process, the demand for [SYF2](/details-gene/25949)-mediated activity may be lower in quiescent or terminally differentiated cells compared to those undergoing rapid division or differentiation. ## Pathways and Molecular Function The molecular function of [SYF2](/details-gene/25949) is well-defined as a core component of the RNA processing machinery. It is an essential constituent of the [Prp19 complex](/details-go/GO:0000974), which is critical for the activation of the spliceosome. Functional annotations confirm its direct involvement in [mRNA splicing, via spliceosome](/details-go/GO:0000398) and its localization to the [catalytic step 2 spliceosome](/details-go/GO:0071013), where the final ligation of exons occurs ([Link](https://doi.org/10.1038/nature21079)). Reactome pathway analysis further places it within the major pathways of [Metabolism of rna](/details-reactome/R-HSA-8953854) and [Processing of capped intron-containing pre-mrna](/details-reactome/R-HSA-72203). Beyond its canonical role in splicing, GO annotations link [SYF2](/details-gene/25949) to broader biological processes that are downstream of correct gene expression. Its involvement in [embryonic organ development](/details-go/GO:0048568), [gastrulation](/details-go/GO:0007369), and [positive regulation of cell population proliferation](/details-go/GO:0008284) is consistent with its high expression in stem cells and progenitors. Furthermore, its association with [mitotic g2 dna damage checkpoint signaling](/details-go/GO:0007095) suggests a potential role in coupling the splicing of key regulatory transcripts to cell cycle control and genome integrity, particularly in rapidly dividing cells. ## Research Directions The widespread yet differential expression of [SYF2](/details-gene/25949) suggests that its function, while fundamentally related to splicing, may have cell-type-specific consequences that are critical for normal physiology and potentially implicated in disease. **Proposed Hypotheses:** 1. Given its high significance in hematopoietic progenitors and its role in cell proliferation, haploinsufficiency or mutation of [SYF2](/details-gene/25949) may lead to bone marrow failure syndromes. We hypothesize that reduced [SYF2](/details-gene/25949) activity in [hematopoietic stem cell](/details-cell/CL0000037)s causes widespread alternative splicing defects in transcripts essential for lineage commitment and differentiation, leading to impaired hematopoiesis. 2. The annotation linking [SYF2](/details-gene/25949) to the G2/M DNA damage checkpoint suggests it could be a nodal point in coordinating RNA processing with cell cycle progression. We hypothesize that in response to genotoxic stress, [SYF2](/details-gene/25949) is post-translationally modified to alter its splicing activity, prioritizing the maturation of transcripts for DNA repair and checkpoint proteins over those for proliferation in cells like [keratinocyte](/details-cell/CL0000312)s. **Key Experimental Approach:** To test the first hypothesis regarding its role in hematopoiesis, one could utilize a conditional knockout mouse model or an shRNA-mediated knockdown of [SYF2](/details-gene/25949) in primary human CD34+ hematopoietic stem and progenitor cells (HSPCs). Following knockdown, these cells would be subjected to *in vitro* differentiation assays, such as colony-forming unit (CFU) assays, to assess their capacity to form myeloid, erythroid, and lymphoid colonies. Concurrently, RNA-sequencing of the knockdown HSPCs would be performed to identify global changes in splicing patterns and pinpoint specific transcripts and pathways (e.g., cell cycle, lineage-specific transcription factors) that are dysregulated, thereby linking the molecular defect to the functional impairment in differentiation. **Therapeutic Potential:** As a core component of the essential spliceosome machinery, [SYF2](/details-gene/25949) is likely indispensable for the viability of most cells, making it a challenging direct therapeutic target due to the high risk of on-target toxicity. However, many cancers exhibit a phenomenon known as "splicing addiction," where they are hypersensitive to the inhibition of the splicing machinery due to high transcriptional demand and reliance on specific oncogenic splicing isoforms. Therefore, partial inhibition of [SYF2](/details-gene/25949) or targeting its specific interactions within the spliceosome could represent a viable strategy. It would be a candidate for inhibition via small molecules, potentially offering a therapeutic window in cancers that are highly proliferative and demonstrate pre-existing splicing factor mutations, rather than a target for activation.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Pre-mRNA-splicing factor SYF2

Genular Protein ID: 424328139

Symbol: SYF2_HUMAN

Name: Pre-mRNA-splicing factor SYF2

UniProtKB Accession Codes:

O95926 Q5TH73

Database IDs:

Citations:

PubMed ID: 11118353

Title: p29, a novel GCIP-interacting protein, localizes in the nucleus.

PubMed ID: 11118353

DOI: 10.1006/bbrc.2000.3992

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

Sequence Information:

Length: 243
Mass: 28722
Checksum: 6F910C13BC09A7F7
Sequence:

MAAIAASEVL VDSAEEGSLA AAAELAAQKR EQRLRKFREL HLMRNEARKL NHQEVVEEDK 
RLKLPANWEA KKARLEWELK EEEKKKECAA RGEDYEKVKL LEISAEDAER WERKKKRKNP 
DLGFSDYAAA QLRQYHRLTK QIKPDMETYE RLREKHGEEF FPTSNSLLHG THVPSTEEID 
RMVIDLEKQI EKRDKYSRRR PYNDDADIDY INERNAKFNK KAERFYGKYT AEIKQNLERG 
TAV

Details for: SYF2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

p29, a novel GCIP-interacting protein, localizes in the nucleus. PubMed ID: 11118353

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. PubMed ID: 11991638

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

An Atomic Structure of the Human Spliceosome. PubMed ID: 28502770

Cryo-EM structure of a human spliceosome activated for step 2 of splicing. PubMed ID: 28076346