Details for: DDX18
Gene ID: 8886
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DDX18
Ensembl ID: ENSG00000088205
Description: DEAD-box helicase 18
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 42.26rCSI 38.16%PRS 14.73
-
CSI 26.45rCSI 21.39%PRS 16.42
-
CSI 23.34rCSI 31.91%PRS 26.16
-
CSI 19.58rCSI 18.85%PRS 17
-
CSI 19.19rCSI 55.56%PRS 18.64
-
CSI 18.81rCSI 23.61%PRS 21.19
-
CSI 17.97rCSI 17.33%PRS 11.71
-
CSI 17.92rCSI 11.91%PRS 19.78
-
CSI 17.24rCSI 40.98%PRS 24.63
-
CSI 12.63rCSI 40.52%PRS 23.77
-
CSI 11.62rCSI 31.92%PRS 27.07
-
CSI 11.42rCSI 58.95%PRS 32.07
-
CSI 11.07rCSI 9.58%PRS 18.49
-
CSI 10.43rCSI 13.87%PRS 17.97
-
CSI 10.27rCSI 12.07%PRS 19.21
-
CSI 9.68rCSI 10.89%PRS 26.39
-
CSI 9.07rCSI 52.75%PRS 24.59
-
CSI 8.99rCSI 29.43%PRS 43.82
-
CSI 7.5rCSI 36.99%PRS 22.29
-
CSI 6.5rCSI 9.95%PRS 26.7
-
CSI 6.08rCSI 11.04%PRS 13.56
-
CSI 6.03rCSI 21.42%PRS 49.62
-
CSI 5.85rCSI 7.24%PRS 14.37
-
CSI 5.41rCSI 7.52%PRS 16.86
-
CSI 5.28rCSI 4.64%PRS 11.92
-
CSI 5.16rCSI 27.85%PRS 29.78
-
CSI 5.15rCSI 38.7%PRS 29.83
-
CSI 5.08rCSI 7.75%PRS 15.25
-
CSI 4.94rCSI 14.09%PRS 28.27
-
CSI 4.86rCSI 21.31%PRS 30.48
-
CSI 4.8rCSI 7.42%PRS 15.36
-
CSI 4.66rCSI 5.38%PRS 14.38
-
CSI 4.64rCSI 7.39%PRS 13.99
-
CSI 4.32rCSI 7.79%PRS 41.66
-
CSI 4.3rCSI 24.63%PRS 25.11
-
CSI 4.24rCSI 12.59%PRS 23.36
-
CSI 4.24rCSI 12.27%PRS 35.69
-
CSI 4.2rCSI 12.39%PRS 19.81
-
CSI 4.14rCSI 3.27%PRS 11.29
-
CSI 4.11rCSI 3.23%PRS 19.79
-
CSI 4rCSI 7.06%PRS 9.64
-
CSI 3.75rCSI 5.76%PRS 22.82
-
CSI 3.65rCSI 4.54%PRS 17.4
-
CSI 3.62rCSI 5.13%PRS 15.29
-
CSI 3.45rCSI 6.54%PRS 43.85
-
CSI 3.26rCSI 7.61%PRS 38.19
-
CSI 3.17rCSI 6.1%PRS 36.79
-
CSI 3.15rCSI 57.62%PRS 47.05
-
CSI 3.13rCSI 8.43%PRS 21.25
-
CSI 3.04rCSI 3.87%PRS 19.09
-
CSI 2.9rCSI 19.01%PRS 41.72
-
CSI 2.82rCSI 4.48%PRS 21.2
-
CSI 2.74rCSI 5.32%PRS 16.82
-
CSI 2.64rCSI 4.51%PRS 33.13
-
CSI 2.64rCSI 79.07%PRS 36.63
-
CSI 2.32rCSI 1.72%PRS 24.34
-
CSI 2.25rCSI 1.73%PRS 15.11
-
CSI 2.19rCSI 1.74%PRS 29.18
-
CSI 2.08rCSI 5.67%PRS 58.94
-
CSI 2.06rCSI 1.73%PRS 19.65
-
CSI 2.04rCSI 1.42%PRS 19.5
-
CSI 2.01rCSI 4.18%PRS 16.43
-
CSI 1.99rCSI 2.17%PRS 18.68
-
CSI 1.98rCSI 2.49%PRS 62.34
-
CSI 1.93rCSI 2.84%PRS 15.05
-
CSI 1.92rCSI 1.62%PRS 26.24
-
CSI 1.86rCSI 11.96%PRS 37.21
-
CSI 1.86rCSI 2.57%PRS 23.41
-
CSI 1.83rCSI 1.36%PRS 14.47
-
CSI 1.78rCSI 1.86%PRS 46.82
-
CSI 1.78rCSI 1.38%PRS 15.71
-
CSI 1.77rCSI 1.24%PRS 40.13
-
CSI 1.72rCSI 2.06%PRS 28.53
-
CSI 1.71rCSI 2.61%PRS 28.89
-
CSI 1.71rCSI 39.72%PRS 80.57
-
CSI 1.68rCSI 1.35%PRS 29.51
-
CSI 1.65rCSI 18.05%PRS 29.44
-
CSI 1.64rCSI 2.15%PRS 61.51
-
CSI 1.64rCSI 4.61%PRS 22.58
-
CSI 1.63rCSI 21.55%PRS 50
-
CSI 1.62rCSI 1.13%PRS 17.42
-
CSI 1.61rCSI 2.27%PRS 22.8
-
CSI 1.56rCSI 9.45%PRS 36.47
-
CSI 1.54rCSI 3.06%PRS 46
-
CSI 1.53rCSI 4.9%PRS 12.46
-
CSI 1.53rCSI 1.15%PRS 26.45
-
CSI 1.5rCSI 3.47%PRS 13.24
-
CSI 1.5rCSI 1.33%PRS 16.47
-
CSI 1.5rCSI 2.62%PRS 12.28
-
CSI 1.48rCSI 1.28%PRS 26.16
-
CSI 1.46rCSI 1.48%PRS 23.55
-
CSI 1.43rCSI 1.46%PRS 30.5
-
CSI 1.43rCSI 2.22%PRS 24.82
-
CSI 1.42rCSI 0.99%PRS 23.3
-
CSI 1.41rCSI 2.23%PRS 16.49
-
CSI 1.41rCSI 1.15%PRS 17.38
-
CSI 1.36rCSI 1.86%PRS 14.59
-
CSI 1.35rCSI 2.78%PRS 16.38
-
CSI 1.34rCSI 3.55%PRS 19.66
-
CSI 1.33rCSI 5%PRS 13.93
-
CSI -3.5rCSI -8.5%PRS 19.2%
-
CSI -2.5rCSI -5.6%PRS 18.4%
-
CSI -1.4rCSI -9.0%PRS 12.9%
-
CSI -1.3rCSI -7.5%PRS 10.1%
-
CSI -1.2rCSI -6.6%PRS 29.3%
-
CSI -1.1rCSI -1.9%PRS 32.8%
-
CSI -1.1rCSI -4.6%PRS 28.9%
-
CSI -1.0rCSI -3.0%PRS 11.1%
-
CSI -0.8rCSI -2.3%PRS 15.3%
-
CSI -0.6rCSI -2.0%PRS 26.8%
-
CSI -0.5rCSI -1.3%PRS 15.3%
-
CSI -0.4rCSI -1.1%PRS 12.5%
-
CSI -0.2rCSI -1.6%PRS 6.9%
-
CSI 0.0rCSI 0.0%PRS 9.5%
-
CSI 0.0rCSI 0.1%PRS 24.0%
-
CSI 0.0rCSI 0.1%PRS 9.1%
-
CSI 0.1rCSI 0.9%PRS 77.6%
-
CSI 0.1rCSI 0.2%PRS 10.3%
-
CSI 0.1rCSI 0.4%PRS 52.7%
-
CSI 0.1rCSI 0.2%PRS 28.9%
-
CSI 0.1rCSI 0.2%PRS 69.8%
-
CSI 0.1rCSI 0.6%PRS 9.1%
-
CSI 0.1rCSI 0.4%PRS 22.6%
-
CSI 0.1rCSI 0.2%PRS 20.6%
-
CSI 0.1rCSI 0.2%PRS 9.7%
-
CSI 0.1rCSI 2.2%PRS 13.7%
-
CSI 0.1rCSI 0.8%PRS 47.1%
-
CSI 0.1rCSI 2.4%PRS 12.7%
-
CSI 0.1rCSI 0.4%PRS 14.2%
-
CSI 0.1rCSI 0.6%PRS 21.7%
-
CSI 0.1rCSI 2.9%PRS 61.6%
-
CSI 0.1rCSI 1.0%PRS 16.8%
-
CSI 0.1rCSI 3.5%PRS 63.3%
-
CSI 0.1rCSI 2.8%PRS 48.0%
-
CSI 0.2rCSI 0.4%PRS 45.5%
-
CSI 0.2rCSI 1.5%PRS 44.8%
-
CSI 0.2rCSI 0.7%PRS 34.1%
-
CSI 0.2rCSI 0.3%PRS 15.3%
-
CSI 0.2rCSI 0.7%PRS 16.2%
-
CSI 0.2rCSI 0.2%PRS 33.6%
-
CSI 0.2rCSI 0.4%PRS 24.5%
-
CSI 0.2rCSI 0.4%PRS 26.2%
-
CSI 0.2rCSI 0.6%PRS 57.6%
-
CSI 0.2rCSI 0.3%PRS 21.7%
-
CSI 0.2rCSI 2.1%PRS 31.3%
-
CSI 0.2rCSI 1.9%PRS 44.0%
-
CSI 0.2rCSI 0.3%PRS 10.5%
-
CSI 0.2rCSI 1.6%PRS 59.0%
-
CSI 0.2rCSI 0.9%PRS 15.8%
-
CSI 0.2rCSI 0.9%PRS 41.8%
-
CSI 0.2rCSI 0.3%PRS 18.9%
-
CSI 0.2rCSI 0.5%PRS 32.4%
-
CSI 0.2rCSI 0.5%PRS 11.8%
-
CSI 0.2rCSI 5.2%PRS 7.9%
-
CSI 0.2rCSI 0.8%PRS 9.9%
-
CSI 0.2rCSI 1.7%PRS 34.0%
-
CSI 0.2rCSI 0.6%PRS 13.6%
-
CSI 0.2rCSI 1.5%PRS 49.6%
-
CSI 0.2rCSI 0.8%PRS 54.9%
-
CSI 0.2rCSI 2.7%PRS 50.0%
-
CSI 0.2rCSI 0.6%PRS 17.0%
-
CSI 0.2rCSI 5.8%PRS 51.2%
-
CSI 0.3rCSI 6.1%PRS 8.9%
-
CSI 0.3rCSI 0.4%PRS 21.0%
-
CSI 0.3rCSI 2.6%PRS 52.1%
-
CSI 0.3rCSI 0.4%PRS 19.5%
-
CSI 0.3rCSI 0.9%PRS 11.4%
-
CSI 0.3rCSI 1.0%PRS 28.2%
-
CSI 0.3rCSI 1.6%PRS 21.3%
-
CSI 0.3rCSI 1.9%PRS 31.9%
-
CSI 0.3rCSI 0.6%PRS 25.1%
-
CSI 0.3rCSI 0.8%PRS 31.1%
-
CSI 0.3rCSI 1.2%PRS 44.0%
-
CSI 0.3rCSI 3.2%PRS 57.4%
-
CSI 0.3rCSI 1.2%PRS 30.7%
-
CSI 0.3rCSI 0.5%PRS 18.0%
-
CSI 0.3rCSI 3.7%PRS 52.3%
-
CSI 0.3rCSI 1.0%PRS 26.8%
-
CSI 0.3rCSI 1.1%PRS 54.4%
-
CSI 0.3rCSI 0.8%PRS 26.7%
-
CSI 0.3rCSI 0.4%PRS 9.5%
-
CSI 0.3rCSI 0.9%PRS 25.5%
-
CSI 0.3rCSI 0.4%PRS 15.1%
-
CSI 0.3rCSI 0.4%PRS 19.3%
-
CSI 0.3rCSI 0.5%PRS 18.9%
-
CSI 0.3rCSI 1.1%PRS 17.3%
-
CSI 0.3rCSI 0.4%PRS 16.1%
-
CSI 0.3rCSI 0.4%PRS 28.6%
-
CSI 0.4rCSI 0.5%PRS 25.8%
-
CSI 0.4rCSI 0.4%PRS 21.1%
-
CSI 0.4rCSI 1.5%PRS 35.1%
-
CSI 0.4rCSI 1.1%PRS 39.2%
-
CSI 0.4rCSI 2.0%PRS 69.8%
-
CSI 0.4rCSI 0.7%PRS 19.4%
-
CSI 0.4rCSI 2.5%PRS 41.2%
-
CSI 0.4rCSI 1.9%PRS 65.2%
-
CSI 0.4rCSI 1.7%PRS 14.7%
-
CSI 0.4rCSI 2.5%PRS 56.6%
-
CSI 0.4rCSI 0.5%PRS 26.7%
-
CSI 0.4rCSI 0.6%PRS 19.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1322901924
Symbol: DDX18_HUMAN
Name: ATP-dependent RNA helicase DDX18
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8861962
Title: Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.
PubMed ID: 8861962
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 16963496
Title: NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47.
PubMed ID: 16963496
DOI: 10.1093/nar/gkl603
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20813266
Title: The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.
PubMed ID: 20813266
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 20941364
Title: Comparative structural analysis of human DEAD-box RNA helicases.
PubMed ID: 20941364
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 670
- Mass: 75407
- Checksum: 2FE653A98751F9DC
- Sequence:
MSHLPMKLLR KKIEKRNLKL RQRNLKFQGA SNLTLSETQN GDVSEETMGS RKVKKSKQKP MNVGLSETQN GGMSQEAVGN IKVTKSPQKS TVLTNGEAAM QSSNSESKKK KKKKRKMVND AEPDTKKAKT ENKGKSEEES AETTKETENN VEKPDNDEDE SEVPSLPLGL TGAFEDTSFA SLCNLVNENT LKAIKEMGFT NMTEIQHKSI RPLLEGRDLL AAAKTGSGKT LAFLIPAVEL IVKLRFMPRN GTGVLILSPT RELAMQTFGV LKELMTHHVH TYGLIMGGSN RSAEAQKLGN GINIIVATPG RLLDHMQNTP GFMYKNLQCL VIDEADRILD VGFEEELKQI IKLLPTRRQT MLFSATQTRK VEDLARISLK KEPLYVGVDD DKANATVDGL EQGYVVCPSE KRFLLLFTFL KKNRKKKLMV FFSSCMSVKY HYELLNYIDL PVLAIHGKQK QNKRTTTFFQ FCNADSGTLL CTDVAARGLD IPEVDWIVQY DPPDDPKEYI HRVGRTARGL NGRGHALLIL RPEELGFLRY LKQSKVPLSE FDFSWSKISD IQSQLEKLIE KNYFLHKSAQ EAYKSYIRAY DSHSLKQIFN VNNLNLPQVA LSFGFKVPPF VDLNVNSNEG KQKKRGGGGG FGYQKTKKVE KSKIFKHISK KSSDSRQFSH
Genular Protein ID: 1741572088
Symbol: Q8N254_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 408
- Mass: 46644
- Checksum: E2F1462F82062152
- Sequence:
MEQESFGVLK ELMTHHVHTY GLIMGGSNRS AEAQKLGNGI NIIVATPGRL LDHMQNTPGF MYKNLQCLVI DEADRILDVG FEEELKQIIK LLPTRRQTML FSATQTRKVE DLARISLKKE PLYVGVDDDK ANATVDGLEQ GYVVCPSEKR FLLLFTFLKK NRKKKLMVFF SSCMSVKYHY ELLNYIDLPV LAIHGKQKQN KRTTTFFQFC NADSGTLLCT DVAARGLDIP EVDWIVQYDP PDDPKEYIHR VGRTARGLNG RGHALLILRP EELGFLRYLK QSKVPLSEFD FSWSKISYIQ SQLEKLIEKN YFLHKSAQEA YKSYIRAYDS HSLKQIFNVN NLNLPQVALS FGFKVPPFVD LNVNSNEGKQ KKRGGGGGFG YQKTKKVEKS KIFKHISKKS SDSRQFSH