SOCS3 | ENSG00000184557 | NCBI 9021

Details for: SOCS3

Gene ID: 9021

Symbol: SOCS3

Ensembl ID: ENSG00000184557

Description: suppressor of cytokine signaling 3

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Growth hormone receptor signaling
(R-HSA-982772)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-20 family signaling
(R-HSA-8854691)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Ptk6 activates stat3
(R-HSA-8849474)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Regulation of ifng signaling
(R-HSA-877312)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by interleukins
(R-HSA-449147)
Signaling by leptin
(R-HSA-2586552)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx1
(R-HSA-8878171)
1-phosphatidylinositol-3-kinase regulator activity
(GO:0046935)
Branching involved in labyrinthine layer morphogenesis
(GO:0060670)
Cellular response to interleukin-17
(GO:0097398)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Mirna binding
(GO:0035198)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of tyrosine phosphorylation of stat protein
(GO:0042532)
Phosphatidylinositol 3-kinase complex
(GO:0005942)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phosphotyrosine residue binding
(GO:0001784)
Placenta blood vessel development
(GO:0060674)
Positive regulation of cell differentiation
(GO:0045597)
Protein binding
(GO:0005515)
Protein kinase inhibitor activity
(GO:0004860)
Protein tyrosine kinase inhibitor activity
(GO:0030292)
Protein ubiquitination
(GO:0016567)
T-helper 17 cell lineage commitment
(GO:0072540)

Other Information

Proteins

Cytokine-inducible SH2 protein 3

Genular Protein ID: 569629017

Symbol: SOCS3_HUMAN

Name: Cytokine-inducible SH2 protein 3

UniProtKB Accession Codes:

O14543 O14509

Database IDs:

Citations:

PubMed ID: 9266833

Title: Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

PubMed ID: 9266833

DOI: 10.1006/bbrc.1997.7080

PubMed ID: 9344848

Title: Cloning and characterization of novel CIS family genes.

PubMed ID: 9344848

DOI: 10.1006/bbrc.1997.7484

PubMed ID: 11071852

Title: Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.

PubMed ID: 11071852

DOI: 10.1006/bbrc.2000.3762

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10421843

Title: Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.

PubMed ID: 10421843

DOI: 10.1046/j.1365-2443.1999.00263.x

PubMed ID: 12027890

Title: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.

PubMed ID: 12027890

DOI: 10.1046/j.1432-1033.2002.02916.x

PubMed ID: 14559241

Title: SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.

PubMed ID: 14559241

DOI: 10.1016/j.bbrc.2003.09.140

PubMed ID: 15070676

Title: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.

PubMed ID: 15070676

DOI: 10.1182/blood-2003-08-2768

PubMed ID: 15601820

Title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

PubMed ID: 15601820

DOI: 10.1101/gad.1252404

PubMed ID: 16685656

Title: Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.

PubMed ID: 16685656

DOI: 10.1086/504272

PubMed ID: 16410555

Title: Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling.

PubMed ID: 16410555

DOI: 10.1242/jcs.02740

PubMed ID: 23019338

Title: Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.

PubMed ID: 23019338

DOI: 10.1074/jbc.m112.410027

Sequence Information:

Length: 225
Mass: 24770
Checksum: 08581DC411EFFF19
Sequence:

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 
LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR 
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SOCS3

Associated with

Other Information

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. PubMed ID: 9266833

Cloning and characterization of novel CIS family genes. PubMed ID: 9344848

Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. PubMed ID: 11071852

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. PubMed ID: 10421843

A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. PubMed ID: 12027890

SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. PubMed ID: 14559241

Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. PubMed ID: 15070676

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. PubMed ID: 15601820

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis. PubMed ID: 16685656

Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. PubMed ID: 16410555

Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components. PubMed ID: 23019338