SOCS3 | ENSG00000184557 | NCBI 9021

Details for: SOCS3

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Growth hormone receptor signaling
(R-HSA-982772)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-20 family signaling
(R-HSA-8854691)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Ptk6 activates stat3
(R-HSA-8849474)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Regulation of ifng signaling
(R-HSA-877312)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by interleukins
(R-HSA-449147)
Signaling by leptin
(R-HSA-2586552)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx1
(R-HSA-8878171)
Branching involved in labyrinthine layer morphogenesis
(GO:0060670)
Cellular response to interleukin-17
(GO:0097398)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine receptor binding
(GO:0005126)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Mirna binding
(GO:0035198)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Phosphotyrosine residue binding
(GO:0001784)
Placenta blood vessel development
(GO:0060674)
Positive regulation of cell differentiation
(GO:0045597)
Protein binding
(GO:0005515)
Protein kinase inhibitor activity
(GO:0004860)
Protein tyrosine kinase inhibitor activity
(GO:0030292)
Protein ubiquitination
(GO:0016567)
T-helper 17 cell lineage commitment
(GO:0072540)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pulmonary artery endothelial cell CL1001568

CSI 55.65

rCSI 75.72%

PRS 34.38
skin fibroblast CL0002620

CSI 36.61

rCSI 31.56%

PRS 34.73
alveolar type 1 fibroblast cell CL4028004

CSI 35.68

rCSI 39.08%

PRS 25.72
retinal blood vessel endothelial cell CL0002585

CSI 33.23

rCSI 53.06%

PRS 25.13
alveolar adventitial fibroblast CL4028006

CSI 29.04

rCSI 45.86%

PRS 23
epithelial cell of lower respiratory tract CL0002632

CSI 28.41

rCSI 22.02%

PRS 22.12
tendon cell CL0000388

CSI 22.76

rCSI 59.15%

PRS 54.09
group 3 innate lymphoid cell CL0001071

CSI 22.67

rCSI 17.04%

PRS 24.64
interstitial cell of Cajal CL0002088

CSI 22.65

rCSI 28.84%

PRS 26.47
perivascular cell CL4033054

CSI 21.58

rCSI 29.51%

PRS 25.9
endothelial cell of artery CL1000413

CSI 20.35

rCSI 29.81%

PRS 71.85
stromal cell of ovary CL0002132

CSI 19.85

rCSI 54.53%

PRS 37.18
adventitial cell CL0002503

CSI 19.35

rCSI 46.22%

PRS 34.11
vein endothelial cell CL0002543

CSI 18.01

rCSI 49.16%

PRS 66
fibroblast of lung CL0002553

CSI 18.01

rCSI 16.76%

PRS 22.98
alpha-beta T cell CL0000789

CSI 17.29

rCSI 20.26%

PRS 32.11
myofibroblast cell CL0000186

CSI 16.9

rCSI 23.41%

PRS 31.55
capillary endothelial cell CL0002144

CSI 16.82

rCSI 30.83%

PRS 61.09
elicited macrophage CL0000861

CSI 16.25

rCSI 14.92%

PRS 27.23
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 16.23

rCSI 9.59%

PRS 32.38
intestine goblet cell CL0019031

CSI 15.16

rCSI 13.46%

PRS 23.12
pulmonary capillary endothelial cell CL4028001

CSI 15.07

rCSI 28.74%

PRS 35.82
ciliated epithelial cell CL0000067

CSI 14.06

rCSI 12.37%

PRS 16.67
vein endothelial cell of respiratory system CL4033008

CSI 13.7

rCSI 94.05%

PRS 43.2
hematopoietic stem cell CL0000037

CSI 13.59

rCSI 9.03%

PRS 27.5
bronchus fibroblast of lung CL2000093

CSI 13.59

rCSI 11.04%

PRS 24.07
double negative thymocyte CL0002489

CSI 13.52

rCSI 9.4%

PRS 27.77
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 13.34

rCSI 18.9%

PRS 21.2
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 13.31

rCSI 13.08%

PRS 35.59
smooth muscle cell CL0000192

CSI 13.31

rCSI 31.74%

PRS 52.63
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 13.21

rCSI 9.28%

PRS 51.01
fallopian tube secretory epithelial cell CL4030006

CSI 13.18

rCSI 12.69%

PRS 23.73
respiratory basal cell CL0002633

CSI 12.53

rCSI 12.98%

PRS 27.1
blood vessel endothelial cell CL0000071

CSI 12.42

rCSI 25.77%

PRS 22.86
CD4-positive, alpha-beta memory T cell CL0000897

CSI 12.33

rCSI 8.85%

PRS 31.77
stromal cell CL0000499

CSI 12.12

rCSI 34.09%

PRS 29.57
mucous neck cell CL0000651

CSI 12.08

rCSI 17.41%

PRS 35.89
activated CD4-positive, alpha-beta T cell CL0000896

CSI 11.83

rCSI 10.93%

PRS 41.03
epithelial cell of lung CL0000082

CSI 11.81

rCSI 9.79%

PRS 21.79
respiratory suprabasal cell CL4033048

CSI 10.42

rCSI 13.37%

PRS 26.55
endothelial cell of placenta CL0009092

CSI 10.15

rCSI 50.04%

PRS 30.9
naive T cell CL0000898

CSI 10.09

rCSI 7.02%

PRS 32.48
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 10.05

rCSI 22.91%

PRS 23.51
keratocyte CL0002363

CSI 9.8

rCSI 23.56%

PRS 33.24
alveolar macrophage CL0000583

CSI 9.49

rCSI 15.64%

PRS 27.16
pulmonary alveolar type 2 cell CL0002063

CSI 9.44

rCSI 14.65%

PRS 33.75
T follicular helper cell CL0002038

CSI 9.42

rCSI 7.05%

PRS 36.04
endothelial cell of arteriole CL1000412

CSI 9.3

rCSI 51.57%

PRS 54.58
secretory cell CL0000151

CSI 9.1

rCSI 9.5%

PRS 23.51
endothelial cell of uterus CL0009095

CSI 9.01

rCSI 65.87%

PRS 56.26
endothelial cell of lymphatic vessel CL0002138

CSI 8.87

rCSI 17.57%

PRS 56.38
glandular epithelial cell CL0000150

CSI 8.73

rCSI 22.98%

PRS 43.93
IgA plasma cell CL0000987

CSI 8.72

rCSI 8.92%

PRS 41.07
effector CD4-positive, alpha-beta T cell CL0001044

CSI 8.63

rCSI 24.74%

PRS 34.64
enteroglial cell CL4040002

CSI 8.47

rCSI 44.53%

PRS 37.02
pancreatic D cell CL0000173

CSI 8.31

rCSI 8.18%

PRS 24.65
plasmacytoid dendritic cell, human CL0001058

CSI 7.92

rCSI 5.53%

PRS 24.56
pancreatic acinar cell CL0002064

CSI 7.76

rCSI 10.32%

PRS 25.11
chondrocyte CL0000138

CSI 7.55

rCSI 12.02%

PRS 19.34
myeloid leukocyte CL0000766

CSI 7.43

rCSI 6.86%

PRS 24.02
mononuclear phagocyte CL0000113

CSI 7.36

rCSI 16.21%

PRS 26.37
CD14-positive, CD16-positive monocyte CL0002397

CSI 7.27

rCSI 9.52%

PRS 32.83
CD1c-positive myeloid dendritic cell CL0002399

CSI 6.94

rCSI 8.39%

PRS 27.83
lung interstitial macrophage CL4033043

CSI 6.91

rCSI 15.51%

PRS 43.82
CD4-positive helper T cell CL0000492

CSI 6.81

rCSI 5.15%

PRS 31.59
Kupffer cell CL0000091

CSI 6.76

rCSI 15.45%

PRS 22.38
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 6.76

rCSI 8.49%

PRS 73.4
colon epithelial cell CL0011108

CSI 6.61

rCSI 6.92%

PRS 21.38
megakaryocyte-erythroid progenitor cell CL0000050

CSI 6.52

rCSI 5.88%

PRS 20.86
plasma cell CL0000786

CSI 6.45

rCSI 8.45%

PRS 70.77
vasa recta ascending limb cell CL1001131

CSI 6.33

rCSI 28.62%

PRS 62.24
hepatic stellate cell CL0000632

CSI 6.26

rCSI 23.46%

PRS 19.23
regulatory T cell CL0000815

CSI 6.13

rCSI 7.1%

PRS 56.76
respiratory hillock cell CL4030023

CSI 6.08

rCSI 10.85%

PRS 37.51
intermediate monocyte CL0002393

CSI 6.02

rCSI 9.09%

PRS 23.48
IgG plasma cell CL0000985

CSI 5.83

rCSI 6.98%

PRS 39.51
dendritic cell CL0000451

CSI 5.83

rCSI 7.18%

PRS 59.41
myoepithelial cell CL0000185

CSI 5.8

rCSI 14.67%

PRS 28.18
pancreatic A cell CL0000171

CSI 5.72

rCSI 5.99%

PRS 24.33
early lymphoid progenitor CL0000936

CSI 5.72

rCSI 5.02%

PRS 26.58
keratinocyte CL0000312

CSI 5.67

rCSI 4.75%

PRS 27.16
CD14-positive monocyte CL0001054

CSI 5.61

rCSI 6.99%

PRS 32.28
monocyte CL0000576

CSI 5.47

rCSI 9.89%

PRS 53.92
P/D1 enteroendocrine cell CL0002268

CSI 5.43

rCSI 29.56%

PRS 50.22
basal-myoepithelial cell of mammary gland CL0002324

CSI 5.37

rCSI 10.16%

PRS 46.96
Hofbauer cell CL3000001

CSI 5.19

rCSI 9.79%

PRS 29.14
renal principal cell CL0005009

CSI 5.15

rCSI 13.39%

PRS 29.07
pancreatic ductal cell CL0002079

CSI 5.13

rCSI 9.98%

PRS 23.55
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 5.01

rCSI 9.98%

PRS 38.18
CD4-positive, alpha-beta thymocyte CL0000810

CSI 4.98

rCSI 3.99%

PRS 40.7
natural T-regulatory cell CL0000903

CSI 4.96

rCSI 9.4%

PRS 58.2
enteric smooth muscle cell CL0002504

CSI 4.95

rCSI 7.07%

PRS 25.69
pericyte CL0000669

CSI 4.94

rCSI 13.16%

PRS 41.18
vascular associated smooth muscle cell CL0000359

CSI 4.87

rCSI 15.78%

PRS 27.37
mesodermal cell CL0000222

CSI 4.84

rCSI 5.81%

PRS 22.33
tissue-resident macrophage CL0000864

CSI 4.83

rCSI 22.61%

PRS 44.1
lung pericyte CL0009089

CSI 4.8

rCSI 12.66%

PRS 27.39
macrophage CL0000235

CSI 4.67

rCSI 8.5%

PRS 65.65
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.56

rCSI 3.47%

PRS 30.5
type EC enteroendocrine cell CL0000577

CSI 4.53

rCSI 16.1%

PRS 36.74

mature B cell CL0000785

CSI 0.2

rCSI 0.2%

PRS 29.0%
helper T cell CL0000912

CSI 0.2

rCSI 0.3%

PRS 32.1%
hair follicular keratinocyte CL2000092

CSI 0.3

rCSI 4.4%

PRS 69.4%
basal cell of epithelium of trachea CL1000348

CSI 0.4

rCSI 3.1%

PRS 57.6%
group 2 innate lymphoid cell CL0001069

CSI 0.5

rCSI 2.4%

PRS 66.4%
placental villous trophoblast CL2000060

CSI 0.5

rCSI 0.8%

PRS 21.4%
colon macrophage CL0009038

CSI 0.6

rCSI 2.8%

PRS 46.3%
collagen secreting cell CL0000667

CSI 0.6

rCSI 3.7%

PRS 61.1%
bronchial goblet cell CL1000312

CSI 0.7

rCSI 2.8%

PRS 46.5%
uterine smooth muscle cell CL0002601

CSI 0.8

rCSI 5.0%

PRS 74.0%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.8

rCSI 1.0%

PRS 28.0%
pancreatic PP cell CL0002275

CSI 0.8

rCSI 3.3%

PRS 38.5%
tracheal goblet cell CL1000329

CSI 0.9

rCSI 1.9%

PRS 43.3%
luminal cell of prostate epithelium CL0002340

CSI 0.9

rCSI 4.8%

PRS 39.4%
stratified epithelial cell CL0000079

CSI 1.0

rCSI 6.3%

PRS 64.4%
myeloid dendritic cell CL0000782

CSI 1.0

rCSI 1.5%

PRS 34.8%
paneth cell CL0000510

CSI 1.0

rCSI 1.5%

PRS 35.6%
extravillous trophoblast CL0008036

CSI 1.1

rCSI 1.3%

PRS 20.1%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.2

rCSI 3.7%

PRS 33.7%
acinar cell CL0000622

CSI 1.2

rCSI 1.8%

PRS 30.1%
follicular dendritic cell CL0000442

CSI 1.2

rCSI 19.3%

PRS 74.4%
common myeloid progenitor CL0000049

CSI 1.3

rCSI 1.0%

PRS 23.1%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.3

rCSI 14.1%

PRS 66.5%
myeloid dendritic cell, human CL0001057

CSI 1.3

rCSI 7.4%

PRS 62.6%
common dendritic progenitor CL0001029

CSI 1.3

rCSI 1.7%

PRS 29.8%
smooth muscle cell of prostate CL1000487

CSI 1.4

rCSI 8.3%

PRS 63.6%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.4

rCSI 3.4%

PRS 79.2%
transitional stage B cell CL0000818

CSI 1.5

rCSI 4.7%

PRS 56.8%
muscle cell CL0000187

CSI 1.5

rCSI 3.0%

PRS 47.1%
mature alpha-beta T cell CL0000791

CSI 1.5

rCSI 5.3%

PRS 39.3%
forebrain radial glial cell CL0013000

CSI 1.5

rCSI 4.7%

PRS 31.9%
multi-ciliated epithelial cell CL0005012

CSI 1.5

rCSI 1.5%

PRS 19.6%
deuterosomal cell CL4033044

CSI 1.5

rCSI 5.0%

PRS 35.8%
granulocyte monocyte progenitor cell CL0000557

CSI 1.6

rCSI 1.4%

PRS 25.9%
T-helper 17 cell CL0000899

CSI 1.6

rCSI 1.3%

PRS 40.8%
mammary gland epithelial cell CL0002327

CSI 1.6

rCSI 5.8%

PRS 39.2%
tracheobronchial serous cell CL0019001

CSI 1.7

rCSI 7.3%

PRS 41.0%
periportal region hepatocyte CL0019026

CSI 1.9

rCSI 7.2%

PRS 31.1%
BEST4+ enteroycte CL4030026

CSI 1.9

rCSI 2.3%

PRS 24.4%
mesenchymal cell CL0008019

CSI 2.0

rCSI 5.1%

PRS 22.9%
endothelial cell of vascular tree CL0002139

CSI 2.0

rCSI 11.0%

PRS 34.1%
podocyte CL0000653

CSI 2.1

rCSI 9.1%

PRS 22.3%
epicardial adipocyte CL1000309

CSI 2.1

rCSI 6.7%

PRS 27.6%
duct epithelial cell CL0000068

CSI 2.1

rCSI 3.1%

PRS 24.3%
squamous epithelial cell CL0000076

CSI 2.1

rCSI 5.0%

PRS 28.3%
pancreatic stellate cell CL0002410

CSI 2.2

rCSI 12.6%

PRS 33.6%
respiratory goblet cell CL0002370

CSI 2.2

rCSI 24.3%

PRS 42.9%
promonocyte CL0000559

CSI 2.3

rCSI 3.9%

PRS 31.1%
CD14-low, CD16-positive monocyte CL0002396

CSI 2.3

rCSI 1.8%

PRS 21.5%
skeletal muscle satellite stem cell CL0008011

CSI 2.3

rCSI 10.2%

PRS 53.7%
luminal epithelial cell of mammary gland CL0002326

CSI 2.4

rCSI 4.3%

PRS 34.9%
conjunctival epithelial cell CL1000432

CSI 2.4

rCSI 3.6%

PRS 23.1%
memory T cell CL0000813

CSI 2.4

rCSI 4.7%

PRS 50.7%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 2.5

rCSI 4.2%

PRS 43.5%
Langerhans cell CL0000453

CSI 2.5

rCSI 3.8%

PRS 39.8%
mesenchymal stem cell CL0000134

CSI 2.5

rCSI 27.6%

PRS 39.8%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.6

rCSI 1.8%

PRS 28.5%
megakaryocyte CL0000556

CSI 2.7

rCSI 11.6%

PRS 39.2%
mature T cell CL0002419

CSI 2.7

rCSI 2.1%

PRS 33.8%
transit amplifying cell CL0009010

CSI 2.7

rCSI 4.1%

PRS 36.7%
bronchiolar smooth muscle cell CL4033017

CSI 2.8

rCSI 42.3%

PRS 57.4%
intestinal crypt stem cell of small intestine CL0009017

CSI 2.9

rCSI 7.7%

PRS 29.7%
basal cell CL0000646

CSI 3.1

rCSI 4.1%

PRS 25.0%
prostate gland microvascular endothelial cell CL2000059

CSI 3.1

rCSI 74.8%

PRS 60.6%
ionocyte CL0005006

CSI 3.2

rCSI 3.4%

PRS 21.1%
paneth cell of epithelium of small intestine CL1000343

CSI 3.2

rCSI 9.0%

PRS 35.3%
foveolar cell of stomach CL0002179

CSI 3.2

rCSI 6.9%

PRS 36.1%
tracheobronchial smooth muscle cell CL0019019

CSI 3.3

rCSI 5.7%

PRS 29.6%
lung endothelial cell CL1001567

CSI 3.3

rCSI 7.6%

PRS 50.7%
inflammatory macrophage CL0000863

CSI 3.3

rCSI 5.6%

PRS 45.8%
microcirculation associated smooth muscle cell CL0008035

CSI 3.3

rCSI 9.5%

PRS 25.8%
vasa recta descending limb cell CL1001285

CSI 3.4

rCSI 26.8%

PRS 67.7%
adipocyte CL0000136

CSI 3.4

rCSI 4.4%

PRS 22.1%
kidney epithelial cell CL0002518

CSI 3.5

rCSI 6.6%

PRS 47.8%
lung secretory cell CL1000272

CSI 3.5

rCSI 8.7%

PRS 21.3%
cerebral cortex endothelial cell CL1001602

CSI 3.5

rCSI 6.1%

PRS 17.5%
neutrophil CL0000775

CSI 3.5

rCSI 19.8%

PRS 40.7%
smooth muscle cell of the pulmonary artery CL0002591

CSI 3.5

rCSI 27.2%

PRS 54.8%
double-positive, alpha-beta thymocyte CL0000809

CSI 3.7

rCSI 3.8%

PRS 32.8%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 3.8

rCSI 22.8%

PRS 49.0%
nasal mucosa goblet cell CL0002480

CSI 3.8

rCSI 4.4%

PRS 32.9%
T-helper 1 cell CL0000545

CSI 3.8

rCSI 6.9%

PRS 52.9%
lung macrophage CL1001603

CSI 4.0

rCSI 8.9%

PRS 27.0%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 4.0

rCSI 5.4%

PRS 51.4%
fibroblast of breast CL4006000

CSI 4.1

rCSI 17.0%

PRS 52.3%
lung ciliated cell CL1000271

CSI 4.1

rCSI 4.7%

PRS 16.9%
plasmablast CL0000980

CSI 4.1

rCSI 3.2%

PRS 27.9%
alternatively activated macrophage CL0000890

CSI 4.1

rCSI 5.2%

PRS 35.0%
blood vessel smooth muscle cell CL0019018

CSI 4.2

rCSI 33.9%

PRS 22.4%
dendritic cell, human CL0001056

CSI 4.2

rCSI 6.5%

PRS 27.6%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 4.3

rCSI 19.5%

PRS 50.1%
pulmonary ionocyte CL0017000

CSI 4.3

rCSI 5.2%

PRS 28.7%
basal cell of prostate epithelium CL0002341

CSI 4.3

rCSI 12.4%

PRS 46.3%
lung neuroendocrine cell CL1000223

CSI 4.3

rCSI 6.4%

PRS 26.2%
lung microvascular endothelial cell CL2000016

CSI 4.4

rCSI 84.1%

PRS 57.2%
fibroblast CL0000057

CSI 4.4

rCSI 12.6%

PRS 65.9%
granulocyte CL0000094

CSI 4.5

rCSI 6.8%

PRS 29.9%
type EC enteroendocrine cell CL0000577

CSI 4.5

rCSI 16.1%

PRS 36.7%
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.6

rCSI 3.5%

PRS 30.5%
macrophage CL0000235

CSI 4.7

rCSI 8.5%

PRS 65.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [SOCS3](/details-gene/9021) (Suppressor of Cytokine Signaling 3) is a protein-coding gene located on chromosome 17q25.3. It encodes a member of the suppressor of cytokine signaling family, which are critical negative regulators of cytokine signaling. Functioning as a STAT-induced STAT inhibitor (SSI), [SOCS3](/details-gene/9021) plays a fundamental role in the feedback inhibition of the JAK-STAT pathway, thereby controlling the duration and intensity of responses to a wide array of cytokines, hormones, and growth factors. **Overall**, expression data indicates that [SOCS3](/details-gene/9021) is a gene of high significance in various structural and endothelial cells, including [pulmonary artery endothelial cell](/details-cell/CL1001568), [skin fibroblast](/details-cell/CL0002620), and [alveolar type 1 fibroblast cell](/details-cell/CL4028004), suggesting a key role in regulating inflammatory responses and maintaining homeostasis within tissue microenvironments. ## Cellular Roles and Expression Landscape The expression profile of [SOCS3](/details-gene/9021) highlights its prominent role in non-hematopoietic cell types involved in tissue structure, vascular function, and barrier integrity. **Overall**, the gene shows its highest significance in endothelial cells, with [pulmonary artery endothelial cell](/details-cell/CL1001568) (CSI: 55.65) and [retinal blood vessel endothelial cell](/details-cell/CL0002585) (CSI: 33.23) among the top cell types. This is complemented by high significance in various fibroblast populations, such as [skin fibroblast](/details-cell/CL0002620) (CSI: 36.61), [alveolar type 1 fibroblast cell](/details-cell/CL4028004) (CSI: 35.68), and [alveolar adventitial fibroblast](/details-cell/CL4028006) (CSI: 29.04). This strong signature in endothelial and stromal compartments suggests that [SOCS3](/details-gene/9021) is a crucial regulator of local inflammation and tissue remodeling in response to systemic or local cytokine stimuli. While primarily associated with these structural cells, [SOCS3](/details-gene/9021) also shows relevance in specific immune populations like [group 3 innate lymphoid cell](/details-cell/CL0001071) (CSI: 22.67). This pattern suggests that its function extends beyond classical immune cells to orchestrating the cellular crosstalk that governs tissue responses to inflammation and injury. The elevated expression in cells like [epithelial cell of lower respiratory tract](/details-cell/CL0002632) further underscores its role in maintaining barrier function and dampening inflammatory signaling at mucosal surfaces. ## Pathways and Molecular Function [SOCS3](/details-gene/9021) is a well-established negative regulator of signal transduction, primarily through its inhibitory action on the JAK-STAT pathway. This is reflected in its annotation for the biological process of [negative regulation of receptor signaling pathway via jak-stat](/details-go/GO:0046426) and its molecular function as a [protein kinase inhibitor activity](/details-go/GO:0004860). It acts by binding to both JAK kinases and cytokine receptors, preventing the phosphorylation and subsequent activation of STAT transcription factors [Link](https://doi.org/10.1046/j.1365-2443.1999.00263.x). The functional annotations reveal its involvement in a broad spectrum of cytokine signaling pathways within the [immune system](/details-reactome/R-HSA-168256). Specifically, [SOCS3](/details-gene/9021) is implicated in the negative regulation of signaling cascades initiated by [Interferon gamma](/details-reactome/R-HSA-877300), [Interferon alpha/beta](/details-reactome/R-HSA-909733), [Interleukin-6](/details-reactome/R-HSA-1059683), and [Interleukin-4 and interleukin-13](/details-reactome/R-HSA-6785807). This positions [SOCS3](/details-gene/9021) as a central hub for controlling diverse immune and inflammatory outcomes. Furthermore, its role in [protein ubiquitination](/details-go/GO:0016567) and its link to pathways like [Antigen processing: ubiquitination & proteasome degradation](/details-reactome/R-HSA-983168) suggest it functions as part of an E3 ubiquitin ligase complex, targeting signaling components for degradation [Link](https://doi.org/10.1101/gad.1252404). This provides an additional mechanism for terminating cytokine signals. ## Research Directions The function of [SOCS3](/details-gene/9021) as a key feedback inhibitor of cytokine signaling, combined with its high significance in fibroblasts and endothelial cells, suggests a critical role in pathologies characterized by chronic inflammation or fibrosis. Research has already linked elevated expression and genetic association of the [SOCS3](/details-gene/9021) gene to atopic dermatitis [Link](https://doi.org/10.1086/504272), highlighting its clinical relevance in inflammatory diseases. Based on the available data, several testable hypotheses can be proposed: 1. **Hypothesis 1:** In lung tissue, [SOCS3](/details-gene/9021) expression in [alveolar adventitial fibroblast](/details-cell/CL4028006)s acts as a crucial brake on pro-fibrotic signaling pathways (e.g., IL-6/STAT3). Downregulation or functional impairment of [SOCS3](/details-gene/9021) in these cells may lead to unchecked fibroblast activation and contribute to the pathogenesis of pulmonary fibrosis. 2. **Hypothesis 2:** [SOCS3](/details-gene/9021) in [pulmonary artery endothelial cell](/details-cell/CL1001568)s is essential for maintaining vascular integrity during inflammatory insults. Loss of [SOCS3](/details-gene/9021) function could lower the threshold for endothelial activation, leading to increased vascular permeability and leukocyte extravasation in conditions like acute respiratory distress syndrome (ARDS). A key experiment to test the first hypothesis would involve investigating the direct role of [SOCS3](/details-gene/9021) in fibroblast activation. Primary human lung fibroblasts could be cultured and subjected to CRISPR-Cas9-mediated knockdown of [SOCS3](/details-gene/9021). These cells, along with control cells, would then be stimulated with a pro-fibrotic cytokine such as IL-6 or TGF-beta. The impact on fibrosis could be assessed by measuring the expression of key fibrotic markers (e.g., alpha-smooth muscle actin, collagen type I) via qPCR and Western blot, and by quantifying collagen deposition using a Sirius Red assay. As a therapeutic target, [SOCS3](/details-gene/9021) presents a unique opportunity. Because it is an intracellular negative regulator, direct inhibition would likely be pro-inflammatory and detrimental. Instead, therapeutic strategies should focus on **activation** or enhancement of its function. The development of small molecules that stabilize [SOCS3](/details-gene/9021) protein or epigenetic modulators that increase its expression could represent a novel anti-inflammatory or anti-fibrotic approach for diseases driven by excessive cytokine signaling.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytokine-inducible SH2 protein 3

Genular Protein ID: 569629017

Symbol: SOCS3_HUMAN

Name: Cytokine-inducible SH2 protein 3

UniProtKB Accession Codes:

O14543 O14509

Database IDs:

Citations:

PubMed ID: 9266833

Title: Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

PubMed ID: 9266833

DOI: 10.1006/bbrc.1997.7080

PubMed ID: 9344848

Title: Cloning and characterization of novel CIS family genes.

PubMed ID: 9344848

DOI: 10.1006/bbrc.1997.7484

PubMed ID: 11071852

Title: Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor.

PubMed ID: 11071852

DOI: 10.1006/bbrc.2000.3762

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10421843

Title: Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain.

PubMed ID: 10421843

DOI: 10.1046/j.1365-2443.1999.00263.x

PubMed ID: 12027890

Title: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.

PubMed ID: 12027890

DOI: 10.1046/j.1432-1033.2002.02916.x

PubMed ID: 14559241

Title: SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.

PubMed ID: 14559241

DOI: 10.1016/j.bbrc.2003.09.140

PubMed ID: 15070676

Title: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.

PubMed ID: 15070676

DOI: 10.1182/blood-2003-08-2768

PubMed ID: 15601820

Title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

PubMed ID: 15601820

DOI: 10.1101/gad.1252404

PubMed ID: 16685656

Title: Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.

PubMed ID: 16685656

DOI: 10.1086/504272

PubMed ID: 16410555

Title: Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling.

PubMed ID: 16410555

DOI: 10.1242/jcs.02740

PubMed ID: 23019338

Title: Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.

PubMed ID: 23019338

DOI: 10.1074/jbc.m112.410027

Sequence Information:

Length: 225
Mass: 24770
Checksum: 08581DC411EFFF19
Sequence:

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 
LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR 
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

	Overall overall
	Adrenal gland UBERON0002369
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Basal cell carcinoma MONDO0020804
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Fallopian tube UBERON0003889
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Islet of Langerhans UBERON0000006
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Small intestine UBERON0002108
	\|— Small intestine Healthy UBERON0002108_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: SOCS3

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. PubMed ID: 9266833

Cloning and characterization of novel CIS family genes. PubMed ID: 9344848

Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor. PubMed ID: 11071852

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. PubMed ID: 10421843

A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. PubMed ID: 12027890

SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. PubMed ID: 14559241

Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation. PubMed ID: 15070676

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. PubMed ID: 15601820

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis. PubMed ID: 16685656

Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. PubMed ID: 16410555

Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components. PubMed ID: 23019338