Details for: CBX5
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 37.11rCSI 44.54%PRS 46.02
-
CSI 36.13rCSI 28.56%PRS 35.7
-
CSI 34.33rCSI 39.64%PRS 42.19
-
CSI 33.25rCSI 45.3%PRS 41.09
-
CSI 26.44rCSI 21.48%PRS 48.64
-
CSI 24.73rCSI 40.5%PRS 38.5
-
CSI 23.95rCSI 36.51%PRS 44.61
-
CSI 18.64rCSI 16.39%PRS 37.05
-
CSI 17.83rCSI 24.77%PRS 47.42
-
CSI 17.73rCSI 12.32%PRS 57.17
-
CSI 17.63rCSI 16.97%PRS 48.38
-
CSI 15.92rCSI 18.23%PRS 70.51
-
CSI 15.47rCSI 44.16%PRS 62.24
-
CSI 14.74rCSI 60.08%PRS 59.31
-
CSI 14.38rCSI 18.05%PRS 57.97
-
CSI 14.33rCSI 20.31%PRS 44.85
-
CSI 14.1rCSI 45.25%PRS 55.36
-
CSI 12.98rCSI 50.54%PRS 68.6
-
CSI 12.72rCSI 10.53%PRS 49.25
-
CSI 11.8rCSI 46.95%PRS 63.36
-
CSI 10.96rCSI 8.12%PRS 41.49
-
CSI 10.73rCSI 15.32%PRS 50.63
-
CSI 10.14rCSI 12.61%PRS 50.62
-
CSI 9.52rCSI 13.8%PRS 64.4
-
CSI 9.19rCSI 39.86%PRS 63.3
-
CSI 9.04rCSI 11.6%PRS 45.97
-
CSI 8.49rCSI 13.65%PRS 34.11
-
CSI 8.38rCSI 48.33%PRS 49.33
-
CSI 8.04rCSI 6.5%PRS 48.77
-
CSI 7.48rCSI 5.6%PRS 62.71
-
CSI 7.26rCSI 6.56%PRS 44.68
-
CSI 7.17rCSI 9.59%PRS 56.62
-
CSI 7.14rCSI 7.12%PRS 42.12
-
CSI 6.92rCSI 43.23%PRS 40.46
-
CSI 6.73rCSI 7.38%PRS 51.94
-
CSI 6.47rCSI 9.55%PRS 65.56
-
CSI 6.26rCSI 33.77%PRS 62.42
-
CSI 6.06rCSI 5.31%PRS 57.91
-
CSI 6rCSI 15.82%PRS 55.91
-
CSI 5.85rCSI 64.03%PRS 63.75
-
CSI 5.84rCSI 13.09%PRS 32.72
-
CSI 5.79rCSI 8.35%PRS 57.91
-
CSI 5.68rCSI 5.95%PRS 45.04
-
CSI 5.64rCSI 7.71%PRS 57.5
-
CSI 5.51rCSI 4.89%PRS 46.86
-
CSI 5.4rCSI 4.68%PRS 52.07
-
CSI 5.39rCSI 8.73%PRS 46.26
-
CSI 5.37rCSI 4.3%PRS 69.37
-
CSI 5.34rCSI 4.43%PRS 46.64
-
CSI 5.33rCSI 12.09%PRS 53.19
-
CSI 5.21rCSI 11.88%PRS 41.29
-
CSI 5.14rCSI 75.93%PRS 68.87
-
CSI 4.74rCSI 6.3%PRS 53.1
-
CSI 4.72rCSI 4.39%PRS 47.71
-
CSI 4.61rCSI 14.96%PRS 50.52
-
CSI 4.57rCSI 6.33%PRS 52.33
-
CSI 4.46rCSI 13.16%PRS 52.01
-
CSI 4.24rCSI 8.24%PRS 50.19
-
CSI 4.22rCSI 6.73%PRS 41.71
-
CSI 4.2rCSI 4.38%PRS 48.51
-
CSI 4.2rCSI 6.41%PRS 52.82
-
CSI 4.18rCSI 5.71%PRS 53.1
-
CSI 4.17rCSI 6.37%PRS 65.07
-
CSI 3.99rCSI 9.13%PRS 47.41
-
CSI 3.84rCSI 3.02%PRS 54.48
-
CSI 3.75rCSI 3.16%PRS 65.2
-
CSI 3.75rCSI 5.54%PRS 53.23
-
CSI 3.74rCSI 19.32%PRS 71.7
-
CSI 3.71rCSI 2.88%PRS 48.68
-
CSI 3.66rCSI 3.46%PRS 48.78
-
CSI 3.59rCSI 2.39%PRS 51.65
-
CSI 3.49rCSI 3.06%PRS 53.17
-
CSI 3.46rCSI 9.51%PRS 63.44
-
CSI 3.44rCSI 8.16%PRS 53.55
-
CSI 3.41rCSI 4.39%PRS 32.89
-
CSI 3.31rCSI 2.31%PRS 49.97
-
CSI 3.3rCSI 3.86%PRS 63.77
-
CSI 3.29rCSI 5.24%PRS 40.93
-
CSI 3.28rCSI 4.48%PRS 50.49
-
CSI 3.26rCSI 2.73%PRS 52.88
-
CSI 3.26rCSI 5.01%PRS 48.81
-
CSI 3.23rCSI 7.45%PRS 39.18
-
CSI 3.2rCSI 4.28%PRS 49.35
-
CSI 3.11rCSI 3.72%PRS 66.84
-
CSI 3.1rCSI 3.58%PRS 38.21
-
CSI 3.06rCSI 5.43%PRS 28.93
-
CSI 3rCSI 2.59%PRS 56.04
-
CSI 2.98rCSI 11.15%PRS 40.94
-
CSI 2.9rCSI 9.29%PRS 44.99
-
CSI 2.89rCSI 2.51%PRS 57.72
-
CSI 2.86rCSI 5.45%PRS 64.95
-
CSI 2.81rCSI 10.63%PRS 32.87
-
CSI 2.78rCSI 2.68%PRS 38.73
-
CSI 2.75rCSI 3.51%PRS 53.67
-
CSI 2.73rCSI 2.86%PRS 51.2
-
CSI 2.7rCSI 15.48%PRS 58.69
-
CSI 2.69rCSI 64.3%PRS 31.41
-
CSI 2.66rCSI 4.66%PRS 40.4
-
CSI 2.63rCSI 16.91%PRS 69.01
-
CSI 2.62rCSI 16.79%PRS 53.3
-
CSI 0.1rCSI 3.2%PRS 70.6%
-
CSI 0.3rCSI 3.7%PRS 71.4%
-
CSI 0.3rCSI 5.8%PRS 81.1%
-
CSI 0.4rCSI 1.9%PRS 69.5%
-
CSI 0.4rCSI 1.8%PRS 59.9%
-
CSI 0.4rCSI 1.0%PRS 77.7%
-
CSI 0.4rCSI 2.9%PRS 67.5%
-
CSI 0.5rCSI 1.0%PRS 37.9%
-
CSI 0.5rCSI 5.9%PRS 69.1%
-
CSI 0.5rCSI 3.2%PRS 79.5%
-
CSI 0.5rCSI 2.0%PRS 49.7%
-
CSI 0.5rCSI 5.4%PRS 91.8%
-
CSI 0.5rCSI 1.3%PRS 37.0%
-
CSI 0.5rCSI 1.2%PRS 36.0%
-
CSI 0.6rCSI 1.0%PRS 58.5%
-
CSI 0.6rCSI 1.2%PRS 62.5%
-
CSI 0.6rCSI 2.6%PRS 81.5%
-
CSI 0.6rCSI 3.9%PRS 78.2%
-
CSI 0.6rCSI 2.8%PRS 70.1%
-
CSI 0.6rCSI 3.8%PRS 82.0%
-
CSI 0.7rCSI 6.0%PRS 64.2%
-
CSI 0.7rCSI 3.6%PRS 83.6%
-
CSI 0.7rCSI 1.0%PRS 50.4%
-
CSI 0.7rCSI 6.8%PRS 85.9%
-
CSI 0.7rCSI 2.5%PRS 78.4%
-
CSI 0.7rCSI 2.0%PRS 61.3%
-
CSI 0.8rCSI 2.6%PRS 78.7%
-
CSI 0.8rCSI 2.2%PRS 44.5%
-
CSI 0.8rCSI 6.1%PRS 35.9%
-
CSI 0.8rCSI 2.4%PRS 39.2%
-
CSI 0.9rCSI 2.5%PRS 50.2%
-
CSI 0.9rCSI 2.3%PRS 56.8%
-
CSI 0.9rCSI 1.9%PRS 53.2%
-
CSI 0.9rCSI 3.2%PRS 63.0%
-
CSI 0.9rCSI 1.5%PRS 38.6%
-
CSI 1.0rCSI 1.4%PRS 39.1%
-
CSI 1.0rCSI 3.2%PRS 56.8%
-
CSI 1.0rCSI 3.7%PRS 41.0%
-
CSI 1.0rCSI 3.8%PRS 65.6%
-
CSI 1.0rCSI 3.4%PRS 39.0%
-
CSI 1.0rCSI 2.7%PRS 40.6%
-
CSI 1.0rCSI 6.0%PRS 58.7%
-
CSI 1.0rCSI 3.6%PRS 60.2%
-
CSI 1.0rCSI 3.7%PRS 67.3%
-
CSI 1.0rCSI 1.1%PRS 53.9%
-
CSI 1.0rCSI 1.6%PRS 63.9%
-
CSI 1.0rCSI 1.8%PRS 38.8%
-
CSI 1.1rCSI 1.3%PRS 56.1%
-
CSI 1.1rCSI 6.2%PRS 33.4%
-
CSI 1.1rCSI 2.0%PRS 80.7%
-
CSI 1.1rCSI 2.2%PRS 69.5%
-
CSI 1.1rCSI 2.5%PRS 59.8%
-
CSI 1.1rCSI 2.6%PRS 66.4%
-
CSI 1.1rCSI 2.4%PRS 57.7%
-
CSI 1.1rCSI 1.7%PRS 48.6%
-
CSI 1.1rCSI 1.8%PRS 52.1%
-
CSI 1.1rCSI 2.7%PRS 57.9%
-
CSI 1.1rCSI 12.2%PRS 79.5%
-
CSI 1.1rCSI 3.0%PRS 52.9%
-
CSI 1.2rCSI 5.1%PRS 41.1%
-
CSI 1.2rCSI 2.1%PRS 31.0%
-
CSI 1.2rCSI 3.0%PRS 46.0%
-
CSI 1.2rCSI 3.8%PRS 35.6%
-
CSI 1.2rCSI 2.6%PRS 51.1%
-
CSI 1.2rCSI 3.1%PRS 38.4%
-
CSI 1.2rCSI 6.3%PRS 80.9%
-
CSI 1.3rCSI 2.8%PRS 45.5%
-
CSI 1.3rCSI 3.8%PRS 69.6%
-
CSI 1.3rCSI 1.5%PRS 57.9%
-
CSI 1.3rCSI 3.4%PRS 70.2%
-
CSI 1.3rCSI 4.3%PRS 35.8%
-
CSI 1.3rCSI 4.0%PRS 33.2%
-
CSI 1.3rCSI 1.7%PRS 52.8%
-
CSI 1.3rCSI 2.0%PRS 57.3%
-
CSI 1.3rCSI 5.8%PRS 46.9%
-
CSI 1.4rCSI 3.9%PRS 66.2%
-
CSI 1.4rCSI 2.1%PRS 55.4%
-
CSI 1.4rCSI 3.9%PRS 47.3%
-
CSI 1.4rCSI 3.9%PRS 62.2%
-
CSI 1.4rCSI 1.4%PRS 71.9%
-
CSI 1.4rCSI 2.1%PRS 51.3%
-
CSI 1.4rCSI 3.2%PRS 52.1%
-
CSI 1.5rCSI 2.3%PRS 45.8%
-
CSI 1.5rCSI 4.3%PRS 47.7%
-
CSI 1.5rCSI 4.9%PRS 47.1%
-
CSI 1.5rCSI 1.9%PRS 43.9%
-
CSI 1.5rCSI 2.7%PRS 46.1%
-
CSI 1.6rCSI 1.9%PRS 30.3%
-
CSI 1.6rCSI 5.6%PRS 82.8%
-
CSI 1.6rCSI 2.8%PRS 56.3%
-
CSI 1.6rCSI 2.3%PRS 61.3%
-
CSI 1.6rCSI 2.8%PRS 46.6%
-
CSI 1.6rCSI 1.6%PRS 61.4%
-
CSI 1.6rCSI 1.9%PRS 31.8%
-
CSI 1.7rCSI 3.0%PRS 41.5%
-
CSI 1.7rCSI 1.7%PRS 65.8%
-
CSI 1.7rCSI 3.5%PRS 41.6%
-
CSI 1.7rCSI 3.1%PRS 41.4%
-
CSI 1.8rCSI 1.1%PRS 63.8%
-
CSI 1.8rCSI 4.3%PRS 63.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2122137382
Symbol: CBX5_HUMAN
Name: Chromobox protein homolog 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8505380
Title: Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.
PubMed ID: 8505380
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8663349
Title: Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
PubMed ID: 8663349
PubMed ID: 9169472
Title: Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.
PubMed ID: 9169472
PubMed ID: 10460410
Title: Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.
PubMed ID: 10460410
PubMed ID: 11313457
Title: Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
PubMed ID: 11313457
PubMed ID: 11242053
Title: Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
PubMed ID: 11242053
DOI: 10.1038/35065132
PubMed ID: 15502821
Title: A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
PubMed ID: 15502821
DOI: 10.1038/ncb1187
PubMed ID: 15882967
Title: The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.
PubMed ID: 15882967
PubMed ID: 15864296
Title: Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles.
PubMed ID: 15864296
PubMed ID: 15899859
Title: In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation.
PubMed ID: 15899859
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19617346
Title: Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
PubMed ID: 19617346
PubMed ID: 19710015
Title: The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
PubMed ID: 19710015
PubMed ID: 19783980
Title: JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
PubMed ID: 19783980
DOI: 10.1038/nature08448
PubMed ID: 19666599
Title: Human BAHD1 promotes heterochromatic gene silencing.
PubMed ID: 19666599
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20850016
Title: Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.
PubMed ID: 20850016
PubMed ID: 19880879
Title: ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.
PubMed ID: 19880879
PubMed ID: 25750265
Title: Retraction: 'ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1'.
PubMed ID: 25750265
PubMed ID: 20562864
Title: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.
PubMed ID: 20562864
DOI: 10.1038/ncb2075
PubMed ID: 20498703
Title: Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
PubMed ID: 20498703
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21346195
Title: Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
PubMed ID: 21346195
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23542155
Title: Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.
PubMed ID: 23542155
DOI: 10.1038/nsmb.2532
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25906157
Title: A novel role of PRR14 in the regulation of skeletal myogenesis.
PubMed ID: 25906157
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 28977666
Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
PubMed ID: 28977666
DOI: 10.1093/nar/gkx711
PubMed ID: 32051553
Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
PubMed ID: 32051553
PubMed ID: 21047797
Title: Recognition and specificity determinants of the human cbx chromodomains.
PubMed ID: 21047797
PubMed ID: 20042602
Title: The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.
PubMed ID: 20042602
Sequence Information:
- Length: 191
- Mass: 22225
- Checksum: 16FFC476367093B1
- Sequence:
MGKKTKRTAD SSSSEDEEEY VVEKVLDRRV VKGQVEYLLK WKGFSEEHNT WEPEKNLDCP ELISEFMKKY KKMKEGENNK PREKSESNKR KSNFSNSADD IKSKKKREQS NDIARGFERG LEPEKIIGAT DSCGDLMFLM KWKDTDEADL VLAKEANVKC PQIVIAFYEE RLTWHAYPED AENKEKETAK S