Details for: TANC2
Gene ID: 26115
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TANC2
Ensembl ID: ENSG00000170921
Description: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 53.35rCSI 66.37%PRS 44.56
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CSI 51.38rCSI 61.37%PRS 46.19
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CSI 50.96rCSI 65.69%PRS 47.66
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CSI 42.8rCSI 68.83%PRS 48.33
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CSI 39.53rCSI 66.35%PRS 46.38
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CSI 38.05rCSI 69.13%PRS 56.54
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CSI 34.69rCSI 61.27%PRS 45.48
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CSI 34.61rCSI 76.15%PRS 47.83
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CSI 29.29rCSI 63.55%PRS 52.54
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CSI 27.79rCSI 67.55%PRS 44.85
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CSI 27.51rCSI 73.26%PRS 54.23
-
CSI 22.13rCSI 69.17%PRS 48.05
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CSI 21.81rCSI 71.69%PRS 51.76
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CSI 21.64rCSI 32.65%PRS 69.49
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CSI 20.87rCSI 45.93%PRS 68.93
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CSI 20.33rCSI 63.57%PRS 50.46
-
CSI 20.02rCSI 51.75%PRS 59.98
-
CSI 19.72rCSI 36.93%PRS 53.13
-
CSI 19.07rCSI 68.61%PRS 44.69
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CSI 18.88rCSI 23.36%PRS 61.65
-
CSI 18.47rCSI 38.33%PRS 62.15
-
CSI 18.13rCSI 68.53%PRS 47.02
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CSI 17.98rCSI 20.76%PRS 57.84
-
CSI 17.95rCSI 45.54%PRS 54.39
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CSI 16.98rCSI 34.9%PRS 54.71
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CSI 16.58rCSI 37.83%PRS 56.58
-
CSI 16.02rCSI 38.32%PRS 52
-
CSI 15.89rCSI 35.11%PRS 50.93
-
CSI 15.73rCSI 25.76%PRS 54.03
-
CSI 15.44rCSI 52.87%PRS 53.45
-
CSI 14.71rCSI 33.96%PRS 53.6
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CSI 14.48rCSI 20.11%PRS 63.44
-
CSI 14.03rCSI 34.72%PRS 63.55
-
CSI 13.49rCSI 23.33%PRS 55.13
-
CSI 13.36rCSI 34.7%PRS 68.25
-
CSI 13.33rCSI 20.37%PRS 69.24
-
CSI 12.75rCSI 29.16%PRS 64.99
-
CSI 12.6rCSI 12.13%PRS 64.8
-
CSI 12.32rCSI 15.81%PRS 57.14
-
CSI 12.23rCSI 24.56%PRS 53.97
-
CSI 12.13rCSI 17.31%PRS 66.93
-
CSI 11.81rCSI 55.54%PRS 59.28
-
CSI 11.78rCSI 30.7%PRS 64.74
-
CSI 11.55rCSI 68.03%PRS 47.52
-
CSI 11.51rCSI 18.36%PRS 57.29
-
CSI 11.44rCSI 20.06%PRS 57.02
-
CSI 11.22rCSI 8.86%PRS 51.83
-
CSI 11.2rCSI 76.23%PRS 59.77
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CSI 11.15rCSI 23.72%PRS 63.4
-
CSI 11.12rCSI 17.65%PRS 75.76
-
CSI 11.04rCSI 14.17%PRS 61.95
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CSI 10.95rCSI 48.65%PRS 64.96
-
CSI 10.95rCSI 15.52%PRS 61.36
-
CSI 10.81rCSI 14.73%PRS 56.57
-
CSI 10.57rCSI 39.88%PRS 50.46
-
CSI 10.42rCSI 54.81%PRS 59.02
-
CSI 10.39rCSI 16.53%PRS 57.4
-
CSI 10.37rCSI 21.04%PRS 43.87
-
CSI 10.23rCSI 41.69%PRS 58.61
-
CSI 10.09rCSI 66.99%PRS 61.62
-
CSI 10.08rCSI 26.25%PRS 61.87
-
CSI 9.81rCSI 49.36%PRS 64.83
-
CSI 9.72rCSI 10.42%PRS 64.84
-
CSI 9.46rCSI 41.56%PRS 61.26
-
CSI 9.43rCSI 19.46%PRS 65.46
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CSI 9.2rCSI 69.12%PRS 57.93
-
CSI 9.11rCSI 9.5%PRS 65.31
-
CSI 8.9rCSI 15.98%PRS 58.19
-
CSI 8.74rCSI 64.27%PRS 51.48
-
CSI 8.68rCSI 67.21%PRS 61.06
-
CSI 8.56rCSI 7.1%PRS 64.47
-
CSI 8.27rCSI 12.16%PRS 58.2
-
CSI 8.22rCSI 70.79%PRS 52.11
-
CSI 8.14rCSI 58.22%PRS 57.56
-
CSI 8.07rCSI 12.89%PRS 69.16
-
CSI 8.04rCSI 19.64%PRS 58.17
-
CSI 7.99rCSI 7.43%PRS 65.58
-
CSI 7.88rCSI 23.28%PRS 54.73
-
CSI 7.87rCSI 23.37%PRS 74.65
-
CSI 7.79rCSI 12.55%PRS 54.47
-
CSI 7.67rCSI 6.43%PRS 69
-
CSI 7.58rCSI 19.18%PRS 72.7
-
CSI 7.54rCSI 11.51%PRS 65.71
-
CSI 7.46rCSI 15.77%PRS 81.34
-
CSI 7.42rCSI 6.81%PRS 73.93
-
CSI 7.33rCSI 52.37%PRS 64.81
-
CSI 7.3rCSI 5.93%PRS 65.29
-
CSI 7.24rCSI 72.35%PRS 24.14
-
CSI 7.2rCSI 17.08%PRS 68.17
-
CSI 7.2rCSI 23.09%PRS 69.63
-
CSI 7.18rCSI 10.31%PRS 54.5
-
CSI 7.17rCSI 12.24%PRS 86.27
-
CSI 7rCSI 19.89%PRS 62.75
-
CSI 6.84rCSI 8.26%PRS 73.75
-
CSI 6.79rCSI 22.75%PRS 49.79
-
CSI 6.76rCSI 9.03%PRS 65.08
-
CSI 6.72rCSI 4.97%PRS 57.62
-
CSI 6.54rCSI 6.78%PRS 70.76
-
CSI 6.49rCSI 12.86%PRS 77.61
-
CSI 6.48rCSI 7.09%PRS 68.65
-
CSI 0.2rCSI 1.8%PRS 78.7%
-
CSI 0.6rCSI 2.9%PRS 75.7%
-
CSI 0.6rCSI 2.4%PRS 76.5%
-
CSI 0.8rCSI 3.2%PRS 79.3%
-
CSI 0.8rCSI 3.3%PRS 63.6%
-
CSI 1.2rCSI 4.7%PRS 76.5%
-
CSI 1.2rCSI 9.4%PRS 58.3%
-
CSI 1.2rCSI 6.1%PRS 61.8%
-
CSI 1.3rCSI 6.0%PRS 80.2%
-
CSI 1.3rCSI 8.6%PRS 73.9%
-
CSI 1.5rCSI 3.0%PRS 67.9%
-
CSI 1.6rCSI 9.6%PRS 77.9%
-
CSI 1.6rCSI 1.6%PRS 68.5%
-
CSI 1.6rCSI 4.2%PRS 59.0%
-
CSI 1.7rCSI 17.5%PRS 63.0%
-
CSI 1.7rCSI 7.7%PRS 79.8%
-
CSI 1.8rCSI 2.4%PRS 34.6%
-
CSI 1.8rCSI 2.7%PRS 74.1%
-
CSI 1.8rCSI 2.4%PRS 71.4%
-
CSI 1.9rCSI 8.2%PRS 55.0%
-
CSI 1.9rCSI 15.9%PRS 55.5%
-
CSI 1.9rCSI 5.5%PRS 61.3%
-
CSI 2.0rCSI 5.6%PRS 76.1%
-
CSI 2.0rCSI 4.7%PRS 75.5%
-
CSI 2.0rCSI 6.5%PRS 62.8%
-
CSI 2.1rCSI 2.5%PRS 63.1%
-
CSI 2.1rCSI 6.1%PRS 84.6%
-
CSI 2.1rCSI 8.3%PRS 78.6%
-
CSI 2.2rCSI 2.1%PRS 67.7%
-
CSI 2.4rCSI 1.8%PRS 70.6%
-
CSI 2.4rCSI 5.5%PRS 61.0%
-
CSI 2.4rCSI 3.8%PRS 67.5%
-
CSI 2.4rCSI 3.3%PRS 71.0%
-
CSI 2.5rCSI 6.5%PRS 63.9%
-
CSI 2.6rCSI 6.3%PRS 73.0%
-
CSI 2.8rCSI 7.6%PRS 60.3%
-
CSI 2.8rCSI 66.9%PRS 46.2%
-
CSI 2.8rCSI 2.5%PRS 79.3%
-
CSI 2.8rCSI 24.0%PRS 61.5%
-
CSI 2.8rCSI 25.8%PRS 73.7%
-
CSI 2.8rCSI 67.1%PRS 45.4%
-
CSI 2.9rCSI 4.5%PRS 63.4%
-
CSI 2.9rCSI 3.8%PRS 71.2%
-
CSI 3.0rCSI 15.6%PRS 69.6%
-
CSI 3.0rCSI 61.7%PRS 56.9%
-
CSI 3.1rCSI 62.0%PRS 55.4%
-
CSI 3.1rCSI 3.2%PRS 85.2%
-
CSI 3.1rCSI 18.5%PRS 59.3%
-
CSI 3.2rCSI 5.8%PRS 79.5%
-
CSI 3.2rCSI 2.5%PRS 65.8%
-
CSI 3.2rCSI 4.0%PRS 66.6%
-
CSI 3.3rCSI 3.2%PRS 55.9%
-
CSI 3.3rCSI 6.5%PRS 79.9%
-
CSI 3.3rCSI 3.8%PRS 55.3%
-
CSI 3.3rCSI 12.7%PRS 55.5%
-
CSI 3.3rCSI 2.6%PRS 82.3%
-
CSI 3.4rCSI 38.5%PRS 55.5%
-
CSI 3.5rCSI 8.4%PRS 72.0%
-
CSI 3.7rCSI 25.9%PRS 56.9%
-
CSI 3.8rCSI 21.8%PRS 63.2%
-
CSI 3.8rCSI 60.0%PRS 69.3%
-
CSI 4.0rCSI 19.0%PRS 63.1%
-
CSI 4.0rCSI 9.5%PRS 65.6%
-
CSI 4.1rCSI 9.0%PRS 63.1%
-
CSI 4.1rCSI 6.0%PRS 70.1%
-
CSI 4.2rCSI 17.6%PRS 58.1%
-
CSI 4.2rCSI 59.7%PRS 55.9%
-
CSI 4.3rCSI 13.8%PRS 64.8%
-
CSI 4.3rCSI 23.4%PRS 63.1%
-
CSI 4.5rCSI 7.9%PRS 61.5%
-
CSI 4.5rCSI 6.2%PRS 58.0%
-
CSI 4.6rCSI 7.1%PRS 72.1%
-
CSI 4.7rCSI 20.8%PRS 49.0%
-
CSI 4.7rCSI 7.0%PRS 70.3%
-
CSI 4.7rCSI 8.4%PRS 64.2%
-
CSI 4.8rCSI 8.0%PRS 70.3%
-
CSI 4.9rCSI 23.4%PRS 65.0%
-
CSI 4.9rCSI 20.3%PRS 64.3%
-
CSI 4.9rCSI 9.0%PRS 80.3%
-
CSI 5.0rCSI 51.7%PRS 58.9%
-
CSI 5.3rCSI 4.1%PRS 67.6%
-
CSI 5.3rCSI 30.1%PRS 50.1%
-
CSI 5.4rCSI 21.6%PRS 64.0%
-
CSI 5.4rCSI 8.0%PRS 66.2%
-
CSI 5.4rCSI 21.0%PRS 41.9%
-
CSI 5.4rCSI 20.2%PRS 56.8%
-
CSI 5.6rCSI 16.1%PRS 54.5%
-
CSI 5.6rCSI 31.2%PRS 70.9%
-
CSI 5.7rCSI 15.1%PRS 56.0%
-
CSI 5.7rCSI 12.7%PRS 47.1%
-
CSI 5.8rCSI 7.2%PRS 75.6%
-
CSI 5.8rCSI 23.5%PRS 68.9%
-
CSI 5.9rCSI 13.2%PRS 72.8%
-
CSI 6.1rCSI 19.5%PRS 62.1%
-
CSI 6.1rCSI 31.5%PRS 69.9%
-
CSI 6.2rCSI 20.4%PRS 68.6%
-
CSI 6.5rCSI 7.1%PRS 68.7%
-
CSI 6.5rCSI 12.9%PRS 77.6%
-
CSI 6.5rCSI 6.8%PRS 70.8%
-
CSI 6.7rCSI 5.0%PRS 57.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1142814771
Symbol: TANC2_HUMAN
Name: Protein TANC2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 10997877
Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10997877
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10574461
Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
PubMed ID: 10574461
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23033978
Title: Diagnostic exome sequencing in persons with severe intellectual disability.
PubMed ID: 23033978
PubMed ID: 28493397
Title: A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.
PubMed ID: 28493397
DOI: 10.1002/humu.23246
PubMed ID: 30021165
Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites.
PubMed ID: 30021165
PubMed ID: 31616000
Title: Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
PubMed ID: 31616000
Sequence Information:
- Length: 1990
- Mass: 219650
- Checksum: E835D98F5C546365
- Sequence:
MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS TESDCAFEPD YAVPPLPVSE GDAEQELGPP PSVDEAANTL MTRLGFLLGE KVTEVQPGDQ YSMEVQDENQ TSAITQRISP CSTLTSSTAS PPASSPCSTL PPISTNATAK DCSYGAVTSP TSTLESRDSG IIATLTSYSE NVERTKYAGE SSKELGSGGN IKPWQSQKSS MDSCLYRVDE NMTASTYSLN KIPERNLETV LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ SMGGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE IDAQLQSSNA SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS PHASPKHVDA NRELPLTQPP SAHSSITSGS CPGTPEMRRR QEEAMRRLAS QVVAYHYCQA DNAYTCLVPE FVHNVAALLC RSPQLTAYRE QLLREPHLQS MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL IDGLNEAEFH KPDYGDTIVS FLSKMIGKFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS QGSYLYLKLT FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS FDRVMPLLNV AVASLHPLTD EHIFQAINAG SIEGTLEWED FQQRMENLSM FLIKRRDMTR MFVHPSFREW LIWREEGEKT KFLCDPRSGH TLLAFWFSRQ EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW ISYSTEGLSM ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM VALLLEFGAN VDASSESGLT PLGYAAAAGY LSIVVLLCKK RAKVDHLDKN GQCALVHAAL RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS MGYTEIVSYL LDLPEKDEEE VERAQINSFD SLWGETALTA AAGRGKLEVC RLLLEQGAAV AQPNRRGAVP LFSTVRQGHW QIVDLLLTHG ADVNMADKQG RTPLMMAASE GHLGTVDFLL AQGASIALMD KEGLTALSWA CLKGHLSVVR SLVDNGAATD HADKNGRTPL DLAAFYGDAE VVQFLVDHGA MIEHVDYSGM RPLDRAVGCR NTSVVVTLLK KGAKIGPATW AMATSKPDIM IILLSKLMEE GDMFYKKGKV KEAAQRYQYA LKKFPREGFG EDLKTFRELK VSLLLNLSRC RRKMNDFGMA EEFATKALEL KPKSYEAYYA RARAKRSSRQ FAAALEDLNE AIKLCPNNRE IQRLLLRVEE ECRQMQQPQQ PPPPPQPQQQ LPEEAEPEPQ HEDIYSVQDI FEEEYLEQDV ENVSIGLQTE ARPSQGLPVI QSPPSSPPHR DSAYISSSPL GSHQVFDFRS SSSVGSPTRQ TYQSTSPALS PTHQNSHYRP SPPHTSPAHQ GGSYRFSPPP VGGQGKEYPS PPPSPLRRGP QYRASPPAES MSVYRSQSGS PVRYQQETSV SQLPGRPKSP LSKMAQRPYQ MPQLPVAVPQ QGLRLQPAKA QIVRSNQPSP AVHSSTVIPT GAYGQVAHSM ASKYQSSQGD IGVSQSRLVY QGSIGGIVGD GRPVQHVQAS LSAGAICQHG GLTKEDLPQR PSSAYRGGVR YSQTPQIGRS QSASYYPVCH SKLDLERSSS QLGSPDVSHL IRRPISVNPN EIKPHPPTPR PLLHSQSVGL RFSPSSNSIS STSNLTPTFR PSSSIQQMEI PLKPAYERSC DELSPVSPTQ GGYPSEPTRS RTTPFMGIID KTARTQQYPH LHQQNRTWAV SSVDTVLSPT SPGNLPQPES FSPPSSISNI AFYNKTNNAQ NGHLLEDDYY SPHGMLANGS RGDLLERVSQ ASSYPDVKVA RTLPVAQAYQ DNLYRQLSRD SRQGQTSPIK PKRPFVESNV