Details for: WWOX
Gene ID: 51741
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: WWOX
Ensembl ID: ENSG00000186153
Description: WW domain containing oxidoreductase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 55.87rCSI 69.51%PRS 46.12
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CSI 55.25rCSI 66%PRS 47.82
-
CSI 51.74rCSI 70.8%PRS 59.41
-
CSI 50.26rCSI 64.79%PRS 49.32
-
CSI 44.69rCSI 75.01%PRS 48.06
-
CSI 43.73rCSI 56.15%PRS 58.64
-
CSI 41.42rCSI 66.61%PRS 50.01
-
CSI 41.15rCSI 42.94%PRS 66.66
-
CSI 40.67rCSI 38.43%PRS 65.72
-
CSI 39.37rCSI 69.53%PRS 47.12
-
CSI 38.54rCSI 70.03%PRS 58.1
-
CSI 37.84rCSI 76.78%PRS 45.29
-
CSI 37.46rCSI 61.35%PRS 55.77
-
CSI 36.52rCSI 81.87%PRS 48.65
-
CSI 34.99rCSI 51.44%PRS 59.79
-
CSI 32.15rCSI 45.57%PRS 62.99
-
CSI 30.52rCSI 67.15%PRS 50.12
-
CSI 29.96rCSI 77.44%PRS 61.58
-
CSI 29.95rCSI 63.82%PRS 38.18
-
CSI 29.09rCSI 72%PRS 65.31
-
CSI 28.78rCSI 41.3%PRS 56.24
-
CSI 28.16rCSI 58.44%PRS 63.68
-
CSI 27.85rCSI 35.74%PRS 63.45
-
CSI 27.81rCSI 55.83%PRS 55.81
-
CSI 27.75rCSI 70.39%PRS 56.16
-
CSI 27.45rCSI 38.02%PRS 66.66
-
CSI 27.37rCSI 47.98%PRS 58.97
-
CSI 26.99rCSI 72.14%PRS 57.44
-
CSI 25.62rCSI 62.27%PRS 46.43
-
CSI 24.41rCSI 99.46%PRS 60.1
-
CSI 24.29rCSI 28.05%PRS 59.55
-
CSI 24.13rCSI 41.74%PRS 56.97
-
CSI 24.02rCSI 66.21%PRS 61.81
-
CSI 23.59rCSI 52.11%PRS 52.61
-
CSI 22.94rCSI 41.07%PRS 66.13
-
CSI 22.83rCSI 18.05%PRS 53.71
-
CSI 22.33rCSI 69.77%PRS 49.72
-
CSI 22.26rCSI 58.04%PRS 66.58
-
CSI 21.76rCSI 82.12%PRS 51.73
-
CSI 20.82rCSI 60.34%PRS 56.15
-
CSI 20.26rCSI 32.32%PRS 58.95
-
CSI 20.23rCSI 28.11%PRS 65.31
-
CSI 20.22rCSI 63.23%PRS 52.2
-
CSI 19.66rCSI 31.26%PRS 59.31
-
CSI 19.63rCSI 70.66%PRS 46.25
-
CSI 19.36rCSI 97.42%PRS 66.03
-
CSI 19.23rCSI 65.15%PRS 61.39
-
CSI 19.18rCSI 98.21%PRS 71.51
-
CSI 18.82rCSI 100%PRS 57.09
-
CSI 18.77rCSI 16.5%PRS 54.59
-
CSI 18.65rCSI 43.04%PRS 55.07
-
CSI 18.03rCSI 68.13%PRS 48.61
-
CSI 17.13rCSI 64.15%PRS 58.53
-
CSI 17.03rCSI 40.72%PRS 53.74
-
CSI 16.98rCSI 30.5%PRS 59.89
-
CSI 16.72rCSI 25.23%PRS 71.55
-
CSI 16.48rCSI 67.87%PRS 76.24
-
CSI 16.41rCSI 42.62%PRS 69.59
-
CSI 15.95rCSI 38.97%PRS 59.63
-
CSI 15.8rCSI 27.85%PRS 63.27
-
CSI 15.72rCSI 15.16%PRS 57.85
-
CSI 15.53rCSI 44.16%PRS 64.43
-
CSI 15.35rCSI 14.29%PRS 67.44
-
CSI 15.22rCSI 31.42%PRS 67.12
-
CSI 15.21rCSI 40.51%PRS 55.66
-
CSI 14.88rCSI 43.97%PRS 56.11
-
CSI 14.65rCSI 27.44%PRS 54.7
-
CSI 14.57rCSI 49.9%PRS 54.96
-
CSI 14.43rCSI 47.83%PRS 70.7
-
CSI 14.42rCSI 59.93%PRS 66.04
-
CSI 13.72rCSI 22.24%PRS 62.71
-
CSI 13.69rCSI 11.85%PRS 71.65
-
CSI 13.28rCSI 11.13%PRS 70.47
-
CSI 13.17rCSI 55.97%PRS 59.68
-
CSI 12.93rCSI 20.81%PRS 56.26
-
CSI 12.9rCSI 57.31%PRS 66.66
-
CSI 12.17rCSI 27.84%PRS 66.97
-
CSI 12.04rCSI 17.61%PRS 71.52
-
CSI 11.93rCSI 26.25%PRS 70.73
-
CSI 11.81rCSI 34.86%PRS 65.24
-
CSI 11.81rCSI 84.35%PRS 65.97
-
CSI 11.78rCSI 66.58%PRS 51.77
-
CSI 11.73rCSI 37.54%PRS 63.84
-
CSI 11.7rCSI 38.06%PRS 66.12
-
CSI 11.64rCSI 68.52%PRS 49.19
-
CSI 11.61rCSI 32.65%PRS 63.08
-
CSI 11.58rCSI 29.78%PRS 65.28
-
CSI 11.45rCSI 56.95%PRS 63.29
-
CSI 11.44rCSI 46.15%PRS 65.78
-
CSI 11.34rCSI 33.65%PRS 76.45
-
CSI 11.22rCSI 50.13%PRS 50.6
-
CSI 11.14rCSI 13.85%PRS 68.24
-
CSI 11.06rCSI 12.11%PRS 70.46
-
CSI 10.86rCSI 41.99%PRS 79.83
-
CSI 10.79rCSI 17.23%PRS 70.94
-
CSI 10.4rCSI 11.15%PRS 66.73
-
CSI 10.27rCSI 12.79%PRS 77.29
-
CSI 10.18rCSI 40.99%PRS 70.07
-
CSI 10.17rCSI 16.07%PRS 69.25
-
CSI 10.01rCSI 38.12%PRS 57.29
-
CSI 0.5rCSI 1.3%PRS 60.6%
-
CSI 0.6rCSI 3.1%PRS 77.3%
-
CSI 0.8rCSI 3.7%PRS 77.3%
-
CSI 0.8rCSI 1.3%PRS 65.2%
-
CSI 0.8rCSI 9.2%PRS 77.5%
-
CSI 1.0rCSI 1.3%PRS 63.5%
-
CSI 1.1rCSI 4.7%PRS 77.5%
-
CSI 1.2rCSI 8.0%PRS 67.2%
-
CSI 1.3rCSI 5.2%PRS 85.6%
-
CSI 1.4rCSI 3.1%PRS 65.0%
-
CSI 1.5rCSI 9.3%PRS 75.4%
-
CSI 1.6rCSI 1.8%PRS 57.3%
-
CSI 1.7rCSI 2.0%PRS 64.8%
-
CSI 1.7rCSI 19.4%PRS 57.1%
-
CSI 1.8rCSI 5.0%PRS 76.7%
-
CSI 1.8rCSI 26.0%PRS 77.5%
-
CSI 1.8rCSI 13.9%PRS 71.7%
-
CSI 2.0rCSI 2.1%PRS 70.3%
-
CSI 2.1rCSI 29.4%PRS 57.6%
-
CSI 2.2rCSI 12.7%PRS 74.9%
-
CSI 2.4rCSI 20.5%PRS 57.1%
-
CSI 2.5rCSI 2.5%PRS 69.4%
-
CSI 2.7rCSI 4.4%PRS 77.0%
-
CSI 2.9rCSI 6.2%PRS 73.9%
-
CSI 2.9rCSI 70.1%PRS 47.9%
-
CSI 2.9rCSI 70.4%PRS 47.1%
-
CSI 3.0rCSI 15.7%PRS 71.2%
-
CSI 3.1rCSI 62.8%PRS 57.1%
-
CSI 3.1rCSI 63.3%PRS 58.6%
-
CSI 3.3rCSI 6.3%PRS 76.8%
-
CSI 3.7rCSI 10.5%PRS 77.3%
-
CSI 3.7rCSI 39.2%PRS 64.4%
-
CSI 3.8rCSI 26.8%PRS 59.2%
-
CSI 3.9rCSI 3.0%PRS 67.9%
-
CSI 4.1rCSI 11.0%PRS 73.2%
-
CSI 4.2rCSI 5.6%PRS 75.2%
-
CSI 4.3rCSI 18.8%PRS 56.5%
-
CSI 4.4rCSI 20.4%PRS 81.6%
-
CSI 4.4rCSI 24.6%PRS 74.5%
-
CSI 4.8rCSI 11.0%PRS 62.4%
-
CSI 4.9rCSI 11.6%PRS 74.5%
-
CSI 4.9rCSI 3.8%PRS 83.6%
-
CSI 5.0rCSI 28.8%PRS 64.6%
-
CSI 5.0rCSI 17.3%PRS 86.3%
-
CSI 5.1rCSI 41.3%PRS 60.1%
-
CSI 5.3rCSI 10.2%PRS 69.7%
-
CSI 5.3rCSI 4.1%PRS 69.4%
-
CSI 5.4rCSI 33.9%PRS 58.4%
-
CSI 5.5rCSI 7.4%PRS 77.9%
-
CSI 5.5rCSI 12.2%PRS 78.1%
-
CSI 5.6rCSI 48.1%PRS 53.8%
-
CSI 5.6rCSI 6.8%PRS 75.6%
-
CSI 5.7rCSI 5.2%PRS 75.7%
-
CSI 5.7rCSI 42.7%PRS 59.5%
-
CSI 5.8rCSI 4.7%PRS 67.1%
-
CSI 5.9rCSI 50.8%PRS 63.0%
-
CSI 5.9rCSI 6.2%PRS 72.4%
-
CSI 6.0rCSI 4.8%PRS 68.6%
-
CSI 6.0rCSI 17.4%PRS 67.6%
-
CSI 6.3rCSI 6.3%PRS 60.2%
-
CSI 6.4rCSI 66.4%PRS 60.8%
-
CSI 6.5rCSI 9.9%PRS 63.1%
-
CSI 6.6rCSI 4.6%PRS 69.7%
-
CSI 6.6rCSI 9.8%PRS 71.9%
-
CSI 6.7rCSI 59.0%PRS 53.6%
-
CSI 6.7rCSI 42.1%PRS 48.6%
-
CSI 6.8rCSI 30.4%PRS 81.0%
-
CSI 6.8rCSI 32.6%PRS 64.8%
-
CSI 6.9rCSI 36.2%PRS 60.2%
-
CSI 6.9rCSI 10.2%PRS 77.9%
-
CSI 7.0rCSI 49.7%PRS 59.3%
-
CSI 7.1rCSI 52.2%PRS 53.2%
-
CSI 7.2rCSI 5.3%PRS 59.5%
-
CSI 7.2rCSI 39.6%PRS 64.7%
-
CSI 7.5rCSI 44.3%PRS 60.8%
-
CSI 7.6rCSI 11.7%PRS 60.5%
-
CSI 7.6rCSI 16.1%PRS 82.7%
-
CSI 7.6rCSI 36.0%PRS 60.6%
-
CSI 7.8rCSI 5.5%PRS 84.2%
-
CSI 7.8rCSI 17.8%PRS 58.3%
-
CSI 8.1rCSI 54.8%PRS 61.5%
-
CSI 8.1rCSI 9.8%PRS 74.1%
-
CSI 8.2rCSI 33.3%PRS 78.2%
-
CSI 8.2rCSI 27.4%PRS 51.5%
-
CSI 8.4rCSI 27.5%PRS 53.4%
-
CSI 8.4rCSI 21.3%PRS 74.1%
-
CSI 8.5rCSI 15.1%PRS 74.6%
-
CSI 8.6rCSI 27.7%PRS 64.3%
-
CSI 8.7rCSI 33.9%PRS 43.6%
-
CSI 8.7rCSI 14.3%PRS 72.0%
-
CSI 8.8rCSI 23.3%PRS 75.3%
-
CSI 8.8rCSI 8.1%PRS 80.9%
-
CSI 8.9rCSI 17.7%PRS 63.7%
-
CSI 9.0rCSI 8.8%PRS 85.7%
-
CSI 9.2rCSI 20.0%PRS 54.4%
-
CSI 9.2rCSI 12.4%PRS 66.6%
-
CSI 9.3rCSI 36.9%PRS 65.1%
-
CSI 9.3rCSI 62.0%PRS 63.2%
-
CSI 9.4rCSI 12.3%PRS 79.7%
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CSI 9.4rCSI 25.1%PRS 76.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 888027127
Symbol: WWOX_HUMAN
Name: WW domain-containing oxidoreductase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10786676
Title: WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.
PubMed ID: 10786676
PubMed ID: 10861292
Title: Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.
PubMed ID: 10861292
PubMed ID: 11719429
Title: WWOX, the FRA16D gene, behaves as a suppressor of tumor growth.
PubMed ID: 11719429
PubMed ID: 11572989
Title: WWOX: a candidate tumor suppressor gene involved in multiple tumor types.
PubMed ID: 11572989
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14695174
Title: An opposing view on WWOX protein function as a tumor suppressor.
PubMed ID: 14695174
PubMed ID: 12514174
Title: JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis.
PubMed ID: 12514174
PubMed ID: 15266310
Title: Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma.
PubMed ID: 15266310
PubMed ID: 15548692
Title: Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor.
PubMed ID: 15548692
PubMed ID: 15073125
Title: The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.
PubMed ID: 15073125
PubMed ID: 15131042
Title: Loss of WWOX expression in gastric carcinoma.
PubMed ID: 15131042
PubMed ID: 15064722
Title: WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins.
PubMed ID: 15064722
PubMed ID: 15070730
Title: Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
PubMed ID: 15070730
PubMed ID: 16061658
Title: WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.
PubMed ID: 16061658
PubMed ID: 16288044
Title: Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.
PubMed ID: 16288044
PubMed ID: 16219768
Title: WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.
PubMed ID: 16219768
PubMed ID: 16223882
Title: WWOX gene restoration prevents lung cancer growth in vitro and in vivo.
PubMed ID: 16223882
PubMed ID: 19366691
Title: Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1.
PubMed ID: 19366691
PubMed ID: 19465938
Title: Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.
PubMed ID: 19465938
DOI: 10.1038/onc.2009.120
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 22226915
Title: A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma.
PubMed ID: 22226915
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 30285739
Title: VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX.
PubMed ID: 30285739
PubMed ID: 24456803
Title: The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.
PubMed ID: 24456803
PubMed ID: 25411445
Title: WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.
PubMed ID: 25411445
PubMed ID: 11956080
Title: Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma.
PubMed ID: 11956080
PubMed ID: 24369382
Title: The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.
PubMed ID: 24369382
DOI: 10.1093/brain/awt338
Sequence Information:
- Length: 414
- Mass: 46677
- Checksum: E4D9A649E6CB05DF
- Sequence:
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWHKAKVEAM TLDLALLRSV QHFAEAFKAK NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV QLLQDVLCRS APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN ILFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK SMQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG