Details for: LMBRD1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 43.1rCSI 51.49%PRS 12.94
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CSI 41.37rCSI 53.34%PRS 13.7
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CSI 36.39rCSI 61.08%PRS 13.12
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CSI 32.12rCSI 51.66%PRS 14.31
-
CSI 31.26rCSI 75.98%PRS 12.83
-
CSI 26.27rCSI 32.68%PRS 12.28
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CSI 26.12rCSI 81.64%PRS 13.96
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CSI 24.09rCSI 75.33%PRS 15.04
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CSI 23.8rCSI 42.04%PRS 13
-
CSI 20.26rCSI 72.91%PRS 12.33
-
CSI 18.72rCSI 64.13%PRS 19.44
-
CSI 18.32rCSI 69.24%PRS 13.56
-
CSI 15.75rCSI 10.96%PRS 31.3
-
CSI 13.37rCSI 35.62%PRS 19.53
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CSI 12.9rCSI 23.09%PRS 20.52
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CSI 12.03rCSI 70.83%PRS 13.74
-
CSI 11.06rCSI 10.64%PRS 22.96
-
CSI 10.41rCSI 7.47%PRS 30.64
-
CSI 10.37rCSI 20.17%PRS 22.76
-
CSI 9.86rCSI 72.44%PRS 13.46
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CSI 9.47rCSI 9.92%PRS 23.53
-
CSI 8.25rCSI 21.34%PRS 20.61
-
CSI 8.14rCSI 7.08%PRS 27.89
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CSI 8.12rCSI 17.95%PRS 15.78
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CSI 8.08rCSI 35.91%PRS 21.56
-
CSI 7.55rCSI 10.68%PRS 30.81
-
CSI 7.19rCSI 8.94%PRS 23.62
-
CSI 6.96rCSI 5.27%PRS 30.41
-
CSI 6.76rCSI 17.1%PRS 27.26
-
CSI 6.33rCSI 4.98%PRS 26.83
-
CSI 6.1rCSI 36.04%PRS 24.23
-
CSI 5.86rCSI 39.88%PRS 23.6
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CSI 5.72rCSI 6.91%PRS 26.74
-
CSI 5.43rCSI 4.06%PRS 34.85
-
CSI 5.23rCSI 82.46%PRS 21.3
-
CSI 5.23rCSI 7.11%PRS 33.42
-
CSI 5.17rCSI 13.93%PRS 28.74
-
CSI 5.16rCSI 5.91%PRS 43.96
-
CSI 5.12rCSI 4.24%PRS 22.52
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CSI 5.1rCSI 4.37%PRS 35.78
-
CSI 5.08rCSI 8.15%PRS 56.36
-
CSI 5.07rCSI 6.32%PRS 31.17
-
CSI 4.93rCSI 4.08%PRS 21.05
-
CSI 4.92rCSI 6.81%PRS 30.79
-
CSI 4.88rCSI 17.67%PRS 37.99
-
CSI 4.8rCSI 12.66%PRS 26.45
-
CSI 4.78rCSI 4.39%PRS 26.09
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CSI 4.69rCSI 10.93%PRS 42.81
-
CSI 4.55rCSI 3.51%PRS 20.64
-
CSI 4.49rCSI 8.56%PRS 34.67
-
CSI 4.43rCSI 3.93%PRS 22.34
-
CSI 4.43rCSI 5.69%PRS 21.48
-
CSI 4.32rCSI 5.9%PRS 24.67
-
CSI 4.31rCSI 9.11%PRS 43.65
-
CSI 4.21rCSI 6.71%PRS 18.85
-
CSI 4.02rCSI 3.97%PRS 67.65
-
CSI 4.01rCSI 3.95%PRS 23.84
-
CSI 4rCSI 5.36%PRS 65.65
-
CSI 4rCSI 2.81%PRS 50
-
CSI 3.98rCSI 9.73%PRS 21.69
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CSI 3.91rCSI 4.97%PRS 25.61
-
CSI 3.9rCSI 3.43%PRS 25.56
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CSI 3.83rCSI 5.02%PRS 31.58
-
CSI 3.82rCSI 4.47%PRS 30.75
-
CSI 3.81rCSI 12.51%PRS 14.82
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CSI 3.78rCSI 15.68%PRS 38.61
-
CSI 3.73rCSI 52.97%PRS 17.37
-
CSI 3.71rCSI 6.51%PRS 16.92
-
CSI 3.71rCSI 5.16%PRS 22.42
-
CSI 3.71rCSI 3.87%PRS 22.75
-
CSI 3.69rCSI 4.28%PRS 31.85
-
CSI 3.64rCSI 9.67%PRS 34.35
-
CSI 3.64rCSI 2.77%PRS 29.29
-
CSI 3.59rCSI 3.94%PRS 24.92
-
CSI 3.58rCSI 10.02%PRS 34.24
-
CSI 3.44rCSI 2.29%PRS 26.48
-
CSI 3.43rCSI 3.02%PRS 16.12
-
CSI 3.4rCSI 2.69%PRS 15.21
-
CSI 3.37rCSI 80.67%PRS 11.63
-
CSI 3.37rCSI 3.61%PRS 20.41
-
CSI 3.36rCSI 16.08%PRS 27.28
-
CSI 3.35rCSI 2.82%PRS 34.86
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CSI 3.34rCSI 2.67%PRS 39.2
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CSI 3.28rCSI 2.55%PRS 32.59
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CSI 3.27rCSI 78.97%PRS 12.55
-
CSI 3.25rCSI 7.15%PRS 25.39
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CSI 3.24rCSI 3.95%PRS 27.72
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CSI 3.19rCSI 2.59%PRS 23.31
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CSI 3.18rCSI 7.27%PRS 18.98
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CSI 3.18rCSI 19.61%PRS 63.79
-
CSI 3.16rCSI 64.32%PRS 18.22
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CSI 3.14rCSI 4.03%PRS 21.22
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CSI 3.1rCSI 7.09%PRS 21.54
-
CSI 3.06rCSI 2.37%PRS 21.36
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CSI 3.02rCSI 61.45%PRS 19.29
-
CSI 3.01rCSI 14.98%PRS 24.14
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CSI 2.99rCSI 2.76%PRS 23.11
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CSI 2.99rCSI 5.17%PRS 16.9
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CSI 2.97rCSI 8.81%PRS 30.99
-
CSI 2.94rCSI 6.79%PRS 17.87
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CSI -0.4rCSI -0.5%PRS 27.0%
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CSI 0.1rCSI 0.7%PRS 38.6%
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CSI 0.2rCSI 0.9%PRS 32.7%
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CSI 0.2rCSI 1.8%PRS 41.8%
-
CSI 0.2rCSI 1.2%PRS 32.5%
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CSI 0.3rCSI 3.9%PRS 51.4%
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CSI 0.3rCSI 3.1%PRS 54.5%
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CSI 0.3rCSI 2.6%PRS 24.6%
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CSI 0.4rCSI 7.4%PRS 81.4%
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CSI 0.4rCSI 2.3%PRS 17.3%
-
CSI 0.4rCSI 1.0%PRS 22.1%
-
CSI 0.4rCSI 1.1%PRS 28.5%
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CSI 0.4rCSI 1.8%PRS 51.5%
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CSI 0.4rCSI 0.6%PRS 38.5%
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CSI 0.4rCSI 0.4%PRS 20.1%
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CSI 0.4rCSI 0.8%PRS 33.7%
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CSI 0.5rCSI 3.5%PRS 23.8%
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CSI 0.5rCSI 2.3%PRS 45.0%
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CSI 0.5rCSI 5.6%PRS 50.4%
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CSI 0.5rCSI 3.8%PRS 23.5%
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CSI 0.6rCSI 3.7%PRS 24.1%
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CSI 0.6rCSI 1.6%PRS 40.1%
-
CSI 0.6rCSI 1.9%PRS 30.9%
-
CSI 0.6rCSI 1.5%PRS 32.8%
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CSI 0.6rCSI 2.8%PRS 47.0%
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CSI 0.6rCSI 4.7%PRS 40.1%
-
CSI 0.7rCSI 1.1%PRS 20.7%
-
CSI 0.7rCSI 1.4%PRS 46.7%
-
CSI 0.7rCSI 1.6%PRS 35.0%
-
CSI 0.7rCSI 1.6%PRS 42.3%
-
CSI 0.8rCSI 1.8%PRS 22.8%
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CSI 0.8rCSI 3.7%PRS 24.5%
-
CSI 0.8rCSI 1.2%PRS 25.3%
-
CSI 0.8rCSI 1.1%PRS 41.6%
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CSI 0.8rCSI 2.3%PRS 29.1%
-
CSI 0.8rCSI 2.1%PRS 16.8%
-
CSI 0.8rCSI 2.7%PRS 18.1%
-
CSI 0.9rCSI 3.8%PRS 40.3%
-
CSI 0.9rCSI 2.8%PRS 23.1%
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CSI 0.9rCSI 1.6%PRS 28.8%
-
CSI 0.9rCSI 3.0%PRS 56.0%
-
CSI 0.9rCSI 2.2%PRS 14.9%
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CSI 1.0rCSI 4.3%PRS 15.1%
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CSI 1.0rCSI 1.8%PRS 42.5%
-
CSI 1.0rCSI 2.0%PRS 32.8%
-
CSI 1.0rCSI 2.6%PRS 42.7%
-
CSI 1.0rCSI 2.9%PRS 24.9%
-
CSI 1.0rCSI 1.1%PRS 23.1%
-
CSI 1.0rCSI 2.8%PRS 20.7%
-
CSI 1.0rCSI 2.5%PRS 32.4%
-
CSI 1.1rCSI 4.1%PRS 42.4%
-
CSI 1.1rCSI 1.8%PRS 42.2%
-
CSI 1.1rCSI 2.6%PRS 27.4%
-
CSI 1.1rCSI 4.8%PRS 38.1%
-
CSI 1.1rCSI 2.4%PRS 16.3%
-
CSI 1.2rCSI 2.6%PRS 25.9%
-
CSI 1.2rCSI 2.9%PRS 20.5%
-
CSI 1.2rCSI 3.1%PRS 18.5%
-
CSI 1.2rCSI 3.4%PRS 17.0%
-
CSI 1.2rCSI 1.5%PRS 25.7%
-
CSI 1.2rCSI 1.4%PRS 38.4%
-
CSI 1.2rCSI 6.7%PRS 12.9%
-
CSI 1.2rCSI 1.7%PRS 50.3%
-
CSI 1.2rCSI 3.5%PRS 36.8%
-
CSI 1.2rCSI 4.1%PRS 15.9%
-
CSI 1.2rCSI 6.5%PRS 37.5%
-
CSI 1.3rCSI 3.3%PRS 28.3%
-
CSI 1.3rCSI 29.6%PRS 40.9%
-
CSI 1.3rCSI 1.9%PRS 25.1%
-
CSI 1.3rCSI 1.9%PRS 23.5%
-
CSI 1.3rCSI 1.6%PRS 33.8%
-
CSI 1.3rCSI 1.8%PRS 29.7%
-
CSI 1.3rCSI 2.9%PRS 20.5%
-
CSI 1.3rCSI 1.0%PRS 22.3%
-
CSI 1.3rCSI 2.3%PRS 21.6%
-
CSI 1.3rCSI 2.9%PRS 29.6%
-
CSI 1.3rCSI 3.5%PRS 33.5%
-
CSI 1.3rCSI 1.3%PRS 44.2%
-
CSI 1.3rCSI 1.4%PRS 26.2%
-
CSI 1.4rCSI 5.4%PRS 20.2%
-
CSI 1.4rCSI 2.0%PRS 29.0%
-
CSI 1.4rCSI 15.6%PRS 26.2%
-
CSI 1.4rCSI 1.7%PRS 19.4%
-
CSI 1.4rCSI 2.1%PRS 22.6%
-
CSI 1.4rCSI 2.8%PRS 37.1%
-
CSI 1.4rCSI 1.1%PRS 39.4%
-
CSI 1.4rCSI 4.3%PRS 32.9%
-
CSI 1.4rCSI 3.3%PRS 33.3%
-
CSI 1.4rCSI 1.9%PRS 24.3%
-
CSI 1.4rCSI 4.1%PRS 33.3%
-
CSI 1.4rCSI 2.1%PRS 34.8%
-
CSI 1.5rCSI 3.8%PRS 22.5%
-
CSI 1.5rCSI 3.0%PRS 21.7%
-
CSI 1.5rCSI 2.1%PRS 24.9%
-
CSI 1.5rCSI 3.4%PRS 29.2%
-
CSI 1.5rCSI 2.0%PRS 42.6%
-
CSI 1.5rCSI 2.2%PRS 34.5%
-
CSI 1.5rCSI 3.9%PRS 20.6%
-
CSI 1.5rCSI 1.9%PRS 28.7%
-
CSI 1.5rCSI 2.4%PRS 28.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4187673724
Symbol: LMBD1_HUMAN
Name: HDAg-L-interacting protein NESI
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15956556
Title: Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus.
PubMed ID: 15956556
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19136951
Title: Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.
PubMed ID: 19136951
DOI: 10.1038/ng.294
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 25535791
Title: Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4.
PubMed ID: 25535791
PubMed ID: 27456980
Title: Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1.
PubMed ID: 27456980
DOI: 10.1038/srep30183
PubMed ID: 28572511
Title: Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1.
PubMed ID: 28572511
PubMed ID: 33845046
Title: The lysosomal protein ABCD4 can transport vitamin B12 across liposomal membranes in vitro.
PubMed ID: 33845046
Sequence Information:
- Length: 540
- Mass: 61389
- Checksum: CC7578B0F5FD7BA6
- Sequence:
MATSGAASAE LVIGWCIFGL LLLAILAFCW IYVRKYQSRR ESEVVSTITA IFSLAIALIT SALLPVDIFL VSYMKNQNGT FKDWANANVS RQIEDTVLYG YYTLYSVILF CVFFWIPFVY FYYEEKDDDD TSKCTQIKTA LKYTLGFVVI CALLLLVGAF VPLNVPNNKN STEWEKVKSL FEELGSSHGL AALSFSISSL TLIGMLAAIT YTAYGMSALP LNLIKGTRSA AYERLENTED IEEVEQHIQT IKSKSKDGRP LPARDKRALK QFEERLRTLK KRERHLEFIE NSWWTKFCGA LRPLKIVWGI FFILVALLFV ISLFLSNLDK ALHSAGIDSG FIIFGANLSN PLNMLLPLLQ TVFPLDYILI TIIIMYFIFT SMAGIRNIGI WFFWIRLYKI RRGRTRPQAL LFLCMILLLI VLHTSYMIYS LAPQYVMYGS QNYLIETNIT SDNHKGNSTL SVPKRCDADA PEDQCTVTRT YLFLHKFWFF SAAYYFGNWA FLGVFLIGLI VSCCKGKKSV IEGVDEDSDI SDDEPSVYSA