Details for: SAR1A
Gene ID: 56681
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SAR1A
Ensembl ID: ENSG00000079332
Description: secretion associated Ras related GTPase 1A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 26.15rCSI 32.35%PRS 22.34
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CSI 14.22rCSI 21.97%PRS 23.76
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CSI 11.74rCSI 19.01%PRS 25.35
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CSI 11.57rCSI 29.92%PRS 23.41
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CSI 11.25rCSI 16.54%PRS 23.29
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CSI 10.82rCSI 20.84%PRS 54.23
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CSI 10.7rCSI 18.86%PRS 32.43
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CSI 10.48rCSI 10.3%PRS 59.45
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CSI 10.18rCSI 45.22%PRS 24.61
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CSI 10.04rCSI 13.68%PRS 54.37
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CSI 9.5rCSI 7.23%PRS 33.55
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CSI 8.42rCSI 15.94%PRS 61.39
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CSI 8.01rCSI 8.51%PRS 41.28
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CSI 7.15rCSI 78.29%PRS 42.84
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CSI 7.12rCSI 41.41%PRS 36.61
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CSI 6.81rCSI 5.54%PRS 26.49
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CSI 6.73rCSI 32.25%PRS 21.56
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CSI 6.55rCSI 12.38%PRS 50.21
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CSI 6.19rCSI 7.48%PRS 30.55
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CSI 5.61rCSI 7.05%PRS 37.93
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CSI 5.43rCSI 17.61%PRS 29.87
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CSI 5.34rCSI 17.18%PRS 26.04
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CSI 5.13rCSI 9.8%PRS 50.21
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CSI 5.03rCSI 7.69%PRS 40.14
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CSI 4.8rCSI 5.26%PRS 28.3
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CSI 4.39rCSI 3.4%PRS 24.63
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CSI 4.35rCSI 4.2%PRS 18.75
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CSI 4.22rCSI 12.15%PRS 43.88
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CSI 4.21rCSI 4.41%PRS 23.67
-
CSI 4.21rCSI 8.68%PRS 35.8
-
CSI 4.1rCSI 10.81%PRS 30.17
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CSI 4rCSI 6.39%PRS 27.74
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CSI 3.79rCSI 5.37%PRS 23.46
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CSI 3.47rCSI 17.4%PRS 33.41
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CSI 3.45rCSI 7.15%PRS 25.09
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CSI 3.39rCSI 5.94%PRS 19.61
-
CSI 3.24rCSI 20.83%PRS 49.45
-
CSI 3.16rCSI 3.93%PRS 34.81
-
CSI 3.14rCSI 3.14%PRS 21.73
-
CSI 3.14rCSI 2.92%PRS 25.34
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CSI 3.12rCSI 4.17%PRS 32.29
-
CSI 3.1rCSI 4%PRS 15.94
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CSI 3.07rCSI 3.21%PRS 25.97
-
CSI 3.03rCSI 8.7%PRS 37.87
-
CSI 2.99rCSI 17.16%PRS 36.26
-
CSI 2.99rCSI 4.14%PRS 33.7
-
CSI 2.89rCSI 6.45%PRS 29.78
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CSI 2.86rCSI 3.31%PRS 21.91
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CSI 2.78rCSI 2.2%PRS 17.44
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CSI 2.78rCSI 2.57%PRS 44.22
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CSI 2.76rCSI 4.09%PRS 28.82
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CSI 2.76rCSI 2.4%PRS 31.92
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CSI 2.76rCSI 2.51%PRS 38.12
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CSI 2.75rCSI 10.38%PRS 15.91
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CSI 2.7rCSI 2.55%PRS 26.54
-
CSI 2.66rCSI 4.6%PRS 19.42
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CSI 2.66rCSI 2.61%PRS 27.16
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CSI 2.63rCSI 3.15%PRS 42.98
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CSI 2.59rCSI 4.94%PRS 39.38
-
CSI 2.59rCSI 3.71%PRS 33.36
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CSI 2.51rCSI 1.97%PRS 30.67
-
CSI 2.5rCSI 3.84%PRS 30.44
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CSI 2.49rCSI 1.88%PRS 34.61
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CSI 2.45rCSI 1.96%PRS 43.74
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CSI 2.43rCSI 1.8%PRS 21.73
-
CSI 2.42rCSI 4.13%PRS 49.4
-
CSI 2.38rCSI 1.65%PRS 30.6
-
CSI 2.33rCSI 5.42%PRS 46.03
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CSI 2.24rCSI 2.28%PRS 35.76
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CSI 2.2rCSI 1.89%PRS 36.89
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CSI 2.18rCSI 1.93%PRS 25.61
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CSI 2.15rCSI 2.53%PRS 28.95
-
CSI 2.15rCSI 2.94%PRS 27.99
-
CSI 2.15rCSI 3.04%PRS 34.96
-
CSI 2.11rCSI 3.08%PRS 26.89
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CSI 2.07rCSI 4.02%PRS 26.07
-
CSI 2.05rCSI 1.66%PRS 25.56
-
CSI 2.05rCSI 1.79%PRS 33.28
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CSI 2.02rCSI 5.97%PRS 29.5
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CSI 2rCSI 2.66%PRS 27.79
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CSI 2rCSI 1.66%PRS 24.1
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CSI 1.99rCSI 5.82%PRS 61.76
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CSI 1.91rCSI 2.45%PRS 24.21
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CSI 1.86rCSI 2.37%PRS 29.13
-
CSI 1.84rCSI 1.38%PRS 27.16
-
CSI 1.84rCSI 2.52%PRS 46.35
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CSI 1.83rCSI 2.84%PRS 36.39
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CSI 1.79rCSI 5%PRS 38.55
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CSI 1.76rCSI 2.75%PRS 52.97
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CSI 1.76rCSI 1.8%PRS 44.2
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CSI 1.75rCSI 2.38%PRS 21.99
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CSI 1.74rCSI 1.53%PRS 29.2
-
CSI 1.74rCSI 1.25%PRS 34.79
-
CSI 1.73rCSI 2.57%PRS 29.12
-
CSI 1.72rCSI 1.43%PRS 25.77
-
CSI 1.72rCSI 1.16%PRS 31.51
-
CSI 1.69rCSI 1.32%PRS 37.13
-
CSI 1.68rCSI 4.25%PRS 19.34
-
CSI 1.66rCSI 3.76%PRS 32.44
-
CSI 1.64rCSI 2.51%PRS 25.46
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CSI 0.1rCSI 0.3%PRS 39.7%
-
CSI 0.1rCSI 0.6%PRS 36.7%
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CSI 0.1rCSI 0.9%PRS 16.0%
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CSI 0.2rCSI 1.0%PRS 43.6%
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CSI 0.3rCSI 1.7%PRS 46.4%
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CSI 0.3rCSI 2.6%PRS 61.8%
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CSI 0.3rCSI 1.8%PRS 52.1%
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CSI 0.3rCSI 8.4%PRS 84.2%
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CSI 0.3rCSI 2.5%PRS 44.6%
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CSI 0.4rCSI 8.7%PRS 45.8%
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CSI 0.4rCSI 1.9%PRS 49.0%
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CSI 0.4rCSI 1.5%PRS 14.5%
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CSI 0.4rCSI 2.5%PRS 16.1%
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CSI 0.5rCSI 2.0%PRS 41.7%
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CSI 0.5rCSI 2.5%PRS 40.8%
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CSI 0.5rCSI 14.3%PRS 50.6%
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CSI 0.5rCSI 3.2%PRS 58.3%
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CSI 0.5rCSI 2.0%PRS 41.4%
-
CSI 0.5rCSI 1.3%PRS 56.0%
-
CSI 0.5rCSI 1.1%PRS 47.6%
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CSI 0.6rCSI 1.4%PRS 37.0%
-
CSI 0.6rCSI 6.3%PRS 46.1%
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CSI 0.6rCSI 1.8%PRS 16.2%
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CSI 0.6rCSI 1.7%PRS 40.3%
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CSI 0.6rCSI 3.3%PRS 42.1%
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CSI 0.6rCSI 2.6%PRS 54.4%
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CSI 0.6rCSI 2.9%PRS 50.8%
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CSI 0.6rCSI 1.4%PRS 33.4%
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CSI 0.6rCSI 0.9%PRS 38.8%
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CSI 0.6rCSI 2.1%PRS 59.7%
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CSI 0.7rCSI 2.1%PRS 34.4%
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CSI 0.7rCSI 3.3%PRS 34.0%
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CSI 0.7rCSI 0.6%PRS 23.1%
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CSI 0.7rCSI 2.0%PRS 40.5%
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CSI 0.7rCSI 1.8%PRS 24.8%
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CSI 0.7rCSI 5.2%PRS 58.4%
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CSI 0.7rCSI 0.6%PRS 23.8%
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CSI 0.7rCSI 2.0%PRS 32.7%
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CSI 0.7rCSI 1.8%PRS 15.0%
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CSI 0.8rCSI 1.0%PRS 35.8%
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CSI 0.8rCSI 1.7%PRS 23.4%
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CSI 0.8rCSI 4.5%PRS 64.3%
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CSI 0.8rCSI 1.2%PRS 23.3%
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CSI 0.8rCSI 2.7%PRS 18.3%
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CSI 0.8rCSI 6.3%PRS 46.0%
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CSI 0.8rCSI 2.4%PRS 28.3%
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CSI 0.8rCSI 1.0%PRS 27.1%
-
CSI 0.8rCSI 1.2%PRS 37.9%
-
CSI 0.8rCSI 2.3%PRS 71.9%
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CSI 0.8rCSI 0.7%PRS 28.5%
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CSI 0.9rCSI 1.2%PRS 19.8%
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CSI 0.9rCSI 1.3%PRS 38.9%
-
CSI 0.9rCSI 2.1%PRS 36.2%
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CSI 0.9rCSI 3.1%PRS 42.1%
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CSI 0.9rCSI 1.9%PRS 37.5%
-
CSI 0.9rCSI 1.4%PRS 19.4%
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CSI 0.9rCSI 1.6%PRS 23.5%
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CSI 0.9rCSI 1.8%PRS 41.4%
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CSI 0.9rCSI 1.7%PRS 32.2%
-
CSI 0.9rCSI 1.5%PRS 21.3%
-
CSI 0.9rCSI 1.5%PRS 19.6%
-
CSI 0.9rCSI 1.7%PRS 38.3%
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CSI 0.9rCSI 10.4%PRS 65.6%
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CSI 0.9rCSI 3.4%PRS 42.2%
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CSI 1.0rCSI 0.8%PRS 44.1%
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CSI 1.0rCSI 1.6%PRS 36.8%
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CSI 1.0rCSI 0.8%PRS 29.9%
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CSI 1.0rCSI 1.4%PRS 24.7%
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CSI 1.0rCSI 0.9%PRS 26.5%
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CSI 1.0rCSI 4.1%PRS 23.6%
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CSI 1.0rCSI 1.3%PRS 32.7%
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CSI 1.0rCSI 4.0%PRS 33.9%
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CSI 1.1rCSI 1.7%PRS 21.6%
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CSI 1.1rCSI 2.2%PRS 24.2%
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CSI 1.1rCSI 5.5%PRS 69.5%
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CSI 1.1rCSI 4.2%PRS 41.1%
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CSI 1.1rCSI 1.3%PRS 15.1%
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CSI 1.1rCSI 1.3%PRS 24.6%
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CSI 1.1rCSI 1.8%PRS 29.8%
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CSI 1.1rCSI 3.2%PRS 42.6%
-
CSI 1.1rCSI 1.5%PRS 37.2%
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CSI 1.1rCSI 1.4%PRS 14.4%
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CSI 1.1rCSI 1.5%PRS 46.0%
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CSI 1.1rCSI 1.6%PRS 28.6%
-
CSI 1.1rCSI 4.7%PRS 25.7%
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CSI 1.2rCSI 1.8%PRS 42.8%
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CSI 1.2rCSI 1.0%PRS 18.5%
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CSI 1.2rCSI 3.6%PRS 36.5%
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CSI 1.2rCSI 1.8%PRS 26.0%
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CSI 1.2rCSI 2.1%PRS 21.5%
-
CSI 1.2rCSI 2.8%PRS 30.9%
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CSI 1.2rCSI 2.9%PRS 36.7%
-
CSI 1.2rCSI 2.1%PRS 40.4%
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CSI 1.2rCSI 1.9%PRS 32.5%
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CSI 1.2rCSI 2.1%PRS 15.0%
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CSI 1.2rCSI 2.1%PRS 34.0%
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CSI 1.2rCSI 30.8%PRS 58.8%
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CSI 1.3rCSI 3.1%PRS 23.6%
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CSI 1.3rCSI 1.8%PRS 28.1%
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CSI 1.3rCSI 1.4%PRS 18.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3790831924
Symbol: SAR1A_HUMAN
Name: COPII-associated small GTPase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10871277
Title: Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis.
PubMed ID: 10871277
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17005010
Title: Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells.
PubMed ID: 17005010
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19181664
Title: Distinct transport and intracellular activities of two GlcAT-P isoforms.
PubMed ID: 19181664
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23433038
Title: Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.
PubMed ID: 23433038
DOI: 10.1111/tra.12060
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 32690950
Title: STEEP mediates STING ER exit and activation of signaling.
PubMed ID: 32690950
PubMed ID: 32929276
PubMed ID: 32358066
Title: Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.
PubMed ID: 32358066
PubMed ID: 34290409
Title: SAR1B senses leucine levels to regulate mTORC1 signalling.
PubMed ID: 34290409
PubMed ID: 36369712
Title: The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
PubMed ID: 36369712
DOI: 10.1002/prot.26445
Sequence Information:
- Length: 198
- Mass: 22367
- Checksum: 38A869175CBA54F3
- Sequence:
MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID