ODF2L | ENSG00000122417 | NCBI 57489

Details for: ODF2L

Gene ID: 57489

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ODF2L

Ensembl ID: ENSG00000122417

Description: outer dense fiber of sperm tails 2 like

Cell Significance Landscape

Display Count:

Associated with

Cell projection organization
(GO:0030030)
Centriolar satellite
(GO:0034451)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Ciliary basal body
(GO:0036064)
Cytoplasm
(GO:0005737)
Negative regulation of cilium assembly
(GO:1902018)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

multi-ciliated epithelial cell CL0005012

CSI 72.22

rCSI 72.08%

PRS 21.05
ciliated epithelial cell CL0000067

CSI 64.95

rCSI 57.11%

PRS 17.96
lung ciliated cell CL1000271

CSI 63.34

rCSI 73.24%

PRS 18.2
ciliated cell CL0000064

CSI 48.18

rCSI 78.05%

PRS 24.64
ependymal cell CL0000065

CSI 40.37

rCSI 81.91%

PRS 13.3
T-helper 17 cell CL0000899

CSI 33.85

rCSI 26.88%

PRS 42.97
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 29.62

rCSI 67.52%

PRS 25.1
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 27.76

rCSI 67.47%

PRS 14.45
deuterosomal cell CL4033044

CSI 23.95

rCSI 80.98%

PRS 37.55
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 18.82

rCSI 67.73%

PRS 13.93
pvalb GABAergic cortical interneuron CL4023018

CSI 18.07

rCSI 22.49%

PRS 13.83
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 17.32

rCSI 54.17%

PRS 16.89
L6b glutamatergic cortical neuron CL4023038

CSI 16.91

rCSI 52.83%

PRS 15.61
near-projecting glutamatergic cortical neuron CL4023012

CSI 16.68

rCSI 63.03%

PRS 15.28
retinal ganglion cell CL0000740

CSI 15.37

rCSI 33.96%

PRS 17.57
transit amplifying cell CL0009010

CSI 13.48

rCSI 20.62%

PRS 39.13
lamp5 GABAergic cortical interneuron CL4023011

CSI 12.31

rCSI 20.66%

PRS 14.74
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 11.5

rCSI 67.7%

PRS 15.49
epithelial cell of lower respiratory tract CL0002632

CSI 11.36

rCSI 8.81%

PRS 23.79
sst GABAergic cortical interneuron CL4023017

CSI 10.46

rCSI 13.49%

PRS 15.38
central nervous system neuron CL2000029

CSI 10.28

rCSI 75.53%

PRS 15.36
colon goblet cell CL0009039

CSI 9.81

rCSI 23.32%

PRS 35.94
lung pericyte CL0009089

CSI 9.66

rCSI 25.5%

PRS 29.29
Schwann cell CL0002573

CSI 8.91

rCSI 25.33%

PRS 26.92
bronchial goblet cell CL1000312

CSI 8.64

rCSI 34.55%

PRS 48.26
T-helper 1 cell CL0000545

CSI 8.32

rCSI 15.01%

PRS 54.39
CD4-positive helper T cell CL0000492

CSI 8.27

rCSI 6.25%

PRS 33.59
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 8.07

rCSI 14.26%

PRS 14.53
stromal cell CL0000499

CSI 7.3

rCSI 20.52%

PRS 30.79
neuron CL0000540

CSI 7.01

rCSI 18.66%

PRS 21.23
astrocyte of the cerebral cortex CL0002605

CSI 6.98

rCSI 15.66%

PRS 15.39
blood vessel smooth muscle cell CL0019018

CSI 6.97

rCSI 56.7%

PRS 23.55
ON-bipolar cell CL0000749

CSI 6.72

rCSI 9.99%

PRS 28.54
mucosal invariant T cell CL0000940

CSI 6.24

rCSI 5.04%

PRS 36.3
brush cell of tracheobronchial tree CL0002075

CSI 6.09

rCSI 18.08%

PRS 33.74
pulmonary capillary endothelial cell CL4028001

CSI 5.83

rCSI 11.11%

PRS 38.23
melanocyte CL0000148

CSI 5.71

rCSI 4.23%

PRS 21.07
VIP GABAergic cortical interneuron CL4023016

CSI 5.11

rCSI 6.1%

PRS 14.57
retinal cone cell CL0000573

CSI 4.95

rCSI 7.97%

PRS 18.82
club cell CL0000158

CSI 4.95

rCSI 7.25%

PRS 27.5
extravillous trophoblast CL0008036

CSI 4.93

rCSI 6.1%

PRS 21.63
plasmablast CL0000980

CSI 4.91

rCSI 3.86%

PRS 29.81
cerebral cortex endothelial cell CL1001602

CSI 4.9

rCSI 8.48%

PRS 18.78
natural T-regulatory cell CL0000903

CSI 4.84

rCSI 9.16%

PRS 60.2
respiratory goblet cell CL0002370

CSI 4.67

rCSI 50.83%

PRS 45.03
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 4.65

rCSI 3.49%

PRS 60.8
CD4-positive, alpha-beta memory T cell CL0000897

CSI 4.62

rCSI 3.32%

PRS 33.73
invaginating midget bipolar cell CL4033034

CSI 4.57

rCSI 26.96%

PRS 25.93
sncg GABAergic cortical interneuron CL4023015

CSI 4.52

rCSI 7.27%

PRS 16.07
interneuron CL0000099

CSI 4.48

rCSI 8.99%

PRS 18.19
activated CD4-positive, alpha-beta T cell CL0000896

CSI 4.38

rCSI 4.05%

PRS 43.16
naive T cell CL0000898

CSI 4.36

rCSI 3.03%

PRS 34.51
enteroendocrine cell of small intestine CL0009006

CSI 4.35

rCSI 9.58%

PRS 36.5
Mueller cell CL0000636

CSI 4.32

rCSI 9.86%

PRS 21.04
myoepithelial cell CL0000185

CSI 4.18

rCSI 10.58%

PRS 30.12
skin fibroblast CL0002620

CSI 4.16

rCSI 3.59%

PRS 36.11
blood vessel endothelial cell CL0000071

CSI 4.13

rCSI 8.56%

PRS 24.29
vascular leptomeningeal cell CL4023051

CSI 4.08

rCSI 7.15%

PRS 18.9
glioblast CL0000030

CSI 4.04

rCSI 6.45%

PRS 20.91
nasal mucosa goblet cell CL0002480

CSI 3.96

rCSI 4.6%

PRS 34.89
double negative thymocyte CL0002489

CSI 3.96

rCSI 2.75%

PRS 29.63
paneth cell CL0000510

CSI 3.94

rCSI 5.82%

PRS 37.84
unswitched memory B cell CL0000970

CSI 3.92

rCSI 3.3%

PRS 38.68
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.91

rCSI 19.61%

PRS 32.47
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.89

rCSI 3.12%

PRS 42.93
mature T cell CL0002419

CSI 3.84

rCSI 2.99%

PRS 36.02
adipocyte CL0000136

CSI 3.76

rCSI 4.83%

PRS 23.64
hepatic stellate cell CL0000632

CSI 3.74

rCSI 14.03%

PRS 20.61
helper T cell CL0000912

CSI 3.71

rCSI 5.24%

PRS 34.06
pro-B cell CL0000826

CSI 3.68

rCSI 3.05%

PRS 25.04
dendritic cell, human CL0001056

CSI 3.66

rCSI 5.63%

PRS 29.56
parietal epithelial cell CL1000452

CSI 3.65

rCSI 9.76%

PRS 20.38
CD8-positive, alpha-beta thymocyte CL0000811

CSI 3.65

rCSI 5.68%

PRS 52.19
neuroblast (sensu Vertebrata) CL0000031

CSI 3.64

rCSI 4.68%

PRS 23.54
GABAergic amacrine cell CL4030027

CSI 3.63

rCSI 12.43%

PRS 21.13
radial glial cell CL0000681

CSI 3.55

rCSI 4.94%

PRS 24.86
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.46

rCSI 2.63%

PRS 32.59
perivascular cell CL4033054

CSI 3.45

rCSI 4.71%

PRS 27.67
alpha-beta T cell CL0000789

CSI 3.43

rCSI 4.01%

PRS 34.44
small intestine goblet cell CL1000495

CSI 3.4

rCSI 7.46%

PRS 32.44
lung neuroendocrine cell CL1000223

CSI 3.32

rCSI 4.91%

PRS 28.02
luminal epithelial cell of mammary gland CL0002326

CSI 3.32

rCSI 6.02%

PRS 37.21
direct pathway medium spiny neuron CL4023026

CSI 3.3

rCSI 78.97%

PRS 13.47
ON midget ganglion cell CL4033046

CSI 3.27

rCSI 66.67%

PRS 20.29
class switched memory B cell CL0000972

CSI 3.27

rCSI 2.44%

PRS 40.35
indirect pathway medium spiny neuron CL4023029

CSI 3.27

rCSI 78.87%

PRS 14.36
intestine goblet cell CL0019031

CSI 3.25

rCSI 2.88%

PRS 24.8
fallopian tube secretory epithelial cell CL4030006

CSI 3.22

rCSI 3.1%

PRS 25.43
cerebral cortex GABAergic interneuron CL0010011

CSI 3.15

rCSI 9.31%

PRS 28.68
precursor B cell CL0000817

CSI 3.14

rCSI 2.75%

PRS 32.36
OFF midget ganglion cell CL4033047

CSI 3.13

rCSI 63.68%

PRS 21.49
epithelial cell of lung CL0000082

CSI 3.12

rCSI 2.59%

PRS 23.33
pancreatic A cell CL0000171

CSI 3.06

rCSI 3.21%

PRS 26.08
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 3.06

rCSI 3.54%

PRS 21.29
fibroblast of lung CL0002553

CSI 3.06

rCSI 2.85%

PRS 24.52
enteric smooth muscle cell CL0002504

CSI 3.05

rCSI 4.35%

PRS 27.33
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.04

rCSI 1.79%

PRS 34.61
T follicular helper cell CL0002038

CSI 2.98

rCSI 2.23%

PRS 38
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 2.98

rCSI 2.92%

PRS 37.76
enteroendocrine cell CL0000164

CSI 2.87

rCSI 3.92%

PRS 27.2

mesenchymal stem cell CL0000134

CSI 0.0

rCSI 0.3%

PRS 41.7%
prostate gland microvascular endothelial cell CL2000059

CSI 0.1

rCSI 2.2%

PRS 61.2%
odontoblast CL0000060

CSI 0.1

rCSI 3.2%

PRS 70.8%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 0.9%

PRS 35.8%
vein endothelial cell of respiratory system CL4033008

CSI 0.2

rCSI 1.5%

PRS 45.4%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.2

rCSI 0.9%

PRS 39.9%
medium spiny neuron CL1001474

CSI 0.3

rCSI 2.9%

PRS 13.8%
lung goblet cell CL1000143

CSI 0.3

rCSI 3.8%

PRS 65.1%
endothelial cell of venule CL1000414

CSI 0.3

rCSI 3.1%

PRS 66.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.4

rCSI 3.7%

PRS 30.2%
H2 horizontal cell CL0004218

CSI 0.4

rCSI 1.9%

PRS 26.3%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.4

rCSI 2.1%

PRS 46.4%
Cajal-Retzius cell CL0000695

CSI 0.5

rCSI 3.7%

PRS 45.2%
diffuse bipolar 3a cell CL4033029

CSI 0.5

rCSI 3.3%

PRS 25.4%
type EC enteroendocrine cell CL0000577

CSI 0.5

rCSI 1.8%

PRS 38.8%
endothelial cell of uterus CL0009095

CSI 0.5

rCSI 3.7%

PRS 57.7%
mammary gland epithelial cell CL0002327

CSI 0.5

rCSI 1.8%

PRS 41.2%
diffuse bipolar 4 cell CL4033031

CSI 0.5

rCSI 6.2%

PRS 27.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.6

rCSI 3.4%

PRS 19.4%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.6

rCSI 6.5%

PRS 71.2%
intraepithelial lymphocyte CL0002496

CSI 0.6

rCSI 1.5%

PRS 71.2%
vasa recta descending limb cell CL1001285

CSI 0.6

rCSI 4.7%

PRS 68.5%
cone retinal bipolar cell CL0000752

CSI 0.6

rCSI 8.1%

PRS 62.0%
diffuse bipolar 1 cell CL4033027

CSI 0.6

rCSI 4.8%

PRS 25.1%
neuroendocrine cell CL0000165

CSI 0.7

rCSI 2.6%

PRS 45.0%
Hofbauer cell CL3000001

CSI 0.7

rCSI 1.3%

PRS 31.2%
diffuse bipolar 6 cell CL4033032

CSI 0.7

rCSI 3.6%

PRS 28.0%
mesangial cell CL0000650

CSI 0.7

rCSI 2.9%

PRS 34.5%
fibroblast of breast CL4006000

CSI 0.7

rCSI 3.0%

PRS 53.7%
podocyte CL0000653

CSI 0.7

rCSI 3.3%

PRS 23.9%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.8

rCSI 0.9%

PRS 29.1%
diffuse bipolar 2 cell CL4033028

CSI 0.8

rCSI 6.1%

PRS 26.1%
myeloid dendritic cell CL0000782

CSI 0.8

rCSI 1.2%

PRS 36.8%
pancreatic acinar cell CL0002064

CSI 0.9

rCSI 1.2%

PRS 26.9%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 0.9

rCSI 0.6%

PRS 30.5%
keratocyte CL0002363

CSI 0.9

rCSI 2.2%

PRS 35.2%
pancreatic ductal cell CL0002079

CSI 0.9

rCSI 1.8%

PRS 25.2%
epicardial adipocyte CL1000309

CSI 0.9

rCSI 3.0%

PRS 29.2%
pancreatic PP cell CL0002275

CSI 0.9

rCSI 3.7%

PRS 40.4%
diffuse bipolar 3b cell CL4033030

CSI 0.9

rCSI 6.2%

PRS 25.7%
type L enteroendocrine cell CL0002279

CSI 0.9

rCSI 1.8%

PRS 45.7%
intestinal tuft cell CL0019032

CSI 1.0

rCSI 1.4%

PRS 28.0%
intrahepatic cholangiocyte CL0002538

CSI 1.0

rCSI 2.4%

PRS 41.8%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.0

rCSI 2.7%

PRS 31.7%
lung secretory cell CL1000272

CSI 1.0

rCSI 2.5%

PRS 22.8%
hematopoietic multipotent progenitor cell CL0000837

CSI 1.0

rCSI 2.4%

PRS 38.5%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.1

rCSI 3.3%

PRS 35.5%
glial cell CL0000125

CSI 1.1

rCSI 4.1%

PRS 23.0%
conjunctival epithelial cell CL1000432

CSI 1.1

rCSI 1.6%

PRS 24.7%
amacrine cell CL0000561

CSI 1.1

rCSI 3.1%

PRS 19.1%
pancreatic stellate cell CL0002410

CSI 1.1

rCSI 6.3%

PRS 35.6%
midbrain dopaminergic neuron CL2000097

CSI 1.1

rCSI 7.0%

PRS 35.5%
OFF-bipolar cell CL0000750

CSI 1.1

rCSI 1.5%

PRS 36.4%
promyelocyte CL0000836

CSI 1.1

rCSI 1.6%

PRS 34.0%
alveolar adventitial fibroblast CL4028006

CSI 1.1

rCSI 1.7%

PRS 24.7%
renal principal cell CL0005009

CSI 1.1

rCSI 2.9%

PRS 30.7%
common lymphoid progenitor CL0000051

CSI 1.1

rCSI 1.5%

PRS 44.9%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.1

rCSI 3.7%

PRS 16.7%
retina horizontal cell CL0000745

CSI 1.1

rCSI 1.7%

PRS 22.7%
fraction A pre-pro B cell CL0002045

CSI 1.1

rCSI 1.3%

PRS 47.3%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.2

rCSI 2.8%

PRS 16.8%
mesodermal cell CL0000222

CSI 1.2

rCSI 1.4%

PRS 23.9%
eye photoreceptor cell CL0000287

CSI 1.2

rCSI 13.9%

PRS 53.5%
memory T cell CL0000813

CSI 1.3

rCSI 2.5%

PRS 53.1%
adventitial cell CL0002503

CSI 1.3

rCSI 3.1%

PRS 35.7%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.3

rCSI 1.8%

PRS 53.3%
cardiac muscle cell CL0000746

CSI 1.3

rCSI 1.9%

PRS 19.1%
endocardial cell CL0002350

CSI 1.3

rCSI 6.3%

PRS 29.3%
thymocyte CL0000893

CSI 1.3

rCSI 4.8%

PRS 64.8%
hepatocyte CL0000182

CSI 1.3

rCSI 2.4%

PRS 22.8%
glandular epithelial cell CL0000150

CSI 1.4

rCSI 3.6%

PRS 45.9%
mature B cell CL0000785

CSI 1.4

rCSI 1.2%

PRS 31.1%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.4

rCSI 1.8%

PRS 34.8%
IgG plasma cell CL0000985

CSI 1.4

rCSI 1.7%

PRS 41.7%
transitional stage B cell CL0000818

CSI 1.4

rCSI 4.5%

PRS 58.8%
intestinal epithelial cell CL0002563

CSI 1.4

rCSI 1.5%

PRS 25.5%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.4

rCSI 2.8%

PRS 40.3%
glycinergic amacrine cell CL4030028

CSI 1.4

rCSI 3.7%

PRS 24.5%
mesenchymal cell CL0008019

CSI 1.4

rCSI 3.6%

PRS 24.2%
renal interstitial pericyte CL1001318

CSI 1.4

rCSI 4.0%

PRS 22.9%
plasmacytoid dendritic cell, human CL0001058

CSI 1.5

rCSI 1.0%

PRS 26.2%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.5

rCSI 4.4%

PRS 36.8%
ON parasol ganglion cell CL4033052

CSI 1.5

rCSI 21.5%

PRS 19.5%
respiratory basal cell CL0002633

CSI 1.5

rCSI 1.6%

PRS 29.0%
placental villous trophoblast CL2000060

CSI 1.5

rCSI 2.4%

PRS 23.0%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.5

rCSI 1.2%

PRS 23.1%
type B pancreatic cell CL0000169

CSI 1.5

rCSI 3.4%

PRS 22.7%
cardiac endothelial cell CL0010008

CSI 1.6

rCSI 6.4%

PRS 22.8%
tuft cell of colon CL0009041

CSI 1.6

rCSI 3.7%

PRS 45.4%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.6

rCSI 4.2%

PRS 22.7%
basal cell of prostate epithelium CL0002341

CSI 1.6

rCSI 4.7%

PRS 47.6%
squamous epithelial cell CL0000076

CSI 1.7

rCSI 3.9%

PRS 30.0%
retinal pigment epithelial cell CL0002586

CSI 1.7

rCSI 3.3%

PRS 25.5%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.7

rCSI 1.5%

PRS 22.4%
common dendritic progenitor CL0001029

CSI 1.7

rCSI 2.1%

PRS 31.9%
respiratory suprabasal cell CL4033048

CSI 1.7

rCSI 2.2%

PRS 28.3%
chondrocyte CL0000138

CSI 1.7

rCSI 2.8%

PRS 20.7%
regulatory T cell CL0000815

CSI 1.7

rCSI 2.0%

PRS 57.5%
interstitial cell of Cajal CL0002088

CSI 1.8

rCSI 2.2%

PRS 28.3%
transit amplifying cell of colon CL0009011

CSI 1.8

rCSI 2.1%

PRS 28.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- Low
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ODF2L](/details-gene/57489) (Outer Dense Fiber of Sperm Tails 2 Like) is a protein-coding gene located on chromosome 1p22.3. Despite its name, which suggests a role in sperm, its expression profile and functional annotation strongly link it to the organization and regulation of cilia and centrosomes in somatic cells. The gene product is a centriolar satellite protein involved in the negative regulation of ciliogenesis. **Overall**, expression data reveals that [ODF2L](/details-gene/57489) is a highly significant marker for various types of ciliated cells, particularly [multi-ciliated epithelial cell](/details-cell/CL0005012) and [ciliated epithelial cell](/details-cell/CL0000067), where it likely plays a critical role in cellular structure and function. Its presence in specific neuronal subtypes suggests a more widespread role in centriole-based structures beyond motile cilia. ## Cellular Roles and Expression Landscape The expression pattern of [ODF2L](/details-gene/57489) highlights its central role in cells featuring cilia or related microtubule-organizing centers. **Overall**, the gene shows its highest significance in cell types characterized by motile cilia, with top scores in [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 72.22), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 64.95), and [lung ciliated cell](/details-cell/CL1000271) (CSI: 63.34). This functional grouping extends to other ciliated cell types such as [ependymal cell](/details-cell/CL0000065), which line the cerebral ventricles, and [deuterosomal cell](/details-cell/CL4033044), a precursor cell responsible for generating multiple basal bodies for ciliogenesis. This strong and consistent expression pattern establishes [ODF2L](/details-gene/57489) as a key molecular player in the formation and maintenance of ciliated tissues. Interestingly, [ODF2L](/details-gene/57489) also demonstrates significant expression in several distinct neuronal populations, including [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018). While these neurons lack motile cilia, they possess primary cilia, which are centriole-derived sensory organelles. This suggests that the function of [ODF2L](/details-gene/57489) is not limited to motile cilia but may extend to the regulation or structural support of primary cilia in the central nervous system. The highly specific expression within these cell types points towards a specialized role in establishing or maintaining their unique cellular architecture. ## Pathways and Molecular Function Functional annotations for [ODF2L](/details-gene/57489) are highly consistent with its observed cellular expression profile. The gene product is a component of the [centrosome](/details-cell/GO:0005813), [centriole](/details-cell/GO:0005814), [ciliary basal body](/details-cell/GO:0036064), and [centriolar satellite](/details-cell/GO:0034451), which are all structures fundamentally involved in microtubule organization and ciliogenesis. Its association with centriolar satellites is particularly noteworthy, as these structures regulate protein trafficking to and from the centrosome and cilium. Biologically, [ODF2L](/details-gene/57489) is implicated in [cell projection organization](/details-cell/GO:0030030), a broad process that includes the formation of cilia. More specifically, research has identified it as a negative regulator of cilium assembly ([GO:1902018](https://www.ebi.ac.uk/QuickGO/term/GO:1902018)). One study identified the protein, also known as BCAP, as a centriolar satellite component that acts as an inhibitor of ciliogenesis, suggesting it must be downregulated or displaced to permit cilium formation ([Link](https://doi.org/10.1242/jcs.196642)). This regulatory role is critical for controlling the timing and number of cilia produced by a cell, which is consistent with its high expression in precursor cells like the [deuterosomal cell](/details-cell/CL4033044). ## Research Directions The specific role of [ODF2L](/details-gene/57489) as a negative regulator of ciliogenesis, coupled with its high expression in terminally differentiated ciliated cells, presents an intriguing paradox and suggests several avenues for future research. **Proposed Hypotheses:** 1. Given its established role as an inhibitor of ciliogenesis, the persistent high expression of [ODF2L](/details-gene/57489) in mature [multi-ciliated epithelial cell](/details-cell/CL0005012) may indicate a functional switch. After ciliogenesis is complete, [ODF2L](/details-gene/57489) may be repurposed as a structural component that stabilizes the basal body or ciliary rootlet, contributing to the long-term maintenance and integrity of the ciliary apparatus. 2. The significant expression of [ODF2L](/details-gene/57489) in specific neuronal subtypes like [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) suggests a role in regulating the function of primary cilia. It is hypothesized that [ODF2L](/details-gene/57489) modulates the length or protein composition of the primary cilium in these neurons, thereby influencing their ability to sense extracellular signals and regulate neuronal excitability or synaptic plasticity. **Experimental Approach:** To test the first hypothesis regarding a dual role for [ODF2L](/details-gene/57489) in ciliary maintenance, one could utilize an in vitro air-liquid interface (ALI) culture system with primary human bronchial epithelial cells. A conditional knockout of [ODF2L](/details-gene/57489) could be induced *after* the cells have fully differentiated and formed motile cilia. The structural integrity of the cilia could then be assessed over time using transmission electron microscopy, while ciliary function could be measured by analyzing ciliary beat frequency and pattern with high-speed video microscopy. A progressive degradation of ciliary structure or function post-knockout would support a maintenance role for [ODF2L](/details-gene/57489). **Therapeutic Potential:** As a structural and regulatory protein primarily expressed in healthy, specialized cell types, [ODF2L](/details-gene/57489) is not an obvious target for inhibitory small-molecule drugs. However, its fundamental role in ciliogenesis makes it a gene of interest for inherited disorders known as ciliopathies, such as Primary Ciliary Dyskinesia (PCD). Mutations in [ODF2L](/details-gene/57489) could be a potential monogenic cause of ciliopathies. Therefore, its primary clinical relevance may lie in genetic diagnostics for patients with unexplained PCD-like symptoms. Further investigation could also explore its potential as a target for gene-therapy approaches aimed at restoring proper ciliary function in such disorders.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Outer dense fiber protein 2-like

Genular Protein ID: 2844820784

Symbol: ODF2L_HUMAN

Name: Outer dense fiber protein 2-like

UniProtKB Accession Codes:

Q9ULJ1 A8MU56 B4E037 Q05C40 Q5BJG5 Q5TBX3 Q5TBX4 Q86X31

Database IDs:

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17485331

Title: Identification of BCAP, a new protein associated with basal bodies and centrioles.

PubMed ID: 17485331

DOI: 10.2741/2344

PubMed ID: 28775150

Title: BCAP is a centriolar satellite protein and inhibitor of ciliogenesis.

PubMed ID: 28775150

DOI: 10.1242/jcs.196642

Sequence Information:

Length: 636
Mass: 73728
Checksum: D74FAB4F22F21581
Sequence:

MEKAVNDGSH SEELFCHLKT ISEKEDLPRC TSESHLSCLK QDILNEKTEL EATLKEAELV 
THSVELLLPL FKDTIEKINF ENANLSALNL KISEQKEILI KELDTFKSVK LALEHLLRKR 
DYKQTGDNLS SMLLENLTDN ESENTNLKKK VFEKEAHIQE LSCLFQSEKA NTLKANRFSQ 
SVKVVHERLQ IQIHKREAEN DKLKEYVKSL ETKIAKWNLQ SRMNKNEAIV MKEASRQKTV 
ALKKASKVYK QRLDHFTGAI EKLTSQIRDQ EAKLSETISA SNAWKSHYEK IVIEKTELEV 
QIETMKKQII NLLEDLKKME DHGKNSCEEI LRKVHSIEYE NETLNLENTK LKLRFPCRIT 
ESKNMNILIV LDMLCYISSE KTTLAALKDE VVSVENELSE LQEVEKKQKT LIEMYKTQVQ 
KLQEAAEIVK SRCENLLHKN NQITKTKNKN VEKMRGQMES HLKELERVCD SLTAAERRLH 
ECQESLQCCK GKCADQEHTI RELQGQVDGN HNLLTKLSLE EENCLIQLKC ENLQQKLEQM 
DAENKELEKK LANQEECLKH SNLKFKEKSA EYTALARQLE AALEEGRQKV AEEIEKMSSR 
ESALQIKILD LETELRKKNE EQNQLVCKMN SDPETP

Details for: ODF2L

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10574462

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334