Details for: SVIL

Gene ID: 6840

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SVIL

Ensembl ID: ENSG00000197321

Description: supervillin

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac muscle cell CL0000746
    CSI 53.44
    rCSI 76.69%
    PRS 40.98
  • conjunctival epithelial cell CL1000432
    CSI 31.29
    rCSI 47.79%
    PRS 51.06
  • regular atrial cardiac myocyte CL0002129
    CSI 28.24
    rCSI 90.91%
    PRS 49.22
  • enteric smooth muscle cell CL0002504
    CSI 26.44
    rCSI 37.73%
    PRS 52.89
  • mucosal invariant T cell CL0000940
    CSI 24.19
    rCSI 19.55%
    PRS 60.39
  • keratocyte CL0002363
    CSI 23.07
    rCSI 55.47%
    PRS 59.75
  • adipocyte CL0000136
    CSI 21.2
    rCSI 27.22%
    PRS 44.85
  • vascular leptomeningeal cell CL4023051
    CSI 20.53
    rCSI 35.99%
    PRS 42.5
  • stromal cell of ovary CL0002132
    CSI 19.12
    rCSI 52.52%
    PRS 65.49
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 17.97
    rCSI 56.2%
    PRS 37.45
  • rod bipolar cell CL0000751
    CSI 17.68
    rCSI 31.77%
    PRS 43.69
  • duct epithelial cell CL0000068
    CSI 17.44
    rCSI 25.52%
    PRS 53.81
  • epicardial adipocyte CL1000309
    CSI 17.28
    rCSI 56.24%
    PRS 51.78
  • myoepithelial cell CL0000185
    CSI 14.28
    rCSI 36.13%
    PRS 58.7
  • fast muscle cell CL0000190
    CSI 13.61
    rCSI 53.19%
    PRS 58.05
  • retinal ganglion cell CL0000740
    CSI 13.17
    rCSI 29.1%
    PRS 37.89
  • regular ventricular cardiac myocyte CL0002131
    CSI 13.16
    rCSI 82.2%
    PRS 42.57
  • lung secretory cell CL1000272
    CSI 12.98
    rCSI 32.12%
    PRS 48.28
  • retinal blood vessel endothelial cell CL0002585
    CSI 12.33
    rCSI 19.69%
    PRS 54.39
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 12.05
    rCSI 8.46%
    PRS 70.85
  • microcirculation associated smooth muscle cell CL0008035
    CSI 11.67
    rCSI 33.8%
    PRS 52.55
  • parietal epithelial cell CL1000452
    CSI 11.35
    rCSI 30.32%
    PRS 42.44
  • acinar cell CL0000622
    CSI 11.3
    rCSI 16.57%
    PRS 61.87
  • glioblast CL0000030
    CSI 11
    rCSI 17.55%
    PRS 43.94
  • epithelial cell of proximal tubule CL0002306
    CSI 10.89
    rCSI 26.6%
    PRS 45.3
  • sncg GABAergic cortical interneuron CL4023015
    CSI 10.68
    rCSI 17.18%
    PRS 35.82
  • GABAergic neuron CL0000617
    CSI 10.51
    rCSI 35.21%
    PRS 37.39
  • blood vessel endothelial cell CL0000071
    CSI 9.73
    rCSI 20.18%
    PRS 47.94
  • muscle cell CL0000187
    CSI 9.7
    rCSI 19.92%
    PRS 71.25
  • lung neuroendocrine cell CL1000223
    CSI 9.65
    rCSI 14.27%
    PRS 55.77
  • extravillous trophoblast CL0008036
    CSI 9.56
    rCSI 11.83%
    PRS 46.21
  • pulmonary capillary endothelial cell CL4028001
    CSI 9.52
    rCSI 18.15%
    PRS 67.07
  • brush cell of tracheobronchial tree CL0002075
    CSI 9.51
    rCSI 28.23%
    PRS 60.96
  • group 3 innate lymphoid cell CL0001071
    CSI 9.38
    rCSI 7.05%
    PRS 54.62
  • retinal bipolar neuron CL0000748
    CSI 9.06
    rCSI 16.97%
    PRS 39.57
  • corneal epithelial cell CL0000575
    CSI 9.05
    rCSI 25.9%
    PRS 66.11
  • cardiac endothelial cell CL0010008
    CSI 8.85
    rCSI 35.72%
    PRS 48.75
  • CD4-positive helper T cell CL0000492
    CSI 8.38
    rCSI 6.34%
    PRS 63.79
  • epithelial cell CL0000066
    CSI 8
    rCSI 12.3%
    PRS 50.25
  • CD14-positive monocyte CL0001054
    CSI 7.94
    rCSI 9.89%
    PRS 61.61
  • endothelial cell of placenta CL0009092
    CSI 7.67
    rCSI 37.8%
    PRS 62.07
  • cerebral cortex endothelial cell CL1001602
    CSI 7.35
    rCSI 12.71%
    PRS 40.82
  • vascular associated smooth muscle cell CL0000359
    CSI 6.9
    rCSI 22.38%
    PRS 52.61
  • pulmonary ionocyte CL0017000
    CSI 6.85
    rCSI 8.34%
    PRS 58.27
  • smooth muscle cell CL0000192
    CSI 6.75
    rCSI 16.09%
    PRS 61.4
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 6.67
    rCSI 11.19%
    PRS 33.71
  • ciliated cell CL0000064
    CSI 6.54
    rCSI 10.59%
    PRS 48.3
  • inhibitory interneuron CL0000498
    CSI 6.5
    rCSI 15%
    PRS 40.99
  • hepatocyte CL0000182
    CSI 6.5
    rCSI 11.63%
    PRS 48.94
  • keratinocyte CL0000312
    CSI 6.41
    rCSI 5.38%
    PRS 55.39
  • chondrocyte CL0000138
    CSI 6.27
    rCSI 9.98%
    PRS 43.03
  • pancreatic ductal cell CL0002079
    CSI 6.21
    rCSI 12.07%
    PRS 52.64
  • invaginating midget bipolar cell CL4033034
    CSI 6.02
    rCSI 35.52%
    PRS 46.65
  • luminal cell of prostate epithelium CL0002340
    CSI 6.01
    rCSI 32.34%
    PRS 65.09
  • Mueller cell CL0000636
    CSI 5.95
    rCSI 13.58%
    PRS 43.24
  • skin fibroblast CL0002620
    CSI 5.91
    rCSI 5.09%
    PRS 57.79
  • perivascular cell CL4033054
    CSI 5.89
    rCSI 8.06%
    PRS 55.68
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 5.85
    rCSI 6.76%
    PRS 44.47
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 5.83
    rCSI 22.04%
    PRS 34.57
  • placental villous trophoblast CL2000060
    CSI 5.73
    rCSI 8.85%
    PRS 48.22
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 5.64
    rCSI 6.81%
    PRS 58.54
  • secretory cell CL0000151
    CSI 5.56
    rCSI 5.8%
    PRS 50.92
  • lung macrophage CL1001603
    CSI 5.43
    rCSI 12.12%
    PRS 57.4
  • granulocyte monocyte progenitor cell CL0000557
    CSI 5.42
    rCSI 4.69%
    PRS 54.74
  • ependymal cell CL0000065
    CSI 5.41
    rCSI 10.98%
    PRS 31.85
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 5.36
    rCSI 19.3%
    PRS 32.48
  • transit amplifying cell of colon CL0009011
    CSI 5.36
    rCSI 6.29%
    PRS 53.57
  • fibroblast of cardiac tissue CL0002548
    CSI 5.35
    rCSI 25.63%
    PRS 49.28
  • melanocyte CL0000148
    CSI 5.15
    rCSI 3.81%
    PRS 43.43
  • S cone cell CL0003050
    CSI 5.11
    rCSI 22.46%
    PRS 47.54
  • ciliated epithelial cell CL0000067
    CSI 5.06
    rCSI 4.45%
    PRS 39.14
  • colon goblet cell CL0009039
    CSI 4.99
    rCSI 11.86%
    PRS 61.55
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 4.98
    rCSI 5.07%
    PRS 64.05
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.96
    rCSI 6.37%
    PRS 48.29
  • myofibroblast cell CL0000186
    CSI 4.95
    rCSI 6.86%
    PRS 54.05
  • renal interstitial pericyte CL1001318
    CSI 4.78
    rCSI 13.18%
    PRS 46.51
  • mesodermal cell CL0000222
    CSI 4.72
    rCSI 5.66%
    PRS 48.32
  • endothelial cell of vascular tree CL0002139
    CSI 4.69
    rCSI 25.63%
    PRS 51.33
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.65
    rCSI 8.21%
    PRS 32.79
  • radial glial cell CL0000681
    CSI 4.64
    rCSI 6.45%
    PRS 49.79
  • stem cell CL0000034
    CSI 4.63
    rCSI 4.46%
    PRS 40.99
  • bronchus fibroblast of lung CL2000093
    CSI 4.51
    rCSI 3.66%
    PRS 50.92
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 4.34
    rCSI 10.56%
    PRS 32.62
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 4.32
    rCSI 5.66%
    PRS 64.07
  • ionocyte CL0005006
    CSI 4.29
    rCSI 4.59%
    PRS 48.68
  • double negative thymocyte CL0002489
    CSI 4.28
    rCSI 2.97%
    PRS 60.24
  • naive T cell CL0000898
    CSI 4.25
    rCSI 2.96%
    PRS 64.26
  • glutamatergic neuron CL0000679
    CSI 4.24
    rCSI 8.71%
    PRS 43.12
  • peripheral nervous system neuron CL2000032
    CSI 4.23
    rCSI 5.77%
    PRS 43.23
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.19
    rCSI 10.62%
    PRS 40.34
  • myeloid leukocyte CL0000766
    CSI 4.18
    rCSI 3.86%
    PRS 51.37
  • kidney interstitial fibroblast CL1000692
    CSI 4.14
    rCSI 22.02%
    PRS 44.44
  • interneuron CL0000099
    CSI 4.12
    rCSI 8.27%
    PRS 39.93
  • intestine goblet cell CL0019031
    CSI 4.08
    rCSI 3.62%
    PRS 48.94
  • basal cell of prostate epithelium CL0002341
    CSI 4.08
    rCSI 11.8%
    PRS 66.63
  • multi-ciliated epithelial cell CL0005012
    CSI 4.07
    rCSI 4.07%
    PRS 44.34
  • cardiac neuron CL0010022
    CSI 4.05
    rCSI 12.94%
    PRS 47.06
  • granulocyte CL0000094
    CSI 4.03
    rCSI 6.15%
    PRS 59.83
  • neural crest cell CL0011012
    CSI 4.02
    rCSI 3.18%
    PRS 37.74
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.96
    rCSI 5.61%
    PRS 46.95
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.2
    rCSI 5.9%
    PRS 34.1%
  • epithelial cell of urethra CL1000296
    CSI 0.3
    rCSI 6.4%
    PRS 73.7%
  • mesenchymal stem cell CL0000134
    CSI 0.3
    rCSI 2.9%
    PRS 65.7%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.3
    rCSI 1.9%
    PRS 67.1%
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.4
    rCSI 4.4%
    PRS 77.4%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.5
    rCSI 3.4%
    PRS 69.3%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 0.5
    rCSI 11.6%
    PRS 73.9%
  • medium spiny neuron CL1001474
    CSI 0.6
    rCSI 4.7%
    PRS 37.6%
  • tracheobronchial serous cell CL0019001
    CSI 0.7
    rCSI 2.9%
    PRS 66.0%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.7
    rCSI 1.2%
    PRS 66.7%
  • hair follicular keratinocyte CL2000092
    CSI 0.7
    rCSI 12.2%
    PRS 80.8%
  • mesangial cell CL0000650
    CSI 0.7
    rCSI 3.0%
    PRS 61.5%
  • squamous epithelial cell CL0000076
    CSI 0.8
    rCSI 1.9%
    PRS 55.7%
  • basophil CL0000767
    CSI 0.8
    rCSI 1.7%
    PRS 70.3%
  • bronchial goblet cell CL1000312
    CSI 0.8
    rCSI 3.3%
    PRS 70.3%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 0.9
    rCSI 6.1%
    PRS 42.3%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.9
    rCSI 2.7%
    PRS 35.1%
  • smooth muscle cell of prostate CL1000487
    CSI 0.9
    rCSI 5.1%
    PRS 72.6%
  • endothelial cell of venule CL1000414
    CSI 0.9
    rCSI 7.8%
    PRS 74.2%
  • midbrain dopaminergic neuron CL2000097
    CSI 0.9
    rCSI 5.7%
    PRS 54.7%
  • pancreatic acinar cell CL0002064
    CSI 0.9
    rCSI 1.2%
    PRS 55.7%
  • central nervous system neuron CL2000029
    CSI 0.9
    rCSI 6.8%
    PRS 37.8%
  • cell of skeletal muscle CL0000188
    CSI 1.0
    rCSI 11.0%
    PRS 80.2%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 1.0
    rCSI 8.8%
    PRS 49.8%
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.0
    rCSI 1.4%
    PRS 77.5%
  • tuft cell of colon CL0009041
    CSI 1.1
    rCSI 2.5%
    PRS 66.5%
  • glial cell CL0000125
    CSI 1.1
    rCSI 4.0%
    PRS 42.6%
  • diffuse bipolar 3b cell CL4033030
    CSI 1.1
    rCSI 7.2%
    PRS 48.3%
  • myelocyte CL0002193
    CSI 1.2
    rCSI 7.5%
    PRS 81.1%
  • stromal cell CL0000499
    CSI 1.2
    rCSI 3.3%
    PRS 48.9%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.2
    rCSI 9.6%
    PRS 44.2%
  • mucus secreting cell CL0000319
    CSI 1.2
    rCSI 2.0%
    PRS 61.3%
  • mesenchymal cell CL0008019
    CSI 1.3
    rCSI 3.2%
    PRS 45.7%
  • neuroplacodal cell CL0000032
    CSI 1.3
    rCSI 11.6%
    PRS 65.1%
  • respiratory suprabasal cell CL4033048
    CSI 1.3
    rCSI 1.7%
    PRS 55.2%
  • flat midget bipolar cell CL4033033
    CSI 1.3
    rCSI 9.3%
    PRS 44.9%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.3
    rCSI 2.1%
    PRS 51.6%
  • amacrine cell CL0000561
    CSI 1.3
    rCSI 3.8%
    PRS 41.1%
  • renal principal cell CL0005009
    CSI 1.3
    rCSI 3.4%
    PRS 54.9%
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 1.3
    rCSI 7.4%
    PRS 65.1%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.3
    rCSI 7.9%
    PRS 35.1%
  • mammary gland epithelial cell CL0002327
    CSI 1.4
    rCSI 4.8%
    PRS 65.1%
  • intestinal tuft cell CL0019032
    CSI 1.4
    rCSI 2.1%
    PRS 55.1%
  • centrilobular region hepatocyte CL0019029
    CSI 1.4
    rCSI 3.6%
    PRS 57.3%
  • promyelocyte CL0000836
    CSI 1.4
    rCSI 2.0%
    PRS 60.3%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 1.4
    rCSI 7.2%
    PRS 63.3%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.4
    rCSI 3.6%
    PRS 46.1%
  • serous secreting cell CL0000313
    CSI 1.4
    rCSI 7.0%
    PRS 81.8%
  • common myeloid progenitor CL0000049
    CSI 1.4
    rCSI 1.1%
    PRS 51.3%
  • GABAergic interneuron CL0011005
    CSI 1.4
    rCSI 22.1%
    PRS 54.9%
  • promonocyte CL0000559
    CSI 1.5
    rCSI 2.5%
    PRS 59.9%
  • brush cell CL0002204
    CSI 1.5
    rCSI 2.9%
    PRS 72.9%
  • ventricular cardiac muscle cell CL2000046
    CSI 1.5
    rCSI 5.0%
    PRS 79.4%
  • paneth cell CL0000510
    CSI 1.5
    rCSI 2.2%
    PRS 67.8%
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 1.5
    rCSI 6.9%
    PRS 82.9%
  • pancreatic stellate cell CL0002410
    CSI 1.6
    rCSI 9.4%
    PRS 60.9%
  • tissue-resident macrophage CL0000864
    CSI 1.6
    rCSI 7.5%
    PRS 67.8%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.6
    rCSI 9.4%
    PRS 51.1%
  • kidney collecting duct intercalated cell CL1001432
    CSI 1.6
    rCSI 11.7%
    PRS 52.4%
  • interstitial cell of Cajal CL0002088
    CSI 1.6
    rCSI 2.1%
    PRS 56.2%
  • neural progenitor cell CL0011020
    CSI 1.7
    rCSI 7.3%
    PRS 42.9%
  • respiratory hillock cell CL4030023
    CSI 1.7
    rCSI 3.0%
    PRS 65.6%
  • fibroblast of breast CL4006000
    CSI 1.7
    rCSI 7.1%
    PRS 68.9%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.8
    rCSI 18.7%
    PRS 50.2%
  • myeloid dendritic cell CL0000782
    CSI 1.8
    rCSI 2.6%
    PRS 66.9%
  • airway submucosal gland duct basal cell CL4033024
    CSI 1.8
    rCSI 11.5%
    PRS 64.4%
  • skeletal muscle satellite stem cell CL0008011
    CSI 1.8
    rCSI 8.2%
    PRS 71.1%
  • Bergmann glial cell CL0000644
    CSI 1.9
    rCSI 2.5%
    PRS 45.6%
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 1.9
    rCSI 14.3%
    PRS 64.5%
  • respiratory basal cell CL0002633
    CSI 1.9
    rCSI 2.0%
    PRS 56.3%
  • diffuse bipolar 3a cell CL4033029
    CSI 1.9
    rCSI 13.1%
    PRS 47.2%
  • contractile cell CL0000183
    CSI 2.0
    rCSI 5.8%
    PRS 48.6%
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.0
    rCSI 2.6%
    PRS 34.8%
  • renal beta-intercalated cell CL0002201
    CSI 2.0
    rCSI 4.8%
    PRS 51.9%
  • alveolar macrophage CL0000583
    CSI 2.0
    rCSI 3.4%
    PRS 55.9%
  • endothelial cell of lymphatic vessel CL0002138
    CSI 2.0
    rCSI 4.0%
    PRS 70.2%
  • BEST4+ enteroycte CL4030026
    CSI 2.1
    rCSI 2.6%
    PRS 52.8%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.1
    rCSI 1.6%
    PRS 49.7%
  • lung pericyte CL0009089
    CSI 2.2
    rCSI 5.7%
    PRS 58.6%
  • mononuclear phagocyte CL0000113
    CSI 2.2
    rCSI 4.7%
    PRS 54.5%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.2
    rCSI 4.9%
    PRS 48.2%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.2
    rCSI 5.9%
    PRS 58.8%
  • adventitial cell CL0002503
    CSI 2.2
    rCSI 5.2%
    PRS 60.1%
  • skeletal muscle satellite cell CL0000594
    CSI 2.3
    rCSI 6.6%
    PRS 77.0%
  • pulmonary artery endothelial cell CL1001568
    CSI 2.3
    rCSI 3.1%
    PRS 63.0%
  • endocardial cell CL0002350
    CSI 2.4
    rCSI 11.4%
    PRS 50.4%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 2.5
    rCSI 4.4%
    PRS 58.7%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.6
    rCSI 2.8%
    PRS 54.1%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.6
    rCSI 6.7%
    PRS 49.5%
  • lung ciliated cell CL1000271
    CSI 2.6
    rCSI 3.0%
    PRS 40.4%
  • colon epithelial cell CL0011108
    CSI 2.7
    rCSI 2.8%
    PRS 47.3%
  • neutrophil CL0000775
    CSI 2.7
    rCSI 15.3%
    PRS 60.7%
  • small intestine goblet cell CL1000495
    CSI 2.7
    rCSI 6.0%
    PRS 59.8%
  • intermediate monocyte CL0002393
    CSI 2.8
    rCSI 4.2%
    PRS 53.1%
  • lung endothelial cell CL1001567
    CSI 2.8
    rCSI 6.4%
    PRS 73.3%
  • basal cell CL0000646
    CSI 2.8
    rCSI 3.7%
    PRS 51.6%
  • tendon cell CL0000388
    CSI 2.9
    rCSI 7.5%
    PRS 70.8%
  • Kupffer cell CL0000091
    CSI 2.9
    rCSI 6.6%
    PRS 49.8%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 2.9
    rCSI 5.5%
    PRS 72.0%
  • transit amplifying cell CL0009010
    CSI 3.0
    rCSI 4.5%
    PRS 66.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SVIL](/details-gene/6840) encodes supervillin, a large, highly expressed protein primarily involved in the regulation of the actin cytoskeleton. Functional annotations and expression data implicate [SVIL](/details-gene/6840) as a key structural and regulatory component in cells requiring robust cytoskeletal dynamics and mechanical stability. Its expression is particularly prominent in contractile tissues, with the highest significance observed in [cardiac muscle cell](/details-cell/CL0000746)s. Beyond muscle, it is also a significant gene in various epithelial, stromal, and specialized cell types, suggesting a fundamental role in cell adhesion, motility, and division across diverse biological contexts. Research also points to nuclear functions, including a role in cell survival signaling by suppressing p53 ([Link](https://doi.org/10.1074/jbc.m112.416842)). ## Cellular Roles and Expression Landscape The expression profile of [SVIL](/details-gene/6840) highlights its central role in tissues defined by their structural and contractile properties. **Overall**, the gene shows its most significant expression in [cardiac muscle cell](/details-cell/CL0000746) (CSI: 53.44) and [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 28.24), as well as [enteric smooth muscle cell](/details-cell/CL0002504) (CSI: 26.44) and [fast muscle cell](/details-cell/CL0000190) (CSI: 13.61). This pattern is consistent with the function of its muscle-specific isoform, Archvillin, as a key component of the costameric membrane skeleton, which connects the sarcomere to the cell membrane ([Link](https://doi.org/10.1242/jcs.00422), [Link](https://doi.org/10.1016/j.bbrc.2008.07.036)). Beyond muscle, [SVIL](/details-gene/6840) demonstrates significant expression in a variety of other cell types, indicating broader functions in cytoskeletal organization. High significance is noted in [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 31.29), [keratocyte](/details-cell/CL0002363) (CSI: 23.07), and [myoepithelial cell](/details-cell/CL0000185) (CSI: 14.28), cells that rely on cytoskeletal integrity for barrier function, tissue repair, and contractility. Its expression in [adipocyte](/details-cell/CL0000136)s (CSI: 21.20) and [stromal cell of ovary](/details-cell/CL0002132) (CSI: 19.12) suggests a role in maintaining the structure of connective and endocrine tissues. The notable expression in [mucosal invariant T cell](/details-cell/CL0000940) (CSI: 24.19) may indicate a function in immune cell migration or activation, processes heavily dependent on actin dynamics. ## Pathways and Molecular Function The functions of [SVIL](/details-gene/6840) are intrinsically linked to its role as a versatile actin-binding protein. Its molecular functions include direct [actin filament binding](/details-gene/GO:0051015) ([GO:0051015](https://www.ebi.ac.uk/QuickGO/term/GO:0051015)) and the ability to modulate cytoskeletal structure through [actin filament severing](/details-gene/GO:0051014) ([GO:0051014](https://www.ebi.ac.uk/QuickGO/term/GO:0051014)) and [barbed-end actin filament capping](/details-gene/GO:0051016) ([GO:0051016](https://www.ebi.ac.uk/QuickGO/term/GO:0051016)). These activities are crucial for the biological processes of [actin polymerization or depolymerization](/details-gene/GO:0008154) ([GO:0008154](https://www.ebi.ac.uk/QuickGO/term/GO:0008154)). Consistent with its expression profile, [SVIL](/details-gene/6840) is annotated for involvement in [skeletal muscle tissue development](/details-gene/GO:0007519) ([GO:0007519](https://www.ebi.ac.uk/QuickGO/term/GO:0007519)) and is a component of the [costamere](/details-gene/GO:0043034) ([GO:0043034](https://www.ebi.ac.uk/QuickGO/term/GO:0043034)), a critical structure for force transmission in muscle cells. Its localization to the [actin cytoskeleton](/details-gene/GO:0015629) ([GO:0015629](https://www.ebi.ac.uk/QuickGO/term/GO:0015629)), [focal adhesion](/details-gene/GO:0005925) ([GO:0005925](https://www.ebi.ac.uk/QuickGO/term/GO:0005925)) sites, and [cell projection](/details-gene/GO:0042995)s ([GO:0042995](https://www.ebi.ac.uk/QuickGO/term/GO:0042995)) underpins its role in cell adhesion and migration. Indeed, studies have shown that [SVIL](/details-gene/6840) can reorganize the actin cytoskeleton to increase the efficiency of invadopodia, which are structures involved in cell invasion ([Link](https://doi.org/10.1091/mbc.e08-08-0867)). Furthermore, [SVIL](/details-gene/6840) plays a role in cell division, as indicated by its involvement in the [positive regulation of cytokinesis](/details-gene/GO:0032467) ([GO:0032467](https://www.ebi.ac.uk/QuickGO/term/GO:0032467)) and its localization to the [cleavage furrow](/details-gene/GO:0032154) ([GO:0032154](https://www.ebi.ac.uk/QuickGO/term/GO:0032154)) and [midbody](/details-gene/GO:0030496) ([GO:0030496](https://www.ebi.ac.uk/QuickGO/term/GO:0030496)). A less canonical function is suggested by its presence in the [nucleus](/details-gene/GO:0005634) ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)) and its reported ability to suppress the p53 tumor suppressor protein, thereby promoting cell survival ([Link](https://doi.org/10.1074/jbc.m112.416842)). ## Research Directions The diverse functions of [SVIL](/details-gene/6840) in both structural maintenance and dynamic cellular processes present several avenues for future investigation. Its high significance in muscle, coupled with its roles in cell survival and invasion, suggests it may be a key player in both physiological adaptation and pathological conditions. ### Proposed Hypotheses 1. **Hypothesis:** Given its crucial role in costameres and its extremely high significance in [cardiac muscle cell](/details-cell/CL0000746)s, genetic variants or dysregulation of [SVIL](/details-gene/6840) may contribute to the pathogenesis of inherited or stress-induced cardiomyopathies by compromising the structural integrity of the cardiomyocyte cytoskeleton. 2. **Hypothesis:** Based on its demonstrated role in enhancing invadopodia and suppressing p53 ([Link](https://doi.org/10.1091/mbc.e08-08-0867), [Link](https://doi.org/10.1074/jbc.m112.416842)), overexpression of [SVIL](/details-gene/6840) in epithelial-derived cancers likely promotes a metastatic phenotype by coordinating cytoskeletal changes required for invasion while simultaneously providing a survival advantage. ### Experimental Approach To test the role of [SVIL](/details-gene/6840) in cardiac pathology (Hypothesis 1), a conditional knockout mouse model could be generated using a Cre-Lox system with a cardiac-specific driver (e.g., Myh6-Cre). These mice, along with wild-type littermates, would be subjected to a pressure-overload model of cardiac hypertrophy, such as transverse aortic constriction (TAC). Cardiac function could be serially monitored via echocardiography. Post-mortem analysis would involve histology to assess fibrosis and myocyte size, and immunofluorescence microscopy to examine the integrity of costameric structures by staining for key proteins like dystrophin, vinculin, and desmin. ### Therapeutic Potential The potential of [SVIL](/details-gene/6840) as a therapeutic target appears most promising in the context of oncology. Its functions in promoting cell invasion and suppressing apoptosis suggest it acts as a pro-tumorigenic factor. Therefore, therapeutic strategies would likely focus on **inhibition**. Because supervillin is an intracellular protein, developing small molecule inhibitors designed to disrupt its binding to F-actin or its interaction with signaling partners could be a viable strategy to reduce the metastatic potential of cancer cells. Such an approach would require careful consideration of on-target toxicity, particularly in muscle tissues where [SVIL](/details-gene/6840) is highly expressed.

Genular Protein ID: 866758052

Symbol: SVIL_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9867483

Title: Cloning, characterization, and chromosomal localization of human supervillin (SVIL).

PubMed ID: 9867483

DOI: 10.1006/geno.1998.5466

PubMed ID: 12711699

Title: Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton.

PubMed ID: 12711699

DOI: 10.1242/jcs.00422

PubMed ID: 23382381

Title: Supervillin-mediated suppression of p53 protein enhances cell survival.

PubMed ID: 23382381

DOI: 10.1074/jbc.m112.416842

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18639526

Title: Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-terminus.

PubMed ID: 18639526

DOI: 10.1016/j.bbrc.2008.07.036

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19109420

Title: Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.

PubMed ID: 19109420

DOI: 10.1091/mbc.e08-08-0867

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 32779703

Title: Loss of supervillin causes myopathy with myofibrillar disorganization and autophagic vacuoles.

PubMed ID: 32779703

DOI: 10.1093/brain/awaa206

PubMed ID: 19683541

Title: How to arm a supervillin: designing F-actin binding activity into supervillin headpiece.

PubMed ID: 19683541

DOI: 10.1016/j.jmb.2009.08.018

Sequence Information:

  • Length: 2214
  • Mass: 247746
  • Checksum: 6C4793D31FCBDF7C
  • Sequence:
  • MKRKERIARR LEGIENDTQP ILLQSCTGLV THRLLEEDTP RYMRASDPAS PHIGRSNEEE 
    ETSDSSLEKQ TRSKYCTETS GVHGDSPYGS GTMDTHSLES KAERIARYKA ERRRQLAEKY 
    GLTLDPEADS EYLSRYTKSR KEPDAVEKRG GKSDKQEESS RDASSLYPGT ETMGLRTCAG 
    ESKDYALHVG DGSSDPEVLL NIENQRRGQE LSATRQAHDL SPAAESSSTF SFSGRDSSFT 
    EVPRSPKHAH SSSLQQAASR SPSFGDPQLS PEARPSTGKP KHEWFLQKDS EGDTPSLINW 
    PSRVKVREKL VKEESARNSP ELASESVTQR RHQPAPVHYV SFQSEHSAFD RVPSKAAGST 
    RQPIRGYVQP ADTGHTAKLV TPETPENASE CSWVASATQN VPKPPSLTVL EGDGRDSPVL 
    HVCESKAEEE EGEGEGEEKE EDVCFTEALE QSKKTLLALE GDGLVRSPED PSRNEDFGKP 
    AVSTVTLEHQ KELENVAQPP QAPHQPTERT GRSEMVLYIQ SEPVSQDAKP TGHNREASKK 
    RKVRTRSLSD FTGPPQLQAL KYKDPASRRE LELPSSKTEG PYGEISMLDT KVSVAQLRSA 
    FLASANACRR PELKSRVERS AEGPGLPTGV ERERGSRKPR RYFSPGESRK TSERFRTQPI 
    TSAERKESDR CTSHSETPTV DDEEKVDERA KLSVAAKRLL FREMEKSFDE QNVPKRRSRN 
    TAVEQRLRRL QDRSLTQPIT TEEVVIAATE PIPASCSGGT HPVMARLPSP TVARSAVQPA 
    RLQASAHQKA LAKDQTNEGK ELAEQGEPDS STLSLAEKLA LFNKLSQPVS KAISTRNRID 
    TRQRRMNARY QTQPVTLGEV EQVQSGKLIP FSPAVNTSVS TVASTVAPMY AGDLRTKPPL 
    DHNASATDYK FSSSIENSDS PVRSILKSQA WQPLVEGSEN KGMLREYGET ESKRALTGRD 
    SGMEKYGSFE EAEASYPILN RAREGDSHKE SKYAVPRRGS LERANPPITH LGDEPKEFSM 
    AKMNAQGNLD LRDRLPFEEK VEVENVMKRK FSLRAAEFGE PTSEQTGTAA GKTIAQTTAP 
    VSWKPQDSSE QPQEKLCKNP CAMFAAGEIK TPTGEGLLDS PSKTMSIKER LALLKKSGEE 
    DWRNRLSRRQ EGGKAPASSL HTQEAGRSLI KKRVTESRES QMTIEERKQL ITVREEAWKT 
    RGRGAANDST QFTVAGRMVK KGLASPTAIT PVASPICGKT RGTTPVSKPL EDIEARPDMQ 
    LESDLKLDRL ETFLRRLNNK VGGMHETVLT VTGKSVKEVM KPDDDETFAK FYRSVDYNMP 
    RSPVEMDEDF DVIFDPYAPK LTSSVAEHKR AVRPKRRVQA SKNPLKMLAA REDLLQEYTE 
    QRLNVAFMES KRMKVEKMSS NSNFSEVTLA GLASKENFSN VSLRSVNLTE QNSNNSAVPY 
    KRLMLLQIKG RRHVQTRLVE PRASALNSGD CFLLLSPHCC FLWVGEFANV IEKAKASELA 
    TLIQTKRELG CRATYIQTIE EGINTHTHAA KDFWKLLGGQ TSYQSAGDPK EDELYEAAII 
    ETNCIYRLMD DKLVPDDDYW GKIPKCSLLQ PKEVLVFDFG SEVYVWHGKE VTLAQRKIAF 
    QLAKHLWNGT FDYENCDINP LDPGECNPLI PRKGQGRPDW AIFGRLTEHN ETILFKEKFL 
    DWTELKRSNE KNPGELAQHK EDPRTDVKAY DVTRMVSMPQ TTAGTILDGV NVGRGYGLVE 
    GHDRRQFEIT SVSVDVWHIL EFDYSRLPKQ SIGQFHEGDA YVVKWKFMVS TAVGSRQKGE 
    HSVRAAGKEK CVYFFWQGRH STVSEKGTSA LMTVELDEER GAQVQVLQGK EPPCFLQCFQ 
    GGMVVHSGRR EEEEENVQSE WRLYCVRGEV PVEGNLLEVA CHCSSLRSRT SMVVLNVNKA 
    LIYLWHGCKA QAHTKEVGRT AANKIKEQCP LEAGLHSSSK VTIHECDEGS EPLGFWDALG 
    RRDRKAYDCM LQDPGSFNFA PRLFILSSSS GDFAATEFVY PARAPSVVSS MPFLQEDLYS 
    APQPALFLVD NHHEVYLWQG WWPIENKITG SARIRWASDR KSAMETVLQY CKGKNLKKPA 
    PKSYLIHAGL EPLTFTNMFP SWEHREDIAE ITEMDTEVSN QITLVEDVLA KLCKTIYPLA 
    DLLARPLPEG VDPLKLEIYL TDEDFEFALD MTRDEYNALP AWKQVNLKKA KGLF

Genular Protein ID: 3161805019

Symbol: A0A6I8PIX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1904
  • Mass: 213628
  • Checksum: FDF44527E80206F6
  • Sequence:
  • MKRKERIARR LEGIENDTQP ILLQSCTGLV THRLLEEDTP RYMRASDPAS PHIGRSNEEE 
    ETSDSSLEKQ TRSKYCTETS GVHGDSPYGS GTMDTHSLES KAERIARYKA ERRRQLAEKY 
    GLTLDPEADS EYLSRYTKSR KEPDAVEKRG GKSDKQEESS RDASSLYPGT ETMGLRTCAG 
    ESKDYALHVG DGSSDPEVLL NIENQRRGQE LSATRQAHDL SPAAESSSTF SFSGRDSSFT 
    EVPRSPKHAH SSSLQQAASR SPSFGDPQLS PEARPSTGKP KHEWFLQKDS EGDTPSLINW 
    PSSKSRVERS AEGPGLPTGV ERERGSRKPR RYFSPGESRK TSERFRTQPI TSAERKESDR 
    CTSHSETPTV DDEEKVDERA KLSVAAKRLL FREMEKSFDE QNVPKRRSRN TAVEQRLRRL 
    QDRSLTQPIT TEEVVIAATE PIPASCSGGT HPVMARLPSP TVARSAVQPA RLQASAHQKA 
    LAKDQTNEGK ELAEQGEPDS STLSLAEKLA LFNKLSQPVS KAISTRNRID TRQRRMNARY 
    QTQPVTLGEV EQVQSGKLIP FSPAVNTSVS TVASTVAPMY AGDLRTKPPL DHNASATDYK 
    FSSSIENSDS PVRSILKSQA WQPLVEGSEN KGMLREYGET ESKRALTGRD SGMEKYGSFE 
    EAEASYPILN RAREGDSHKE SKYAVPRRGS LERANPPITH LGDEPKEFSM AKMNAQGNLD 
    LRDRLPFEEK VEVENVMKRK FSLRAAEFGE PTSEQTGTAA GKTIAQTTAP VSWKPQDSSE 
    QPQEKLCKNP CAMFAAGEIK TPTGEGLLDS PSKTMSIKER LALLKKSGEE DWRNRLSRRQ 
    EGGKAPASSL HTQEAGRSLI KKRVTESRES QMTIEERKQL ITVREEAWKT RGRGAANDST 
    QFTVAGRMVK KGLASPTAIT PVASPICGKT RGTTPVSKPL EDIEARPDMQ LESDLKLDRL 
    ETFLRRLNNK VGGMHETVLT VTGKSVKEVM KPDDDETFAK FYRSVDYNMP RSPVEMDEDF 
    DVIFDPYAPK LTSSVAEHKR AVRPKRRVQA SKNPLKMLAA REDLLQEYTE QRLNVAFMES 
    KRMKVEKMSS NSNFSEVTLA GLASKENFSN VSLRSVNLTE QNSNNSAVPY KRLMLLQIKG 
    RRHVQTRLVE PRASALNSGD CFLLLSPHCC FLWVGEFANV IEKAKASELA TLIQTKRELG 
    CRATYIQTIE EGINTHTHAA KDFWKLLGGQ TSYQSAGDPK EDELYEAAII ETNCIYRLMD 
    DKLVPDDDYW GKIPKCSLLQ PKEVLVFDFG SEVYVWHGKE VTLAQRKIAF QLAKHLWNGT 
    FDYENCDINP LDPGECNPLI PRKGQGRPDW AIFGRLTEHN ETILFKEKFL DWTELKRSNE 
    KNPGELAQHK EDPRTDVKAY DVTRMVSMPQ TTAGTILDGV NVGRGYGLVE GHDRRQFEIT 
    SVSVDVWHIL EFDYSRLPKQ SIGQFHEGDA YVVKWKFMVS TAVGSRQKGE HSVRAAGKEK 
    CVYFFWQGRH STVSEKGTSA LMTVELDEER GAQVQVLQGK EPPCFLQCFQ GGMVVHSGRR 
    EEEEENVQSE WRLYCVRGEV PVEGNLLEVA CHCSSLRSRT SMVVLNVNKA LIYLWHGCKA 
    QAHTKEVGRT AANKIKEQCP LEAGLHSSSK VTIHECDEGS EPLGFWDALG RRDRKAYDCM 
    LQDPGSFNFA PRLFILSSSS GDFAATEFVY PARAPSVVSS MPFLQEDLYS APQPALFLVD 
    NHHEVYLWQG WWPIENKITG SARIRWASDR KSAMETVLQY CKGKNLKKPA PKSYLIHAGL 
    EPLTFTNMFP SWEHREDIAE ITEMDTEVSN QITLVEDVLA KLCKTIYPLA DLLARPLPEG 
    VDPLKLEIYL TDEDFEFALD MTRDEYNALP AWKQVNLKKA KGLF

Genular Protein ID: 4027591256

Symbol: Q569J5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 81
  • Mass: 9243
  • Checksum: B878DC8ADFCB16CB
  • Sequence:
  • MDTEVSNQIT LVEDVLAKLC KTIYPLADLL ARPLPEGVDP LKLEIYLTDE DFEFALDMTR 
    DEYNALPAWK QVNLKKAKGL F