Details for: PARP8
Gene ID: 79668
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PARP8
Ensembl ID: ENSG00000151883
Description: poly(ADP-ribose) polymerase family member 8
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 34.83rCSI 41.61%PRS 29.81
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CSI 32.68rCSI 52.56%PRS 31.95
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CSI 28.08rCSI 68.24%PRS 29
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CSI 24.27rCSI 58.05%PRS 34.85
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CSI 24.07rCSI 75.24%PRS 31.07
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CSI 23.84rCSI 18.55%PRS 62.22
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CSI 23.35rCSI 57.8%PRS 43.34
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CSI 21.79rCSI 47.27%PRS 35.78
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CSI 21.43rCSI 70.42%PRS 34.37
-
CSI 20.27rCSI 26.13%PRS 30.76
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CSI 19.44rCSI 24.19%PRS 28.35
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CSI 19.44rCSI 69.96%PRS 28.76
-
CSI 18.14rCSI 13.72%PRS 57.66
-
CSI 17.41rCSI 22.26%PRS 76.47
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CSI 16.07rCSI 23.52%PRS 48.41
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CSI 15.75rCSI 31.96%PRS 28.12
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CSI 15.55rCSI 48.64%PRS 33.34
-
CSI 15.03rCSI 38.89%PRS 75.41
-
CSI 15.03rCSI 11.22%PRS 63.77
-
CSI 14.25rCSI 16.03%PRS 61.7
-
CSI 14.21rCSI 22.67%PRS 39.29
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CSI 12.68rCSI 33.78%PRS 37.6
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CSI 12.34rCSI 72.68%PRS 31.22
-
CSI 11.54rCSI 13.83%PRS 64.43
-
CSI 10.55rCSI 19.77%PRS 35.3
-
CSI 10.5rCSI 35.96%PRS 36.86
-
CSI 10.22rCSI 13.68%PRS 74.31
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CSI 9.77rCSI 6.8%PRS 58.17
-
CSI 9.64rCSI 7.79%PRS 55.87
-
CSI 9.38rCSI 68.98%PRS 33.57
-
CSI 9.22rCSI 8.08%PRS 54.96
-
CSI 9.1rCSI 6.53%PRS 58.28
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CSI 8.88rCSI 20.31%PRS 44.72
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CSI 8.86rCSI 33.47%PRS 30.78
-
CSI 8.31rCSI 13.12%PRS 46.36
-
CSI 8.27rCSI 14.61%PRS 28.89
-
CSI 8.14rCSI 9.86%PRS 40.26
-
CSI 8.13rCSI 10.13%PRS 56.51
-
CSI 8.06rCSI 20.72%PRS 47.82
-
CSI 8.02rCSI 8.38%PRS 74.32
-
CSI 7.85rCSI 11.99%PRS 45.84
-
CSI 7.69rCSI 5.4%PRS 67.21
-
CSI 7.64rCSI 6.01%PRS 51.76
-
CSI 7.62rCSI 8.93%PRS 60.77
-
CSI 7.51rCSI 24.02%PRS 42.36
-
CSI 7.47rCSI 9.59%PRS 40.76
-
CSI 7.3rCSI 12.63%PRS 36.25
-
CSI 7.26rCSI 7.14%PRS 71.91
-
CSI 7.2rCSI 4.8%PRS 70.85
-
CSI 7.05rCSI 6.05%PRS 54.04
-
CSI 6.97rCSI 8.42%PRS 53.11
-
CSI 6.94rCSI 13.84%PRS 63.08
-
CSI 6.87rCSI 5.15%PRS 77.15
-
CSI 6.76rCSI 15.61%PRS 37.13
-
CSI 6.63rCSI 9.51%PRS 36.8
-
CSI 6.61rCSI 16.77%PRS 36.08
-
CSI 6.58rCSI 18.5%PRS 45.18
-
CSI 6.54rCSI 10.6%PRS 43.81
-
CSI 6.41rCSI 11.37%PRS 27.95
-
CSI 6.22rCSI 18.01%PRS 36.84
-
CSI 6.1rCSI 11.86%PRS 47.45
-
CSI 6.01rCSI 7.06%PRS 83.14
-
CSI 5.88rCSI 13.4%PRS 43.83
-
CSI 5.54rCSI 4.43%PRS 66.76
-
CSI 5.52rCSI 29%PRS 42.32
-
CSI 5.47rCSI 5.37%PRS 60.73
-
CSI 5.46rCSI 4.04%PRS 38.92
-
CSI 5.35rCSI 12.86%PRS 55.4
-
CSI 5.3rCSI 4.59%PRS 49.04
-
CSI 5.25rCSI 4.42%PRS 62.6
-
CSI 5.14rCSI 4.52%PRS 34.69
-
CSI 5.13rCSI 3.82%PRS 58.59
-
CSI 5.13rCSI 3.91%PRS 56.66
-
CSI 4.97rCSI 28.65%PRS 47.03
-
CSI 4.95rCSI 3.92%PRS 33.3
-
CSI 4.94rCSI 3.83%PRS 45.81
-
CSI 4.79rCSI 9.61%PRS 35.37
-
CSI 4.63rCSI 4.28%PRS 65.35
-
CSI 4.53rCSI 11.82%PRS 44.38
-
CSI 4.53rCSI 5.4%PRS 65.65
-
CSI 4.5rCSI 6.16%PRS 41.55
-
CSI 4.5rCSI 30.63%PRS 43.08
-
CSI 4.48rCSI 13.31%PRS 56.71
-
CSI 4.32rCSI 3.43%PRS 67.37
-
CSI 4.24rCSI 20.31%PRS 46.59
-
CSI 4.19rCSI 4.37%PRS 45.92
-
CSI 4.14rCSI 7.43%PRS 38.84
-
CSI 4.11rCSI 9.32%PRS 50.63
-
CSI 4.08rCSI 14.77%PRS 64.49
-
CSI 4.01rCSI 3.32%PRS 46.27
-
CSI 3.96rCSI 8.72%PRS 49.18
-
CSI 3.94rCSI 2.74%PRS 53.94
-
CSI 3.94rCSI 5.85%PRS 47.82
-
CSI 3.91rCSI 6.23%PRS 38.47
-
CSI 3.88rCSI 15.19%PRS 22.65
-
CSI 3.86rCSI 10.63%PRS 42.05
-
CSI 3.85rCSI 22.76%PRS 42.49
-
CSI 3.76rCSI 8.39%PRS 51.86
-
CSI 3.74rCSI 6.55%PRS 37.87
-
CSI 3.72rCSI 8.82%PRS 51.05
-
CSI 0.3rCSI 2.8%PRS 83.6%
-
CSI 0.4rCSI 2.7%PRS 69.6%
-
CSI 0.5rCSI 5.7%PRS 39.0%
-
CSI 0.6rCSI 4.1%PRS 41.0%
-
CSI 0.6rCSI 7.9%PRS 81.9%
-
CSI 0.6rCSI 1.1%PRS 61.6%
-
CSI 0.6rCSI 1.7%PRS 59.7%
-
CSI 0.6rCSI 2.8%PRS 32.0%
-
CSI 0.6rCSI 4.8%PRS 40.8%
-
CSI 0.7rCSI 2.9%PRS 38.9%
-
CSI 0.7rCSI 3.9%PRS 57.3%
-
CSI 0.7rCSI 2.2%PRS 47.3%
-
CSI 0.7rCSI 1.0%PRS 54.0%
-
CSI 0.7rCSI 1.6%PRS 66.0%
-
CSI 0.8rCSI 3.7%PRS 67.7%
-
CSI 0.9rCSI 2.8%PRS 44.6%
-
CSI 0.9rCSI 5.6%PRS 51.1%
-
CSI 0.9rCSI 1.7%PRS 55.6%
-
CSI 0.9rCSI 2.0%PRS 33.9%
-
CSI 0.9rCSI 7.6%PRS 40.8%
-
CSI 1.0rCSI 1.1%PRS 35.7%
-
CSI 1.0rCSI 5.2%PRS 53.5%
-
CSI 1.0rCSI 4.7%PRS 63.9%
-
CSI 1.0rCSI 2.8%PRS 54.0%
-
CSI 1.2rCSI 3.0%PRS 41.6%
-
CSI 1.2rCSI 1.0%PRS 54.8%
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CSI 1.2rCSI 2.6%PRS 55.0%
-
CSI 1.2rCSI 2.1%PRS 53.9%
-
CSI 1.2rCSI 1.9%PRS 43.1%
-
CSI 1.3rCSI 1.0%PRS 44.2%
-
CSI 1.3rCSI 6.0%PRS 42.7%
-
CSI 1.3rCSI 1.8%PRS 66.1%
-
CSI 1.3rCSI 11.3%PRS 33.1%
-
CSI 1.4rCSI 1.7%PRS 55.1%
-
CSI 1.4rCSI 3.1%PRS 42.7%
-
CSI 1.4rCSI 1.4%PRS 39.6%
-
CSI 1.4rCSI 2.2%PRS 52.4%
-
CSI 1.5rCSI 2.2%PRS 61.5%
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CSI 1.5rCSI 2.6%PRS 66.0%
-
CSI 1.5rCSI 4.0%PRS 50.3%
-
CSI 1.5rCSI 6.6%PRS 60.7%
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CSI 1.5rCSI 1.4%PRS 52.7%
-
CSI 1.6rCSI 3.0%PRS 75.1%
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CSI 1.6rCSI 4.2%PRS 44.9%
-
CSI 1.6rCSI 1.5%PRS 36.2%
-
CSI 1.6rCSI 12.4%PRS 43.0%
-
CSI 1.6rCSI 3.1%PRS 78.7%
-
CSI 1.6rCSI 2.3%PRS 42.4%
-
CSI 1.7rCSI 9.2%PRS 62.8%
-
CSI 1.7rCSI 11.2%PRS 44.1%
-
CSI 1.7rCSI 3.7%PRS 59.7%
-
CSI 1.7rCSI 4.5%PRS 53.1%
-
CSI 1.7rCSI 1.8%PRS 51.1%
-
CSI 1.8rCSI 5.1%PRS 62.0%
-
CSI 1.8rCSI 3.3%PRS 71.6%
-
CSI 1.8rCSI 1.5%PRS 45.9%
-
CSI 1.9rCSI 2.3%PRS 41.2%
-
CSI 1.9rCSI 2.5%PRS 50.2%
-
CSI 2.0rCSI 5.6%PRS 63.1%
-
CSI 2.0rCSI 3.2%PRS 36.2%
-
CSI 2.0rCSI 1.7%PRS 43.9%
-
CSI 2.0rCSI 6.7%PRS 33.8%
-
CSI 2.0rCSI 2.1%PRS 48.1%
-
CSI 2.1rCSI 1.5%PRS 59.9%
-
CSI 2.1rCSI 17.1%PRS 40.0%
-
CSI 2.2rCSI 9.0%PRS 46.2%
-
CSI 2.3rCSI 3.6%PRS 56.0%
-
CSI 2.3rCSI 3.5%PRS 54.6%
-
CSI 2.3rCSI 1.6%PRS 47.1%
-
CSI 2.3rCSI 2.9%PRS 48.0%
-
CSI 2.3rCSI 2.2%PRS 45.0%
-
CSI 2.3rCSI 1.4%PRS 60.6%
-
CSI 2.4rCSI 3.7%PRS 55.1%
-
CSI 2.6rCSI 12.7%PRS 44.9%
-
CSI 2.6rCSI 2.8%PRS 49.2%
-
CSI 2.7rCSI 3.6%PRS 72.9%
-
CSI 2.7rCSI 4.5%PRS 29.9%
-
CSI 2.7rCSI 6.1%PRS 30.6%
-
CSI 2.8rCSI 5.7%PRS 39.6%
-
CSI 2.8rCSI 6.6%PRS 47.4%
-
CSI 2.8rCSI 13.9%PRS 56.3%
-
CSI 2.8rCSI 5.0%PRS 39.0%
-
CSI 2.8rCSI 2.5%PRS 60.2%
-
CSI 2.8rCSI 5.8%PRS 51.3%
-
CSI 2.8rCSI 11.4%PRS 43.8%
-
CSI 2.9rCSI 16.2%PRS 57.6%
-
CSI 2.9rCSI 2.9%PRS 47.7%
-
CSI 2.9rCSI 3.0%PRS 58.5%
-
CSI 3.0rCSI 4.5%PRS 47.3%
-
CSI 3.0rCSI 4.5%PRS 50.4%
-
CSI 3.1rCSI 11.4%PRS 38.5%
-
CSI 3.1rCSI 8.0%PRS 53.4%
-
CSI 3.1rCSI 52.0%PRS 77.2%
-
CSI 3.1rCSI 4.8%PRS 72.3%
-
CSI 3.2rCSI 18.0%PRS 32.0%
-
CSI 3.3rCSI 2.5%PRS 48.8%
-
CSI 3.3rCSI 5.9%PRS 43.7%
-
CSI 3.3rCSI 9.4%PRS 45.2%
-
CSI 3.5rCSI 14.2%PRS 42.6%
-
CSI 3.5rCSI 14.0%PRS 55.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 340099364
Symbol: PARP8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 20106667
Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.
PubMed ID: 20106667
PubMed ID: 25043379
Title: Family-wide analysis of poly(ADP-ribose) polymerase activity.
PubMed ID: 25043379
DOI: 10.1038/ncomms5426
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 854
- Mass: 95871
- Checksum: D3287F5F46BA2B63
- Sequence:
MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPRSV SYSVHVSEDY PDNTYVSSSE NDEDVLVTTE PIPVIFHRIA TELRKTNDIN CCLSIKSKLQ KENGEESRQN STVEEDSEGD NDSEEFYYGG QVNYDGELHK HPQLEADLSA VREIYGPHAV SLREYGAIDD VDIDLHIDVS FLDEEIAVAW EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL GHQLKKIMQT FVTQQWKQSK EKSNCLHNKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS KSKLKSEQDG ISKTHKLLRR TCSSTVKTDD VCVTKSHRTF GRSLSSDPRA EQAMTAIKSH KLLNRPCPAA VKSEECLTLK SHRLLTRSCS GDPRCEHNTN LKPHKLLSRS YSSNLRMEEL YGLKNHKLLS KSYSSAPKSS KTELFKEPNA EGRRLSLTSG LIGILTPSSS SSSQLAPNGA KCIPVRDRGF LVQTIEFAEQ RIPVLNEYCV VCDEPHVFQN GPMLRPTVCE RELCVFAFQT LGVMNEAADE IATGAQVVDL LVSMCRSALE SPRKVVIFEP YPSVVDPNDP QMLAFNPRKK NYDRVMKALD SITSIREMTQ APYLEIKKQM DKQDPLAHPL LQWVISSNRS HIVKLPVNRQ LKFMHTPHQF LLLSSPPAKE SNFRAAKKLF GSTFAFHGSH IENWHSILRN GLVVASNTRL QLHGAMYGSG IYLSPMSSIS FGYSGMNKKQ KVSAKDEPAS SSKSSNTSQS QKKGQQSQFL QSRNLKCIAL CEVITSSDLH KHGEIWVVPN TDHVCTRFFF VYEDGQVGDA NINTQEGGIH KEILRVIGNQ TATG
Genular Protein ID: 2655741615
Symbol: E9PFI7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 833
- Mass: 93381
- Checksum: 574C4E4E3F716CD3
- Sequence:
MEPAALRCAY FRYSDSTFTF TYVGGPRSVS YSVHVSEDYP DNTYVSSSEN DEDVLVTTEP IPVIFHRIAT ELRKTNDINC CLSIKSKLQK ENGEESRQNS TVEEDSEGDN DSEEFYYGGQ VNYDGELHKH PQLEADLSAV REIYGPHAVS LREYGAIDDV DIDLHIDVSF LDEEIAVAWE VIRTEPIIVR LHCSLTQYLN GPVPTVDVFQ ISTKERFGLG HQLKKIMQTF VTQQWKQSKE KSNCLHNKKL SEKKVKSPLH LFSTLRRSPS YPPPGCGKSK SKLKSEQDGI SKTHKLLRRT CSSTVKTDDV CVTKSHRTFG RSLSSDPRAE QAMTAIKSHK LLNRPCPAAV KSEECLTLKS HRLLTRSCSG DPRCEHNTNL KPHKLLSRSY SSNLRMEELY GLKNHKLLSK SYSSAPKSSK TELFKEPNAE GRRLSLTSGL IGILTPSSSS SSQLAPNGAK CIPVRDRGFL VQTIEFAEQR IPVLNEYCVV CDEPHVFQNG PMLRPTVCER ELCVFAFQTL GVMNEAADEI ATGAQVVDLL VSMCRSALES PRKVVIFEPY PSVVDPNDPQ MLAFNPRKKN YDRVMKALDS ITSIREMTQA PYLEIKKQMD KQDPLAHPLL QWVISSNRSH IVKLPVNRQL KFMHTPHQFL LLSSPPAKES NFRAAKKLFG STFAFHGSHI ENWHSILRNG LVVASNTRLQ LHGAMYGSGI YLSPMSSISF GYSGMNKKQK VSAKDEPASS SKSSNTSQSQ KKGQQSQFLQ SRNLKCIALC EVITSSDLHK HGEIWVVPNT DHVCTRFFFV YEDGQVGDAN INTQEGGIHK EILRVIGNQT ATG
Genular Protein ID: 3904120070
Symbol: B2RB27_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 854
- Mass: 95878
- Checksum: 084E591D24AD795B
- Sequence:
MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPRSV SYSVHVSEDY PDNTYVSSSE NDEDVLVTTE PIPVIFHRIA TELRKTNDIN CCLSIKSKLQ KENGEESRQN STVEEDSEGD NDSEEFYYGG QVNYDGELHK HPQLEADLSA VREIYGPHAV SLREYGAIDD VDIDLHIDVS FLDEEIAVAW EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL GHQLKKIMQT FVTQQWKQSK EKSNCLHNKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS KSKLKSEQDG ISKTHKLLRR TCSSTVKTDD VCVTKSHRTF GRSLSSDPRA EQAMTAIKSH KLLNRPCPAA VKSEECLTLK SHRLLTRSCS GDPRCEHNTN LKPHKLLSRS YSSNLRMEEL YGLKNHKLLS KSYSSAPKSS KTELFKEPNA EGRRLSLTSG LIGILTPSSS SSSQLAPNGA KCIPVRDRGF LVQTIEFAEQ RIPVLNEYCV VCDEPHVFQN GPMLRPTVCE RELCVFAFQT LGVMNEAADE IATGAQVVDL LVSMCRSAFE SPRKVVIFEP YPSVVDPNDP QMLAFNPRKK NYDRVMKALD SITSIREMTQ APYLEIKKQM DKQDPLAHPL LQWVISSNRS HIVKLPVNRQ LKFMHTPHQF LLLSSPPAKE SNFRAAKKLF GSTFAFHGSH IENWHSILRN GLVVASNTRL QLHGAMYGSG IYLSPMSSIS FGYSGMNKKQ KVSAKDEPAS SSKSSNTSQS QKKGQQSQFL QSRNLKCIAL CEVITSSDLH KHGEIWVVPN TDHVCTRFFF VYEDGQVGDA NISTQEGGIH KEILRVIGNQ TATG