FUBP1 | ENSG00000162613 | NCBI 8880

Details for: FUBP1

Associated with

Cytoplasm
(GO:0005737)
Mrna binding
(GO:0003729)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna binding
(GO:0003723)
Single-stranded dna binding
(GO:0003697)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD4-positive helper T cell CL0000492

CSI 20.69

rCSI 15.65%

PRS 39.28
double-positive, alpha-beta thymocyte CL0000809

CSI 17.07

rCSI 17.39%

PRS 40.5
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 12.61

rCSI 15.28%

PRS 32.07
T follicular helper cell CL0002038

CSI 11.08

rCSI 8.29%

PRS 43.19
enteroendocrine cell CL0000164

CSI 10.22

rCSI 13.96%

PRS 31.98
podocyte CL0000653

CSI 10.15

rCSI 45.08%

PRS 28.19
CD14-low, CD16-positive monocyte CL0002396

CSI 9.86

rCSI 7.6%

PRS 27.57
megakaryocyte-erythroid progenitor cell CL0000050

CSI 9.37

rCSI 8.46%

PRS 26.65
IgA plasma cell CL0000987

CSI 9.01

rCSI 9.22%

PRS 48.06
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 8.4

rCSI 14.37%

PRS 50.25
parietal epithelial cell CL1000452

CSI 8.1

rCSI 21.65%

PRS 24.51
myeloid lineage restricted progenitor cell CL0000839

CSI 8.07

rCSI 41.66%

PRS 51.97
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 7.85

rCSI 13.86%

PRS 17.59
mesenchymal cell CL0008019

CSI 7.41

rCSI 18.81%

PRS 28.09
CD4-positive, alpha-beta memory T cell CL0000897

CSI 7.39

rCSI 5.3%

PRS 39.49
helper T cell CL0000912

CSI 6.82

rCSI 9.64%

PRS 38.99
goblet cell CL0000160

CSI 6.77

rCSI 6.4%

PRS 30.39
medium spiny neuron CL1001474

CSI 6.46

rCSI 55.68%

PRS 18.44
lymphoid lineage restricted progenitor cell CL0000838

CSI 6.16

rCSI 23.99%

PRS 46.45
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 6.07

rCSI 8.61%

PRS 27.17
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 5.99

rCSI 5.88%

PRS 43.17
dendritic cell, human CL0001056

CSI 5.91

rCSI 9.08%

PRS 34.5
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 5.88

rCSI 18.39%

PRS 20.61
type EC enteroendocrine cell CL0000577

CSI 5.67

rCSI 20.14%

PRS 43.85
cardiac muscle cell CL0000746

CSI 5.53

rCSI 7.94%

PRS 23.02
pulmonary alveolar type 1 cell CL0002062

CSI 5.4

rCSI 31.16%

PRS 33.82
naive T cell CL0000898

CSI 4.93

rCSI 3.43%

PRS 40.04
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 4.53

rCSI 9.03%

PRS 46.21
astrocyte of the cerebral cortex CL0002605

CSI 4.52

rCSI 10.14%

PRS 18.73
suprabasal keratinocyte CL4033013

CSI 4.51

rCSI 7.36%

PRS 16.8
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 4.45

rCSI 9.66%

PRS 22.3
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.42

rCSI 3.37%

PRS 38.13
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.24

rCSI 5.56%

PRS 40.29
Mueller cell CL0000636

CSI 4.24

rCSI 9.68%

PRS 25.04
kidney distal convoluted tubule epithelial cell CL1000849

CSI 4.13

rCSI 43.78%

PRS 33.69
sncg GABAergic cortical interneuron CL4023015

CSI 4.1

rCSI 6.59%

PRS 19.7
cerebral cortex endothelial cell CL1001602

CSI 4.09

rCSI 7.08%

PRS 22.48
pulmonary artery endothelial cell CL1001568

CSI 4.07

rCSI 5.53%

PRS 41.51
promonocyte CL0000559

CSI 3.86

rCSI 6.61%

PRS 37.98
cytotoxic T cell CL0000910

CSI 3.82

rCSI 21.88%

PRS 41.11
dopaminergic neuron CL0000700

CSI 3.7

rCSI 20.94%

PRS 18.75
GABAergic interneuron CL0011005

CSI 3.57

rCSI 56.29%

PRS 30.47
basal cell of epidermis CL0002187

CSI 3.49

rCSI 6.19%

PRS 20.74
immature B cell CL0000816

CSI 3.31

rCSI 2.46%

PRS 40.89
transit amplifying cell of colon CL0009011

CSI 3.28

rCSI 3.85%

PRS 33
cerebral cortex GABAergic interneuron CL0010011

CSI 3.24

rCSI 9.58%

PRS 33.79
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.19

rCSI 2.55%

PRS 48.74
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 3.16

rCSI 2.22%

PRS 56.58
endocardial cell CL0002350

CSI 3.15

rCSI 15.1%

PRS 33.32
epithelial cell of lower respiratory tract CL0002632

CSI 3.08

rCSI 2.39%

PRS 28.59
perivascular cell CL4033054

CSI 3.06

rCSI 4.18%

PRS 32.9
double negative thymocyte CL0002489

CSI 3.02

rCSI 2.1%

PRS 35.21
VIP GABAergic cortical interneuron CL4023016

CSI 2.98

rCSI 3.56%

PRS 17.91
precursor B cell CL0000817

CSI 2.97

rCSI 2.6%

PRS 37.62
neural progenitor cell CL0011020

CSI 2.96

rCSI 13.01%

PRS 25.78
ON-bipolar cell CL0000749

CSI 2.96

rCSI 4.39%

PRS 32.7
pulmonary ionocyte CL0017000

CSI 2.95

rCSI 3.6%

PRS 35.77
hematopoietic precursor cell CL0008001

CSI 2.95

rCSI 3.04%

PRS 44.63
naive B cell CL0000788

CSI 2.94

rCSI 2.52%

PRS 40.84
cardiac neuron CL0010022

CSI 2.91

rCSI 9.3%

PRS 25.62
activated CD8-positive, alpha-beta T cell CL0000906

CSI 2.81

rCSI 2.77%

PRS 62.08
melanocyte CL0000148

CSI 2.75

rCSI 2.04%

PRS 25.12
lung macrophage CL1001603

CSI 2.74

rCSI 6.12%

PRS 33.97
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.72

rCSI 1.6%

PRS 40.6
neural crest cell CL0011012

CSI 2.7

rCSI 2.13%

PRS 20.34
chondrocyte CL0000138

CSI 2.66

rCSI 4.22%

PRS 24.64
Bergmann glial cell CL0000644

CSI 2.62

rCSI 3.59%

PRS 28.16
mucosal invariant T cell CL0000940

CSI 2.61

rCSI 2.11%

PRS 40.87
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.6

rCSI 7.45%

PRS 42.99
renal beta-intercalated cell CL0002201

CSI 2.52

rCSI 6%

PRS 32.15
interneuron CL0000099

CSI 2.52

rCSI 5.05%

PRS 21.91
brush cell of tracheobronchial tree CL0002075

CSI 2.5

rCSI 7.42%

PRS 39.01
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.5

rCSI 4.19%

PRS 18.11
unswitched memory B cell CL0000970

CSI 2.47

rCSI 2.08%

PRS 44.32
hematopoietic stem cell CL0000037

CSI 2.47

rCSI 1.64%

PRS 33.65
colon epithelial cell CL0011108

CSI 2.44

rCSI 2.56%

PRS 27.29
fibroblast of cardiac tissue CL0002548

CSI 2.42

rCSI 11.6%

PRS 26.21
retinal rod cell CL0000604

CSI 2.42

rCSI 4.27%

PRS 28.44
indirect pathway medium spiny neuron CL4023029

CSI 2.41

rCSI 58.2%

PRS 17.98
direct pathway medium spiny neuron CL4023026

CSI 2.36

rCSI 56.55%

PRS 17.18
pulmonary capillary endothelial cell CL4028001

CSI 2.35

rCSI 4.48%

PRS 44.42
cardiac endothelial cell CL0010008

CSI 2.35

rCSI 9.47%

PRS 27.72
bronchus fibroblast of lung CL2000093

CSI 2.34

rCSI 1.9%

PRS 30.22
skeletal muscle satellite cell CL0000594

CSI 2.32

rCSI 6.78%

PRS 64.75
hepatic stellate cell CL0000632

CSI 2.29

rCSI 8.6%

PRS 24.64
pro-B cell CL0000826

CSI 2.26

rCSI 1.87%

PRS 29.59
renal alpha-intercalated cell CL0005011

CSI 2.25

rCSI 3.01%

PRS 36.34
lung pericyte CL0009089

CSI 2.23

rCSI 5.9%

PRS 34.64
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI 2.22

rCSI 5.75%

PRS 62.26
adipocyte CL0000136

CSI 2.22

rCSI 2.85%

PRS 27.71
basal cell CL0000646

CSI 2.22

rCSI 2.96%

PRS 31.23
granulocyte CL0000094

CSI 2.2

rCSI 3.35%

PRS 36.89
plasmablast CL0000980

CSI 2.17

rCSI 1.71%

PRS 34.68
ionocyte CL0005006

CSI 2.15

rCSI 2.3%

PRS 27.1
alpha-beta T cell CL0000789

CSI 2.15

rCSI 2.52%

PRS 40.77
extravillous trophoblast CL0008036

CSI 2.14

rCSI 2.65%

PRS 25.85
early lymphoid progenitor CL0000936

CSI 2.13

rCSI 1.87%

PRS 33.18
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.1

rCSI 10.54%

PRS 37.95
ciliated cell CL0000064

CSI 2.09

rCSI 3.39%

PRS 28.96
epithelial cell of lung CL0000082

CSI 2.09

rCSI 1.73%

PRS 27.85

epithelial cell of urethra CL1000296

CSI 0.1

rCSI 3.0%

PRS 61.4%
megakaryocyte CL0000556

CSI 0.1

rCSI 0.6%

PRS 45.7%
prostate gland microvascular endothelial cell CL2000059

CSI 0.2

rCSI 3.6%

PRS 63.5%
respiratory goblet cell CL0002370

CSI 0.2

rCSI 2.2%

PRS 50.5%
vein endothelial cell of respiratory system CL4033008

CSI 0.2

rCSI 1.5%

PRS 50.3%
acinar cell of salivary gland CL0002623

CSI 0.3

rCSI 5.9%

PRS 50.8%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.5%

PRS 40.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.3

rCSI 1.7%

PRS 23.6%
mesangial cell CL0000650

CSI 0.3

rCSI 1.3%

PRS 40.2%
thymocyte CL0000893

CSI 0.3

rCSI 1.2%

PRS 68.8%
myelocyte CL0002193

CSI 0.4

rCSI 2.3%

PRS 67.3%
paneth cell of colon CL0009009

CSI 0.4

rCSI 3.4%

PRS 59.4%
myeloid dendritic cell CL0000782

CSI 0.4

rCSI 0.5%

PRS 42.9%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.4

rCSI 1.2%

PRS 21.1%
pancreatic stellate cell CL0002410

CSI 0.4

rCSI 2.1%

PRS 40.7%
invaginating midget bipolar cell CL4033034

CSI 0.4

rCSI 2.3%

PRS 29.8%
H2 horizontal cell CL0004218

CSI 0.4

rCSI 2.0%

PRS 30.7%
mucus secreting cell CL0000319

CSI 0.4

rCSI 0.7%

PRS 37.3%
erythroblast CL0000765

CSI 0.5

rCSI 1.2%

PRS 42.1%
mammary gland epithelial cell CL0002327

CSI 0.5

rCSI 1.6%

PRS 45.9%
diffuse bipolar 3a cell CL4033029

CSI 0.5

rCSI 3.1%

PRS 29.3%
microcirculation associated smooth muscle cell CL0008035

CSI 0.5

rCSI 1.4%

PRS 32.2%
eosinophil CL0000771

CSI 0.5

rCSI 3.1%

PRS 62.2%
alveolar adventitial fibroblast CL4028006

CSI 0.5

rCSI 0.8%

PRS 29.6%
antibody secreting cell CL0000946

CSI 0.5

rCSI 2.1%

PRS 76.7%
type B pancreatic cell CL0000169

CSI 0.5

rCSI 1.1%

PRS 27.0%
mature alpha-beta T cell CL0000791

CSI 0.5

rCSI 1.8%

PRS 46.6%
cerebral cortex pyramidal neuron CL4023111

CSI 0.5

rCSI 3.1%

PRS 56.7%
pancreatic PP cell CL0002275

CSI 0.5

rCSI 2.0%

PRS 45.5%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.5

rCSI 1.2%

PRS 21.1%
S cone cell CL0003050

CSI 0.5

rCSI 2.3%

PRS 27.3%
GABAergic amacrine cell CL4030027

CSI 0.5

rCSI 1.8%

PRS 24.9%
diffuse bipolar 3b cell CL4033030

CSI 0.5

rCSI 3.5%

PRS 29.7%
enterocyte of epithelium of large intestine CL0002071

CSI 0.5

rCSI 2.8%

PRS 45.4%
transit amplifying cell of small intestine CL0009012

CSI 0.5

rCSI 2.3%

PRS 49.1%
primitive red blood cell CL0002355

CSI 0.5

rCSI 2.9%

PRS 44.8%
stromal cell of ovary CL0002132

CSI 0.5

rCSI 1.5%

PRS 44.9%
transitional stage B cell CL0000818

CSI 0.6

rCSI 1.9%

PRS 63.6%
intestinal crypt stem cell of colon CL0009043

CSI 0.6

rCSI 4.3%

PRS 49.2%
endothelial cell of placenta CL0009092

CSI 0.6

rCSI 2.8%

PRS 38.6%
retinal ganglion cell CL0000740

CSI 0.6

rCSI 1.4%

PRS 21.1%
deuterosomal cell CL4033044

CSI 0.7

rCSI 2.2%

PRS 41.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.7

rCSI 1.7%

PRS 22.6%
regular atrial cardiac myocyte CL0002129

CSI 0.7

rCSI 2.2%

PRS 30.0%
colon macrophage CL0009038

CSI 0.7

rCSI 3.1%

PRS 52.6%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.7

rCSI 0.8%

PRS 34.8%
paneth cell of epithelium of small intestine CL1000343

CSI 0.7

rCSI 1.9%

PRS 43.4%
germinal center B cell CL0000844

CSI 0.7

rCSI 2.0%

PRS 54.9%
natural T-regulatory cell CL0000903

CSI 0.7

rCSI 1.3%

PRS 65.3%
progenitor cell CL0011026

CSI 0.7

rCSI 1.5%

PRS 38.3%
glycinergic amacrine cell CL4030028

CSI 0.7

rCSI 1.8%

PRS 29.3%
late pro-B cell CL0002048

CSI 0.7

rCSI 1.8%

PRS 62.7%
intraepithelial lymphocyte CL0002496

CSI 0.7

rCSI 2.0%

PRS 73.8%
central nervous system neuron CL2000029

CSI 0.7

rCSI 5.3%

PRS 19.6%
GABAergic neuron CL0000617

CSI 0.7

rCSI 2.4%

PRS 21.5%
epithelial cell of proximal tubule CL0002306

CSI 0.7

rCSI 1.8%

PRS 27.8%
memory T cell CL0000813

CSI 0.7

rCSI 1.4%

PRS 58.9%
colon goblet cell CL0009039

CSI 0.7

rCSI 1.8%

PRS 41.3%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.8%

PRS 44.1%
keratocyte CL0002363

CSI 0.8

rCSI 1.8%

PRS 40.5%
L6b glutamatergic cortical neuron CL4023038

CSI 0.8

rCSI 2.4%

PRS 19.0%
Cajal-Retzius cell CL0000695

CSI 0.8

rCSI 6.2%

PRS 49.2%
OFFx cell CL4033036

CSI 0.8

rCSI 3.8%

PRS 29.9%
innate lymphoid cell CL0001065

CSI 0.8

rCSI 1.7%

PRS 39.2%
melanocyte of skin CL1000458

CSI 0.8

rCSI 1.1%

PRS 16.3%
pancreatic ductal cell CL0002079

CSI 0.8

rCSI 1.6%

PRS 30.2%
promyelocyte CL0000836

CSI 0.8

rCSI 1.2%

PRS 38.6%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.9

rCSI 3.1%

PRS 17.2%
BEST4+ enteroycte CL4030026

CSI 0.9

rCSI 1.1%

PRS 31.2%
lung neuroendocrine cell CL1000223

CSI 0.9

rCSI 1.3%

PRS 33.1%
conjunctival epithelial cell CL1000432

CSI 0.9

rCSI 1.3%

PRS 29.5%
lung ciliated cell CL1000271

CSI 0.9

rCSI 1.0%

PRS 21.9%
intestine goblet cell CL0019031

CSI 0.9

rCSI 0.8%

PRS 29.1%
pluripotent stem cell CL0002248

CSI 0.9

rCSI 26.9%

PRS 55.0%
tracheobronchial smooth muscle cell CL0019019

CSI 0.9

rCSI 1.6%

PRS 36.7%
respiratory basal cell CL0002633

CSI 0.9

rCSI 1.0%

PRS 34.1%
enteroendocrine cell of small intestine CL0009006

CSI 0.9

rCSI 2.0%

PRS 42.5%
basal cell of prostate epithelium CL0002341

CSI 0.9

rCSI 2.7%

PRS 51.8%
retinal bipolar neuron CL0000748

CSI 0.9

rCSI 1.8%

PRS 21.7%
renal interstitial pericyte CL1001318

CSI 1.0

rCSI 2.6%

PRS 27.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.0

rCSI 5.7%

PRS 19.1%
acinar cell CL0000622

CSI 1.0

rCSI 1.4%

PRS 37.9%
intestinal epithelial cell CL0002563

CSI 1.0

rCSI 1.0%

PRS 29.9%
OFF midget ganglion cell CL4033047

CSI 1.0

rCSI 19.9%

PRS 25.8%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.0

rCSI 1.8%

PRS 25.2%
renal principal cell CL0005009

CSI 1.0

rCSI 2.6%

PRS 35.3%
erythrocyte CL0000232

CSI 1.0

rCSI 2.3%

PRS 36.2%
glutamatergic neuron CL0000679

CSI 1.0

rCSI 2.1%

PRS 27.4%
retinal pigment epithelial cell CL0002586

CSI 1.0

rCSI 2.1%

PRS 29.8%
myoepithelial cell CL0000185

CSI 1.1

rCSI 2.7%

PRS 35.7%
epicardial adipocyte CL1000309

CSI 1.1

rCSI 3.5%

PRS 33.2%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.1

rCSI 4.0%

PRS 18.9%
transit amplifying cell CL0009010

CSI 1.1

rCSI 1.6%

PRS 44.8%
enteric neuron CL0007011

CSI 1.1

rCSI 15.9%

PRS 56.4%
pancreatic A cell CL0000171

CSI 1.1

rCSI 1.1%

PRS 31.0%
class switched memory B cell CL0000972

CSI 1.1

rCSI 0.8%

PRS 46.2%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.1

rCSI 2.8%

PRS 26.9%
tendon cell CL0000388

CSI 1.1

rCSI 2.9%

PRS 58.5%
amacrine cell CL0000561

CSI 1.1

rCSI 3.2%

PRS 23.2%
mesodermal cell CL0000222

CSI 1.1

rCSI 1.3%

PRS 28.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
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- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [FUBP1](/details-gene/8880) (Far Upstream Element Binding Protein 1) is a protein-coding gene located on chromosome 1p31.1. It functions as a sequence-specific, single-stranded DNA-binding protein and also exhibits RNA-binding activity. [FUBP1](/details-gene/8880) is primarily involved in the positive regulation of gene expression and transcription by RNA polymerase II. It is historically known for its role in activating the transcription of the c-myc proto-oncogene ([Link](https://doi.org/10.1101/gad.8.4.465)). Expression data indicates that [FUBP1](/details-gene/8880) has a particularly significant role in the adaptive immune system, with its highest expression levels observed in T lymphocyte populations, such as [CD4-positive helper T cell](/details-cell/CL0000492) and developing [double-positive, alpha-beta thymocyte](/details-cell/CL0000809), suggesting a critical function in T cell development and activation. ## Cellular Roles and Expression Landscape The expression profile of [FUBP1](/details-gene/8880) highlights its profound importance within the immune system, specifically in the T cell lineage. **Overall**, the gene shows the highest significance in [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 20.69) and [double-positive, alpha-beta thymocyte](/details-cell/CL0000809) (CSI: 17.07), indicating a central role in both T cell development in the thymus and the function of mature helper T cells. This pattern extends to other T cell subsets, including [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203), [T follicular helper cell](/details-cell/CL0002038), and [activated CD8-positive, alpha-beta T cell, human](/details-cell/CL0001049), which is consistent with its function as a transcriptional regulator required for cellular proliferation and differentiation. Beyond T cells, [FUBP1](/details-gene/8880) is also significantly expressed in several other distinct cell types. Its high CSI in progenitor cells, such as [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) and [myeloid lineage restricted progenitor cell](/details-cell/CL0000839), suggests a broader role in hematopoiesis. Furthermore, notable expression in highly specialized, terminally differentiated cells like [enteroendocrine cell](/details-cell/CL0000164) and [podocyte](/details-cell/CL0000653) may indicate a function in maintaining specific transcriptional programs essential for their unique cellular identities. ## Pathways and Molecular Function Functionally, [FUBP1](/details-gene/8880) is annotated as a nucleic acid-binding protein with a clear role in gene expression regulation. Its molecular functions include [single-stranded dna binding](/details-cell/GO:0003697), [mrna binding](/details-cell/GO:0003729), and general [rna binding](/details-cell/GO:0003723), as supported by early studies ([Link](https://doi.org/10.1101/gad.8.4.465)). These binding activities are integral to its primary biological process of [positive regulation of gene expression](/details-cell/GO:0010628) and [regulation of transcription by rna polymerase ii](/details-cell/GO:0006357). The protein is localized to both the [nucleus](/details-cell/GO:0005634), including the [nucleoplasm](/details-cell/GO:0005654), and the [cytoplasm](/details-cell/GO:0005737). This dual localization suggests it may shuttle between compartments to regulate transcription in the nucleus and potentially post-transcriptional processes, such as mRNA stability or translation, in the cytoplasm. Its established role as an activator of the far upstream element (FUSE) of the c-myc promoter directly links its molecular function to the control of cell cycle progression and proliferation, which is highly relevant to its expression pattern in rapidly dividing lymphocytes and progenitor cells. ## Research Directions The high and specific expression of [FUBP1](/details-gene/8880) in developing and activated T cells, combined with its known function as a transcriptional regulator of c-myc, provides a strong basis for further investigation into its role in immunology and oncology. **Testable Hypotheses:** 1. Given its high significance in [double-positive, alpha-beta thymocyte](/details-cell/CL0000809), [FUBP1](/details-gene/8880) is essential for the massive proliferative expansion and metabolic reprogramming that occurs during T cell positive selection in the thymus. Its deletion would lead to a severe block in T cell development. 2. The high expression of [FUBP1](/details-gene/8880) in memory T cell subsets, such as [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203), suggests that it is required for the maintenance of the memory cell state or for the rapid recall response upon secondary antigen exposure, potentially by maintaining an open chromatin state at key effector gene loci. **Proposed Experimental Approach:** To test the first hypothesis regarding its role in thymocyte development, a T cell-specific conditional knockout mouse model could be generated (e.g., Fubp1-floxed mice crossed with CD4-Cre mice). Thymocytes and peripheral T cells from these mice would be analyzed using flow cytometry to identify specific developmental blocks (e.g., a reduction in CD4 or CD8 single-positive thymocytes). Subsequently, sorted [double-positive, alpha-beta thymocyte](/details-cell/CL0000809) populations from knockout and wild-type mice could be subjected to RNA-sequencing and ATAC-sequencing to determine how the loss of [FUBP1](/details-gene/8880) affects the transcriptome, specifically c-myc target genes, and the chromatin accessibility landscape during this critical developmental checkpoint. **Therapeutic Potential:** As a key activator of the c-myc oncogene, [FUBP1](/details-gene/8880) represents a compelling therapeutic target, particularly in hematological malignancies like T-cell acute lymphoblastic leukemia (T-ALL) that are often dependent on high levels of c-myc. Its role as a DNA/RNA-binding protein makes it amenable to small molecule inhibition. A therapeutic strategy would likely focus on **inhibition**, aiming to disrupt the FUBP1-FUSE interaction to reduce c-myc transcription and thereby suppress cancer cell proliferation. The development of specific inhibitors could offer a more targeted approach to downregulating myc activity compared to broader, more toxic interventions.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 195025622

Symbol: FUBP1_HUMAN

Name: Far upstream element-binding protein 1

UniProtKB Accession Codes:

Q96AE4 Q12828

Database IDs:

Citations:

PubMed ID: 8125259

Title: A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif.

PubMed ID: 8125259

DOI: 10.1101/gad.8.4.465

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11222755

Title: Identification of human DNA helicase V with the far upstream element-binding protein.

PubMed ID: 11222755

DOI: 10.1093/nar/29.5.1061

PubMed ID: 12176931

Title: Large-scale proteomic analysis of the human spliceosome.

PubMed ID: 12176931

DOI: 10.1101/gr.473902

PubMed ID: 10882074

Title: The FBP interacting repressor targets TFIIH to inhibit activated transcription.

PubMed ID: 10882074

DOI: 10.1016/s1097-2765(00)80428-1

PubMed ID: 12819782

Title: Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.

PubMed ID: 12819782

DOI: 10.1038/ng1182

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 11875576

Title: Structure and dynamics of KH domains from FBP bound to single-stranded DNA.

PubMed ID: 11875576

DOI: 10.1038/4151051a

Sequence Information:

Length: 644
Mass: 67560
Checksum: 1FD422EA2FC49531
Sequence:

MADYSTVPPP SSGSAGGGGG GGGGGGVNDA FKDALQRARQ IAAKIGGDAG TSLNSNDYGY 
GGQKRPLEDG DQPDAKKVAP QNDSFGTQLP PMHQQQSRSV MTEEYKVPDG MVGFIIGRGG 
EQISRIQQES GCKIQIAPDS GGLPERSCML TGTPESVQSA KRLLDQIVEK GRPAPGFHHG 
DGPGNAVQEI MIPASKAGLV IGKGGETIKQ LQERAGVKMV MIQDGPQNTG ADKPLRITGD 
PYKVQQAKEM VLELIRDQGG FREVRNEYGS RIGGNEGIDV PIPRFAVGIV IGRNGEMIKK 
IQNDAGVRIQ FKPDDGTTPE RIAQITGPPD RCQHAAEIIT DLLRSVQAGN PGGPGPGGRG 
RGRGQGNWNM GPPGGLQEFN FIVPTGKTGL IIGKGGETIK SISQQSGARI ELQRNPPPNA 
DPNMKLFTIR GTPQQIDYAR QLIEEKIGGP VNPLGPPVPH GPHGVPGPHG PPGPPGPGTP 
MGPYNPAPYN PGPPGPAPHG PPAPYAPQGW GNAYPHWQQQ APPDPAKAGT DPNSAAWAAY 
YAHYYQQQAQ PPPAAPAGAP TTTQTNGQGD QQNPAPAGQV DYTKAWEEYY KKMGQAVPAP 
TGAPPGGQPD YSAAWAEYYR QQAAYYAQTS PQGMPQHPPA PQGQ

Genular Protein ID: 2200510766

Symbol: A0A384MDX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384MDX9

Database IDs:

Sequence Information:

Length: 653
Mass: 68605
Checksum: 52CB50319085539A
Sequence:

MADYSTVPPP SSGSAGGGGG GGGGGGVNDA FKDALQRARQ IAAKIGGDAG TSLNSNDYGY 
GGQKRPLEDG DQPDAKKVAP QNDSFGTQLP PMHQQQRSVM TEEYKVPDGM VGFIIGRGGE 
QISRIQQESG CKIQIAPDSG GLPERSCMLT GTPESVQSAK RLLDQIVEKG RPAPGFHHGD 
GPGNAVQEIM IPASKAGLVI GKGGETIKQL QERAGVKMVM IQDGPQNTGA DKPLRITGDP 
YKVQQAKEMV LELIRDQGGF REVRNEYGSR IGGNEGIDVP IPRFAVGIVI GRNGEMIKKI 
QNDAGVRIQF KPDDGTTPER IAQITGPPDR CQHAAEIITD LLRSVQAGNP GGPGPGGRGR 
GRGQGNWNMG PPGGLQEFNF IVPTGKTGLI IGKGGETIKS ISQQSGARIE LQRNPPPNAD 
PNMKLFTIRG TPQQIDYARQ LIEEKIGGPV NPLGPPVPHG PHGVPGPHGP PGPPGPGTPM 
GPYNPAPYNP GPPGPAPHGP PAPYAPQGWG NAYPHWQQQA PPDPAKAGTD PNSAAWAAYY 
AHYYQQQAQP PPAAPAGAPT TTQTNGQGDQ QNPAPAGQVD YTKAWEEYYK KMGQAVPAPT 
GAPPGGQPDY SAAWAEYYRQ QAAYYAQTSP QGMPQHPPAP QCRFDPASIE LAL

Genular Protein ID: 1195400340

Symbol: B4DT31_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DT31 E9PCF5

Database IDs:

Sequence Information:

Length: 665
Mass: 69865
Checksum: 5E639AFE97354D99
Sequence:

MADYSTVPPP SSGSAGGGGG GGGGGGVNDA FKDALQRARQ IAAKIGGDAG TSLNSNDYGY 
GGQKRPLEDG DGSWTSPSST THWEGMPSPF KDQPDAKKVA PQNDSFGTQL PPMHQQQSRS 
VMTEEYKVPD GMVGFIIGRG GEQISRIQQE SGCKIQIAPD SGGLPERSCM LTGTPESVQS 
AKRLLDQIVE KGRPAPGFHH GDGPGNAVQE IMIPASKAGL VIGKGGETIK QLQERAGVKM 
VMIQDGPQNT GADKPLRITG DPYKVQQAKE MVLELIRDQG GFREVRNEYG SRIGGNEGID 
VPIPRFAVGI VIGRNGEMIK KIQNDAGVRI QFKPDDGTTP ERIAQITGPP DRCQHAAEII 
TDLLRSVQAG NPGGPGPGGR GRGRGQGNWN MGPPGGLQEF NFIVPTGKTG LIIGKGGETI 
KSISQQSGAR IELQRNPPPN ADPNMKLFTI RGTPQQIDYA RQLIEEKIGG PVNPLGPPVP 
HGPHGVPGPH GPPGPPGPGT PMGPYNPAPY NPGPPGPAPH GPPAPYAPQG WGNAYPHWQQ 
QAPPDPAKAG TDPNSAAWAA YYAHYYQQQA QPPPAAPAGA PTTTQTNGQG DQQNPAPAGQ 
VDYTKAWEEY YKKMGQAVPA PTGAPPGGQP DYSAAWAEYY RQQAAYYAQT SPQGMPQHPP 
APQGQ

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Primary motor cortex UBERON0001384
	\|— Primary motor cortex Healthy UBERON0001384_PATO0000461
	Primary visual cortex UBERON0002436
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: FUBP1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. PubMed ID: 8125259

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of human DNA helicase V with the far upstream element-binding protein. PubMed ID: 11222755

Large-scale proteomic analysis of the human spliceosome. PubMed ID: 12176931

The FBP interacting repressor targets TFIIH to inhibit activated transcription. PubMed ID: 10882074

Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. PubMed ID: 12819782

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Structure and dynamics of KH domains from FBP bound to single-stranded DNA. PubMed ID: 11875576

PubMed ID: 8125259

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 11222755

PubMed ID: 12176931

PubMed ID: 10882074

PubMed ID: 12819782

PubMed ID: 15592455

PubMed ID: 17081983

PubMed ID: 16964243

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 24129315

PubMed ID: 11875576