Details for: SLC38A2
Gene ID: 54407
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SLC38A2
Ensembl ID: ENSG00000134294
Description: solute carrier family 38 member 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 48.32rCSI 73.81%PRS 16.95
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CSI 48.09rCSI 40.31%PRS 20.14
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CSI 42.89rCSI 46.98%PRS 19.15
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CSI 41.01rCSI 73.4%PRS 15.65
-
CSI 38.9rCSI 49.89%PRS 19.47
-
CSI 36.73rCSI 88.31%PRS 25.09
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CSI 28.89rCSI 63.27%PRS 22.57
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CSI 27.76rCSI 44.33%PRS 18.5
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CSI 27.38rCSI 26.36%PRS 17.45
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CSI 25.84rCSI 79.63%PRS 25.27
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CSI 24.16rCSI 69.95%PRS 19.11
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CSI 22.26rCSI 61.17%PRS 27.77
-
CSI 21.27rCSI 51.03%PRS 30.17
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CSI 19.83rCSI 27.1%PRS 19.14
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CSI 19.59rCSI 51.11%PRS 26.12
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CSI 18.33rCSI 90.34%PRS 22.87
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CSI 18.27rCSI 17%PRS 16.89
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CSI 17.62rCSI 22.11%PRS 21.78
-
CSI 16.34rCSI 38.84%PRS 25.26
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CSI 15.25rCSI 65.89%PRS 31.31
-
CSI 14.47rCSI 76.05%PRS 29.22
-
CSI 14.19rCSI 12.59%PRS 16.9
-
CSI 13.47rCSI 92.49%PRS 32.56
-
CSI 13.27rCSI 16.41%PRS 14.77
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CSI 12.25rCSI 32.25%PRS 32.75
-
CSI 12rCSI 8.34%PRS 20.04
-
CSI 11.9rCSI 28.41%PRS 25.87
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CSI 10.98rCSI 9.46%PRS 26.72
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CSI 10.75rCSI 25.23%PRS 24.63
-
CSI 10.55rCSI 22.45%PRS 26.94
-
CSI 9.83rCSI 18.59%PRS 36.06
-
CSI 9.71rCSI 58.18%PRS 27.5
-
CSI 9.41rCSI 18.64%PRS 46.8
-
CSI 8.88rCSI 7.21%PRS 17.83
-
CSI 8.66rCSI 63.3%PRS 44.39
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CSI 8.07rCSI 18.82%PRS 39.12
-
CSI 7.98rCSI 12.27%PRS 23.4
-
CSI 7.9rCSI 22.22%PRS 23.07
-
CSI 7.84rCSI 30.49%PRS 23.08
-
CSI 7.41rCSI 34.66%PRS 34.08
-
CSI 7.27rCSI 9.73%PRS 18.47
-
CSI 7.11rCSI 24.05%PRS 27.37
-
CSI 6.98rCSI 7.23%PRS 19.81
-
CSI 6.7rCSI 35.16%PRS 29.22
-
CSI 6.24rCSI 16.81%PRS 21.8
-
CSI 5.97rCSI 23.87%PRS 35.9
-
CSI 5.92rCSI 4.14%PRS 17.89
-
CSI 5.78rCSI 21.66%PRS 14.31
-
CSI 5.64rCSI 23.72%PRS 41.56
-
CSI 5.53rCSI 7.97%PRS 23.61
-
CSI 5.37rCSI 11.88%PRS 15.66
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CSI 5.31rCSI 8.66%PRS 9.86
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CSI 5.25rCSI 32.42%PRS 56.51
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CSI 5.19rCSI 12.38%PRS 45.17
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CSI 5.17rCSI 8%PRS 15.76
-
CSI 5.08rCSI 14.71%PRS 36.44
-
CSI 5.04rCSI 75.64%PRS 48.08
-
CSI 4.88rCSI 6.97%PRS 19.02
-
CSI 4.87rCSI 7.23%PRS 20.31
-
CSI 4.74rCSI 27.6%PRS 25.19
-
CSI 4.73rCSI 6.2%PRS 62.5
-
CSI 4.72rCSI 6.28%PRS 18.44
-
CSI 4.69rCSI 7.41%PRS 16.93
-
CSI 4.58rCSI 14.86%PRS 20.49
-
CSI 4.48rCSI 28.73%PRS 25.18
-
CSI 4.47rCSI 86.27%PRS 48.65
-
CSI 4.45rCSI 4.21%PRS 17.61
-
CSI 4.32rCSI 5.26%PRS 21.23
-
CSI 4.25rCSI 12.17%PRS 29.67
-
CSI 4.09rCSI 3.07%PRS 17.76
-
CSI 3.91rCSI 3.13%PRS 30.32
-
CSI 3.77rCSI 7.12%PRS 21.2
-
CSI 3.73rCSI 27.99%PRS 30.61
-
CSI 3.69rCSI 4.93%PRS 32.09
-
CSI 3.55rCSI 6.4%PRS 42.46
-
CSI 3.53rCSI 82.17%PRS 31.18
-
CSI 3.52rCSI 8.36%PRS 20.96
-
CSI 3.51rCSI 3.24%PRS 17.38
-
CSI 3.38rCSI 4.05%PRS 29.28
-
CSI 3.38rCSI 2.24%PRS 20.29
-
CSI 3.32rCSI 4.6%PRS 23.98
-
CSI 3.3rCSI 2.98%PRS 15.12
-
CSI 3.27rCSI 73.93%PRS 62.2
-
CSI 3.19rCSI 34.98%PRS 30.18
-
CSI 3.16rCSI 6.02%PRS 26.77
-
CSI 3.04rCSI 4.46%PRS 65.1
-
CSI 3.01rCSI 10.21%PRS 16.04
-
CSI 3rCSI 3.82%PRS 19.61
-
CSI 2.97rCSI 51.76%PRS 59.55
-
CSI 2.97rCSI 3.04%PRS 31.25
-
CSI 2.96rCSI 4.34%PRS 19.48
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CSI 2.95rCSI 16.79%PRS 54.96
-
CSI 2.94rCSI 2.18%PRS 14.81
-
CSI 2.88rCSI 3.49%PRS 21.41
-
CSI 2.87rCSI 2.77%PRS 12.06
-
CSI 2.77rCSI 12.79%PRS 34.91
-
CSI 2.75rCSI 2.06%PRS 46.4
-
CSI 2.69rCSI 4.6%PRS 33.43
-
CSI 2.62rCSI 2.17%PRS 17.06
-
CSI 2.6rCSI 21.15%PRS 17.16
-
CSI -4.7rCSI -11.3%PRS 19.7%
-
CSI -4.0rCSI -2.8%PRS 23.1%
-
CSI -4.0rCSI -9.6%PRS 16.6%
-
CSI -3.9rCSI -8.8%PRS 10.4%
-
CSI -2.9rCSI -9.3%PRS 12.8%
-
CSI -2.3rCSI -3.9%PRS 9.9%
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CSI -2.3rCSI -7.4%PRS 24.4%
-
CSI -2.3rCSI -7.1%PRS 10.6%
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CSI -1.5rCSI -1.9%PRS 9.2%
-
CSI -1.3rCSI -3.0%PRS 18.9%
-
CSI -1.1rCSI -2.2%PRS 12.5%
-
CSI -0.7rCSI -1.4%PRS 8.1%
-
CSI -0.4rCSI -2.7%PRS 9.4%
-
CSI -0.3rCSI -0.4%PRS 16.4%
-
CSI -0.2rCSI -0.6%PRS 9.8%
-
CSI -0.2rCSI -0.3%PRS 16.8%
-
CSI -0.1rCSI -0.2%PRS 10.8%
-
CSI 0.0rCSI 0.1%PRS 44.8%
-
CSI 0.0rCSI 0.9%PRS 66.6%
-
CSI 0.1rCSI 0.1%PRS 12.1%
-
CSI 0.1rCSI 0.1%PRS 16.8%
-
CSI 0.1rCSI 0.1%PRS 9.9%
-
CSI 0.1rCSI 0.7%PRS 71.3%
-
CSI 0.1rCSI 0.5%PRS 13.2%
-
CSI 0.1rCSI 0.2%PRS 10.1%
-
CSI 0.1rCSI 0.5%PRS 22.3%
-
CSI 0.1rCSI 1.6%PRS 40.8%
-
CSI 0.1rCSI 0.3%PRS 46.6%
-
CSI 0.1rCSI 0.6%PRS 17.9%
-
CSI 0.1rCSI 0.2%PRS 23.0%
-
CSI 0.1rCSI 3.8%PRS 82.9%
-
CSI 0.1rCSI 0.2%PRS 9.4%
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CSI 0.1rCSI 1.0%PRS 34.9%
-
CSI 0.1rCSI 0.3%PRS 12.1%
-
CSI 0.1rCSI 0.4%PRS 14.0%
-
CSI 0.1rCSI 0.8%PRS 25.7%
-
CSI 0.1rCSI 0.4%PRS 31.9%
-
CSI 0.1rCSI 0.7%PRS 30.4%
-
CSI 0.2rCSI 4.7%PRS 37.6%
-
CSI 0.2rCSI 0.3%PRS 45.0%
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CSI 0.2rCSI 0.3%PRS 15.7%
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CSI 0.2rCSI 1.7%PRS 52.9%
-
CSI 0.2rCSI 1.9%PRS 58.6%
-
CSI 0.2rCSI 1.4%PRS 59.7%
-
CSI 0.2rCSI 4.7%PRS 48.8%
-
CSI 0.2rCSI 1.1%PRS 24.7%
-
CSI 0.2rCSI 0.2%PRS 14.4%
-
CSI 0.2rCSI 0.2%PRS 16.6%
-
CSI 0.2rCSI 0.2%PRS 15.5%
-
CSI 0.2rCSI 2.8%PRS 68.9%
-
CSI 0.2rCSI 0.3%PRS 13.0%
-
CSI 0.2rCSI 0.3%PRS 15.5%
-
CSI 0.2rCSI 1.0%PRS 16.6%
-
CSI 0.2rCSI 0.3%PRS 19.7%
-
CSI 0.3rCSI 0.4%PRS 27.4%
-
CSI 0.3rCSI 0.9%PRS 9.3%
-
CSI 0.3rCSI 1.4%PRS 40.2%
-
CSI 0.3rCSI 0.4%PRS 25.2%
-
CSI 0.3rCSI 2.6%PRS 61.9%
-
CSI 0.3rCSI 1.2%PRS 29.7%
-
CSI 0.3rCSI 0.6%PRS 33.1%
-
CSI 0.3rCSI 1.3%PRS 42.7%
-
CSI 0.3rCSI 0.4%PRS 20.0%
-
CSI 0.3rCSI 1.9%PRS 50.7%
-
CSI 0.3rCSI 1.8%PRS 43.5%
-
CSI 0.3rCSI 0.4%PRS 10.5%
-
CSI 0.3rCSI 0.8%PRS 17.1%
-
CSI 0.3rCSI 2.2%PRS 48.1%
-
CSI 0.3rCSI 3.1%PRS 45.7%
-
CSI 0.3rCSI 7.8%PRS 8.2%
-
CSI 0.3rCSI 1.8%PRS 30.0%
-
CSI 0.3rCSI 3.6%PRS 69.0%
-
CSI 0.3rCSI 0.5%PRS 21.8%
-
CSI 0.3rCSI 0.3%PRS 21.1%
-
CSI 0.3rCSI 1.8%PRS 57.4%
-
CSI 0.3rCSI 0.5%PRS 23.3%
-
CSI 0.3rCSI 1.9%PRS 51.1%
-
CSI 0.4rCSI 2.1%PRS 10.4%
-
CSI 0.4rCSI 2.1%PRS 57.4%
-
CSI 0.4rCSI 0.5%PRS 17.8%
-
CSI 0.4rCSI 0.3%PRS 25.6%
-
CSI 0.4rCSI 1.7%PRS 54.6%
-
CSI 0.4rCSI 1.3%PRS 20.4%
-
CSI 0.4rCSI 1.1%PRS 29.0%
-
CSI 0.4rCSI 0.8%PRS 37.8%
-
CSI 0.4rCSI 1.6%PRS 10.2%
-
CSI 0.4rCSI 0.4%PRS 26.5%
-
CSI 0.4rCSI 1.4%PRS 17.7%
-
CSI 0.4rCSI 1.5%PRS 27.5%
-
CSI 0.4rCSI 1.7%PRS 33.6%
-
CSI 0.4rCSI 2.0%PRS 44.5%
-
CSI 0.5rCSI 1.4%PRS 11.4%
-
CSI 0.5rCSI 11.1%PRS 9.2%
-
CSI 0.5rCSI 0.4%PRS 15.9%
-
CSI 0.5rCSI 1.0%PRS 37.8%
-
CSI 0.5rCSI 0.5%PRS 18.3%
-
CSI 0.5rCSI 2.1%PRS 17.2%
-
CSI 0.5rCSI 2.0%PRS 37.0%
-
CSI 0.5rCSI 1.0%PRS 33.0%
-
CSI 0.5rCSI 0.5%PRS 24.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3736519287
Symbol: S38A2_HUMAN
Name: Amino acid transporter A2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10930503
Title: Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.
PubMed ID: 10930503
PubMed ID: 10718198
Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10718198
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14623874
Title: Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.
PubMed ID: 14623874
PubMed ID: 15922329
Title: SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.
PubMed ID: 15922329
PubMed ID: 15774260
Title: Functional expression and adaptive regulation of Na+ -dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition.
PubMed ID: 15774260
PubMed ID: 16621798
Title: Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.
PubMed ID: 16621798
PubMed ID: 16616430
Title: Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex.
PubMed ID: 16616430
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26374858
Title: Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR.
PubMed ID: 26374858
DOI: 10.1042/cs20150511
Sequence Information:
- Length: 506
- Mass: 56026
- Checksum: 125C70875793D031
- Sequence:
MKKAEMGRFS ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH LLLKTANEGG SLLYEQLGYK AFGLVGKLAA SGSITMQNIG AMSSYLFIVK YELPLVIQAL TNIEDKTGLW YLNGNYLVLL VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK FQVPCPVEAA LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF YEHVESELLH TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH LLCASKDFSW WRHSLITVSI LAFTNLLVIF VPTIRDIFGF IGASAASMLI FILPSAFYIK LVKKEPMKSV QKIGALFFLL SGVLVMTGSM ALIVLDWVHN APGGGH
Genular Protein ID: 3956174081
Symbol: Q8NHT5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 52
- Mass: 6421
- Checksum: 3EAFB3417072BF8F
- Sequence:
MSSWKELLTL YLRPAREYQE LFLQTFFFFF VWEKILWQPG RNGKKILFST AN