EIF2S2 | ENSG00000125977 | NCBI 8894

Details for: EIF2S2

Gene ID: 8894

Symbol: EIF2S2

Ensembl ID: ENSG00000125977

Description: eukaryotic translation initiation factor 2 subunit beta

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to mitochondrial stress
(R-HSA-9840373)
Cellular response to starvation
(R-HSA-9711097)
Cytokine signaling in immune system
(R-HSA-1280215)
Eukaryotic translation initiation
(R-HSA-72613)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Immune system
(R-HSA-168256)
Interferon signaling
(R-HSA-913531)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Metabolism of proteins
(R-HSA-392499)
Perk regulates gene expression
(R-HSA-381042)
Pkr-mediated signaling
(R-HSA-9833482)
Recycling of eif2:gdp
(R-HSA-72731)
Response of eif2ak1 (hri) to heme deficiency
(R-HSA-9648895)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Translation
(R-HSA-72766)
Translation initiation complex formation
(R-HSA-72649)
Transport of small molecules
(R-HSA-382551)
Unfolded protein response (upr)
(R-HSA-381119)
Cytoplasm
(GO:0005737)
Cytoplasmic translational initiation
(GO:0002183)
Cytosol
(GO:0005829)
Eukaryotic translation initiation factor 2 complex
(GO:0005850)
Formation of translation preinitiation complex
(GO:0001731)
In utero embryonic development
(GO:0001701)
Male germ cell proliferation
(GO:0002176)
Male gonad development
(GO:0008584)
Metal ion binding
(GO:0046872)
Mrna binding
(GO:0003729)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Synapse
(GO:0045202)
Translational initiation
(GO:0006413)
Translation factor activity, rna binding
(GO:0008135)
Translation initiation factor activity
(GO:0003743)
Translation initiation factor binding
(GO:0031369)

Other Information

Proteins

Eukaryotic translation initiation factor 2 subunit 2

Genular Protein ID: 2610236781

Symbol: IF2B_HUMAN

Name: Eukaryotic translation initiation factor 2 subunit 2

UniProtKB Accession Codes:

P20042 Q9BVU0 Q9UJE4

Database IDs:

Citations:

PubMed ID: 3044606

Title: Structure of the beta subunit of translational initiation factor eIF-2.

PubMed ID: 3044606

DOI: 10.1016/s0092-8674(88)80007-2

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21745818

Title: Mechanisms of translational regulation by a human eIF5-mimic protein.

PubMed ID: 21745818

DOI: 10.1093/nar/gkr339

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22813744

Title: The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta.

PubMed ID: 22813744

DOI: 10.1016/j.celrep.2012.04.007

PubMed ID: 23063529

Title: eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.

PubMed ID: 23063529

DOI: 10.1016/j.molcel.2012.09.005

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25147208

Title: Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.

PubMed ID: 25147208

DOI: 10.1093/nar/gku670

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31836389

Title: Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.

PubMed ID: 31836389

DOI: 10.1016/j.molcel.2019.11.008

PubMed ID: 32690955

Title: Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.

PubMed ID: 32690955

DOI: 10.1038/s41564-020-0759-0

PubMed ID: 34260931

Title: Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.

PubMed ID: 34260931

DOI: 10.1016/j.celrep.2021.109376

PubMed ID: 35031321

Title: Stepwise assembly of the eukaryotic translation initiation factor 2 complex.

PubMed ID: 35031321

DOI: 10.1016/j.jbc.2022.101583

PubMed ID: 31048492

Title: Structural basis for eIF2B inhibition in integrated stress response.

PubMed ID: 31048492

DOI: 10.1126/science.aaw4104

Sequence Information:

Length: 333
Mass: 38388
Checksum: 3E9FD4B48AA61A51
Sequence:

MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD TQTEETQPSE TKEVEPEPTE DKDLEADEED 
TRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEGVKD LKIESDVQEP TEPEDDLDIM 
LGNKKKKKKN VKFPDEDEIL EKDEALEDED NKKDDGISFS NQTGPAWAGS ERDYTYEELL 
NRVFNIMREK NPDMVAGEKR KFVMKPPQVV RVGTKKTSFV NFTDICKLLH RQPKHLLAFL 
LAELGTSGSI DGNNQLVIKG RFQQKQIENV LRRYIKEYVT CHTCRSPDTI LQKDTRLYFL 
QCETCHSRCS VASIKTGFQA VTGKRAQLRA KAN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EIF2S2

Associated with

Other Information

Structure of the beta subunit of translational initiation factor eIF-2. PubMed ID: 3044606

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Mechanisms of translational regulation by a human eIF5-mimic protein. PubMed ID: 21745818

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta. PubMed ID: 22813744

eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. PubMed ID: 23063529

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression. PubMed ID: 25147208

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. PubMed ID: 31836389

Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. PubMed ID: 32690955

Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism. PubMed ID: 34260931

Stepwise assembly of the eukaryotic translation initiation factor 2 complex. PubMed ID: 35031321

Structural basis for eIF2B inhibition in integrated stress response. PubMed ID: 31048492