Details for: EIF2S2
Gene ID: 8894
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EIF2S2
Ensembl ID: ENSG00000125977
Description: eukaryotic translation initiation factor 2 subunit beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 76.67rCSI 60.31%PRS 9.19
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CSI 74.41rCSI 71.63%PRS 7.98
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CSI 70.81rCSI 63.94%PRS 6.81
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CSI 66.93rCSI 66.8%PRS 6.6
-
CSI 66.69rCSI 53.92%PRS 7.59
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CSI 62.09rCSI 76.81%PRS 6.76
-
CSI 59.79rCSI 92.39%PRS 7.25
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CSI 57.77rCSI 50.02%PRS 8.59
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CSI 55.46rCSI 48.77%PRS 5.58
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CSI 54.41rCSI 52.46%PRS 4.87
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CSI 47.19rCSI 59.22%PRS 9.82
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CSI 45.54rCSI 60.53%PRS 8.38
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CSI 44.9rCSI 52.73%PRS 9.23
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CSI 43.84rCSI 36.75%PRS 9.22
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CSI 43.82rCSI 50.16%PRS 16.02
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CSI 42.75rCSI 42.05%PRS 8.37
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CSI 41.56rCSI 43.44%PRS 8.11
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CSI 38.14rCSI 25.35%PRS 9.2
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CSI 35.58rCSI 51.31%PRS 10.76
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CSI 33.55rCSI 35.14%PRS 7.17
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CSI 30.63rCSI 26.9%PRS 8.66
-
CSI 30.02rCSI 51.42%PRS 10.34
-
CSI 29.23rCSI 55.17%PRS 9.58
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CSI 27.79rCSI 40.05%PRS 12.47
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CSI 27.65rCSI 53.78%PRS 7.85
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CSI 26.01rCSI 61.83%PRS 11.59
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CSI 23.55rCSI 36.03%PRS 12.56
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CSI 23.21rCSI 26.84%PRS 5.64
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CSI 23.1rCSI 41.19%PRS 13.24
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CSI 23.09rCSI 51.12%PRS 7.16
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CSI 22.94rCSI 66.41%PRS 8.75
-
CSI 21.64rCSI 75.94%PRS 14.03
-
CSI 21.32rCSI 49.71%PRS 19.38
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CSI 21.27rCSI 17.63%PRS 7.31
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CSI 20.58rCSI 43.81%PRS 12.5
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CSI 19.67rCSI 56.67%PRS 15.46
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CSI 19.53rCSI 30.01%PRS 11.07
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CSI 18.99rCSI 50%PRS 15.11
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CSI 18.54rCSI 53.63%PRS 17.43
-
CSI 18.43rCSI 90.84%PRS 10.44
-
CSI 18.15rCSI 61.35%PRS 13.21
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CSI 17.88rCSI 15.87%PRS 7.7
-
CSI 17.58rCSI 13.54%PRS 6.98
-
CSI 17.49rCSI 23.9%PRS 8.76
-
CSI 17.36rCSI 49.55%PRS 13.69
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CSI 16.23rCSI 44.61%PRS 12.81
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CSI 16.19rCSI 30.9%PRS 18.64
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CSI 15.85rCSI 11.07%PRS 8.11
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CSI 15.83rCSI 42.68%PRS 9.97
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CSI 15.59rCSI 34.04%PRS 15.71
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CSI 15.36rCSI 23.46%PRS 7.74
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CSI 15.27rCSI 27.74%PRS 11.77
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CSI 14.82rCSI 19.8%PRS 14.74
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CSI 14.66rCSI 65.2%PRS 33.67
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CSI 14.3rCSI 18.74%PRS 37.95
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CSI 14.16rCSI 22.83%PRS 12.43
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CSI 14.04rCSI 14.71%PRS 8.21
-
CSI 14.04rCSI 75.74%PRS 14.79
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CSI 13.51rCSI 78.6%PRS 11.64
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CSI 13.14rCSI 36.84%PRS 12.04
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CSI 13.03rCSI 57.21%PRS 14.47
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CSI 12.96rCSI 15.56%PRS 7.64
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CSI 12.62rCSI 19.57%PRS 12.02
-
CSI 12.54rCSI 64.76%PRS 15.5
-
CSI 12.3rCSI 10.35%PRS 12.78
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CSI 12.1rCSI 47.09%PRS 12.74
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CSI 11.66rCSI 9.34%PRS 14.04
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CSI 11.25rCSI 9.32%PRS 7.73
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CSI 11.13rCSI 11.35%PRS 11.1
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CSI 10.09rCSI 15.38%PRS 7.27
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CSI 9.96rCSI 8.58%PRS 12.72
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CSI 9.72rCSI 11.61%PRS 4.54
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CSI 9.69rCSI 45.18%PRS 18.93
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CSI 9.55rCSI 18.21%PRS 12.4
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CSI 9.51rCSI 6.61%PRS 9.03
-
CSI 9.47rCSI 15.13%PRS 8.43
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CSI 9.37rCSI 13.02%PRS 8
-
CSI 9.31rCSI 9.72%PRS 7.92
-
CSI 8.62rCSI 8.14%PRS 8.06
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CSI 8.55rCSI 5.95%PRS 11.12
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CSI 8.4rCSI 26.95%PRS 11.5
-
CSI 8.32rCSI 6.45%PRS 7.33
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CSI 8.3rCSI 24.51%PRS 9.67
-
CSI 8.26rCSI 33.01%PRS 17.06
-
CSI 8.09rCSI 11.02%PRS 6.91
-
CSI 7.97rCSI 28.31%PRS 12.69
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CSI 7.93rCSI 28.17%PRS 24.81
-
CSI 7.84rCSI 20.37%PRS 23.04
-
CSI 7.66rCSI 6.06%PRS 5.32
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CSI 7.62rCSI 24.96%PRS 23.1
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CSI 7.33rCSI 27.47%PRS 6.65
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CSI 7.31rCSI 9.38%PRS 8.9
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CSI 7.16rCSI 14.7%PRS 18.51
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CSI 7.06rCSI 8.15%PRS 6.89
-
CSI 6.95rCSI 6.41%PRS 7.84
-
CSI 6.93rCSI 10.58%PRS 13.5
-
CSI 6.81rCSI 10.06%PRS 12.19
-
CSI 6.79rCSI 6.28%PRS 14.16
-
CSI 6.68rCSI 9.78%PRS 8.17
-
CSI 6.52rCSI 40.24%PRS 25.52
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CSI -9.0rCSI -10.5%PRS 11.3%
-
CSI -8.1rCSI -14.0%PRS 5.9%
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CSI -7.0rCSI -15.7%PRS 4.8%
-
CSI -5.5rCSI -12.4%PRS 17.7%
-
CSI -4.7rCSI -8.2%PRS 10.2%
-
CSI -4.4rCSI -27.4%PRS 6.3%
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CSI -3.8rCSI -9.2%PRS 4.4%
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CSI -3.6rCSI -21.0%PRS 4.8%
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CSI -2.5rCSI -6.4%PRS 10.8%
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CSI -1.9rCSI -9.0%PRS 4.8%
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CSI -1.7rCSI -4.3%PRS 9.7%
-
CSI -1.4rCSI -4.0%PRS 11.2%
-
CSI -1.3rCSI -4.9%PRS 4.7%
-
CSI -1.2rCSI -2.5%PRS 8.5%
-
CSI -1.1rCSI -2.0%PRS 5.8%
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CSI -1.0rCSI -3.2%PRS 5.3%
-
CSI -1.0rCSI -1.7%PRS 6.8%
-
CSI -0.8rCSI -2.9%PRS 34.0%
-
CSI -0.4rCSI -0.6%PRS 8.9%
-
CSI -0.3rCSI -0.5%PRS 21.5%
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CSI -0.2rCSI -0.4%PRS 5.8%
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CSI -0.1rCSI -0.5%PRS 4.2%
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CSI -0.1rCSI -1.0%PRS 8.1%
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CSI -0.1rCSI -0.2%PRS 6.0%
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CSI 0.0rCSI 0.1%PRS 4.9%
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CSI 0.0rCSI 0.2%PRS 11.7%
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CSI 0.1rCSI 1.6%PRS 51.7%
-
CSI 0.1rCSI 2.2%PRS 3.3%
-
CSI 0.1rCSI 2.7%PRS 40.0%
-
CSI 0.2rCSI 0.1%PRS 8.2%
-
CSI 0.2rCSI 1.5%PRS 44.8%
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CSI 0.2rCSI 4.2%PRS 4.1%
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CSI 0.2rCSI 2.2%PRS 23.2%
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CSI 0.2rCSI 1.3%PRS 24.9%
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CSI 0.3rCSI 0.2%PRS 12.0%
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CSI 0.3rCSI 6.5%PRS 58.4%
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CSI 0.3rCSI 0.5%PRS 6.8%
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CSI 0.3rCSI 1.6%PRS 19.6%
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CSI 0.3rCSI 2.0%PRS 50.5%
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CSI 0.3rCSI 0.7%PRS 9.5%
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CSI 0.3rCSI 0.4%PRS 11.0%
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CSI 0.3rCSI 0.5%PRS 4.5%
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CSI 0.3rCSI 3.6%PRS 34.0%
-
CSI 0.3rCSI 1.5%PRS 32.1%
-
CSI 0.4rCSI 0.6%PRS 5.0%
-
CSI 0.4rCSI 1.5%PRS 16.5%
-
CSI 0.4rCSI 0.9%PRS 11.9%
-
CSI 0.4rCSI 2.3%PRS 35.0%
-
CSI 0.4rCSI 7.9%PRS 26.6%
-
CSI 0.4rCSI 6.2%PRS 25.5%
-
CSI 0.5rCSI 1.4%PRS 13.6%
-
CSI 0.5rCSI 0.7%PRS 5.9%
-
CSI 0.5rCSI 1.5%PRS 6.3%
-
CSI 0.5rCSI 0.8%PRS 11.1%
-
CSI 0.6rCSI 4.4%PRS 33.6%
-
CSI 0.6rCSI 1.1%PRS 17.1%
-
CSI 0.6rCSI 3.4%PRS 37.9%
-
CSI 0.6rCSI 1.3%PRS 5.5%
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CSI 0.6rCSI 3.4%PRS 33.0%
-
CSI 0.6rCSI 3.2%PRS 34.9%
-
CSI 0.7rCSI 1.7%PRS 12.3%
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CSI 0.7rCSI 2.6%PRS 12.0%
-
CSI 0.7rCSI 2.0%PRS 11.1%
-
CSI 0.7rCSI 1.5%PRS 16.6%
-
CSI 0.7rCSI 7.7%PRS 45.7%
-
CSI 0.7rCSI 3.2%PRS 7.7%
-
CSI 0.7rCSI 1.9%PRS 8.0%
-
CSI 0.8rCSI 1.5%PRS 17.6%
-
CSI 0.8rCSI 5.7%PRS 24.6%
-
CSI 0.8rCSI 1.9%PRS 17.8%
-
CSI 0.9rCSI 3.8%PRS 7.7%
-
CSI 0.9rCSI 1.1%PRS 13.5%
-
CSI 0.9rCSI 7.9%PRS 57.1%
-
CSI 0.9rCSI 1.6%PRS 4.6%
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CSI 0.9rCSI 5.0%PRS 26.3%
-
CSI 0.9rCSI 3.2%PRS 32.8%
-
CSI 1.0rCSI 1.7%PRS 7.3%
-
CSI 1.0rCSI 1.7%PRS 16.4%
-
CSI 1.0rCSI 4.3%PRS 26.1%
-
CSI 1.0rCSI 3.2%PRS 9.4%
-
CSI 1.0rCSI 4.7%PRS 16.6%
-
CSI 1.0rCSI 1.0%PRS 12.2%
-
CSI 1.1rCSI 5.6%PRS 14.4%
-
CSI 1.1rCSI 5.8%PRS 27.0%
-
CSI 1.1rCSI 3.0%PRS 34.2%
-
CSI 1.1rCSI 7.3%PRS 26.0%
-
CSI 1.1rCSI 1.5%PRS 11.9%
-
CSI 1.1rCSI 2.7%PRS 14.4%
-
CSI 1.1rCSI 1.5%PRS 16.4%
-
CSI 1.1rCSI 6.4%PRS 11.0%
-
CSI 1.1rCSI 19.6%PRS 32.0%
-
CSI 1.1rCSI 1.2%PRS 12.5%
-
CSI 1.1rCSI 1.1%PRS 16.6%
-
CSI 1.2rCSI 2.7%PRS 8.1%
-
CSI 1.2rCSI 1.8%PRS 8.9%
-
CSI 1.2rCSI 3.0%PRS 7.9%
-
CSI 1.2rCSI 6.1%PRS 48.7%
-
CSI 1.3rCSI 5.3%PRS 21.1%
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CSI 1.3rCSI 2.3%PRS 7.8%
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CSI 1.3rCSI 4.6%PRS 13.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2610236781
Symbol: IF2B_HUMAN
Name: Eukaryotic translation initiation factor 2 subunit 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3044606
Title: Structure of the beta subunit of translational initiation factor eIF-2.
PubMed ID: 3044606
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21745818
Title: Mechanisms of translational regulation by a human eIF5-mimic protein.
PubMed ID: 21745818
DOI: 10.1093/nar/gkr339
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22813744
Title: The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2beta.
PubMed ID: 22813744
PubMed ID: 23063529
Title: eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.
PubMed ID: 23063529
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25147208
Title: Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.
PubMed ID: 25147208
DOI: 10.1093/nar/gku670
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 31836389
Title: Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
PubMed ID: 31836389
PubMed ID: 32690955
Title: Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.
PubMed ID: 32690955
PubMed ID: 34260931
Title: Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
PubMed ID: 34260931
PubMed ID: 35031321
Title: Stepwise assembly of the eukaryotic translation initiation factor 2 complex.
PubMed ID: 35031321
PubMed ID: 31048492
Title: Structural basis for eIF2B inhibition in integrated stress response.
PubMed ID: 31048492
Sequence Information:
- Length: 333
- Mass: 38388
- Checksum: 3E9FD4B48AA61A51
- Sequence:
MSGDEMIFDP TMSKKKKKKK KPFMLDEEGD TQTEETQPSE TKEVEPEPTE DKDLEADEED TRKKDASDDL DDLNFFNQKK KKKKTKKIFD IDEAEEGVKD LKIESDVQEP TEPEDDLDIM LGNKKKKKKN VKFPDEDEIL EKDEALEDED NKKDDGISFS NQTGPAWAGS ERDYTYEELL NRVFNIMREK NPDMVAGEKR KFVMKPPQVV RVGTKKTSFV NFTDICKLLH RQPKHLLAFL LAELGTSGSI DGNNQLVIKG RFQQKQIENV LRRYIKEYVT CHTCRSPDTI LQKDTRLYFL QCETCHSRCS VASIKTGFQA VTGKRAQLRA KAN