R3HDM1 | ENSG00000048991 | NCBI 23518

Details for: R3HDM1

Gene ID: 23518

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: R3HDM1

Ensembl ID: ENSG00000048991

Description: R3H domain containing 1

Cell Significance Landscape

Display Count:

Associated with

Protein binding
(GO:0005515)
Rna binding
(GO:0003723)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pvalb GABAergic cortical interneuron CL4023018

CSI 58.11

rCSI 72.29%

PRS 54.42
VIP GABAergic cortical interneuron CL4023016

CSI 57.05

rCSI 68.15%

PRS 56.42
sst GABAergic cortical interneuron CL4023017

CSI 51.07

rCSI 65.84%

PRS 57.71
sncg GABAergic cortical interneuron CL4023015

CSI 43.86

rCSI 70.54%

PRS 58.18
lamp5 GABAergic cortical interneuron CL4023011

CSI 41.53

rCSI 69.71%

PRS 56.45
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 37.44

rCSI 66.12%

PRS 55.64
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 36.43

rCSI 79.03%

PRS 62.37
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 33.19

rCSI 79.38%

PRS 61.57
CD14-low, CD16-positive monocyte CL0002396

CSI 31.22

rCSI 24.06%

PRS 77.42
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 29.35

rCSI 71.33%

PRS 54.54
neuron CL0000540

CSI 25.58

rCSI 68.11%

PRS 62.82
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 23.32

rCSI 72.94%

PRS 60.67
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 23.3

rCSI 76.58%

PRS 61.24
L6b glutamatergic cortical neuron CL4023038

CSI 23.17

rCSI 72.41%

PRS 58.18
glutamatergic neuron CL0000679

CSI 21.77

rCSI 44.75%

PRS 62.92
retinal ganglion cell CL0000740

CSI 20.64

rCSI 45.6%

PRS 60.55
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 20.02

rCSI 72.05%

PRS 54.5
near-projecting glutamatergic cortical neuron CL4023012

CSI 18.66

rCSI 70.52%

PRS 56.85
lung ciliated cell CL1000271

CSI 16.52

rCSI 19.1%

PRS 66.74
epithelial cell of lower respiratory tract CL0002632

CSI 15.63

rCSI 12.12%

PRS 78.54
glioblast CL0000030

CSI 15.16

rCSI 24.19%

PRS 66.71
retinal rod cell CL0000604

CSI 14.7

rCSI 25.92%

PRS 70.99
oligodendrocyte precursor cell CL0002453

CSI 14.5

rCSI 31.91%

PRS 58.45
double negative thymocyte CL0002489

CSI 14.25

rCSI 9.91%

PRS 86.43
blood vessel endothelial cell CL0000071

CSI 14

rCSI 29.05%

PRS 72.06
inhibitory interneuron CL0000498

CSI 13.48

rCSI 31.12%

PRS 63
immature B cell CL0000816

CSI 13.29

rCSI 9.87%

PRS 86.81
mucosal invariant T cell CL0000940

CSI 13.18

rCSI 10.65%

PRS 84.61
hematopoietic stem cell CL0000037

CSI 13.13

rCSI 8.72%

PRS 78.05
myeloid leukocyte CL0000766

CSI 13.02

rCSI 12.02%

PRS 76.71
retinal pigment epithelial cell CL0002586

CSI 12.76

rCSI 25.35%

PRS 71.21
cerebral cortex endothelial cell CL1001602

CSI 12.68

rCSI 21.93%

PRS 65.94
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 11.74

rCSI 69.11%

PRS 57.3
GABAergic amacrine cell CL4030027

CSI 11.71

rCSI 40.11%

PRS 61.84
early lymphoid progenitor CL0000936

CSI 11.56

rCSI 10.15%

PRS 80.38
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 11.45

rCSI 29.6%

PRS 70.2
glycinergic amacrine cell CL4030028

CSI 11.33

rCSI 29.52%

PRS 70.46
diffuse bipolar 6 cell CL4033032

CSI 10.51

rCSI 55.25%

PRS 67.61
naive B cell CL0000788

CSI 10.33

rCSI 8.86%

PRS 81.95
H2 horizontal cell CL0004218

CSI 10.15

rCSI 50.46%

PRS 70.39
podocyte CL0000653

CSI 9.91

rCSI 44.05%

PRS 75.47
adipocyte CL0000136

CSI 9.6

rCSI 12.33%

PRS 65.6
CD1c-positive myeloid dendritic cell CL0002399

CSI 9.56

rCSI 11.55%

PRS 83.39
central nervous system neuron CL2000029

CSI 9.47

rCSI 69.59%

PRS 61.81
rod bipolar cell CL0000751

CSI 9.21

rCSI 16.55%

PRS 68.14
retinal cone cell CL0000573

CSI 9.01

rCSI 14.49%

PRS 64.65
hepatic stellate cell CL0000632

CSI 8.8

rCSI 32.95%

PRS 67.11
effector CD8-positive, alpha-beta T cell CL0001050

CSI 8.74

rCSI 6.65%

PRS 87.69
invaginating midget bipolar cell CL4033034

CSI 8.7

rCSI 51.35%

PRS 67.73
hematopoietic precursor cell CL0008001

CSI 8.62

rCSI 8.86%

PRS 88.09
interneuron CL0000099

CSI 8.58

rCSI 17.22%

PRS 64.62
Kupffer cell CL0000091

CSI 8.48

rCSI 19.4%

PRS 75.77
radial glial cell CL0000681

CSI 8.23

rCSI 11.44%

PRS 73.66
alveolar adventitial fibroblast CL4028006

CSI 8.19

rCSI 12.93%

PRS 76.86
medium spiny neuron CL1001474

CSI 8.15

rCSI 70.18%

PRS 62.15
neural crest cell CL0011012

CSI 8.11

rCSI 6.41%

PRS 62.84
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 8.11

rCSI 9.37%

PRS 67.17
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 7.96

rCSI 11.29%

PRS 71.46
diffuse bipolar 3b cell CL4033030

CSI 7.78

rCSI 51.64%

PRS 70.51
pulmonary alveolar type 2 cell CL0002063

CSI 7.74

rCSI 12%

PRS 80.1
respiratory suprabasal cell CL4033048

CSI 7.7

rCSI 9.87%

PRS 78.77
diffuse bipolar 3a cell CL4033029

CSI 7.48

rCSI 50.89%

PRS 68.83
granulocyte monocyte progenitor cell CL0000557

CSI 7.46

rCSI 6.46%

PRS 79.57
Mueller cell CL0000636

CSI 7.41

rCSI 16.92%

PRS 66.24
neuroblast (sensu Vertebrata) CL0000031

CSI 7.39

rCSI 9.48%

PRS 71.36
ependymal cell CL0000065

CSI 7.16

rCSI 14.53%

PRS 53.16
retinal bipolar neuron CL0000748

CSI 7.06

rCSI 13.22%

PRS 62.81
retina horizontal cell CL0000745

CSI 7.01

rCSI 10.69%

PRS 71.68
melanocyte CL0000148

CSI 6.91

rCSI 5.12%

PRS 67.99
mononuclear phagocyte CL0000113

CSI 6.81

rCSI 14.98%

PRS 79.19
pro-B cell CL0000826

CSI 6.75

rCSI 5.59%

PRS 77.61
endothelial cell of vascular tree CL0002139

CSI 6.6

rCSI 36.09%

PRS 72.3
vascular leptomeningeal cell CL4023051

CSI 6.5

rCSI 11.39%

PRS 68.01
hepatocyte CL0000182

CSI 6.45

rCSI 11.54%

PRS 74.33
GABAergic neuron CL0000617

CSI 6.4

rCSI 21.43%

PRS 59.04
neural cell CL0002319

CSI 6.2

rCSI 23.41%

PRS 58.16
precursor B cell CL0000817

CSI 6.14

rCSI 5.38%

PRS 83.01
retinal blood vessel endothelial cell CL0002585

CSI 6.13

rCSI 9.79%

PRS 78.82
chondrocyte CL0000138

CSI 6.04

rCSI 9.6%

PRS 67.65
erythroblast CL0000765

CSI 5.72

rCSI 15.17%

PRS 82.13
diffuse bipolar 2 cell CL4033028

CSI 5.71

rCSI 44.2%

PRS 70.06
CD14-positive monocyte CL0001054

CSI 5.61

rCSI 6.99%

PRS 84.84
diffuse bipolar 1 cell CL4033027

CSI 5.59

rCSI 42.05%

PRS 67
epithelial cell of proximal tubule CL0002306

CSI 5.49

rCSI 13.41%

PRS 67.83
astrocyte of the cerebral cortex CL0002605

CSI 5.47

rCSI 12.27%

PRS 57.13
fallopian tube secretory epithelial cell CL4030006

CSI 5.42

rCSI 5.22%

PRS 74.42
central nervous system macrophage CL0000878

CSI 5.37

rCSI 17.79%

PRS 79.98
cerebral cortex neuron CL0010012

CSI 5.32

rCSI 21.69%

PRS 67.37
lung secretory cell CL1000272

CSI 5.32

rCSI 13.17%

PRS 74.29
CD4-positive, alpha-beta memory T cell CL0000897

CSI 5.28

rCSI 3.79%

PRS 88.09
mesothelial cell CL0000077

CSI 5.27

rCSI 20.62%

PRS 52.61
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 5.25

rCSI 3.1%

PRS 90.61
differentiation-committed oligodendrocyte precursor CL4023059

CSI 5.18

rCSI 9.41%

PRS 65.99
small intestine goblet cell CL1000495

CSI 5.07

rCSI 11.11%

PRS 81.23
ON-bipolar cell CL0000749

CSI 5.05

rCSI 7.51%

PRS 75.46
H1 horizontal cell CL0004217

CSI 4.99

rCSI 19.75%

PRS 71.77
lung neuroendocrine cell CL1000223

CSI 4.98

rCSI 7.37%

PRS 79.82
Schwann cell CL0002573

CSI 4.9

rCSI 13.94%

PRS 71.48
intermediate monocyte CL0002393

CSI 4.83

rCSI 7.29%

PRS 80.46
pulmonary alveolar type 1 cell CL0002062

CSI 4.8

rCSI 27.68%

PRS 72.36

cytotoxic T cell CL0000910

CSI 0.3

rCSI 1.5%

PRS 80.7%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.5

rCSI 2.0%

PRS 91.2%
pancreatic ductal cell CL0002079

CSI 0.7

rCSI 1.4%

PRS 78.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.7

rCSI 7.8%

PRS 71.8%
regular ventricular cardiac myocyte CL0002131

CSI 0.9

rCSI 5.4%

PRS 66.5%
Hofbauer cell CL3000001

CSI 0.9

rCSI 1.7%

PRS 84.1%
enteroglial cell CL4040002

CSI 0.9

rCSI 4.6%

PRS 77.5%
mesangial cell CL0000650

CSI 0.9

rCSI 3.9%

PRS 85.4%
type B pancreatic cell CL0000169

CSI 1.0

rCSI 2.1%

PRS 74.1%
forebrain radial glial cell CL0013000

CSI 1.0

rCSI 3.2%

PRS 78.1%
cerebellar neuron CL1001611

CSI 1.1

rCSI 10.0%

PRS 63.5%
mesenchymal cell CL0008019

CSI 1.2

rCSI 3.0%

PRS 68.6%
endothelial cell of placenta CL0009092

CSI 1.2

rCSI 6.0%

PRS 83.9%
extravillous trophoblast CL0008036

CSI 1.3

rCSI 1.6%

PRS 72.5%
thymocyte CL0000893

CSI 1.4

rCSI 4.9%

PRS 94.8%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.4

rCSI 12.2%

PRS 70.3%
blood vessel smooth muscle cell CL0019018

CSI 1.5

rCSI 11.8%

PRS 68.7%
placental villous trophoblast CL2000060

CSI 1.5

rCSI 2.3%

PRS 74.1%
keratocyte CL0002363

CSI 1.5

rCSI 3.6%

PRS 79.4%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.6

rCSI 4.3%

PRS 80.8%
glial cell CL0000125

CSI 1.6

rCSI 6.1%

PRS 65.5%
intestinal tuft cell CL0019032

CSI 1.6

rCSI 2.5%

PRS 79.3%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.7

rCSI 4.8%

PRS 92.0%
cerebral cortex pyramidal neuron CL4023111

CSI 1.7

rCSI 10.6%

PRS 83.3%
late pro-B cell CL0002048

CSI 1.8

rCSI 4.5%

PRS 90.7%
large pre-B-II cell CL0000957

CSI 2.0

rCSI 5.6%

PRS 82.2%
macroglial cell CL0000126

CSI 2.1

rCSI 5.3%

PRS 72.4%
regular atrial cardiac myocyte CL0002129

CSI 2.1

rCSI 6.7%

PRS 72.1%
conjunctival epithelial cell CL1000432

CSI 2.1

rCSI 3.2%

PRS 75.4%
neural progenitor cell CL0011020

CSI 2.1

rCSI 9.3%

PRS 63.7%
epicardial adipocyte CL1000309

CSI 2.2

rCSI 7.3%

PRS 73.4%
midbrain dopaminergic neuron CL2000097

CSI 2.3

rCSI 14.6%

PRS 73.1%
parietal epithelial cell CL1000452

CSI 2.4

rCSI 6.4%

PRS 66.1%
pulmonary ionocyte CL0017000

CSI 2.5

rCSI 3.1%

PRS 82.1%
duct epithelial cell CL0000068

CSI 2.6

rCSI 3.8%

PRS 80.1%
pancreatic D cell CL0000173

CSI 2.6

rCSI 2.5%

PRS 77.9%
class switched memory B cell CL0000972

CSI 2.6

rCSI 2.0%

PRS 88.3%
starburst amacrine cell CL0004232

CSI 2.6

rCSI 22.2%

PRS 64.4%
pulmonary artery endothelial cell CL1001568

CSI 2.7

rCSI 3.6%

PRS 84.8%
tracheobronchial smooth muscle cell CL0019019

CSI 2.7

rCSI 4.7%

PRS 81.4%
peripheral nervous system neuron CL2000032

CSI 2.7

rCSI 3.7%

PRS 66.5%
myeloid dendritic cell CL0000782

CSI 2.7

rCSI 4.0%

PRS 88.4%
endocardial cell CL0002350

CSI 2.7

rCSI 13.1%

PRS 72.3%
lung pericyte CL0009089

CSI 2.8

rCSI 7.3%

PRS 82.7%
indirect pathway medium spiny neuron CL4023029

CSI 2.8

rCSI 67.8%

PRS 55.6%
direct pathway medium spiny neuron CL4023026

CSI 2.8

rCSI 68.0%

PRS 55.0%
renal interstitial pericyte CL1001318

CSI 2.8

rCSI 7.8%

PRS 69.9%
mature B cell CL0000785

CSI 2.9

rCSI 2.5%

PRS 85.0%
dendritic cell, human CL0001056

CSI 2.9

rCSI 4.5%

PRS 84.2%
common dendritic progenitor CL0001029

CSI 3.0

rCSI 3.8%

PRS 84.5%
small pre-B-II cell CL0000954

CSI 3.1

rCSI 2.9%

PRS 90.5%
renal beta-intercalated cell CL0002201

CSI 3.1

rCSI 7.4%

PRS 75.3%
OFF midget ganglion cell CL4033047

CSI 3.1

rCSI 63.7%

PRS 66.1%
ON midget ganglion cell CL4033046

CSI 3.2

rCSI 64.6%

PRS 64.6%
stromal cell CL0000499

CSI 3.2

rCSI 9.0%

PRS 70.5%
mature astrocyte CL0002627

CSI 3.2

rCSI 13.5%

PRS 67.3%
hematopoietic multipotent progenitor cell CL0000837

CSI 3.2

rCSI 7.8%

PRS 89.1%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 3.3

rCSI 16.3%

PRS 87.1%
plasmacytoid dendritic cell, human CL0001058

CSI 3.3

rCSI 2.3%

PRS 78.5%
flat midget bipolar cell CL4033033

CSI 3.3

rCSI 23.6%

PRS 67.0%
common myeloid progenitor CL0000049

CSI 3.3

rCSI 2.7%

PRS 77.3%
microglial cell CL0000129

CSI 3.4

rCSI 13.5%

PRS 77.4%
enteroendocrine cell of small intestine CL0009006

CSI 3.4

rCSI 7.5%

PRS 84.5%
renal principal cell CL0005009

CSI 3.4

rCSI 8.9%

PRS 76.7%
pancreatic A cell CL0000171

CSI 3.5

rCSI 3.6%

PRS 78.4%
innate lymphoid cell CL0001065

CSI 3.5

rCSI 7.3%

PRS 73.5%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 3.6

rCSI 2.4%

PRS 88.1%
group 3 innate lymphoid cell CL0001071

CSI 3.6

rCSI 2.7%

PRS 81.2%
S cone cell CL0003050

CSI 3.6

rCSI 15.9%

PRS 70.7%
dopaminergic neuron CL0000700

CSI 3.7

rCSI 20.6%

PRS 60.5%
diffuse bipolar 4 cell CL4033031

CSI 3.7

rCSI 41.8%

PRS 64.7%
cardiac endothelial cell CL0010008

CSI 3.7

rCSI 15.0%

PRS 74.5%
fibroblast of cardiac tissue CL0002548

CSI 3.8

rCSI 18.1%

PRS 74.9%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 3.8

rCSI 11.7%

PRS 80.3%
BEST4+ enteroycte CL4030026

CSI 3.8

rCSI 4.7%

PRS 76.4%
lung macrophage CL1001603

CSI 3.8

rCSI 8.5%

PRS 82.8%
naive T cell CL0000898

CSI 3.9

rCSI 2.7%

PRS 89.1%
kidney connecting tubule epithelial cell CL1000768

CSI 3.9

rCSI 10.0%

PRS 65.0%
fibroblast of lung CL0002553

CSI 4.0

rCSI 3.7%

PRS 75.8%
alveolar macrophage CL0000583

CSI 4.1

rCSI 6.8%

PRS 79.8%
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.1

rCSI 5.4%

PRS 86.9%
Bergmann glial cell CL0000644

CSI 4.2

rCSI 5.7%

PRS 67.0%
OFFx cell CL4033036

CSI 4.2

rCSI 19.7%

PRS 68.3%
neuroendocrine cell CL0000165

CSI 4.2

rCSI 16.2%

PRS 85.6%
ON parasol ganglion cell CL4033052

CSI 4.3

rCSI 60.7%

PRS 65.7%
kidney interstitial alternatively activated macrophage CL1000695

CSI 4.3

rCSI 11.3%

PRS 75.6%
amacrine cell CL0000561

CSI 4.4

rCSI 12.6%

PRS 64.1%
cardiac muscle cell CL0000746

CSI 4.4

rCSI 6.3%

PRS 64.5%
cardiac neuron CL0010022

CSI 4.4

rCSI 14.2%

PRS 72.2%
basal cell CL0000646

CSI 4.5

rCSI 6.0%

PRS 74.0%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 4.5

rCSI 4.1%

PRS 87.7%
GABAergic interneuron CL0011005

CSI 4.5

rCSI 70.6%

PRS 77.5%
mature T cell CL0002419

CSI 4.5

rCSI 3.5%

PRS 90.1%
serotonergic neuron CL0000850

CSI 4.6

rCSI 20.3%

PRS 58.8%
stem cell CL0000034

CSI 4.6

rCSI 4.5%

PRS 67.6%
plasmablast CL0000980

CSI 4.6

rCSI 3.7%

PRS 81.1%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 4.7

rCSI 4.2%

PRS 72.9%
cerebellar granule cell CL0001031

CSI 4.7

rCSI 6.9%

PRS 67.8%
choroid plexus epithelial cell CL0000706

CSI 4.8

rCSI 7.8%

PRS 64.3%
alveolar type 1 fibroblast cell CL4028004

CSI 4.8

rCSI 5.3%

PRS 77.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its expression specificity (CSI Z-Score), [R3HDM1](/details-gene/23518) appears to be a broadly expressed gene rather than a specific marker for any particular cell type. The data indicates its presence in a wide range of neuronal subtypes, including both GABAergic and glutamatergic neurons, as well as some immune cells. However, its expression levels do not show statistically significant enrichment in any of these populations, suggesting a potential role in general cellular functions, consistent with its annotated molecular functions in protein and RNA binding. ## Cellular Roles and Expression Landscape The expression profile of [R3HDM1](/details-gene/23518), when evaluated for cell-type specificity, reveals a notable lack of uniquely high expression in any single population. In the **Overall** context, [R3HDM1](/details-gene/23518) is detected in numerous neuronal cell types, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), [VIP GABAergic cortical interneuron](/details-cell/CL4023016), and various intratelencephalic projecting glutamatergic neurons such as [L2/3](/details-cell/CL4030059) and [L4](/details-cell/CL4030063). Despite its presence in these cells, the key statistical indicators point away from a role as a defining marker. The CSI (Z-SCORE) is consistently 0.00 with non-significant p-values (all p > 0.05) across all top-listed cells. This indicates that the expression level of [R3HDM1](/details-gene/23518) within these cells is at the mean of all expressed genes, showing no specific enrichment. Furthermore, its Percentile Rank Scores (PRS) hover between 54% and 63%, placing it in the mid-range of expressed genes and reinforcing that it is not a standout transcript. This pattern of widespread but non-specific expression suggests that [R3HDM1](/details-gene/23518) may be involved in basal or housekeeping functions common to many neuronal subtypes rather than processes that define cellular identity. ## Pathways and Molecular Function The known molecular functions of [R3HDM1](/details-gene/23518) are consistent with its broad, non-specific expression pattern. Gene Ontology annotations indicate its involvement in fundamental molecular interactions, including [protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515))] and [RNA binding ([GO:0003723](https://www.ebi.ac.uk/QuickGO/term/GO:0003723))]. The R3H domain is known to bind single-stranded nucleic acids, suggesting a potential role in post-transcriptional regulation, mRNA stability, or transport. This profile is supported by the history of the gene's identification, which originates from large-scale cDNA sequencing projects rather than function-specific investigations ([Nagase et al., 1995](https://doi.org/10.1093/dnares/1.1.27); [Ota et al., 2004](https://doi.org/10.1038/ng1285)). Subsequent large phosphoproteomic screens have also detected R3HDM1 protein and its phosphorylation, particularly during mitosis and T-cell receptor signaling ([Olsen et al., 2010](https://doi.org/10.1126/scisignal.2000475); [Mayya et al., 2009](https://doi.org/10.1126/scisignal.2000007)), further cementing its identity as a component of core cellular machinery rather than a specialized functional element. ## Research Directions The widespread but non-specific expression of [R3HDM1](/details-gene/23518) suggests its importance in fundamental biological processes common to many cell types, particularly neurons. Future research should focus on elucidating its precise role within this general context. ### Testable Hypotheses 1. **[R3HDM1](/details-gene/23518) functions as a general regulator of mRNA stability or translation in neurons.** Given its RNA-binding capacity via the R3H domain and its broad expression, it may be part of a ubiquitous mechanism that maintains neuronal homeostasis by controlling the lifecycle of key transcripts. * **Experimental Approach:** Utilize CRISPR-mediated knockdown of [R3HDM1](/details-gene/23518) in a human iPSC-derived cortical neuron model. Perform RNA-sequencing combined with ribosomal profiling (Ribo-seq) to identify transcripts whose stability and translation efficiency are significantly altered upon [R3HDM1](/details-gene/23518) depletion. 2. **The function of [R3HDM1](/details-gene/23518) is modulated by post-translational modifications in response to cellular stress.** Its identification in multiple phosphoproteomic studies suggests its activity could be regulated by phosphorylation. This regulation may become critical under conditions of metabolic or oxidative stress common in neurodegenerative states. * **Experimental Approach:** Subject primary neuronal cultures to oxidative stress (e.g., H2O2 treatment) and perform immunoprecipitation of R3HDM1 followed by mass spectrometry (IP-MS) to map stress-induced changes in its phosphorylation status and identify interacting protein partners. 3. **[R3HDM1](/details-gene/23518) contributes to the formation or function of RNA granules in neuronal processes.** Many RNA-binding proteins are known to dynamically associate with membraneless organelles like stress granules or P-bodies to regulate mRNA fate. [R3HDM1](/details-gene/23518) may play such a role, which would not be evident from static single-cell transcriptomic data. * **Experimental Approach:** Generate a fluorescently tagged [R3HDM1](/details-gene/23518) (e.g., R3HDM1-GFP) expressing neuronal cell line. Use live-cell imaging to monitor its subcellular localization in response to stimuli that induce RNA granule formation, such as arsenite treatment, and perform co-localization studies with known granule markers like G3BP1 or DDX6. ### Therapeutic Potential Due to its ubiquitous expression across a wide range of neuronal subtypes, [R3HDM1](/details-gene/23518) is unlikely to be a suitable target for cell-type-specific therapeutic intervention, as targeting it would likely cause broad off-target effects. However, if its role in maintaining fundamental neuronal processes like RNA metabolism is confirmed, understanding its dysregulation could provide valuable insights into the pathophysiology of neurological disorders characterized by widespread neuronal dysfunction.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

R3H domain-containing protein 1

Genular Protein ID: 3970995465

Symbol: R3HD1_HUMAN

Name: R3H domain-containing protein 1

UniProtKB Accession Codes:

Q15032 A8K1V0 B3KXQ9 E9PBB4 E9PG42 G5E9G8 Q8IW32

Database IDs:

Citations:

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 1099
Mass: 120696
Checksum: 67782B9163702174
Sequence:

MRMSDTVTVK DETATMKDLE AEVKDTTRVE NLIKSENYGK ILVEKNEHCI ENNIDLQRPL 
QSFGQTGKRS KSSSKLKLVR SLAVCEESPP PPAPEISQEN QEKIQIQLTQ SFEKEEKPSK 
DEAEKEKASD KLPRKMLSRD SSQEYTDSTG IDLHEFLVNT LKNNPRDRMM LLKLEQEILD 
FIGNNESPRK KFPPMTSYHR MLLHRVAAYF GLDHNVDQSG KSVIVNKTSN TRIPDQKFNE 
HIKDDKGEDF QKRYILKRDN SSFDKDDNQM RIRLKDDRRS KSIEEREEEY QRARDRIFSQ 
DSLCSQENYI IDKRLQDEDA SSTQQRRQIF RVNKDASGRS TNSHQSSTEN ELKYSEPRPW 
SSTDSDSSLR NLKPAVTKAS SFSGISVLTR GDSSGSSKSI GRLSKTGSES SGSVGSSTGS 
LSHIQQPLPG TALSQSSHGA PVVYPTVSTH SSLSFDGGLN GQVASPSTSF FLLPLEAAGI 
PPGSILINPQ TGQPFINPDG SPVVYNPPMT QQPVRSQVPG PPQPPLPAPP QQPAANHIFS 
QDNLGSQFSH MSLARQPSAD GSDPHAAMFQ STVVLQSPQQ SGYIMTAAPP PHPPPPPPPP 
PPPPPLPPGQ PVPTAGYPAS GHPVSQPVLQ QQGYIQQPSP QMPACYCAPG HYHSSQPQYR 
PVPSVHYNSH LNQPLPQPAQ QTGYQVIPNQ QQNYQGIVGV QQPQSQSLVS GQPNSIGNQI 
QGVVIPYTSV PTYQVSLPQG SQGIPHQTYQ QPVMFPNQSN QGSMPTTGMP VYYSVIPPGQ 
QNNLSSSVGY LQHPGSEQVQ FPRTTSPCSS QQLQGHQCTA GPPPPPGGGM VMMQLSVPNN 
PQSCAHSPPQ WKQNKYYCDH QRGQKCVEFS SVDNIVQHSP QLSSPIISPA QSPAPAQLST 
LKTVRPSGPP LSIMPQFSRP FVPGQGDSRY PLLGQPLQYN PPAVLHGHIP NQQGQPGSRH 
GNRGRRQAKK AASTDLGAGE TVVGKVLEIT ELPDGITRME AEKLFGELFK IGAKIRWLRD 
PQSQPRRHPL CCGSGDNTAN PERSKPSDLA STYTVLATFP SISAAQNALK KQINSVNKFK 
LRTSKKHYDF HILERASSQ

Details for: R3HDM1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. PubMed ID: 7584026

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315