ARLN | ENSG00000164096 | NCBI 401152

Details for: ARLN

Associated with

Endoplasmic reticulum membrane
(GO:0005789)
Protein binding
(GO:0005515)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

ciliated epithelial cell CL0000067

CSI 100

rCSI 87.93%

PRS 3.42
intestinal epithelial cell CL0002563

CSI 71.51

rCSI 74.75%

PRS 5.02
multi-ciliated epithelial cell CL0005012

CSI 65.43

rCSI 65.3%

PRS 4.03
epithelial cell of lung CL0000082

CSI 58.43

rCSI 48.44%

PRS 4.46
enteric smooth muscle cell CL0002504

CSI 50.98

rCSI 72.75%

PRS 5.38
lung ciliated cell CL1000271

CSI 50.4

rCSI 58.28%

PRS 3.43
fallopian tube secretory epithelial cell CL4030006

CSI 48.59

rCSI 46.77%

PRS 4.89
placental villous trophoblast CL2000060

CSI 45.52

rCSI 70.34%

PRS 4.43
plasmablast CL0000980

CSI 44.71

rCSI 35.17%

PRS 5.63
keratinocyte CL0000312

CSI 44.3

rCSI 37.14%

PRS 5.68
hematopoietic stem cell CL0000037

CSI 44.04

rCSI 29.27%

PRS 5.63
CD14-low, CD16-positive monocyte CL0002396

CSI 39.59

rCSI 30.51%

PRS 4.27
megakaryocyte-erythroid progenitor cell CL0000050

CSI 38.82

rCSI 35.06%

PRS 4.16
fraction A pre-pro B cell CL0002045

CSI 38

rCSI 43.5%

PRS 9.84
common myeloid progenitor CL0000049

CSI 33.38

rCSI 26.99%

PRS 4.64
common dendritic progenitor CL0001029

CSI 33.33

rCSI 41.83%

PRS 6
extravillous trophoblast CL0008036

CSI 33.08

rCSI 40.92%

PRS 4.14
kidney epithelial cell CL0002518

CSI 32.13

rCSI 61.34%

PRS 11.62
Hofbauer cell CL3000001

CSI 31.16

rCSI 58.82%

PRS 5.89
granulocyte monocyte progenitor cell CL0000557

CSI 29.77

rCSI 25.78%

PRS 5.26
colon epithelial cell CL0011108

CSI 29.58

rCSI 30.99%

PRS 4.41
early lymphoid progenitor CL0000936

CSI 28.4

rCSI 24.94%

PRS 5.29
promyelocyte CL0000836

CSI 27.88

rCSI 40.21%

PRS 6.57
microcirculation associated smooth muscle cell CL0008035

CSI 27.65

rCSI 80.05%

PRS 5.35
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 27.43

rCSI 62.53%

PRS 4.95
stem cell CL0000034

CSI 26.98

rCSI 26.02%

PRS 2.55
ciliated cell CL0000064

CSI 26.65

rCSI 43.18%

PRS 4.8
enterocyte CL0000584

CSI 25.83

rCSI 41.64%

PRS 7.69
promonocyte CL0000559

CSI 24.35

rCSI 41.72%

PRS 6.32
type B pancreatic cell CL0000169

CSI 23.63

rCSI 52.3%

PRS 4.43
mesodermal cell CL0000222

CSI 21.57

rCSI 25.89%

PRS 4.72
retinal cone cell CL0000573

CSI 21.38

rCSI 34.42%

PRS 3.66
small pre-B-II cell CL0000954

CSI 19.44

rCSI 18.7%

PRS 10.29
stromal cell of ovary CL0002132

CSI 19.39

rCSI 53.27%

PRS 7.92
tracheal goblet cell CL1000329

CSI 19.28

rCSI 42.1%

PRS 9.69
peripheral nervous system neuron CL2000032

CSI 19.26

rCSI 26.25%

PRS 4.28
M cell of gut CL0000682

CSI 18.48

rCSI 19.63%

PRS 8.47
pancreatic D cell CL0000173

CSI 17.45

rCSI 17.16%

PRS 5.17
interstitial cell of Cajal CL0002088

CSI 16.87

rCSI 21.48%

PRS 5.51
elicited macrophage CL0000861

CSI 15.89

rCSI 14.59%

PRS 5.4
acinar cell CL0000622

CSI 15.88

rCSI 23.28%

PRS 6.22
large pre-B-II cell CL0000957

CSI 15.54

rCSI 44.36%

PRS 8.4
pancreatic ductal cell CL0002079

CSI 15.47

rCSI 30.09%

PRS 4.82
nasal mucosa goblet cell CL0002480

CSI 15.22

rCSI 17.65%

PRS 7.09
pancreatic PP cell CL0002275

CSI 14.99

rCSI 59.68%

PRS 8.47
luminal epithelial cell of mammary gland CL0002326

CSI 14.3

rCSI 25.98%

PRS 7.24
retina horizontal cell CL0000745

CSI 14.18

rCSI 21.62%

PRS 4.43
intestine goblet cell CL0019031

CSI 14.03

rCSI 12.45%

PRS 4.73
deuterosomal cell CL4033044

CSI 13.99

rCSI 47.28%

PRS 8.15
bronchus fibroblast of lung CL2000093

CSI 13.86

rCSI 11.26%

PRS 5.01
mammary gland epithelial cell CL0002327

CSI 13.66

rCSI 47.92%

PRS 8.6
epithelial cell CL0000066

CSI 13.63

rCSI 20.95%

PRS 6.83
pancreatic A cell CL0000171

CSI 13.54

rCSI 14.18%

PRS 5.06
CD4-positive, alpha-beta thymocyte CL0000810

CSI 13.08

rCSI 10.48%

PRS 8.82
pancreatic stellate cell CL0002410

CSI 13.08

rCSI 76.11%

PRS 7.1
double-positive, alpha-beta thymocyte CL0000809

CSI 12.8

rCSI 13.04%

PRS 6.84
CD1c-positive myeloid dendritic cell CL0002399

CSI 12.58

rCSI 15.19%

PRS 5.53
conventional dendritic cell CL0000990

CSI 12.46

rCSI 10.4%

PRS 15.45
myofibroblast cell CL0000186

CSI 11.78

rCSI 16.31%

PRS 6.81
epithelial cell of proximal tubule CL0002306

CSI 10.83

rCSI 26.44%

PRS 4.89
pancreatic epsilon cell CL0005019

CSI 10.6

rCSI 49.42%

PRS 11.89
group 3 innate lymphoid cell CL0001071

CSI 10.46

rCSI 7.86%

PRS 4.87
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 9.93

rCSI 60.08%

PRS 11.15
perivascular cell CL4033054

CSI 9.79

rCSI 13.38%

PRS 5.36
mesangial cell CL0000650

CSI 9.46

rCSI 38.54%

PRS 7.67
pulmonary artery endothelial cell CL1001568

CSI 9.26

rCSI 12.6%

PRS 7.26
pancreatic acinar cell CL0002064

CSI 9.2

rCSI 12.22%

PRS 5.16
colon macrophage CL0009038

CSI 9.04

rCSI 41.74%

PRS 10.38
epithelial cell of esophagus CL0002252

CSI 8.97

rCSI 88.57%

PRS 19.43
lung endothelial cell CL1001567

CSI 8.89

rCSI 20.74%

PRS 12.62
retinal ganglion cell CL0000740

CSI 8.82

rCSI 19.49%

PRS 3.41
endothelial cell of placenta CL0009092

CSI 8.82

rCSI 43.46%

PRS 6.41
germinal center B cell CL0000844

CSI 8.82

rCSI 26.29%

PRS 12.85
colon goblet cell CL0009039

CSI 8.75

rCSI 20.79%

PRS 7.2
CD14-positive, CD16-positive monocyte CL0002397

CSI 8.65

rCSI 11.33%

PRS 6.62
dendritic cell, human CL0001056

CSI 8.63

rCSI 13.25%

PRS 5.49
basal cell CL0000646

CSI 8.6

rCSI 11.5%

PRS 5.17
group 2 innate lymphoid cell CL0001069

CSI 8.54

rCSI 46.2%

PRS 16.76
skin fibroblast CL0002620

CSI 8.54

rCSI 7.36%

PRS 7.84
myeloid leukocyte CL0000766

CSI 8.5

rCSI 7.85%

PRS 4.78
squamous epithelial cell CL0000076

CSI 8.46

rCSI 20.07%

PRS 6.34
double negative thymocyte CL0002489

CSI 8.39

rCSI 5.83%

PRS 5.55
syncytiotrophoblast cell CL0000525

CSI 8.31

rCSI 23.94%

PRS 9.66
cardiac muscle cell CL0000746

CSI 8.14

rCSI 11.68%

PRS 3.95
ionocyte CL0005006

CSI 8.09

rCSI 8.68%

PRS 4.36
renal principal cell CL0005009

CSI 8.06

rCSI 20.94%

PRS 6.91
T-helper 1 cell CL0000545

CSI 7.96

rCSI 14.36%

PRS 14.33
type EC enteroendocrine cell CL0000577

CSI 7.92

rCSI 28.13%

PRS 7.79
pulmonary alveolar type 2 cell CL0002063

CSI 7.89

rCSI 12.24%

PRS 7.56
activated type II NK T cell CL0000931

CSI 7.76

rCSI 8.73%

PRS 7.89
epithelial cell of lower respiratory tract CL0002632

CSI 7.71

rCSI 5.98%

PRS 4.49
conjunctival epithelial cell CL1000432

CSI 7.67

rCSI 11.71%

PRS 4.72
plasmacytoid dendritic cell, human CL0001058

CSI 7.58

rCSI 5.29%

PRS 4.99
alveolar adventitial fibroblast CL4028006

CSI 7.53

rCSI 11.89%

PRS 4.74
mature B cell CL0000785

CSI 7.47

rCSI 6.49%

PRS 5.82
club cell CL0000158

CSI 7.33

rCSI 10.74%

PRS 5.61
paneth cell CL0000510

CSI 7.28

rCSI 10.75%

PRS 7.48
muscle cell CL0000187

CSI 7.11

rCSI 14.6%

PRS 11.49
Mueller cell CL0000636

CSI 7

rCSI 15.98%

PRS 4.39
plasma cell CL0000786

CSI 6.99

rCSI 9.15%

PRS 25.36

lung neuroendocrine cell CL1000223

CSI -20.3

rCSI -30.1%

PRS 5.4%
retinal pigment epithelial cell CL0002586

CSI -10.5

rCSI -20.9%

PRS 5.2%
Schwann cell CL0002573

CSI -9.5

rCSI -26.9%

PRS 6.4%
near-projecting glutamatergic cortical neuron CL4023012

CSI -8.7

rCSI -33.0%

PRS 3.0%
regular ventricular cardiac myocyte CL0002131

CSI -8.6

rCSI -53.9%

PRS 3.9%
vascular leptomeningeal cell CL4023051

CSI -7.9

rCSI -13.9%

PRS 3.6%
astrocyte of the cerebral cortex CL0002605

CSI -6.7

rCSI -15.0%

PRS 3.0%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI -5.8

rCSI -20.7%

PRS 2.6%
inhibitory interneuron CL0000498

CSI -5.4

rCSI -12.4%

PRS 4.3%
pulmonary capillary endothelial cell CL4028001

CSI -5.3

rCSI -10.1%

PRS 7.6%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -4.9

rCSI -4.5%

PRS 7.4%
skeletal muscle satellite cell CL0000594

CSI -4.9

rCSI -14.3%

PRS 19.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -4.4

rCSI -13.7%

PRS 3.3%
naive T cell CL0000898

CSI -3.8

rCSI -2.7%

PRS 6.9%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI -3.6

rCSI -4.3%

PRS 8.3%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI -3.4

rCSI -8.2%

PRS 2.8%
alveolar type 1 fibroblast cell CL4028004

CSI -2.9

rCSI -3.2%

PRS 5.5%
platelet CL0000233

CSI -2.1

rCSI -8.5%

PRS 14.0%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -2.0

rCSI -5.7%

PRS 6.9%
inflammatory macrophage CL0000863

CSI -1.5

rCSI -2.5%

PRS 9.8%
centrilobular region hepatocyte CL0019029

CSI -1.5

rCSI -3.8%

PRS 8.4%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI -1.3

rCSI -1.3%

PRS 7.6%
serous secreting cell CL0000313

CSI -1.3

rCSI -6.5%

PRS 23.9%
decidual natural killer cell, human CL0002343

CSI -0.8

rCSI -7.9%

PRS 42.4%
lung pericyte CL0009089

CSI -0.7

rCSI -1.9%

PRS 5.7%
brush cell CL0002204

CSI -0.7

rCSI -1.3%

PRS 13.8%
lung resident memory CD8-positive, alpha-beta T cell CL4033039

CSI -0.6

rCSI -1.6%

PRS 16.7%
primordial germ cell CL0000670

CSI -0.6

rCSI -3.0%

PRS 34.1%
exhausted T cell CL0011025

CSI -0.6

rCSI -9.7%

PRS 24.3%
retinal bipolar neuron CL0000748

CSI -0.6

rCSI -1.1%

PRS 3.6%
ON midget ganglion cell CL4033046

CSI -0.4

rCSI -8.9%

PRS 4.7%
ON parasol ganglion cell CL4033052

CSI -0.2

rCSI -2.6%

PRS 3.7%
cord blood hematopoietic stem cell CL2000095

CSI -0.1

rCSI -2.2%

PRS 38.7%
L6b glutamatergic cortical neuron CL4023038

CSI 0.0

rCSI 0.1%

PRS 3.0%
NKp44-negative group 3 innate lymphoid cell, human CL0001080

CSI 0.1

rCSI 2.1%

PRS 55.0%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.1

rCSI 0.4%

PRS 6.2%
eye photoreceptor cell CL0000287

CSI 0.1

rCSI 1.1%

PRS 16.4%
kidney loop of Henle epithelial cell CL1000909

CSI 0.1

rCSI 2.3%

PRS 40.1%
BEST4+ enteroycte CL4030026

CSI 0.1

rCSI 0.2%

PRS 5.1%
double negative T regulatory cell CL0011024

CSI 0.2

rCSI 3.1%

PRS 39.1%
glycinergic amacrine cell CL4030028

CSI 0.2

rCSI 0.5%

PRS 6.0%
basophil CL0000767

CSI 0.2

rCSI 0.4%

PRS 10.5%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.2

rCSI 0.6%

PRS 9.5%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 4.4%

PRS 5.1%
cytotoxic T cell CL0000910

CSI 0.3

rCSI 1.5%

PRS 7.4%
endothelial cell of venule CL1000414

CSI 0.3

rCSI 2.3%

PRS 28.8%
renal beta-intercalated cell CL0002201

CSI 0.3

rCSI 0.6%

PRS 6.1%
H2 horizontal cell CL0004218

CSI 0.3

rCSI 1.3%

PRS 7.1%
Merkel cell CL0000242

CSI 0.3

rCSI 6.9%

PRS 35.0%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.3

rCSI 0.5%

PRS 2.9%
intestinal crypt stem cell of colon CL0009043

CSI 0.3

rCSI 2.5%

PRS 9.0%
Bergmann glial cell CL0000644

CSI 0.4

rCSI 0.5%

PRS 5.2%
B-2 B cell CL0000822

CSI 0.4

rCSI 7.4%

PRS 30.1%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 0.4

rCSI 0.9%

PRS 33.3%
intraepithelial lymphocyte CL0002496

CSI 0.4

rCSI 1.0%

PRS 22.9%
uterine smooth muscle cell CL0002601

CSI 0.4

rCSI 2.7%

PRS 36.1%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 0.4

rCSI 0.6%

PRS 10.2%
erythrocyte CL0000232

CSI 0.4

rCSI 1.0%

PRS 6.8%
sst GABAergic cortical interneuron CL4023017

CSI 0.5

rCSI 0.6%

PRS 3.0%
renal intercalated cell CL0005010

CSI 0.5

rCSI 4.2%

PRS 41.0%
cerebral cortex neuron CL0010012

CSI 0.5

rCSI 2.0%

PRS 5.7%
basal cell of prostate epithelium CL0002341

CSI 0.5

rCSI 1.5%

PRS 10.7%
kidney interstitial cell CL1000500

CSI 0.5

rCSI 8.3%

PRS 45.5%
keratocyte CL0002363

CSI 0.5

rCSI 1.3%

PRS 7.4%
smooth muscle cell of prostate CL1000487

CSI 0.6

rCSI 3.3%

PRS 26.3%
mature alpha-beta T cell CL0000791

CSI 0.6

rCSI 2.0%

PRS 8.2%
follicular B cell CL0000843

CSI 0.6

rCSI 2.1%

PRS 23.6%
hepatic stellate cell CL0000632

CSI 0.6

rCSI 2.1%

PRS 4.1%
kidney connecting tubule epithelial cell CL1000768

CSI 0.6

rCSI 1.6%

PRS 3.8%
basophil mast progenitor cell CL0002028

CSI 0.7

rCSI 3.4%

PRS 15.3%
helper T cell CL0000912

CSI 0.7

rCSI 1.0%

PRS 7.1%
neural progenitor cell CL0011020

CSI 0.7

rCSI 3.0%

PRS 4.8%
enteroendocrine cell of colon CL0009042

CSI 0.7

rCSI 3.2%

PRS 13.2%
vasa recta ascending limb cell CL1001131

CSI 0.7

rCSI 3.2%

PRS 21.9%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.8

rCSI 5.8%

PRS 26.7%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.8

rCSI 2.1%

PRS 4.5%
VIP GABAergic cortical interneuron CL4023016

CSI 0.9

rCSI 1.0%

PRS 2.8%
duct epithelial cell CL0000068

CSI 0.9

rCSI 1.3%

PRS 5.0%
cerebral cortex endothelial cell CL1001602

CSI 0.9

rCSI 1.6%

PRS 3.6%
enterocyte of epithelium of small intestine CL1000334

CSI 1.0

rCSI 14.7%

PRS 12.5%
glial cell CL0000125

CSI 1.0

rCSI 3.7%

PRS 5.2%
hematopoietic precursor cell CL0008001

CSI 1.0

rCSI 1.0%

PRS 7.7%
erythroblast CL0000765

CSI 1.0

rCSI 2.7%

PRS 8.1%
neuroendocrine cell CL0000165

CSI 1.0

rCSI 4.0%

PRS 10.3%
granulocyte CL0000094

CSI 1.0

rCSI 1.6%

PRS 5.9%
adipocyte CL0000136

CSI 1.0

rCSI 1.3%

PRS 5.9%
retinal blood vessel endothelial cell CL0002585

CSI 1.1

rCSI 1.7%

PRS 5.2%
mature T cell CL0002419

CSI 1.1

rCSI 0.8%

PRS 6.8%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.1

rCSI 11.8%

PRS 23.5%
tracheobronchial smooth muscle cell CL0019019

CSI 1.1

rCSI 2.0%

PRS 6.3%
osteoblast CL0000062

CSI 1.1

rCSI 28.2%

PRS 41.6%
myoepithelial cell CL0000185

CSI 1.1

rCSI 2.9%

PRS 6.0%
mast cell CL0000097

CSI 1.2

rCSI 2.5%

PRS 28.0%
pulmonary ionocyte CL0017000

CSI 1.2

rCSI 1.4%

PRS 6.0%
choroid plexus epithelial cell CL0000706

CSI 1.2

rCSI 1.9%

PRS 3.7%
innate lymphoid cell CL0001065

CSI 1.2

rCSI 2.5%

PRS 7.8%
intermediate monocyte CL0002393

CSI 1.2

rCSI 1.8%

PRS 4.6%
intrahepatic cholangiocyte CL0002538

CSI 1.3

rCSI 3.0%

PRS 9.0%
pulmonary alveolar type 1 cell CL0002062

CSI 1.3

rCSI 7.2%

PRS 7.1%
P/D1 enteroendocrine cell CL0002268

CSI 1.3

rCSI 7.0%

PRS 12.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ARLN](/details-gene/401152) (allregulin) is a protein-coding gene located on chromosome 4q26 in *Homo sapiens*. It is currently described as an uncharacterized protein (C4orf3) with annotations suggesting it is an integral component of the endoplasmic reticulum membrane ([GO:0005789](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)) involved in protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). Expression data reveals a highly specific profile, with its significance overwhelmingly concentrated in various types of epithelial cells, particularly [ciliated epithelial cell](/details-cell/CL0000067) and [intestinal epithelial cell](/details-cell/CL0002563). This distinct expression pattern points towards a specialized role in mucosal barrier function, secretion, or ciliary processes. ## Cellular Roles and Expression Landscape The expression profile of [ARLN](/details-gene/401152) strongly indicates a primary function within epithelial tissues responsible for interfacing with the external environment. **Overall**, the gene shows the highest significance in [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 100.00), [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 65.43), and [lung ciliated cell](/details-cell/CL1000271) (CSI: 50.40), suggesting a fundamental role in the structure or function of cilia, which are critical for mucociliary clearance in the respiratory tract. This epithelial association is further supported by high significance in other barrier and secretory cell types, including [intestinal epithelial cell](/details-cell/CL0002563), [epithelial cell of lung](/details-cell/CL0000082), and [fallopian tube secretory epithelial cell](/details-cell/CL4030006). Its activity in [placental villous trophoblast](/details-cell/CL2000060) and [keratinocyte](/details-cell/CL0000312) reinforces its role in specialized epithelial layers. While showing some significance in hematopoietic progenitors like [hematopoietic stem cell](/details-cell/CL0000037) and [plasmablast](/details-cell/CL0000980), its role appears to be predominantly outside of mature immune cell lineages. The specificity of [ARLN](/details-gene/401152) function is underscored by its notably low to negative significance in a wide range of other cell types. It is effectively an anti-marker for neuronal and glial cells, such as [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012) and [Schwann cell](/details-cell/CL0002573). Similarly, it shows minimal relevance in cardiac muscle ([regular ventricular cardiac myocyte](/details-cell/CL0002131)), endothelial cells ([pulmonary capillary endothelial cell](/details-cell/CL4028001)), and mature T-lymphocyte populations, including [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) and [CD8-positive, alpha-beta cytotoxic T cell](/details-cell/CL0000794). This tightly restricted expression pattern suggests a highly specialized function that is not required for general cellular housekeeping, neuronal signaling, or adaptive immunity. ## Pathways and Molecular Function Functional annotations for [ARLN](/details-gene/401152) are broad but provide foundational clues to its molecular role. The gene product is localized to the endoplasmic reticulum membrane ([GO:0005789](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)), a key site for protein synthesis, modification, and transport. This localization, combined with its predicted protein-binding capacity ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)), is consistent with a role in the secretory pathway, which is highly active in the secretory epithelial cells where [ARLN](/details-gene/401152) is prominently expressed. One study has suggested that its expression can be transactivated by the Hepatitis C virus F protein, hinting at a potential role in host-pathogen interactions at epithelial surfaces [Link](https://pubmed.ncbi.nlm.nih.gov/16174453/). ## Research Directions The highly specific expression of [ARLN](/details-gene/401152) in ciliated and secretory epithelia, coupled with its uncharacterized nature, presents several avenues for future investigation. **Proposed Testable Hypotheses:** 1. Given its pronounced significance in multiple ciliated cell types, [ARLN](/details-gene/401152) is a candidate gene for regulating ciliogenesis or ciliary function. Loss-of-function mutations in [ARLN](/details-gene/401152) may contribute to the pathology of ciliopathies such as primary ciliary dyskinesia (PCD) or exacerbate mucus clearance defects in conditions like cystic fibrosis or COPD. 2. Based on its ER membrane localization and expression in secretory cells, [ARLN](/details-gene/401152) may function as a chaperone or adaptor protein involved in the proper folding, quality control, or export of secreted proteins (e.g., mucins, antimicrobial peptides) that are critical for mucosal defense. 3. The finding that [ARLN](/details-gene/401152) can be upregulated by a viral protein suggests it may be a host factor co-opted during viral infection. It could be involved in viral entry, replication, or the host's inflammatory response within epithelial barrier cells. **Key Experimental Approach:** To directly test the hypothesis that [ARLN](/details-gene/401152) is critical for ciliary function (Hypothesis 1), a targeted gene-editing study could be performed. Using a well-established air-liquid interface (ALI) culture system with primary human bronchial epithelial cells, which recapitulates the differentiation of ciliated cells *in vitro*, one could employ CRISPR-Cas9 to generate an [ARLN](/details-gene/401152) knockout. The functional consequences would be assessed by measuring ciliary beat frequency with high-speed videomicroscopy and examining ultrastructural defects in cilia via transmission electron microscopy. Parallel transcriptomic analysis (RNA-seq) of knockout versus wild-type cells would reveal downstream effects on the gene networks controlling ciliogenesis. **Therapeutic Potential:** The therapeutic potential of [ARLN](/details-gene/401152) is speculative but intriguing due to its restricted expression profile, which could minimize off-target effects. If [ARLN](/details-gene/401152) is identified as a host factor essential for viral replication (e.g., for Hepatitis C or respiratory viruses), it could represent a novel target for **inhibition** with small molecules or siRNAs to create host-directed antiviral therapies. Conversely, if loss-of-function is linked to ciliopathies, strategies for **activation** or gene replacement therapy could be considered, though this remains a significant technical challenge.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Uncharacterized protein C4orf3

Genular Protein ID: 1589392421

Symbol: CD003_HUMAN

Name: Uncharacterized protein C4orf3

UniProtKB Accession Codes:

Q8WVX3 Q6J203

Database IDs:

Citations:

PubMed ID: 16174453

Title: Screening and cloning target genes transactivated by hepatitis C virus F protein using suppression subtractive hybridization technique.

PubMed ID: 16174453

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

Length: 66
Mass: 7604
Checksum: 6973371B80AE75CC
Sequence:

MEVDAPGVDG RDGLRERRGF SEGGRQNFDV RPQSGANGLP KHSYWLDLWL FILFDVVVFL 
FVYFLP

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Ascending colon UBERON0001156
	\|— Ascending colon Healthy UBERON0001156_PATO0000461
	Atherosclerosis MONDO0005311
	Axilla UBERON0009472
	\|— Axilla Breast cancer UBERON0009472_MONDO0007254
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fallopian tube UBERON0003889
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Breast cancer UBERON0002107_MONDO0007254
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: ARLN

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Screening and cloning target genes transactivated by hepatitis C virus F protein using suppression subtractive hybridization technique. PubMed ID: 16174453

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

PubMed ID: 16174453

PubMed ID: 15815621

PubMed ID: 15489334

PubMed ID: 22814378