Details for: PRP4K
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 38.11rCSI 33.51%PRS 14.3
-
CSI 25.45rCSI 31.66%PRS 20.94
-
CSI 18.89rCSI 18.18%PRS 20.37
-
CSI 14.74rCSI 40.52%PRS 32.18
-
CSI 12.29rCSI 53.96%PRS 36.09
-
CSI 12.1rCSI 8.15%PRS 24.03
-
CSI 11.09rCSI 24.5%PRS 14.08
-
CSI 9.98rCSI 52.43%PRS 33.57
-
CSI 9.29rCSI 7.03%PRS 26.93
-
CSI 9.08rCSI 19.9%PRS 26.3
-
CSI 8.87rCSI 28.47%PRS 28.13
-
CSI 8.31rCSI 19.37%PRS 38.91
-
CSI 8.27rCSI 60.8%PRS 11.48
-
CSI 6.35rCSI 7.46%PRS 22.72
-
CSI 6.29rCSI 21.53%PRS 17.06
-
CSI 6.11rCSI 13.98%PRS 19.11
-
CSI 5.52rCSI 14.87%PRS 25.47
-
CSI 5.5rCSI 15.91%PRS 22.24
-
CSI 5.36rCSI 6.2%PRS 14.46
-
CSI 4.88rCSI 24.06%PRS 26.64
-
CSI 4.88rCSI 39.65%PRS 19.8
-
CSI 4.67rCSI 11.1%PRS 29.37
-
CSI 4.53rCSI 23.37%PRS 38.07
-
CSI 3.88rCSI 8.26%PRS 31.27
-
CSI 3.83rCSI 13.79%PRS 10.91
-
CSI 3.83rCSI 3.68%PRS 39.54
-
CSI 3.66rCSI 87.56%PRS 9.96
-
CSI 3.63rCSI 87.68%PRS 10.91
-
CSI 3.63rCSI 10.71%PRS 23.71
-
CSI 3.61rCSI 2.89%PRS 34.98
-
CSI 3.57rCSI 72.74%PRS 15.79
-
CSI 3.49rCSI 49.53%PRS 14.95
-
CSI 3.46rCSI 5.11%PRS 30.73
-
CSI 3.3rCSI 8.76%PRS 31.24
-
CSI 3.3rCSI 67.12%PRS 16.83
-
CSI 3.04rCSI 22.86%PRS 35.72
-
CSI 2.68rCSI 9.71%PRS 33.61
-
CSI 2.64rCSI 2.19%PRS 19.92
-
CSI 2.61rCSI 8.56%PRS 50.76
-
CSI 2.53rCSI 2.28%PRS 17.68
-
CSI 2.39rCSI 14.45%PRS 42.89
-
CSI 2.36rCSI 1.91%PRS 19.69
-
CSI 2.36rCSI 9.19%PRS 32.25
-
CSI 2.24rCSI 12.11%PRS 34.25
-
CSI 2.15rCSI 9.57%PRS 19.28
-
CSI 2.15rCSI 6.02%PRS 30.42
-
CSI 2.13rCSI 4.31%PRS 9.89
-
CSI 2.1rCSI 2.81%PRS 37.22
-
CSI 2.09rCSI 32.4%PRS 46.73
-
CSI 2.07rCSI 5.91%PRS 33.15
-
CSI 2.07rCSI 48.18%PRS 36.46
-
CSI 2.03rCSI 6.59%PRS 23.87
-
CSI 2.02rCSI 1.55%PRS 18.2
-
CSI 1.95rCSI 2.26%PRS 28.53
-
CSI 1.93rCSI 7.87%PRS 20.04
-
CSI 1.8rCSI 5.33%PRS 27.68
-
CSI 1.67rCSI 26.4%PRS 17.04
-
CSI 1.64rCSI 2.44%PRS 23.46
-
CSI 1.57rCSI 1.18%PRS 52.5
-
CSI 1.45rCSI 5.14%PRS 57.02
-
CSI 1.41rCSI 1.18%PRS 23.43
-
CSI 1.38rCSI 1.58%PRS 39.57
-
CSI 1.36rCSI 1.86%PRS 22.27
-
CSI 1.35rCSI 1.05%PRS 28.72
-
CSI 1.33rCSI 2.28%PRS 39.38
-
CSI 1.29rCSI 5.5%PRS 23.66
-
CSI 1.27rCSI 1.01%PRS 34.81
-
CSI 1.25rCSI 1.78%PRS 18.25
-
CSI 1.24rCSI 1.06%PRS 32.17
-
CSI 1.2rCSI 3.75%PRS 13.33
-
CSI 1.19rCSI 35.73%PRS 42.88
-
CSI 1.17rCSI 1.47%PRS 68.01
-
CSI 1.17rCSI 4.41%PRS 11.95
-
CSI 1.15rCSI 1.65%PRS 22.14
-
CSI 1.14rCSI 1.46%PRS 19.09
-
CSI 1.13rCSI 1.62%PRS 15.27
-
CSI 1.12rCSI 20.43%PRS 53.89
-
CSI 1.11rCSI 2.92%PRS 38
-
CSI 1.11rCSI 1.41%PRS 64.35
-
CSI 1.07rCSI 0.71%PRS 46.73
-
CSI 1.06rCSI 4.95%PRS 39.09
-
CSI 1.04rCSI 1.98%PRS 31.06
-
CSI 1.01rCSI 1.38%PRS 30.69
-
CSI 0.98rCSI 0.86%PRS 22.6
-
CSI 0.98rCSI 2.29%PRS 28.35
-
CSI 0.97rCSI 1.14%PRS 26.89
-
CSI 0.95rCSI 0.94%PRS 21.26
-
CSI 0.95rCSI 0.77%PRS 30.65
-
CSI 0.95rCSI 1.81%PRS 42.82
-
CSI 0.93rCSI 9.8%PRS 25.65
-
CSI 0.91rCSI 0.64%PRS 45.6
-
CSI 0.9rCSI 1.38%PRS 19.8
-
CSI 0.9rCSI 2.25%PRS 52.4
-
CSI 0.89rCSI 1.69%PRS 41.38
-
CSI 0.88rCSI 0.69%PRS 18.85
-
CSI 0.87rCSI 1.21%PRS 27.78
-
CSI 0.86rCSI 1.32%PRS 18.28
-
CSI 0.85rCSI 1.09%PRS 19
-
CSI 0.84rCSI 1.13%PRS 25.56
-
CSI 0.84rCSI 1.89%PRS 38.65
-
CSI -2.3rCSI -3.3%PRS 20.8%
-
CSI -1.2rCSI -5.2%PRS 34.1%
-
CSI -1.2rCSI -3.3%PRS 18.3%
-
CSI -0.7rCSI -0.6%PRS 23.0%
-
CSI -0.6rCSI -1.6%PRS 19.8%
-
CSI -0.5rCSI -1.2%PRS 12.1%
-
CSI -0.5rCSI -0.8%PRS 11.6%
-
CSI -0.4rCSI -2.0%PRS 18.5%
-
CSI -0.3rCSI -0.6%PRS 29.9%
-
CSI -0.2rCSI -4.0%PRS 61.9%
-
CSI -0.1rCSI -0.9%PRS 13.0%
-
CSI -0.1rCSI -0.2%PRS 19.6%
-
CSI 0.0rCSI -0.2%PRS 50.7%
-
CSI 0.0rCSI 0.1%PRS 24.8%
-
CSI 0.0rCSI 0.2%PRS 56.9%
-
CSI 0.1rCSI 0.3%PRS 60.0%
-
CSI 0.1rCSI 0.6%PRS 34.9%
-
CSI 0.1rCSI 0.1%PRS 22.5%
-
CSI 0.1rCSI 0.3%PRS 33.6%
-
CSI 0.1rCSI 0.1%PRS 19.8%
-
CSI 0.1rCSI 0.4%PRS 28.8%
-
CSI 0.1rCSI 0.3%PRS 26.7%
-
CSI 0.1rCSI 0.6%PRS 37.9%
-
CSI 0.1rCSI 0.2%PRS 39.0%
-
CSI 0.1rCSI 1.1%PRS 64.4%
-
CSI 0.1rCSI 0.3%PRS 44.5%
-
CSI 0.1rCSI 1.3%PRS 55.9%
-
CSI 0.1rCSI 0.5%PRS 23.3%
-
CSI 0.1rCSI 0.3%PRS 31.9%
-
CSI 0.1rCSI 0.9%PRS 9.7%
-
CSI 0.1rCSI 1.0%PRS 50.0%
-
CSI 0.1rCSI 0.1%PRS 21.6%
-
CSI 0.1rCSI 0.8%PRS 39.1%
-
CSI 0.1rCSI 0.4%PRS 20.6%
-
CSI 0.1rCSI 2.1%PRS 65.6%
-
CSI 0.1rCSI 0.7%PRS 33.2%
-
CSI 0.1rCSI 0.7%PRS 29.2%
-
CSI 0.1rCSI 0.2%PRS 25.3%
-
CSI 0.1rCSI 0.8%PRS 15.4%
-
CSI 0.1rCSI 0.6%PRS 49.7%
-
CSI 0.1rCSI 0.2%PRS 20.5%
-
CSI 0.1rCSI 0.2%PRS 12.7%
-
CSI 0.2rCSI 0.2%PRS 29.5%
-
CSI 0.2rCSI 0.4%PRS 22.6%
-
CSI 0.2rCSI 0.2%PRS 23.2%
-
CSI 0.2rCSI 0.2%PRS 26.6%
-
CSI 0.2rCSI 0.4%PRS 34.5%
-
CSI 0.2rCSI 0.4%PRS 22.8%
-
CSI 0.2rCSI 0.5%PRS 15.6%
-
CSI 0.2rCSI 1.1%PRS 48.6%
-
CSI 0.2rCSI 0.4%PRS 12.6%
-
CSI 0.2rCSI 1.0%PRS 29.5%
-
CSI 0.2rCSI 0.6%PRS 31.2%
-
CSI 0.2rCSI 0.3%PRS 51.1%
-
CSI 0.2rCSI 1.7%PRS 67.6%
-
CSI 0.2rCSI 0.6%PRS 12.3%
-
CSI 0.2rCSI 0.8%PRS 17.5%
-
CSI 0.2rCSI 1.1%PRS 56.6%
-
CSI 0.2rCSI 0.3%PRS 15.1%
-
CSI 0.2rCSI 0.2%PRS 22.2%
-
CSI 0.2rCSI 0.6%PRS 16.4%
-
CSI 0.2rCSI 0.2%PRS 18.1%
-
CSI 0.2rCSI 0.5%PRS 29.2%
-
CSI 0.2rCSI 0.2%PRS 31.2%
-
CSI 0.2rCSI 1.8%PRS 64.1%
-
CSI 0.2rCSI 0.3%PRS 19.2%
-
CSI 0.2rCSI 0.3%PRS 23.5%
-
CSI 0.2rCSI 4.3%PRS 53.5%
-
CSI 0.2rCSI 0.4%PRS 47.3%
-
CSI 0.2rCSI 0.3%PRS 30.2%
-
CSI 0.2rCSI 0.6%PRS 26.4%
-
CSI 0.2rCSI 1.5%PRS 42.8%
-
CSI 0.2rCSI 5.3%PRS 66.9%
-
CSI 0.2rCSI 2.6%PRS 37.3%
-
CSI 0.2rCSI 0.7%PRS 29.2%
-
CSI 0.3rCSI 0.3%PRS 17.4%
-
CSI 0.3rCSI 0.3%PRS 28.0%
-
CSI 0.3rCSI 0.3%PRS 22.9%
-
CSI 0.3rCSI 1.7%PRS 20.6%
-
CSI 0.3rCSI 0.4%PRS 26.6%
-
CSI 0.3rCSI 0.8%PRS 12.4%
-
CSI 0.3rCSI 0.3%PRS 17.2%
-
CSI 0.3rCSI 0.6%PRS 26.4%
-
CSI 0.3rCSI 0.3%PRS 12.2%
-
CSI 0.3rCSI 0.6%PRS 38.0%
-
CSI 0.3rCSI 0.6%PRS 30.9%
-
CSI 0.3rCSI 1.0%PRS 19.2%
-
CSI 0.3rCSI 1.2%PRS 60.1%
-
CSI 0.3rCSI 0.5%PRS 18.2%
-
CSI 0.3rCSI 0.5%PRS 25.8%
-
CSI 0.3rCSI 0.4%PRS 25.8%
-
CSI 0.3rCSI 0.6%PRS 13.5%
-
CSI 0.3rCSI 0.7%PRS 16.7%
-
CSI 0.3rCSI 0.3%PRS 29.9%
-
CSI 0.3rCSI 0.3%PRS 23.5%
-
CSI 0.3rCSI 1.2%PRS 27.7%
-
CSI 0.3rCSI 0.3%PRS 18.4%
-
CSI 0.3rCSI 0.8%PRS 25.4%
-
CSI 0.3rCSI 0.5%PRS 16.3%
-
CSI 0.3rCSI 0.8%PRS 48.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3803747678
Symbol: PRP4K_HUMAN
Name: Serine/threonine-protein kinase PRP4 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11418604
Title: Cloning of human PRP4 reveals interaction with Clk1.
PubMed ID: 11418604
PubMed ID: 12077342
Title: Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
PubMed ID: 12077342
PubMed ID: 9628581
Title: Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9628581
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9102632
Title: Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue.
PubMed ID: 9102632
PubMed ID: 10799319
Title: Characterization of hPRP4 kinase activation: potential role in signaling.
PubMed ID: 10799319
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17998396
Title: PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores.
PubMed ID: 17998396
PubMed ID: 17513757
Title: Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.
PubMed ID: 17513757
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20118938
Title: Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
PubMed ID: 20118938
DOI: 10.1038/nsmb.1718
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25114211
Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
PubMed ID: 25114211
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29695716
Title: Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.
PubMed ID: 29695716
PubMed ID: 35281802
Title: Tinker, Tailor, Tumour Suppressor: The Many Functions of PRP4K.
PubMed ID: 35281802
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1007
- Mass: 116987
- Checksum: EC8C1538A61EDA78
- Sequence:
MAAAETQSLR EQPEMEDANS EKSINEENGE VSEDQSQNKH SRHKKKKHKH RSKHKKHKHS SEEDKDKKHK HKHKHKKHKR KEIIDASDKE GMSPAKRTKL DDLALLEDLE KQRALIKAEL DNELMEGKVQ SGMGLILQGY ESGSEEEGEI HEKARNGNRS STRSSSTKGK LELVDNKITT KKRSKSRSKE RTRHRSDKKK SKGGIEIVKE KTTRSKSKER KKSKSPSKRS KSQDQARKSK SPTLRRRSQE KIGKARSPTD DKVKIEDKSK SKDRKKSPII NESRSRDRGK KSRSPVDLRG KSKDRRSRSK ERKSKRSETD KEKKPIKSPS KDASSGKENR SPSRRPGRSP KRRSLSPKPR DKSRRSRSPL LNDRRSKQSK SPSRTLSPGR RAKSRSLERK RREPERRRLS SPRTRPRDDI LSRRERSKDA SPINRWSPTR RRSRSPIRRR SRSPLRRSRS PRRRSRSPRR RDRGRRSRSR LRRRSRSRGG RRRRSRSKVK EDKFKGSLSE GMKVEQESSS DDNLEDFDVE EEDEEALIEQ RRIQRQAIVQ KYKYLAEDSN MSVPSEPSSP QSSTRTRSPS PDDILERVAA DVKEYERENV DTFEASVKAK HNLMTVEQNN GSSQKKLLAP DMFTESDDMF AAYFDSARLR AAGIGKDFKE NPNLRDNWTD AEGYYRVNIG EVLDKRYNVY GYTGQGVFSN VVRARDNARA NQEVAVKIIR NNELMQKTGL KELEFLKKLN DADPDDKFHC LRLFRHFYHK QHLCLVFEPL SMNLREVLKK YGKDVGLHIK AVRSYSQQLF LALKLLKRCN ILHADIKPDN ILVNESKTIL KLCDFGSASH VADNDITPYL VSRFYRAPEI IIGKSYDYGI DMWSVGCTLY ELYTGKILFP GKTNNHMLKL AMDLKGKMPN KMIRKGVFKD QHFDQNLNFM YIEVDKVTER EKVTVMSTIN PTKDLLADLI GCQRLPEDQR KKVHQLKDLL DQILMLDPAK RISINQALQH AFIQEKI