PUM1 | ENSG00000134644 | NCBI 9698

Details for: PUM1

Gene ID: 9698

Symbol: PUM1

Ensembl ID: ENSG00000134644

Description: pumilio RNA binding family member 1

Associated with

Golgi associated vesicle biogenesis
(R-HSA-432722)
Membrane trafficking
(R-HSA-199991)
Trans-golgi network vesicle budding
(R-HSA-199992)
Vesicle-mediated transport
(R-HSA-5653656)
3'-utr-mediated mrna destabilization
(GO:0061158)
Adult locomotory behavior
(GO:0008344)
Axon
(GO:0030424)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Mirna binding
(GO:0035198)
Mirna processing
(GO:0035196)
Mrna 3'-utr binding
(GO:0003730)
Mrna destabilization
(GO:0061157)
Nucleoplasm
(GO:0005654)
P-body
(GO:0000932)
Positive regulation of mirna-mediated gene silencing
(GO:2000637)
Positive regulation of rig-i signaling pathway
(GO:1900246)
Post-transcriptional gene silencing
(GO:0016441)
Post-transcriptional regulation of gene expression
(GO:0010608)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of chromosome segregation
(GO:0051983)
Regulation of mirna-mediated gene silencing
(GO:0060964)
Regulation of mrna stability
(GO:0043488)
Regulation of translation
(GO:0006417)
Rna binding
(GO:0003723)
Spermatogenesis
(GO:0007283)
Stem cell differentiation
(GO:0048863)

Other Information

Proteins

PUM1_HUMAN

Genular Protein ID: 2961418852

Symbol: PUM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q14671 A8K6W4 B4DG92 D3DPN3 E9PCJ0 Q53HH5 Q5VXY7 Q9HAN1

Database IDs:

Citations:

PubMed ID: 12459267

Title: Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.

PubMed ID: 12459267

DOI: 10.1016/s0378-1119(02)01060-0

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12771951

Title: Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.

PubMed ID: 12771951

DOI: 10.1038/sj.onc.1206537

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18776931

Title: Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.

PubMed ID: 18776931

DOI: 10.1371/journal.pone.0003164

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20818387

Title: A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

PubMed ID: 20818387

DOI: 10.1038/ncb2105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20860814

Title: A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions.

PubMed ID: 20860814

DOI: 10.1186/1758-907x-1-17

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21572425

Title: A universal code for RNA recognition by PUF proteins.

PubMed ID: 21572425

DOI: 10.1038/nchembio.577

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22345517

Title: Pumilio facilitates miRNA regulation of the E2F3 oncogene.

PubMed ID: 22345517

DOI: 10.1101/gad.182568.111

PubMed ID: 22955276

Title: Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.

PubMed ID: 22955276

DOI: 10.1074/jbc.m112.373522

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23125361

Title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.

PubMed ID: 23125361

DOI: 10.1093/nar/gks1032

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25340845

Title: A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.

PubMed ID: 25340845

DOI: 10.1371/journal.ppat.1004417

PubMed ID: 25768905

Title: Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.

PubMed ID: 25768905

DOI: 10.1016/j.cell.2015.02.012

PubMed ID: 26724866

Title: Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins.

PubMed ID: 26724866

DOI: 10.1016/j.cell.2015.12.017

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

PubMed ID: 29474920

Title: A mild PUM1 mutation is associated with adult-onset ataxia, whereas haploinsufficiency causes developmental delay and seizures.

PubMed ID: 29474920

DOI: 10.1016/j.cell.2018.02.006

PubMed ID: 11336708

Title: Crystal structure of a Pumilio homology domain.

PubMed ID: 11336708

DOI: 10.1016/s1097-2765(01)00229-5

PubMed ID: 12202039

Title: Modular recognition of RNA by a human pumilio-homology domain.

PubMed ID: 12202039

DOI: 10.1016/s0092-8674(02)00873-5

PubMed ID: 18328718

Title: Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity.

PubMed ID: 18328718

DOI: 10.1016/j.str.2008.01.006

PubMed ID: 21653694

Title: Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains.

PubMed ID: 21653694

DOI: 10.1074/jbc.m111.244889

PubMed ID: 21397187

Title: Alternate modes of cognate RNA recognition by human PUMILIO proteins.

PubMed ID: 21397187

DOI: 10.1016/j.str.2010.12.019

Sequence Information:

Length: 1186
Mass: 126473
Checksum: E1E0D8B3B0181308
Sequence:

MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT 
HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH 
QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS 
DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF 
GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG 
NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF 
DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA 
PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA 
AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG 
QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA 
AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL 
FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT 
SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG 
SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR 
YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY 
VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH 
VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD 
QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN 
VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV 
MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PUM1

Associated with

Other Information

Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. PubMed ID: 12459267

Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7788527

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. PubMed ID: 12771951

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system. PubMed ID: 18776931

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. PubMed ID: 20818387

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions. PubMed ID: 20860814

Initial characterization of the human central proteome. PubMed ID: 21269460

A universal code for RNA recognition by PUF proteins. PubMed ID: 21572425

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Pumilio facilitates miRNA regulation of the E2F3 oncogene. PubMed ID: 22345517

Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs. PubMed ID: 22955276

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. PubMed ID: 23125361

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection. PubMed ID: 25340845

Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. PubMed ID: 25768905

Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins. PubMed ID: 26724866

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. PubMed ID: 28431233

A mild PUM1 mutation is associated with adult-onset ataxia, whereas haploinsufficiency causes developmental delay and seizures. PubMed ID: 29474920

Crystal structure of a Pumilio homology domain. PubMed ID: 11336708

Modular recognition of RNA by a human pumilio-homology domain. PubMed ID: 12202039

Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity. PubMed ID: 18328718

Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains. PubMed ID: 21653694

Alternate modes of cognate RNA recognition by human PUMILIO proteins. PubMed ID: 21397187