Details for: PUM1
Gene ID: 9698
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PUM1
Ensembl ID: ENSG00000134644
Description: pumilio RNA binding family member 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 38.28rCSI 58.47%PRS 17.91
-
CSI 34.53rCSI 57.96%PRS 10.48
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CSI 32.9rCSI 52.91%PRS 11.4
-
CSI 28.9rCSI 70.24%PRS 10.31
-
CSI 23.68rCSI 74.01%PRS 11.21
-
CSI 20.05rCSI 19.3%PRS 18.43
-
CSI 19.84rCSI 28.12%PRS 16.54
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CSI 18.57rCSI 66.81%PRS 9.86
-
CSI 18.13rCSI 21.66%PRS 10.27
-
CSI 17.84rCSI 67.43%PRS 10.8
-
CSI 17.79rCSI 31.42%PRS 10.45
-
CSI 16.17rCSI 23.87%PRS 27.8
-
CSI 15.55rCSI 40.39%PRS 23
-
CSI 15.18rCSI 40.91%PRS 23.03
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CSI 14.09rCSI 37.65%PRS 14.78
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CSI 13.31rCSI 78.36%PRS 11.01
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CSI 12.41rCSI 38.81%PRS 12.05
-
CSI 12.03rCSI 14.88%PRS 15.6
-
CSI 11.94rCSI 48.15%PRS 15.99
-
CSI 11.84rCSI 22.36%PRS 22.42
-
CSI 11.33rCSI 67.89%PRS 29.46
-
CSI 11.25rCSI 55.45%PRS 24.08
-
CSI 11.09rCSI 24.41%PRS 27.06
-
CSI 11.05rCSI 41.38%PRS 15.05
-
CSI 10.34rCSI 22.85%PRS 12.73
-
CSI 10.04rCSI 29.8%PRS 25.11
-
CSI 9.26rCSI 46.04%PRS 18.97
-
CSI 8.97rCSI 11.56%PRS 10.99
-
CSI 8.95rCSI 25.6%PRS 31.32
-
CSI 8.86rCSI 22.48%PRS 13.48
-
CSI 8.72rCSI 11.2%PRS 17.37
-
CSI 8.71rCSI 19.08%PRS 23.84
-
CSI 7.95rCSI 58.41%PRS 10.05
-
CSI 7.93rCSI 20.7%PRS 27.41
-
CSI 7.85rCSI 6.5%PRS 18.03
-
CSI 7.72rCSI 8.91%PRS 15.59
-
CSI 7.16rCSI 8.91%PRS 9.77
-
CSI 7.13rCSI 13.87%PRS 18.21
-
CSI 6.84rCSI 35.9%PRS 30.7
-
CSI 6.72rCSI 17.9%PRS 14.57
-
CSI 6.65rCSI 49.96%PRS 32.37
-
CSI 6.26rCSI 50.88%PRS 18.04
-
CSI 5.65rCSI 8.73%PRS 16.67
-
CSI 5.64rCSI 10.1%PRS 16.45
-
CSI 5.62rCSI 7.05%PRS 23.06
-
CSI 5.52rCSI 8.33%PRS 17.95
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CSI 5.5rCSI 4.63%PRS 28.41
-
CSI 5.45rCSI 23.94%PRS 33.01
-
CSI 5.39rCSI 12.86%PRS 20.68
-
CSI 5.38rCSI 34.47%PRS 26.77
-
CSI 5.36rCSI 13.97%PRS 16.39
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CSI 5.36rCSI 6.66%PRS 18.88
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CSI 5.24rCSI 12.53%PRS 10.94
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CSI 5.22rCSI 7.25%PRS 18.25
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CSI 5.16rCSI 14.45%PRS 27.53
-
CSI 5.14rCSI 15.84%PRS 26.61
-
CSI 5.08rCSI 7.76%PRS 31.36
-
CSI 5.05rCSI 8.73%PRS 13.56
-
CSI 5.01rCSI 54.47%PRS 33.86
-
CSI 4.97rCSI 13.18%PRS 28.7
-
CSI 4.72rCSI 32.14%PRS 18.13
-
CSI 4.57rCSI 20.07%PRS 15.15
-
CSI 4.36rCSI 10.49%PRS 26.41
-
CSI 4rCSI 3.16%PRS 12.19
-
CSI 3.99rCSI 9.75%PRS 17.57
-
CSI 3.82rCSI 4.9%PRS 17.23
-
CSI 3.63rCSI 86.98%PRS 8.78
-
CSI 3.63rCSI 5.84%PRS 13.64
-
CSI 3.58rCSI 8.2%PRS 17.29
-
CSI 3.56rCSI 85.81%PRS 9.72
-
CSI 3.55rCSI 7.05%PRS 18.85
-
CSI 3.53rCSI 10.41%PRS 16.24
-
CSI 3.49rCSI 81.38%PRS 33
-
CSI 3.48rCSI 5.55%PRS 15.26
-
CSI 3.44rCSI 5.29%PRS 24.58
-
CSI 3.41rCSI 2.73%PRS 31.87
-
CSI 3.33rCSI 6.76%PRS 8.62
-
CSI 3.28rCSI 2.28%PRS 21.2
-
CSI 3.25rCSI 8.56%PRS 34.46
-
CSI 3.2rCSI 24.76%PRS 18.69
-
CSI 2.99rCSI 5.36%PRS 14.75
-
CSI 2.96rCSI 7.65%PRS 16.59
-
CSI 2.95rCSI 3.04%PRS 28.87
-
CSI 2.95rCSI 2.29%PRS 26.01
-
CSI 2.92rCSI 9.47%PRS 21.56
-
CSI 2.84rCSI 6.49%PRS 15.32
-
CSI 2.84rCSI 40.26%PRS 13.1
-
CSI 2.71rCSI 6.86%PRS 22.02
-
CSI 2.71rCSI 10.54%PRS 24.25
-
CSI 2.66rCSI 9.1%PRS 15.32
-
CSI 2.66rCSI 10.57%PRS 30.75
-
CSI 2.6rCSI 3.54%PRS 41.76
-
CSI 2.55rCSI 16.34%PRS 45.2
-
CSI 2.44rCSI 5.3%PRS 11.57
-
CSI 2.41rCSI 6.28%PRS 17.55
-
CSI 2.41rCSI 3.7%PRS 21.23
-
CSI 2.36rCSI 3.75%PRS 15.05
-
CSI 2.34rCSI 47.7%PRS 13.99
-
CSI 2.3rCSI 3.3%PRS 13.75
-
CSI 2.3rCSI 11.61%PRS 60.42
-
CSI -9.7rCSI -6.9%PRS 24.5%
-
CSI -4.3rCSI -5.9%PRS 28.0%
-
CSI -3.9rCSI -6.6%PRS 35.1%
-
CSI -1.6rCSI -2.4%PRS 41.3%
-
CSI -1.2rCSI -0.9%PRS 26.4%
-
CSI -1.1rCSI -2.9%PRS 17.9%
-
CSI -1.1rCSI -1.0%PRS 32.2%
-
CSI -0.8rCSI -3.7%PRS 10.1%
-
CSI -0.8rCSI -1.1%PRS 24.3%
-
CSI -0.4rCSI -1.3%PRS 20.1%
-
CSI -0.2rCSI -0.9%PRS 56.8%
-
CSI -0.2rCSI -0.6%PRS 61.0%
-
CSI 0.0rCSI 0.0%PRS 24.7%
-
CSI 0.0rCSI 0.2%PRS 27.1%
-
CSI 0.0rCSI 0.6%PRS 50.6%
-
CSI 0.0rCSI 1.0%PRS 53.6%
-
CSI 0.0rCSI 0.5%PRS 31.8%
-
CSI 0.1rCSI 0.4%PRS 34.4%
-
CSI 0.1rCSI 0.2%PRS 29.3%
-
CSI 0.1rCSI 0.7%PRS 11.0%
-
CSI 0.1rCSI 0.2%PRS 17.9%
-
CSI 0.1rCSI 0.2%PRS 16.5%
-
CSI 0.1rCSI 0.6%PRS 13.8%
-
CSI 0.1rCSI 0.1%PRS 20.0%
-
CSI 0.1rCSI 0.7%PRS 26.6%
-
CSI 0.1rCSI 0.4%PRS 28.9%
-
CSI 0.1rCSI 0.7%PRS 31.7%
-
CSI 0.1rCSI 0.2%PRS 27.1%
-
CSI 0.1rCSI 0.1%PRS 22.3%
-
CSI 0.1rCSI 2.2%PRS 43.1%
-
CSI 0.2rCSI 0.4%PRS 38.1%
-
CSI 0.2rCSI 1.2%PRS 19.9%
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CSI 0.2rCSI 0.9%PRS 23.6%
-
CSI 0.2rCSI 0.8%PRS 33.0%
-
CSI 0.2rCSI 0.3%PRS 23.0%
-
CSI 0.2rCSI 0.9%PRS 24.2%
-
CSI 0.2rCSI 2.2%PRS 46.9%
-
CSI 0.2rCSI 1.1%PRS 17.4%
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CSI 0.3rCSI 0.6%PRS 20.6%
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CSI 0.3rCSI 0.2%PRS 21.7%
-
CSI 0.3rCSI 0.3%PRS 20.6%
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CSI 0.3rCSI 0.2%PRS 24.8%
-
CSI 0.3rCSI 0.7%PRS 28.2%
-
CSI 0.3rCSI 0.8%PRS 13.6%
-
CSI 0.3rCSI 4.4%PRS 42.6%
-
CSI 0.3rCSI 1.4%PRS 40.1%
-
CSI 0.3rCSI 0.7%PRS 22.1%
-
CSI 0.3rCSI 0.8%PRS 23.4%
-
CSI 0.3rCSI 0.4%PRS 36.1%
-
CSI 0.4rCSI 0.7%PRS 37.8%
-
CSI 0.4rCSI 1.9%PRS 34.6%
-
CSI 0.4rCSI 0.8%PRS 28.7%
-
CSI 0.4rCSI 0.3%PRS 18.8%
-
CSI 0.4rCSI 1.3%PRS 28.8%
-
CSI 0.4rCSI 0.8%PRS 26.7%
-
CSI 0.4rCSI 0.5%PRS 27.4%
-
CSI 0.4rCSI 0.3%PRS 28.5%
-
CSI 0.4rCSI 0.6%PRS 20.4%
-
CSI 0.4rCSI 0.4%PRS 30.8%
-
CSI 0.4rCSI 4.6%PRS 42.5%
-
CSI 0.4rCSI 4.3%PRS 20.1%
-
CSI 0.4rCSI 1.6%PRS 5.3%
-
CSI 0.4rCSI 0.7%PRS 23.4%
-
CSI 0.4rCSI 0.4%PRS 20.4%
-
CSI 0.4rCSI 0.6%PRS 28.2%
-
CSI 0.4rCSI 0.9%PRS 28.3%
-
CSI 0.4rCSI 1.6%PRS 17.4%
-
CSI 0.4rCSI 2.3%PRS 31.6%
-
CSI 0.4rCSI 0.6%PRS 23.4%
-
CSI 0.5rCSI 0.7%PRS 16.5%
-
CSI 0.5rCSI 2.0%PRS 16.9%
-
CSI 0.5rCSI 0.6%PRS 21.3%
-
CSI 0.5rCSI 0.7%PRS 28.8%
-
CSI 0.5rCSI 2.5%PRS 28.4%
-
CSI 0.5rCSI 1.9%PRS 24.5%
-
CSI 0.5rCSI 2.0%PRS 43.5%
-
CSI 0.5rCSI 2.9%PRS 53.6%
-
CSI 0.5rCSI 2.7%PRS 9.1%
-
CSI 0.5rCSI 1.4%PRS 33.5%
-
CSI 0.5rCSI 1.0%PRS 34.9%
-
CSI 0.5rCSI 1.5%PRS 18.6%
-
CSI 0.5rCSI 3.1%PRS 39.5%
-
CSI 0.5rCSI 3.0%PRS 11.7%
-
CSI 0.5rCSI 2.3%PRS 35.7%
-
CSI 0.5rCSI 1.8%PRS 30.5%
-
CSI 0.5rCSI 0.7%PRS 20.6%
-
CSI 0.5rCSI 0.7%PRS 25.3%
-
CSI 0.5rCSI 0.8%PRS 10.6%
-
CSI 0.5rCSI 0.7%PRS 19.5%
-
CSI 0.5rCSI 1.8%PRS 52.9%
-
CSI 0.5rCSI 1.1%PRS 30.0%
-
CSI 0.5rCSI 0.4%PRS 31.6%
-
CSI 0.6rCSI 0.5%PRS 20.8%
-
CSI 0.6rCSI 1.3%PRS 31.8%
-
CSI 0.6rCSI 1.3%PRS 18.4%
-
CSI 0.6rCSI 2.2%PRS 35.4%
-
CSI 0.6rCSI 4.3%PRS 46.5%
-
CSI 0.6rCSI 1.1%PRS 29.7%
-
CSI 0.6rCSI 0.5%PRS 17.8%
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CSI 0.6rCSI 1.9%PRS 13.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2961418852
Symbol: PUM1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12459267
Title: Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.
PubMed ID: 12459267
PubMed ID: 7788527
Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
PubMed ID: 7788527
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12771951
Title: Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.
PubMed ID: 12771951
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18776931
Title: Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.
PubMed ID: 18776931
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20818387
Title: A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.
PubMed ID: 20818387
DOI: 10.1038/ncb2105
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20860814
Title: A structural-based statistical approach suggests a cooperative activity of PUM1 and miR-410 in human 3'-untranslated regions.
PubMed ID: 20860814
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21572425
Title: A universal code for RNA recognition by PUF proteins.
PubMed ID: 21572425
DOI: 10.1038/nchembio.577
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22345517
Title: Pumilio facilitates miRNA regulation of the E2F3 oncogene.
PubMed ID: 22345517
PubMed ID: 22955276
Title: Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.
PubMed ID: 22955276
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23125361
Title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
PubMed ID: 23125361
DOI: 10.1093/nar/gks1032
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25340845
Title: A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.
PubMed ID: 25340845
PubMed ID: 25768905
Title: Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.
PubMed ID: 25768905
PubMed ID: 26724866
Title: Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins.
PubMed ID: 26724866
PubMed ID: 28431233
Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
PubMed ID: 28431233
PubMed ID: 11336708
Title: Crystal structure of a Pumilio homology domain.
PubMed ID: 11336708
PubMed ID: 12202039
Title: Modular recognition of RNA by a human pumilio-homology domain.
PubMed ID: 12202039
PubMed ID: 18328718
Title: Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity.
PubMed ID: 18328718
PubMed ID: 21653694
Title: Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains.
PubMed ID: 21653694
PubMed ID: 21397187
Title: Alternate modes of cognate RNA recognition by human PUMILIO proteins.
PubMed ID: 21397187
PubMed ID: 29474920
Title: A mild PUM1 mutation is associated with adult-onset ataxia, whereas haploinsufficiency causes developmental delay and seizures.
PubMed ID: 29474920
PubMed ID: 30903679
Title: PADDAS syndrome associated with hair dysplasia caused by a de novo missense variant of PUM1.
PubMed ID: 30903679
DOI: 10.1002/ajmg.a.61127
PubMed ID: 31859446
Title: PUM1 haploinsufficiency is associated with syndromic neurodevelopmental delay and epilepsy.
PubMed ID: 31859446
DOI: 10.1002/ajmg.a.61463
PubMed ID: 35386260
Title: A de novo PUM1 Variant in a Girl With a Dravet-Like Syndrome: Case Report and Literature Review.
PubMed ID: 35386260
Sequence Information:
- Length: 1186
- Mass: 126473
- Checksum: E1E0D8B3B0181308
- Sequence:
MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH QVRSMDELNH DFQALALEGR AMGEQLLPGK KFWETDESSK DGPKGIFLGD QWRDSAWGTS DHSVSQPIMV QRRPGQSFHV NSEVNSVLSP RSESGGLGVS MVEYVLSSSP GDSCLRKGGF GPRDADSDEN DKGEKKNKGT FDGDKLGDLK EEGDVMDKTN GLPVQNGIDA DVKDFSRTPG NCQNSANEVD LLGPNQNGSE GLAQLTSTNG AKPVEDFSNM ESQSVPLDPM EHVGMEPLQF DYSGTQVPVD SAAATVGLFD YNSQQQLFQR PNALAVQQLT AAQQQQYALA AAHQPHIGLA PAAFVPNPYI ISAAPPGTDP YTAGLAAAAT LGPAVVPHQY YGVTPWGVYP ASLFQQQAAA AAAATNSANQ QTTPQAQQGQ QQVLRGGASQ RPLTPNQNQQ GQQTDPLVAA AAVNSALAFG QGLAAGMPGY PVLAPAAYYD QTGALVVNAG ARNGLGAPVR LVAPAPVIIS SSAAQAAVAA AAASANGAAG GLAGTTNGPF RPLGTQQPQP QPQQQPNNNL ASSSFYGNNS LNSNSQSSSL FSQGSAQPAN TSLGFGSSSS LGATLGSALG GFGTAVANSN TGSGSRRDSL TGSSDLYKRT SSSLTPIGHS FYNGLSFSSS PGPVGMPLPS QGPGHSQTPP PSLSSHGSSS SLNLGGLTNG SGRYISAAPG AEAKYRSASS ASSLFSPSST LFSSSRLRYG MSDVMPSGRS RLLEDFRNNR YPNLQLREIA GHIMEFSQDQ HGSRFIQLKL ERATPAERQL VFNEILQAAY QLMVDVFGNY VIQKFFEFGS LEQKLALAER IRGHVLSLAL QMYGCRVIQK ALEFIPSDQQ NEMVRELDGH VLKCVKDQNG NHVVQKCIEC VQPQSLQFII DAFKGQVFAL STHPYGCRVI QRILEHCLPD QTLPILEELH QHTEQLVQDQ YGNYVIQHVL EHGRPEDKSK IVAEIRGNVL VLSQHKFASN VVEKCVTHAS RTERAVLIDE VCTMNDGPHS ALYTMMKDQY ANYVVQKMID VAEPGQRKIV MHKIRPHIAT LRKYTYGKHI LAKLEKYYMK NGVDLGPICG PPNGII