Details for: PIP4K2A
Gene ID: 5305
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PIP4K2A
Ensembl ID: ENSG00000150867
Description: phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 31.71rCSI 93.71%PRS 26.85
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CSI 20.28rCSI 36.85%PRS 27.87
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CSI 19.97rCSI 25.43%PRS 36.76
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CSI 16.71rCSI 34.67%PRS 31.35
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CSI 16.51rCSI 31.18%PRS 40.55
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CSI 16.5rCSI 59.36%PRS 19.29
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CSI 14.41rCSI 11.64%PRS 43.7
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CSI 12.42rCSI 18%PRS 46.72
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CSI 12.25rCSI 25.91%PRS 54.7
-
CSI 10.51rCSI 13.09%PRS 42.65
-
CSI 10.44rCSI 32.16%PRS 44.16
-
CSI 9.59rCSI 24.82%PRS 65.15
-
CSI 9.48rCSI 7.37%PRS 46.42
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CSI 9.04rCSI 24.91%PRS 30.1
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CSI 8.44rCSI 18.57%PRS 22.95
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CSI 7.88rCSI 17.6%PRS 37.41
-
CSI 7.8rCSI 6.01%PRS 30.62
-
CSI 7.39rCSI 12.67%PRS 41.2
-
CSI 7.34rCSI 5.8%PRS 22.63
-
CSI 7.04rCSI 11.11%PRS 32.7
-
CSI 6.99rCSI 8.95%PRS 71.3
-
CSI 6.96rCSI 13.04%PRS 24.31
-
CSI 6.48rCSI 5.56%PRS 43.32
-
CSI 6.37rCSI 25.69%PRS 30.89
-
CSI 6.24rCSI 14.41%PRS 26.53
-
CSI 6.22rCSI 30.64%PRS 42.16
-
CSI 6.17rCSI 14.1%PRS 31.67
-
CSI 6.15rCSI 16.22%PRS 37.93
-
CSI 5.48rCSI 32.26%PRS 21.35
-
CSI 5.33rCSI 6.25%PRS 44.88
-
CSI 5.18rCSI 19.39%PRS 27.31
-
CSI 5.04rCSI 5.82%PRS 28.13
-
CSI 5.01rCSI 8.77%PRS 25.88
-
CSI 4.89rCSI 3.67%PRS 67.6
-
CSI 4.69rCSI 10.65%PRS 38.9
-
CSI 4.39rCSI 3.51%PRS 52.5
-
CSI 4.24rCSI 6.47%PRS 50
-
CSI 4.15rCSI 5.03%PRS 33.58
-
CSI 4.08rCSI 23.04%PRS 21.34
-
CSI 4.07rCSI 3.74%PRS 38.1
-
CSI 3.96rCSI 6.17%PRS 59.79
-
CSI 3.91rCSI 6.91%PRS 19.65
-
CSI 3.91rCSI 12.95%PRS 34.83
-
CSI 3.85rCSI 11.15%PRS 25.75
-
CSI 3.8rCSI 4.88%PRS 30.76
-
CSI 3.65rCSI 29.66%PRS 29.38
-
CSI 3.6rCSI 5.9%PRS 25.25
-
CSI 3.57rCSI 2.48%PRS 43.55
-
CSI 3.57rCSI 2.56%PRS 43.07
-
CSI 3.57rCSI 3.72%PRS 66.45
-
CSI 3.56rCSI 2.69%PRS 42.97
-
CSI 3.53rCSI 14.22%PRS 47.62
-
CSI 3.42rCSI 3.85%PRS 47.45
-
CSI 3.32rCSI 5.57%PRS 20.28
-
CSI 3.26rCSI 5.58%PRS 53.41
-
CSI 3.22rCSI 2.26%PRS 58.7
-
CSI 3.18rCSI 9.96%PRS 22.96
-
CSI 3.14rCSI 2.9%PRS 33.25
-
CSI 3.13rCSI 4.25%PRS 44.51
-
CSI 3.11rCSI 2.07%PRS 60.55
-
CSI 3.09rCSI 4.66%PRS 33.25
-
CSI 3.08rCSI 9.98%PRS 36.41
-
CSI 3.06rCSI 7.48%PRS 30.21
-
CSI 2.97rCSI 25.63%PRS 21.31
-
CSI 2.96rCSI 2.06%PRS 38.75
-
CSI 2.92rCSI 4.47%PRS 40.35
-
CSI 2.91rCSI 3.74%PRS 30.18
-
CSI 2.91rCSI 69.59%PRS 19.61
-
CSI 2.87rCSI 4.14%PRS 41.82
-
CSI 2.83rCSI 2.15%PRS 41.69
-
CSI 2.82rCSI 68.09%PRS 20.38
-
CSI 2.74rCSI 14.97%PRS 39.77
-
CSI 2.7rCSI 2.77%PRS 48.21
-
CSI 2.69rCSI 7.01%PRS 31.15
-
CSI 2.6rCSI 3.55%PRS 35.97
-
CSI 2.56rCSI 2.52%PRS 64.17
-
CSI 2.48rCSI 7.18%PRS 35
-
CSI 2.47rCSI 4.35%PRS 31.32
-
CSI 2.41rCSI 3.57%PRS 36.29
-
CSI 2.4rCSI 12.6%PRS 43.76
-
CSI 2.38rCSI 1.41%PRS 44.44
-
CSI 2.35rCSI 5.61%PRS 35.17
-
CSI 2.33rCSI 10.11%PRS 48.63
-
CSI 2.32rCSI 4.65%PRS 24.38
-
CSI 2.29rCSI 9.75%PRS 32.47
-
CSI 2.27rCSI 8.56%PRS 21.08
-
CSI 2.26rCSI 2.81%PRS 19.1
-
CSI 2.26rCSI 6.67%PRS 31.17
-
CSI 2.26rCSI 7.06%PRS 21.24
-
CSI 2.23rCSI 2.06%PRS 52.04
-
CSI 2.23rCSI 3.06%PRS 53.19
-
CSI 2.22rCSI 4.91%PRS 23.44
-
CSI 2.22rCSI 2.43%PRS 35.59
-
CSI 2.21rCSI 3.12%PRS 42.11
-
CSI 2.19rCSI 5.42%PRS 30.41
-
CSI 2.16rCSI 4.94%PRS 27.64
-
CSI 2.13rCSI 4.78%PRS 20.82
-
CSI 2.13rCSI 6.81%PRS 28.98
-
CSI 2.09rCSI 3.45%PRS 37.02
-
CSI 2.07rCSI 1.55%PRS 34.55
-
CSI 0.2rCSI 2.5%PRS 36.3%
-
CSI 0.2rCSI 1.7%PRS 52.9%
-
CSI 0.3rCSI 0.5%PRS 25.1%
-
CSI 0.3rCSI 1.4%PRS 41.4%
-
CSI 0.4rCSI 2.2%PRS 44.3%
-
CSI 0.5rCSI 3.0%PRS 65.0%
-
CSI 0.5rCSI 1.5%PRS 32.7%
-
CSI 0.5rCSI 1.7%PRS 50.3%
-
CSI 0.5rCSI 3.1%PRS 68.2%
-
CSI 0.6rCSI 4.1%PRS 22.4%
-
CSI 0.6rCSI 1.3%PRS 25.1%
-
CSI 0.6rCSI 1.9%PRS 23.7%
-
CSI 0.6rCSI 3.7%PRS 58.8%
-
CSI 0.6rCSI 1.8%PRS 35.8%
-
CSI 0.7rCSI 3.0%PRS 55.6%
-
CSI 0.7rCSI 3.6%PRS 47.6%
-
CSI 0.7rCSI 2.7%PRS 50.5%
-
CSI 0.7rCSI 1.7%PRS 23.9%
-
CSI 0.7rCSI 1.8%PRS 47.9%
-
CSI 0.7rCSI 3.5%PRS 53.4%
-
CSI 0.8rCSI 4.9%PRS 26.4%
-
CSI 0.8rCSI 3.6%PRS 31.0%
-
CSI 0.8rCSI 1.0%PRS 50.5%
-
CSI 0.8rCSI 0.7%PRS 35.5%
-
CSI 0.9rCSI 1.3%PRS 30.5%
-
CSI 0.9rCSI 2.2%PRS 37.4%
-
CSI 0.9rCSI 4.9%PRS 43.3%
-
CSI 0.9rCSI 3.5%PRS 43.6%
-
CSI 0.9rCSI 2.4%PRS 45.3%
-
CSI 0.9rCSI 0.6%PRS 40.2%
-
CSI 0.9rCSI 1.3%PRS 25.6%
-
CSI 0.9rCSI 7.1%PRS 57.6%
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CSI 0.9rCSI 1.3%PRS 61.1%
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CSI 1.0rCSI 2.3%PRS 43.3%
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CSI 1.0rCSI 2.6%PRS 75.6%
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CSI 1.0rCSI 3.2%PRS 66.4%
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CSI 1.0rCSI 3.3%PRS 24.0%
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CSI 1.0rCSI 1.2%PRS 24.3%
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CSI 1.0rCSI 6.5%PRS 55.6%
-
CSI 1.0rCSI 2.6%PRS 25.1%
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CSI 1.1rCSI 17.7%PRS 70.4%
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CSI 1.1rCSI 3.1%PRS 47.0%
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CSI 1.1rCSI 1.0%PRS 39.8%
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CSI 1.1rCSI 1.5%PRS 30.8%
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CSI 1.1rCSI 2.2%PRS 32.6%
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CSI 1.1rCSI 2.0%PRS 47.0%
-
CSI 1.1rCSI 2.2%PRS 62.2%
-
CSI 1.1rCSI 1.4%PRS 40.6%
-
CSI 1.1rCSI 1.4%PRS 28.7%
-
CSI 1.1rCSI 1.7%PRS 37.9%
-
CSI 1.2rCSI 3.0%PRS 29.5%
-
CSI 1.2rCSI 2.2%PRS 61.3%
-
CSI 1.2rCSI 6.8%PRS 56.5%
-
CSI 1.2rCSI 2.9%PRS 43.8%
-
CSI 1.2rCSI 1.1%PRS 29.5%
-
CSI 1.2rCSI 0.9%PRS 49.7%
-
CSI 1.3rCSI 17.2%PRS 78.3%
-
CSI 1.3rCSI 2.2%PRS 30.4%
-
CSI 1.3rCSI 1.7%PRS 54.3%
-
CSI 1.3rCSI 1.6%PRS 45.2%
-
CSI 1.3rCSI 2.0%PRS 29.9%
-
CSI 1.3rCSI 1.7%PRS 43.9%
-
CSI 1.3rCSI 1.6%PRS 38.3%
-
CSI 1.3rCSI 4.5%PRS 27.2%
-
CSI 1.3rCSI 3.9%PRS 57.5%
-
CSI 1.4rCSI 2.2%PRS 27.2%
-
CSI 1.4rCSI 3.0%PRS 70.3%
-
CSI 1.4rCSI 5.7%PRS 44.5%
-
CSI 1.4rCSI 2.8%PRS 29.8%
-
CSI 1.4rCSI 28.2%PRS 28.4%
-
CSI 1.4rCSI 3.1%PRS 45.9%
-
CSI 1.4rCSI 1.7%PRS 34.4%
-
CSI 1.5rCSI 29.5%PRS 27.2%
-
CSI 1.5rCSI 2.3%PRS 35.0%
-
CSI 1.5rCSI 3.0%PRS 41.7%
-
CSI 1.5rCSI 4.0%PRS 27.2%
-
CSI 1.5rCSI 1.2%PRS 32.3%
-
CSI 1.5rCSI 3.8%PRS 39.1%
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CSI 1.5rCSI 2.7%PRS 40.0%
-
CSI 1.5rCSI 3.3%PRS 35.9%
-
CSI 1.5rCSI 2.9%PRS 68.4%
-
CSI 1.6rCSI 7.8%PRS 33.5%
-
CSI 1.6rCSI 2.4%PRS 32.6%
-
CSI 1.6rCSI 7.7%PRS 29.8%
-
CSI 1.6rCSI 1.5%PRS 46.3%
-
CSI 1.6rCSI 6.6%PRS 32.0%
-
CSI 1.6rCSI 2.0%PRS 20.1%
-
CSI 1.7rCSI 4.3%PRS 42.8%
-
CSI 1.7rCSI 1.5%PRS 36.6%
-
CSI 1.7rCSI 2.2%PRS 36.7%
-
CSI 1.7rCSI 2.6%PRS 29.9%
-
CSI 1.8rCSI 4.3%PRS 19.7%
-
CSI 1.8rCSI 1.7%PRS 32.1%
-
CSI 1.8rCSI 5.1%PRS 33.7%
-
CSI 1.8rCSI 2.1%PRS 51.1%
-
CSI 1.8rCSI 2.3%PRS 21.0%
-
CSI 1.8rCSI 2.6%PRS 30.0%
-
CSI 1.8rCSI 1.5%PRS 52.6%
-
CSI 1.9rCSI 4.8%PRS 38.2%
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CSI 1.9rCSI 8.0%PRS 36.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2552388849
Symbol: PI42A_HUMAN
Name: 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7852364
Title: The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases.
PubMed ID: 7852364
PubMed ID: 7639683
Title: The cloning and sequence of the C isoform of PtdIns4P 5-kinase.
PubMed ID: 7639683
DOI: 10.1042/bj3090715
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9367159
Title: A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
PubMed ID: 9367159
DOI: 10.1038/36621
PubMed ID: 18364242
Title: Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha.
PubMed ID: 18364242
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20583997
Title: PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.
PubMed ID: 20583997
DOI: 10.1042/bj20100341
PubMed ID: 19896968
Title: Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases.
PubMed ID: 19896968
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23326584
Title: A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.
PubMed ID: 23326584
PubMed ID: 26774281
Title: The Lipid Kinase PI5P4Kbeta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
PubMed ID: 26774281
PubMed ID: 31091439
Title: PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
PubMed ID: 31091439
PubMed ID: 24081551
Title: Enzyme activity of the PIP4K2A gene product polymorphism that is implicated in schizophrenia.
PubMed ID: 24081551
PubMed ID: 29353240
Title: PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis.
PubMed ID: 29353240
DOI: 10.1194/jlr.m082149
PubMed ID: 32130941
Title: Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
PubMed ID: 32130941
Sequence Information:
- Length: 406
- Mass: 46225
- Checksum: 5BAF0A27CC9EF376
- Sequence:
MATPGNLGSS VLASKTKTKK KHFVAQKVKL FRASDPLLSV LMWGVNHSIN ELSHVQIPVM LMPDDFKAYS KIKVDNHLFN KENMPSHFKF KEYCPMVFRN LRERFGIDDQ DFQNSLTRSA PLPNDSQARS GARFHTSYDK RYIIKTITSE DVAEMHNILK KYHQYIVECH GITLLPQFLG MYRLNVDGVE IYVIVTRNVF SHRLSVYRKY DLKGSTVARE ASDKEKAKEL PTLKDNDFIN EGQKIYIDDN NKKVFLEKLK KDVEFLAQLK LMDYSLLVGI HDVERAEQEE VECEENDGEE EGESDGTHPV GTPPDSPGNT LNSSPPLAPG EFDPNIDVYG IKCHENSPRK EVYFMAIIDI LTHYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFLDF IGHILT