USP47 | ENSG00000170242 | NCBI 55031

Details for: USP47

Gene ID: 55031

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: USP47

Ensembl ID: ENSG00000170242

Description: ubiquitin specific peptidase 47

Cell Significance Landscape

Display Count:

Associated with

Deubiquitination
(R-HSA-5688426)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Ub-specific processing proteases
(R-HSA-5689880)
Base-excision repair
(GO:0006284)
Cellular response to uv
(GO:0034644)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Deubiquitinase activity
(GO:0101005)
Dna damage response
(GO:0006974)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Monoubiquitinated protein deubiquitination
(GO:0035520)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of g2/m transition of mitotic cell cycle
(GO:0010972)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell growth
(GO:0030307)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Proteolysis
(GO:0006508)
Regulation of protein stability
(GO:0031647)
Response to xenobiotic stimulus
(GO:0009410)
Scf ubiquitin ligase complex
(GO:0019005)
Wd40-repeat domain binding
(GO:0071987)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

lamp5 GABAergic cortical interneuron CL4023011

CSI 45.16

rCSI 75.8%

PRS 12.38
sncg GABAergic cortical interneuron CL4023015

CSI 40.18

rCSI 64.61%

PRS 13.51
pvalb GABAergic cortical interneuron CL4023018

CSI 35.16

rCSI 43.74%

PRS 11.57
VIP GABAergic cortical interneuron CL4023016

CSI 33.86

rCSI 40.44%

PRS 12.18
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 32.14

rCSI 78.11%

PRS 12.15
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 28.4

rCSI 50.16%

PRS 12.3
cardiac muscle cell CL0000746

CSI 27.58

rCSI 39.57%

PRS 16.21
sst GABAergic cortical interneuron CL4023017

CSI 24.97

rCSI 32.2%

PRS 12.98
L6b glutamatergic cortical neuron CL4023038

CSI 22.68

rCSI 70.87%

PRS 13.2
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 21.95

rCSI 79%

PRS 11.66
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 21.85

rCSI 68.35%

PRS 14.22
hepatocyte CL0000182

CSI 19.21

rCSI 34.38%

PRS 19.36
conjunctival epithelial cell CL1000432

CSI 18.92

rCSI 28.9%

PRS 21.07
near-projecting glutamatergic cortical neuron CL4023012

CSI 18.03

rCSI 68.16%

PRS 12.78
GABAergic amacrine cell CL4030027

CSI 16.7

rCSI 57.21%

PRS 18.33
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 16.09

rCSI 34.9%

PRS 14.98
renal alpha-intercalated cell CL0005011

CSI 14.82

rCSI 19.82%

PRS 27.03
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 13.36

rCSI 78.65%

PRS 12.98
renal principal cell CL0005009

CSI 12.98

rCSI 33.71%

PRS 26.79
neuron CL0000540

CSI 12.97

rCSI 34.55%

PRS 18.18
retinal ganglion cell CL0000740

CSI 12.43

rCSI 27.46%

PRS 14.96
neural crest cell CL0011012

CSI 10.77

rCSI 8.51%

PRS 14.38
central nervous system neuron CL2000029

CSI 10.32

rCSI 75.82%

PRS 12.48
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 10.29

rCSI 26.59%

PRS 19.45
oligodendrocyte CL0000128

CSI 9.99

rCSI 29.51%

PRS 19.79
diffuse bipolar 3a cell CL4033029

CSI 9.39

rCSI 63.94%

PRS 22.29
small intestine goblet cell CL1000495

CSI 9

rCSI 19.71%

PRS 27.94
keratocyte CL0002363

CSI 8.9

rCSI 21.39%

PRS 30.73
parietal epithelial cell CL1000452

CSI 8.59

rCSI 22.94%

PRS 17.43
H2 horizontal cell CL0004218

CSI 8.4

rCSI 41.76%

PRS 22.76
adipocyte CL0000136

CSI 7.77

rCSI 9.97%

PRS 20.33
enteroendocrine cell of small intestine CL0009006

CSI 7.52

rCSI 16.56%

PRS 31.66
blood vessel smooth muscle cell CL0019018

CSI 7.26

rCSI 59.07%

PRS 20.92
kidney connecting tubule epithelial cell CL1000768

CSI 6.36

rCSI 16.13%

PRS 15.86
medium spiny neuron CL1001474

CSI 6.2

rCSI 53.44%

PRS 10.82
hepatic stellate cell CL0000632

CSI 5.94

rCSI 22.25%

PRS 17.65
melanocyte CL0000148

CSI 5.43

rCSI 4.02%

PRS 18.09
mural cell CL0008034

CSI 4.94

rCSI 16.74%

PRS 21.39
periportal region hepatocyte CL0019026

CSI 4.88

rCSI 18.97%

PRS 28.54
epithelial cell of proximal tubule CL0002306

CSI 4.86

rCSI 11.88%

PRS 20.56
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 4.81

rCSI 11.5%

PRS 13.82
midbrain dopaminergic neuron CL2000097

CSI 4.77

rCSI 30.54%

PRS 32.21
erythroblast CL0000765

CSI 4.67

rCSI 12.4%

PRS 32.91
retinal pigment epithelial cell CL0002586

CSI 4.54

rCSI 9.01%

PRS 22
GABAergic interneuron CL0011005

CSI 4.36

rCSI 68.74%

PRS 19.35
unswitched memory B cell CL0000970

CSI 4.32

rCSI 3.64%

PRS 32.91
retinal bipolar neuron CL0000748

CSI 4.32

rCSI 8.09%

PRS 15.03
extravillous trophoblast CL0008036

CSI 4.25

rCSI 5.26%

PRS 18.33
cholangiocyte CL1000488

CSI 4.2

rCSI 25.17%

PRS 36.5
oligodendrocyte precursor cell CL0002453

CSI 4.09

rCSI 8.99%

PRS 17.51
common dendritic progenitor CL0001029

CSI 4

rCSI 5.01%

PRS 27.13
type L enteroendocrine cell CL0002279

CSI 3.91

rCSI 7.34%

PRS 40.45
intestinal crypt stem cell of small intestine CL0009017

CSI 3.81

rCSI 10.26%

PRS 27.09
perivascular cell CL4033054

CSI 3.71

rCSI 5.07%

PRS 23.62
ON midget ganglion cell CL4033046

CSI 3.65

rCSI 74.33%

PRS 16.99
renal beta-intercalated cell CL0002201

CSI 3.63

rCSI 8.66%

PRS 23.9
OFF midget ganglion cell CL4033047

CSI 3.6

rCSI 73.33%

PRS 18.07
direct pathway medium spiny neuron CL4023026

CSI 3.58

rCSI 85.76%

PRS 10.79
placental villous trophoblast CL2000060

CSI 3.57

rCSI 5.52%

PRS 19.54
indirect pathway medium spiny neuron CL4023029

CSI 3.55

rCSI 85.64%

PRS 11.77
diffuse bipolar 3b cell CL4033030

CSI 3.42

rCSI 22.72%

PRS 22.72
transit amplifying cell of colon CL0009011

CSI 3.41

rCSI 4%

PRS 24.03
endothelial cell of placenta CL0009092

CSI 3.33

rCSI 16.41%

PRS 28.24
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.31

rCSI 4.7%

PRS 19.35
enteroendocrine cell CL0000164

CSI 3.31

rCSI 4.52%

PRS 23.26
radial glial cell CL0000681

CSI 3.3

rCSI 4.59%

PRS 21.33
ON parasol ganglion cell CL4033052

CSI 3.3

rCSI 46.8%

PRS 16.12
alpha-beta T cell CL0000789

CSI 3.27

rCSI 3.83%

PRS 28.82
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.24

rCSI 2.46%

PRS 27.7
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 3.23

rCSI 9.95%

PRS 31.13
glioblast CL0000030

CSI 3.2

rCSI 5.1%

PRS 17.89
Hofbauer cell CL3000001

CSI 3.12

rCSI 5.89%

PRS 26.49
ependymal cell CL0000065

CSI 3.04

rCSI 6.17%

PRS 10.78
brush cell of tracheobronchial tree CL0002075

CSI 3.04

rCSI 9.01%

PRS 29.3
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 2.97

rCSI 9.75%

PRS 13.62
type B pancreatic cell CL0000169

CSI 2.95

rCSI 6.53%

PRS 19.4
Schwann cell CL0002573

CSI 2.94

rCSI 8.35%

PRS 23.84
epicardial adipocyte CL1000309

CSI 2.92

rCSI 9.52%

PRS 25.66
chondrocyte CL0000138

CSI 2.9

rCSI 4.61%

PRS 17.64
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 2.89

rCSI 3.34%

PRS 18.28
interneuron CL0000099

CSI 2.86

rCSI 5.74%

PRS 15.49
paneth cell of epithelium of small intestine CL1000343

CSI 2.85

rCSI 7.99%

PRS 32.29
granulocyte CL0000094

CSI 2.82

rCSI 4.31%

PRS 27.1
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 2.79

rCSI 24.1%

PRS 31.88
neuroblast (sensu Vertebrata) CL0000031

CSI 2.78

rCSI 3.56%

PRS 20.17
neural cell CL0002319

CSI 2.7

rCSI 10.2%

PRS 27.31
pulmonary ionocyte CL0017000

CSI 2.7

rCSI 3.29%

PRS 26.12
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.67

rCSI 1.91%

PRS 28.81
BEST4+ enteroycte CL4030026

CSI 2.65

rCSI 3.3%

PRS 22.27
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.64

rCSI 2.44%

PRS 37.57
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 2.62

rCSI 1.96%

PRS 55.3
epithelial cell CL0000066

CSI 2.58

rCSI 3.96%

PRS 28.47
mucosal invariant T cell CL0000940

CSI 2.57

rCSI 2.08%

PRS 32.52
diffuse bipolar 2 cell CL4033028

CSI 2.56

rCSI 19.8%

PRS 23.13
respiratory basal cell CL0002633

CSI 2.54

rCSI 2.63%

PRS 24.64
mononuclear phagocyte CL0000113

CSI 2.5

rCSI 5.51%

PRS 23.81
hematopoietic multipotent progenitor cell CL0000837

CSI 2.5

rCSI 6.02%

PRS 33.15
kidney collecting duct intercalated cell CL1001432

CSI 2.46

rCSI 17.55%

PRS 37.65
naive T cell CL0000898

CSI 2.44

rCSI 1.7%

PRS 29.53
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 2.43

rCSI 1.71%

PRS 47.82

colon epithelial cell CL0011108

CSI -1.0

rCSI -1.0%

PRS 19.5%
natural T-regulatory cell CL0000903

CSI -0.6

rCSI -1.1%

PRS 54.2%
respiratory hillock cell CL4030023

CSI -0.5

rCSI -0.9%

PRS 34.5%
myeloid lineage restricted progenitor cell CL0000839

CSI -0.3

rCSI -1.4%

PRS 40.3%
promonocyte CL0000559

CSI -0.3

rCSI -0.5%

PRS 28.4%
kidney epithelial cell CL0002518

CSI -0.3

rCSI -0.5%

PRS 44.7%
mesenchymal stem cell CL0000134

CSI -0.2

rCSI -2.6%

PRS 36.8%
fallopian tube secretory epithelial cell CL4030006

CSI -0.2

rCSI -0.2%

PRS 21.6%
microcirculation associated smooth muscle cell CL0008035

CSI -0.2

rCSI -0.6%

PRS 23.6%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.3%

PRS 30.7%
type EC enteroendocrine cell CL0000577

CSI 0.1

rCSI 0.3%

PRS 33.8%
large pre-B-II cell CL0000957

CSI 0.1

rCSI 0.3%

PRS 35.1%
IgG plasma cell CL0000985

CSI 0.1

rCSI 0.1%

PRS 36.2%
enteric neuron CL0007011

CSI 0.1

rCSI 1.8%

PRS 48.2%
group 2 innate lymphoid cell CL0001069

CSI 0.1

rCSI 0.8%

PRS 62.8%
tracheal goblet cell CL1000329

CSI 0.2

rCSI 0.3%

PRS 40.1%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.2

rCSI 0.3%

PRS 43.7%
syncytiotrophoblast cell CL0000525

CSI 0.2

rCSI 0.5%

PRS 38.3%
paneth cell of colon CL0009009

CSI 0.2

rCSI 1.9%

PRS 52.1%
enterocyte of epithelium of small intestine CL1000334

CSI 0.2

rCSI 3.1%

PRS 49.2%
serotonergic neuron CL0000850

CSI 0.2

rCSI 1.0%

PRS 14.0%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 0.2

rCSI 0.2%

PRS 25.8%
vein endothelial cell of respiratory system CL4033008

CSI 0.2

rCSI 1.6%

PRS 40.0%
elicited macrophage CL0000861

CSI 0.2

rCSI 0.2%

PRS 24.6%
P/D1 enteroendocrine cell CL0002268

CSI 0.2

rCSI 1.3%

PRS 47.1%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 2.7%

PRS 39.5%
transit amplifying cell of small intestine CL0009012

CSI 0.3

rCSI 1.2%

PRS 38.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.3

rCSI 0.3%

PRS 25.1%
cerebellar neuron CL1001611

CSI 0.3

rCSI 2.5%

PRS 15.1%
granulocyte monocyte progenitor cell CL0000557

CSI 0.3

rCSI 0.2%

PRS 23.6%
enteroendocrine cell of colon CL0009042

CSI 0.3

rCSI 1.4%

PRS 50.6%
T-helper 17 cell CL0000899

CSI 0.3

rCSI 0.2%

PRS 37.3%
mucus secreting cell CL0000319

CSI 0.3

rCSI 0.5%

PRS 26.9%
pancreatic PP cell CL0002275

CSI 0.4

rCSI 1.4%

PRS 35.5%
colon macrophage CL0009038

CSI 0.4

rCSI 1.6%

PRS 43.2%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.4

rCSI 0.4%

PRS 25.8%
eye photoreceptor cell CL0000287

CSI 0.4

rCSI 4.0%

PRS 48.1%
mature B cell CL0000785

CSI 0.4

rCSI 0.3%

PRS 26.3%
pancreatic acinar cell CL0002064

CSI 0.4

rCSI 0.5%

PRS 22.9%
pancreatic D cell CL0000173

CSI 0.4

rCSI 0.4%

PRS 22.6%
squamous epithelial cell CL0000076

CSI 0.4

rCSI 0.9%

PRS 25.8%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 0.4

rCSI 0.7%

PRS 40.3%
eosinophil CL0000771

CSI 0.4

rCSI 2.6%

PRS 51.2%
foveolar cell of stomach CL0002179

CSI 0.4

rCSI 0.9%

PRS 33.1%
luminal epithelial cell of mammary gland CL0002326

CSI 0.4

rCSI 0.8%

PRS 31.8%
luminal cell of prostate epithelium CL0002340

CSI 0.4

rCSI 2.3%

PRS 36.6%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 2.6%

PRS 30.9%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.5

rCSI 0.5%

PRS 36.3%
memory T cell CL0000813

CSI 0.5

rCSI 0.9%

PRS 46.5%
acinar cell CL0000622

CSI 0.5

rCSI 0.7%

PRS 27.4%
mesodermal cell CL0000222

CSI 0.5

rCSI 0.6%

PRS 20.4%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.8%

PRS 16.0%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.5

rCSI 1.0%

PRS 34.9%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.5

rCSI 0.4%

PRS 18.9%
diffuse bipolar 6 cell CL4033032

CSI 0.5

rCSI 2.6%

PRS 25.0%
intestinal epithelial cell CL0002563

CSI 0.5

rCSI 0.5%

PRS 21.8%
erythroid lineage cell CL0000764

CSI 0.5

rCSI 3.2%

PRS 44.4%
class switched memory B cell CL0000972

CSI 0.5

rCSI 0.4%

PRS 35.1%
pulmonary artery endothelial cell CL1001568

CSI 0.5

rCSI 0.7%

PRS 31.6%
mesenchymal cell CL0008019

CSI 0.5

rCSI 1.3%

PRS 21.0%
lung ciliated cell CL1000271

CSI 0.5

rCSI 0.6%

PRS 15.4%
S cone cell CL0003050

CSI 0.5

rCSI 2.3%

PRS 19.2%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.5

rCSI 1.2%

PRS 21.6%
intestinal crypt stem cell of colon CL0009043

CSI 0.5

rCSI 4.1%

PRS 37.9%
amacrine cell CL0000561

CSI 0.5

rCSI 1.6%

PRS 16.1%
neuroendocrine cell CL0000165

CSI 0.6

rCSI 2.2%

PRS 40.6%
platelet CL0000233

CSI 0.6

rCSI 2.4%

PRS 37.3%
Langerhans cell CL0000453

CSI 0.6

rCSI 0.9%

PRS 36.4%
diffuse bipolar 4 cell CL4033031

CSI 0.6

rCSI 6.7%

PRS 24.9%
club cell CL0000158

CSI 0.6

rCSI 0.9%

PRS 23.8%
neuroplacodal cell CL0000032

CSI 0.6

rCSI 5.5%

PRS 51.9%
lung neuroendocrine cell CL1000223

CSI 0.6

rCSI 0.9%

PRS 23.8%
progenitor cell CL0011026

CSI 0.6

rCSI 1.3%

PRS 32.2%
IgA plasma cell CL0000987

CSI 0.6

rCSI 0.6%

PRS 38.4%
mature alpha-beta T cell CL0000791

CSI 0.6

rCSI 2.2%

PRS 35.9%
tracheobronchial smooth muscle cell CL0019019

CSI 0.6

rCSI 1.1%

PRS 27.3%
fraction A pre-pro B cell CL0002045

CSI 0.6

rCSI 0.7%

PRS 41.9%
mesangial cell CL0000650

CSI 0.6

rCSI 2.5%

PRS 29.8%
double-positive, alpha-beta thymocyte CL0000809

CSI 0.6

rCSI 0.7%

PRS 29.9%
megakaryocyte CL0000556

CSI 0.7

rCSI 2.9%

PRS 36.1%
fibroblast of breast CL4006000

CSI 0.7

rCSI 2.9%

PRS 49.3%
basket cell CL0000118

CSI 0.7

rCSI 4.3%

PRS 15.1%
dopaminergic neuron CL0000700

CSI 0.7

rCSI 3.9%

PRS 11.9%
intraepithelial lymphocyte CL0002496

CSI 0.7

rCSI 1.9%

PRS 67.3%
GABAergic neuron CL0000617

CSI 0.7

rCSI 2.4%

PRS 15.0%
macroglial cell CL0000126

CSI 0.7

rCSI 1.8%

PRS 27.2%
innate lymphoid cell CL0001065

CSI 0.7

rCSI 1.5%

PRS 31.0%
colonocyte CL1000347

CSI 0.7

rCSI 1.1%

PRS 28.1%
alveolar adventitial fibroblast CL4028006

CSI 0.8

rCSI 1.2%

PRS 21.0%
basophil CL0000767

CSI 0.8

rCSI 1.6%

PRS 41.4%
multi-ciliated epithelial cell CL0005012

CSI 0.8

rCSI 0.8%

PRS 17.9%
myoepithelial cell CL0000185

CSI 0.8

rCSI 2.0%

PRS 25.9%
brain vascular cell CL4023072

CSI 0.8

rCSI 8.2%

PRS 24.5%
stromal cell of ovary CL0002132

CSI 0.8

rCSI 2.2%

PRS 34.2%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 0.8

rCSI 0.7%

PRS 32.0%
OFF-bipolar cell CL0000750

CSI 0.8

rCSI 1.1%

PRS 32.2%
tendon cell CL0000388

CSI 0.8

rCSI 2.1%

PRS 51.5%
transit amplifying cell CL0009010

CSI 0.8

rCSI 1.3%

PRS 33.7%
erythrocyte CL0000232

CSI 0.8

rCSI 1.9%

PRS 27.9%
retina horizontal cell CL0000745

CSI 0.9

rCSI 1.3%

PRS 19.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [USP47](/details-gene/55031) (Ubiquitin Specific Peptidase 47) is a protein-coding gene located on chromosome 11p15.3. It encodes a deubiquitinating enzyme (DUB) belonging to the cysteine-type peptidase family. Functionally, [USP47](/details-gene/55031) is critically involved in protein deubiquitination, a process essential for regulating protein stability, signaling pathways, and cellular homeostasis. Its annotated functions are strongly linked to the DNA damage response, particularly base-excision repair ([GO:0006284](https://www.ebi.ac.uk/QuickGO/term/GO:0006284)), and the negative regulation of apoptosis. Expression data indicates that **Overall**, [USP47](/details-gene/55031) is a highly significant gene in the central nervous system, showing prominent expression in numerous subtypes of GABAergic and glutamatergic neurons, which suggests a crucial role in maintaining neuronal function and integrity. ## Cellular Roles and Expression Landscape The expression profile of [USP47](/details-gene/55031) reveals a primary association with neuronal cell types. **Overall**, it demonstrates the highest significance in various classes of cortical interneurons, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 45.16), [sncg GABAergic cortical interneuron](/details-cell/CL4023015) (CSI: 40.18), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 35.16). High significance is also observed in glutamatergic neurons, such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 32.14). This strong and specific expression pattern across diverse neuronal populations suggests a fundamental role in maintaining the function and survival of these post-mitotic cells. Beyond the nervous system, [USP47](/details-gene/55031) also shows notable significance in other metabolically active cells like the [cardiac muscle cell](/details-cell/CL0000746) (CSI: 27.58) and [hepatocyte](/details-cell/CL0000182) (CSI: 19.21), indicating a broader role in cellular maintenance in tissues with high protein turnover and energy demands. Conversely, the gene's significance is exceptionally low in cell types such as [colon epithelial cell](/details-cell/CL0011108) (CSI: -0.96), various progenitor cells including [myeloid lineage restricted progenitor cell](/details-cell/CL0000839) (CSI: -0.28), and [mesenchymal stem cell](/details-cell/CL0000134) (CSI: -0.23). This restricted expression pattern highlights its specialized function, suggesting a more critical role in terminally differentiated, long-lived cells compared to rapidly proliferating or progenitor populations. ## Pathways and Molecular Function [USP47](/details-gene/55031) functions as a cysteine-type deubiquitinase ([GO:0004843](https://www.ebi.ac.uk/QuickGO/term/GO:0004843)), playing a key role in the post-translational modification of proteins through its involvement in [Deubiquitination](https://reactome.org/content/detail/R-HSA-5688426). Its molecular activities are integral to several critical cellular processes. A primary function of [USP47](/details-gene/55031) is its participation in the DNA damage response ([GO:0006974](https://www.ebi.ac.uk/QuickGO/term/GO:0006974)). Specifically, it has been shown to regulate base excision repair ([GO:0006284](https://www.ebi.ac.uk/QuickGO/term/GO:0006284)) by controlling the steady-state levels of DNA Polymerase beta, a key enzyme in this repair pathway [Link](https://doi.org/10.1016/j.molcel.2011.02.016). This function is highly consistent with its prominent expression in long-lived, non-dividing cells like neurons, which rely on efficient DNA repair mechanisms to maintain genomic integrity over a lifetime. Furthermore, [USP47](/details-gene/55031) is implicated in cell survival and the regulation of apoptosis. It contributes to the negative regulation of the apoptotic process ([GO:0043066](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)) and has been identified as an interactor of beta-TRCP, a component of the SCF ubiquitin ligase complex, thereby regulating cell survival [Link](https://doi.org/10.1038/onc.2009.430). The gene is also annotated in the positive regulation of the canonical Wnt signaling pathway ([GO:0090263](https://www.ebi.ac.uk/QuickGO/term/GO:0090263)), suggesting a role in developmental and homeostatic processes governed by this pathway. ## Research Directions The strong expression of [USP47](/details-gene/55031) in neuronal populations, coupled with its established role in DNA repair and cell survival, provides a foundation for several compelling research avenues. **Testable Hypotheses:** 1. Given its function in base-excision repair and its high expression in cortical interneurons, dysfunction or downregulation of [USP47](/details-gene/55031) may lead to an accumulation of DNA damage in these neurons, contributing to the pathology of age-related neurodegenerative disorders such as Alzheimer's disease or certain forms of dementia. 2. Based on its annotated role in the positive regulation of Wnt signaling, [USP47](/details-gene/55031) may modulate synaptic function and plasticity in the cortex by deubiquitinating and stabilizing key components of the Wnt pathway at the synapse, thereby influencing learning and memory. **Proposed Experiment:** To test the first hypothesis regarding the role of [USP47](/details-gene/55031) in neuronal genomic stability, a conditional knockout mouse model could be generated. Specifically, *Usp47* could be deleted in a specific neuronal subpopulation, such as Pvalb-positive interneurons, by crossing a floxed *Usp47* mouse with a Pvalb-Cre driver line. The resulting mice could be aged and their brains analyzed for an accumulation of DNA damage markers (e.g., γH2AX foci), signs of neurodegeneration (e.g., neuronal loss via histology), and associated cognitive or behavioral deficits. This would directly assess whether [USP47](/details-gene/55031) is essential for maintaining the health and integrity of these neurons over time. **Therapeutic Potential:** As a deubiquitinating enzyme, [USP47](/details-gene/55031) is a potentially druggable target. Its role in promoting cell survival and facilitating DNA repair makes it an attractive candidate for therapeutic **inhibition** in oncology. By inhibiting [USP47](/details-gene/55031), cancer cells could be sensitized to DNA-damaging agents like chemotherapy or radiation. However, its high expression in critical, non-cancerous tissues such as the brain and heart poses a significant challenge for systemic therapies, raising concerns about on-target toxicity. Therefore, the therapeutic potential of targeting [USP47](/details-gene/55031) would likely depend on developing highly specific inhibitors or targeted delivery systems for tumor types where it is aberrantly overexpressed or upon which the cancer cells are uniquely dependent.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ubiquitin carboxyl-terminal hydrolase 47
Q68D97_HUMAN

Genular Protein ID: 1709050774

Symbol: UBP47_HUMAN

Name: Ubiquitin carboxyl-terminal hydrolase 47

UniProtKB Accession Codes:

Q96K76 B3KXF5 E9PM46 Q658U0 Q86Y73 Q8TEP6 Q9BWI0 Q9NWN1

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14715245

Title: Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.

PubMed ID: 14715245

DOI: 10.1016/j.bbrc.2003.12.050

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19966869

Title: The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.

PubMed ID: 19966869

DOI: 10.1038/onc.2009.430

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21362556

Title: USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta.

PubMed ID: 21362556

DOI: 10.1016/j.molcel.2011.02.016

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 1375
Mass: 157311
Checksum: 1EDEAA9B5AFC97FE
Sequence:

MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI 
TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG 
KKNFLHLTDK DGEQPQILLE DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL 
NKSETGYVGL VNQAMTCYLN SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF 
VLLQTSKKRA IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL 
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN 
QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF 
IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL 
EKNSLIYELF SVMVHSGSAA GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS 
GSRGYYSSAF ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR 
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK 
YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV 
VDLKAESVAA PITVRAYLNQ TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT 
LKAEGFFRSN KVFVESSETL DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT 
AYQKAGGDSG NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST 
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD 
ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD 
ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF 
KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF 
LLDAVFAKGM TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI 
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS 
EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK 
TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD

Genular Protein ID: 1662329606

Symbol: Q68D97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D97

Database IDs:

Sequence Information:

Length: 61
Mass: 7160
Checksum: 77EC9E9D540555CB
Sequence:

MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVFMTG 
L

Details for: USP47

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. PubMed ID: 14715245

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. PubMed ID: 19966869

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta. PubMed ID: 21362556

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569