Details for: MPZL1
Gene ID: 9019
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MPZL1
Ensembl ID: ENSG00000197965
Description: myelin protein zero like 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 24.39rCSI 30.17%PRS 27.46
-
CSI 18.49rCSI 28.57%PRS 29.16
-
CSI 10.28rCSI 9.01%PRS 39.61
-
CSI 7.45rCSI 13.06%PRS 24.74
-
CSI 7.14rCSI 15.49%PRS 24.01
-
CSI 6.23rCSI 6.13%PRS 33
-
CSI 6.07rCSI 35.34%PRS 42.43
-
CSI 6.03rCSI 9.72%PRS 41.94
-
CSI 5.96rCSI 4.42%PRS 26.64
-
CSI 5.95rCSI 10.82%PRS 26.81
-
CSI 5.67rCSI 21.59%PRS 27.95
-
CSI 5.4rCSI 7.38%PRS 33.6
-
CSI 4.82rCSI 4.16%PRS 41.55
-
CSI 4.77rCSI 15.36%PRS 31.62
-
CSI 4.48rCSI 7.66%PRS 56.27
-
CSI 4.39rCSI 7.82%PRS 46.63
-
CSI 4.26rCSI 4.44%PRS 31.47
-
CSI 3.8rCSI 5.84%PRS 36.98
-
CSI 3.66rCSI 5.94%PRS 30.41
-
CSI 3.53rCSI 2.65%PRS 33.13
-
CSI 3.52rCSI 15.22%PRS 48.87
-
CSI 3.51rCSI 3.12%PRS 30.63
-
CSI 3.41rCSI 3.57%PRS 32.73
-
CSI 3.39rCSI 8.24%PRS 18.87
-
CSI 3.31rCSI 13.36%PRS 29.65
-
CSI 3.1rCSI 2.73%PRS 22.81
-
CSI 3.08rCSI 7.12%PRS 25.47
-
CSI 2.85rCSI 2.32%PRS 31.84
-
CSI 2.78rCSI 2.15%PRS 30.4
-
CSI 2.64rCSI 3.36%PRS 35.3
-
CSI 2.57rCSI 3.08%PRS 48.94
-
CSI 2.53rCSI 7.51%PRS 40.97
-
CSI 2.52rCSI 2.93%PRS 41.69
-
CSI 2.49rCSI 3.2%PRS 29.25
-
CSI 2.46rCSI 15.38%PRS 25.22
-
CSI 2.46rCSI 5.49%PRS 36.03
-
CSI 2.43rCSI 2.3%PRS 31.98
-
CSI 2.43rCSI 1.87%PRS 29.33
-
CSI 2.43rCSI 3.24%PRS 38.1
-
CSI 2.34rCSI 3.21%PRS 29.7
-
CSI 2.3rCSI 2.08%PRS 28.23
-
CSI 2.28rCSI 2.11%PRS 32.01
-
CSI 2.28rCSI 2.67%PRS 34.48
-
CSI 2.26rCSI 4.54%PRS 23.28
-
CSI 2.19rCSI 2.04%PRS 30.84
-
CSI 2.15rCSI 2.35%PRS 34.22
-
CSI 2.12rCSI 4.75%PRS 19.95
-
CSI 2.11rCSI 5.36%PRS 29.39
-
CSI 2.1rCSI 1.69%PRS 31.05
-
CSI 2.09rCSI 3.01%PRS 24.5
-
CSI 2.08rCSI 2.21%PRS 46.84
-
CSI 2.07rCSI 2.94%PRS 28.73
-
CSI 2.07rCSI 3.3%PRS 26.37
-
CSI 2.06rCSI 3.89%PRS 55.83
-
CSI 2.05rCSI 3.85%PRS 23.23
-
CSI 2.05rCSI 7.69%PRS 26.2
-
CSI 2.05rCSI 4.26%PRS 30.21
-
CSI 2.05rCSI 5.07%PRS 29.12
-
CSI 2.05rCSI 1.97%PRS 23.5
-
CSI 2.04rCSI 3.71%PRS 45.34
-
CSI 2.04rCSI 1.69%PRS 29.42
-
CSI 2.04rCSI 2.9%PRS 33.62
-
CSI 1.97rCSI 6.4%PRS 34.79
-
CSI 1.93rCSI 5.59%PRS 53.17
-
CSI 1.9rCSI 4.35%PRS 30.41
-
CSI 1.9rCSI 2.19%PRS 23.25
-
CSI 1.89rCSI 2.8%PRS 34.92
-
CSI 1.88rCSI 4.38%PRS 59.01
-
CSI 1.86rCSI 1.86%PRS 26.43
-
CSI 1.86rCSI 4.96%PRS 26.13
-
CSI 1.85rCSI 3.03%PRS 24.2
-
CSI 1.85rCSI 44.25%PRS 18.64
-
CSI 1.84rCSI 2.46%PRS 32.95
-
CSI 1.84rCSI 10.6%PRS 35.5
-
CSI 1.82rCSI 2.88%PRS 31.41
-
CSI 1.81rCSI 1.43%PRS 21.61
-
CSI 1.78rCSI 4.64%PRS 29.93
-
CSI 1.78rCSI 4.5%PRS 37.67
-
CSI 1.76rCSI 1.62%PRS 36.66
-
CSI 1.75rCSI 1.22%PRS 32.46
-
CSI 1.75rCSI 2.43%PRS 31.04
-
CSI 1.75rCSI 1.45%PRS 31.4
-
CSI 1.7rCSI 4.43%PRS 36.9
-
CSI 1.7rCSI 3.45%PRS 17.9
-
CSI 1.69rCSI 2.31%PRS 34.61
-
CSI 1.66rCSI 1.31%PRS 36.51
-
CSI 1.64rCSI 2.51%PRS 31.23
-
CSI 1.63rCSI 2.61%PRS 33.74
-
CSI 1.62rCSI 1.69%PRS 28.83
-
CSI 1.61rCSI 1.55%PRS 31.73
-
CSI 1.61rCSI 2.47%PRS 36.44
-
CSI 1.58rCSI 1.89%PRS 19.18
-
CSI 1.58rCSI 1.92%PRS 37.49
-
CSI 1.57rCSI 4.64%PRS 35.45
-
CSI 1.57rCSI 2.81%PRS 29.07
-
CSI 1.57rCSI 1.95%PRS 32.92
-
CSI 1.56rCSI 2.13%PRS 26.69
-
CSI 1.56rCSI 1.67%PRS 28.78
-
CSI 1.55rCSI 2.74%PRS 30.04
-
CSI 1.55rCSI 1.99%PRS 29.44
-
CSI 0.1rCSI 1.2%PRS 48.7%
-
CSI 0.2rCSI 1.7%PRS 20.2%
-
CSI 0.3rCSI 4.0%PRS 60.3%
-
CSI 0.3rCSI 1.7%PRS 41.8%
-
CSI 0.3rCSI 0.6%PRS 39.0%
-
CSI 0.4rCSI 1.1%PRS 22.0%
-
CSI 0.4rCSI 4.0%PRS 52.1%
-
CSI 0.4rCSI 3.2%PRS 28.5%
-
CSI 0.4rCSI 3.3%PRS 51.0%
-
CSI 0.4rCSI 2.6%PRS 20.4%
-
CSI 0.5rCSI 1.9%PRS 47.2%
-
CSI 0.5rCSI 1.4%PRS 46.3%
-
CSI 0.6rCSI 2.5%PRS 29.7%
-
CSI 0.6rCSI 1.7%PRS 33.8%
-
CSI 0.6rCSI 0.9%PRS 31.9%
-
CSI 0.6rCSI 4.6%PRS 21.3%
-
CSI 0.7rCSI 3.7%PRS 67.9%
-
CSI 0.7rCSI 2.7%PRS 54.2%
-
CSI 0.7rCSI 2.6%PRS 20.2%
-
CSI 0.7rCSI 1.0%PRS 46.6%
-
CSI 0.7rCSI 1.9%PRS 46.8%
-
CSI 0.7rCSI 1.1%PRS 45.1%
-
CSI 0.7rCSI 2.6%PRS 18.4%
-
CSI 0.7rCSI 2.6%PRS 45.3%
-
CSI 0.8rCSI 1.8%PRS 42.1%
-
CSI 0.8rCSI 2.6%PRS 23.0%
-
CSI 0.8rCSI 2.2%PRS 28.9%
-
CSI 0.8rCSI 1.9%PRS 28.6%
-
CSI 0.9rCSI 2.3%PRS 31.2%
-
CSI 0.9rCSI 1.3%PRS 32.9%
-
CSI 0.9rCSI 4.7%PRS 47.6%
-
CSI 0.9rCSI 2.6%PRS 49.6%
-
CSI 0.9rCSI 4.0%PRS 50.7%
-
CSI 0.9rCSI 1.8%PRS 32.0%
-
CSI 1.0rCSI 2.6%PRS 39.2%
-
CSI 1.0rCSI 2.1%PRS 52.0%
-
CSI 1.0rCSI 3.0%PRS 20.3%
-
CSI 1.0rCSI 2.3%PRS 43.0%
-
CSI 1.0rCSI 4.1%PRS 58.6%
-
CSI 1.0rCSI 4.8%PRS 40.6%
-
CSI 1.0rCSI 4.7%PRS 34.9%
-
CSI 1.0rCSI 5.3%PRS 46.9%
-
CSI 1.0rCSI 1.6%PRS 39.3%
-
CSI 1.0rCSI 2.3%PRS 22.4%
-
CSI 1.1rCSI 5.0%PRS 52.1%
-
CSI 1.1rCSI 1.6%PRS 39.9%
-
CSI 1.1rCSI 2.3%PRS 28.8%
-
CSI 1.1rCSI 1.8%PRS 21.1%
-
CSI 1.1rCSI 26.6%PRS 52.9%
-
CSI 1.2rCSI 1.1%PRS 54.9%
-
CSI 1.2rCSI 5.6%PRS 28.4%
-
CSI 1.2rCSI 3.0%PRS 28.5%
-
CSI 1.2rCSI 2.6%PRS 44.5%
-
CSI 1.2rCSI 2.1%PRS 18.8%
-
CSI 1.2rCSI 1.5%PRS 35.3%
-
CSI 1.2rCSI 1.9%PRS 26.1%
-
CSI 1.2rCSI 2.7%PRS 40.0%
-
CSI 1.3rCSI 1.9%PRS 35.0%
-
CSI 1.3rCSI 1.5%PRS 29.8%
-
CSI 1.3rCSI 2.2%PRS 19.4%
-
CSI 1.3rCSI 1.8%PRS 38.9%
-
CSI 1.3rCSI 5.7%PRS 27.1%
-
CSI 1.3rCSI 4.2%PRS 35.2%
-
CSI 1.3rCSI 1.4%PRS 35.9%
-
CSI 1.3rCSI 1.9%PRS 33.0%
-
CSI 1.4rCSI 2.1%PRS 41.9%
-
CSI 1.4rCSI 1.2%PRS 35.7%
-
CSI 1.4rCSI 1.8%PRS 42.4%
-
CSI 1.4rCSI 3.6%PRS 59.5%
-
CSI 1.4rCSI 4.6%PRS 33.8%
-
CSI 1.4rCSI 7.1%PRS 73.5%
-
CSI 1.4rCSI 1.8%PRS 18.2%
-
CSI 1.4rCSI 2.1%PRS 46.1%
-
CSI 1.4rCSI 3.6%PRS 24.0%
-
CSI 1.4rCSI 1.5%PRS 31.4%
-
CSI 1.4rCSI 2.0%PRS 44.5%
-
CSI 1.4rCSI 1.7%PRS 26.9%
-
CSI 1.5rCSI 4.1%PRS 45.2%
-
CSI 1.5rCSI 2.2%PRS 28.6%
-
CSI 1.5rCSI 1.9%PRS 39.1%
-
CSI 1.5rCSI 5.2%PRS 47.6%
-
CSI 1.5rCSI 1.6%PRS 49.5%
-
CSI 1.5rCSI 2.0%PRS 20.1%
-
CSI 1.5rCSI 2.7%PRS 23.9%
-
CSI 1.5rCSI 3.7%PRS 42.6%
-
CSI 1.5rCSI 2.0%PRS 34.0%
-
CSI 1.5rCSI 37.2%PRS 19.4%
-
CSI 1.6rCSI 2.0%PRS 29.4%
-
CSI 1.6rCSI 2.7%PRS 30.0%
-
CSI 1.6rCSI 1.7%PRS 28.8%
-
CSI 1.6rCSI 2.1%PRS 26.7%
-
CSI 1.6rCSI 2.0%PRS 32.9%
-
CSI 1.6rCSI 2.8%PRS 29.1%
-
CSI 1.6rCSI 4.6%PRS 35.5%
-
CSI 1.6rCSI 1.9%PRS 37.5%
-
CSI 1.6rCSI 1.9%PRS 19.2%
-
CSI 1.6rCSI 2.5%PRS 36.4%
-
CSI 1.6rCSI 1.6%PRS 31.7%
-
CSI 1.6rCSI 1.7%PRS 28.8%
-
CSI 1.6rCSI 2.6%PRS 33.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 781510641
Symbol: MPZL1_HUMAN
Name: Myelin protein zero-like protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9792637
Title: Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2.
PubMed ID: 9792637
PubMed ID: 12075424
Title: Cloning of human myelin protein zero-like genes by bioinformatics strategy.
PubMed ID: 12075424
PubMed ID: 12684038
Title: Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs.
PubMed ID: 12684038
PubMed ID: 12410637
Title: Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration.
PubMed ID: 12410637
DOI: 10.1042/bj20020935
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10681522
Title: Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
PubMed ID: 10681522
PubMed ID: 11751924
Title: Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling.
PubMed ID: 11751924
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30392906
Title: Structural and biochemical studies of the extracellular domain of Myelin protein zero-like protein 1.
PubMed ID: 30392906
Sequence Information:
- Length: 269
- Mass: 29082
- Checksum: A1B299041EE59425
- Sequence:
MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI YAQLDHSGGH HSDKINKSES VVYADIRKN