Details for: HNRNPA0
Gene ID: 10949
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HNRNPA0
Ensembl ID: ENSG00000177733
Description: heterogeneous nuclear ribonucleoprotein A0
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 82.18rCSI 74.22%PRS 6.07
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CSI 76.66rCSI 67.33%PRS 7.71
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CSI 71.95rCSI 54.06%PRS 7.07
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CSI 62.84rCSI 85.63%PRS 6.17
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CSI 61.95rCSI 51.3%PRS 6.89
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CSI 60.95rCSI 76.5%PRS 8.75
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CSI 60.81rCSI 58.63%PRS 4.21
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CSI 60.02rCSI 68.71%PRS 14.26
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CSI 59.68rCSI 68.92%PRS 6.13
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CSI 59.03rCSI 61.7%PRS 7.23
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CSI 58.81rCSI 39.62%PRS 8.3
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CSI 58.61rCSI 49.13%PRS 8.23
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CSI 57.5rCSI 46.49%PRS 6.75
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CSI 55.47rCSI 36.87%PRS 8.18
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CSI 52.7rCSI 63.26%PRS 6.81
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CSI 52.35rCSI 41.56%PRS 12.14
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CSI 49.28rCSI 70.32%PRS 7.77
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CSI 45.7rCSI 53.67%PRS 8.22
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CSI 41.73rCSI 57.98%PRS 7.12
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CSI 40.93rCSI 39.36%PRS 14.86
-
CSI 40.33rCSI 38.83%PRS 7.12
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CSI 39.97rCSI 33.13%PRS 6.54
-
CSI 39.32rCSI 27.45%PRS 7.24
-
CSI 35.68rCSI 47.68%PRS 13.16
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CSI 35.17rCSI 45.14%PRS 6.73
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CSI 34.82rCSI 30.15%PRS 7.64
-
CSI 30.13rCSI 22.79%PRS 9.56
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CSI 28.97rCSI 25.48%PRS 4.96
-
CSI 27.94rCSI 55.7%PRS 11.77
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CSI 27.08rCSI 77.3%PRS 12.24
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CSI 26.82rCSI 18.65%PRS 8.04
-
CSI 26.21rCSI 66.56%PRS 7
-
CSI 25.26rCSI 22.42%PRS 6.87
-
CSI 24.29rCSI 20.44%PRS 11.44
-
CSI 24.1rCSI 34.75%PRS 9.59
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CSI 22.58rCSI 40.76%PRS 20.16
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CSI 22.44rCSI 23.51%PRS 6.39
-
CSI 22.39rCSI 71.85%PRS 10.32
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CSI 22.35rCSI 30.96%PRS 9.91
-
CSI 22.26rCSI 30.42%PRS 7.61
-
CSI 21.3rCSI 16.83%PRS 4.73
-
CSI 21.19rCSI 18.42%PRS 8.47
-
CSI 21.11rCSI 58.01%PRS 11.4
-
CSI 20.77rCSI 26.64%PRS 7.93
-
CSI 20.64rCSI 73.35%PRS 22.25
-
CSI 20.61rCSI 14.47%PRS 19.64
-
CSI 20rCSI 18.49%PRS 12.58
-
CSI 19.16rCSI 15.99%PRS 21.84
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CSI 18.85rCSI 47.23%PRS 22.25
-
CSI 18.62rCSI 16.31%PRS 9.23
-
CSI 18.29rCSI 33.23%PRS 10.5
-
CSI 18.2rCSI 13.62%PRS 11.23
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CSI 17.85rCSI 30.58%PRS 9.22
-
CSI 17.83rCSI 27.24%PRS 8.63
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CSI 17.61rCSI 22.41%PRS 7.96
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CSI 17.39rCSI 26.6%PRS 11.23
-
CSI 17.3rCSI 14.84%PRS 15.52
-
CSI 17.19rCSI 49.73%PRS 15.53
-
CSI 16.93rCSI 59.39%PRS 12.57
-
CSI 16.66rCSI 16.45%PRS 29.04
-
CSI 15.69rCSI 46.3%PRS 8.64
-
CSI 15.67rCSI 18.98%PRS 9.94
-
CSI 15.64rCSI 33.27%PRS 12.9
-
CSI 15.51rCSI 23.83%PRS 9.89
-
CSI 15.12rCSI 35.95%PRS 10.35
-
CSI 14.95rCSI 11.16%PRS 11.64
-
CSI 14.94rCSI 18.48%PRS 6.02
-
CSI 14.26rCSI 73.62%PRS 13.8
-
CSI 13.47rCSI 10.38%PRS 6.21
-
CSI 13.35rCSI 25.29%PRS 19.59
-
CSI 13.32rCSI 13.58%PRS 9.87
-
CSI 13rCSI 22.23%PRS 14.8
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CSI 12.74rCSI 33.1%PRS 20.78
-
CSI 12.69rCSI 69.11%PRS 17.48
-
CSI 12.66rCSI 10.29%PRS 7.33
-
CSI 12.51rCSI 36.21%PRS 7.8
-
CSI 12.26rCSI 12.42%PRS 41.33
-
CSI 12.25rCSI 65.35%PRS 25.11
-
CSI 12.22rCSI 9.05%PRS 6.28
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CSI 12.22rCSI 40%PRS 20.72
-
CSI 12.21rCSI 18.03%PRS 10.87
-
CSI 12.07rCSI 15.17%PRS 34.55
-
CSI 12.04rCSI 11.84%PRS 7.44
-
CSI 11.8rCSI 16.13%PRS 7.81
-
CSI 11.66rCSI 8.74%PRS 20.3
-
CSI 11.38rCSI 44.28%PRS 11.39
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CSI 11.36rCSI 6.71%PRS 9.53
-
CSI 11.04rCSI 25.19%PRS 6.24
-
CSI 11.03rCSI 8.92%PRS 13.91
-
CSI 10.99rCSI 16.98%PRS 6.45
-
CSI 10.97rCSI 10.12%PRS 6.97
-
CSI 10.94rCSI 11.43%PRS 21.67
-
CSI 10.85rCSI 71.17%PRS 18.24
-
CSI 10.67rCSI 9.19%PRS 11.39
-
CSI 10.34rCSI 7.2%PRS 9.93
-
CSI 10.32rCSI 8.12%PRS 8.18
-
CSI 10.31rCSI 10.68%PRS 8.08
-
CSI 10.31rCSI 55.77%PRS 24.21
-
CSI 10.3rCSI 10.28%PRS 5.9
-
CSI 10.3rCSI 7.65%PRS 10.3
-
CSI -10.2rCSI -16.5%PRS 7.0%
-
CSI -9.9rCSI -23.6%PRS 9.2%
-
CSI -7.5rCSI -12.2%PRS 5.3%
-
CSI -6.2rCSI -38.9%PRS 5.6%
-
CSI -5.9rCSI -9.7%PRS 8.1%
-
CSI -5.6rCSI -13.1%PRS 16.0%
-
CSI -5.3rCSI -11.9%PRS 4.2%
-
CSI -4.7rCSI -10.2%PRS 14.1%
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CSI -4.0rCSI -5.0%PRS 10.0%
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CSI -3.3rCSI -13.6%PRS 18.1%
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CSI -2.9rCSI -7.6%PRS 8.2%
-
CSI -2.4rCSI -2.9%PRS 12.0%
-
CSI -2.0rCSI -8.2%PRS 7.6%
-
CSI -1.8rCSI -3.6%PRS 7.4%
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CSI -1.8rCSI -4.1%PRS 6.7%
-
CSI -1.8rCSI -9.9%PRS 24.0%
-
CSI -1.7rCSI -6.4%PRS 12.5%
-
CSI -1.4rCSI -1.6%PRS 10.2%
-
CSI -1.3rCSI -13.5%PRS 53.3%
-
CSI -1.2rCSI -1.4%PRS 10.3%
-
CSI -1.0rCSI -1.6%PRS 8.9%
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CSI -0.9rCSI -2.6%PRS 8.9%
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CSI -0.8rCSI -5.0%PRS 4.3%
-
CSI -0.8rCSI -2.9%PRS 4.2%
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CSI -0.4rCSI -1.2%PRS 4.3%
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CSI -0.4rCSI -0.6%PRS 4.5%
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CSI -0.3rCSI -0.7%PRS 8.6%
-
CSI -0.3rCSI -0.8%PRS 9.9%
-
CSI -0.2rCSI -0.6%PRS 29.8%
-
CSI -0.2rCSI -1.1%PRS 46.9%
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CSI 0.1rCSI 0.4%PRS 23.8%
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CSI 0.1rCSI 0.3%PRS 4.7%
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CSI 0.1rCSI 1.0%PRS 27.3%
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CSI 0.1rCSI 0.2%PRS 22.7%
-
CSI 0.1rCSI 3.0%PRS 11.2%
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CSI 0.2rCSI 0.7%PRS 35.8%
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CSI 0.2rCSI 1.6%PRS 41.6%
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CSI 0.2rCSI 0.4%PRS 4.9%
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CSI 0.3rCSI 6.7%PRS 54.7%
-
CSI 0.3rCSI 1.1%PRS 3.7%
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CSI 0.3rCSI 1.5%PRS 17.0%
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CSI 0.3rCSI 0.6%PRS 5.2%
-
CSI 0.4rCSI 3.2%PRS 53.1%
-
CSI 0.4rCSI 7.4%PRS 51.1%
-
CSI 0.4rCSI 0.8%PRS 19.4%
-
CSI 0.4rCSI 2.5%PRS 11.4%
-
CSI 0.5rCSI 2.4%PRS 13.1%
-
CSI 0.5rCSI 0.8%PRS 4.0%
-
CSI 0.5rCSI 1.3%PRS 31.3%
-
CSI 0.5rCSI 1.0%PRS 11.1%
-
CSI 0.5rCSI 1.3%PRS 43.9%
-
CSI 0.6rCSI 3.3%PRS 10.4%
-
CSI 0.6rCSI 4.2%PRS 22.2%
-
CSI 0.6rCSI 3.4%PRS 22.4%
-
CSI 0.6rCSI 0.8%PRS 4.3%
-
CSI 0.6rCSI 0.8%PRS 10.6%
-
CSI 0.7rCSI 10.3%PRS 17.5%
-
CSI 0.7rCSI 4.1%PRS 16.0%
-
CSI 0.7rCSI 0.9%PRS 7.3%
-
CSI 0.7rCSI 3.6%PRS 9.0%
-
CSI 0.8rCSI 1.0%PRS 9.6%
-
CSI 0.8rCSI 8.2%PRS 67.4%
-
CSI 0.8rCSI 16.9%PRS 40.8%
-
CSI 0.8rCSI 4.9%PRS 35.2%
-
CSI 0.9rCSI 1.9%PRS 10.6%
-
CSI 0.9rCSI 3.6%PRS 10.9%
-
CSI 1.0rCSI 1.4%PRS 7.3%
-
CSI 1.0rCSI 2.0%PRS 14.8%
-
CSI 1.0rCSI 1.8%PRS 6.5%
-
CSI 1.0rCSI 2.8%PRS 13.9%
-
CSI 1.0rCSI 6.5%PRS 23.6%
-
CSI 1.0rCSI 4.9%PRS 17.3%
-
CSI 1.1rCSI 3.6%PRS 7.9%
-
CSI 1.1rCSI 2.7%PRS 3.9%
-
CSI 1.1rCSI 1.4%PRS 4.0%
-
CSI 1.1rCSI 2.0%PRS 9.1%
-
CSI 1.2rCSI 36.9%PRS 65.1%
-
CSI 1.2rCSI 9.7%PRS 7.2%
-
CSI 1.2rCSI 2.6%PRS 7.5%
-
CSI 1.2rCSI 1.2%PRS 10.9%
-
CSI 1.2rCSI 3.4%PRS 10.7%
-
CSI 1.2rCSI 19.7%PRS 41.9%
-
CSI 1.3rCSI 7.3%PRS 14.9%
-
CSI 1.4rCSI 30.5%PRS 36.6%
-
CSI 1.4rCSI 4.7%PRS 5.4%
-
CSI 1.4rCSI 2.1%PRS 6.7%
-
CSI 1.5rCSI 2.6%PRS 8.5%
-
CSI 1.5rCSI 2.2%PRS 10.1%
-
CSI 1.5rCSI 39.8%PRS 37.7%
-
CSI 1.6rCSI 2.3%PRS 6.8%
-
CSI 1.6rCSI 15.7%PRS 21.6%
-
CSI 1.7rCSI 32.2%PRS 24.4%
-
CSI 1.8rCSI 3.4%PRS 8.5%
-
CSI 1.8rCSI 2.8%PRS 12.1%
-
CSI 1.9rCSI 3.2%PRS 14.2%
-
CSI 1.9rCSI 6.8%PRS 11.9%
-
CSI 1.9rCSI 4.9%PRS 21.8%
-
CSI 1.9rCSI 8.5%PRS 6.9%
-
CSI 2.0rCSI 2.8%PRS 14.6%
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CSI 2.0rCSI 4.4%PRS 37.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3115866506
Symbol: ROA0_HUMAN
Name: Heterogeneous nuclear ribonucleoprotein A0
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7585247
Title: Isolation and characterization of a novel, low abundance hnRNP protein: A0.
PubMed ID: 7585247
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12456657
Title: Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.
PubMed ID: 12456657
DOI: 10.1093/emboj/cdf639
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20932473
Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
PubMed ID: 20932473
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 305
- Mass: 30841
- Checksum: 9A976A39345AA149
- Sequence:
MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF GFVTYSNVEE ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL FVGGLKGDVA EGDLIEHFSQ FGTVEKAEII ADKQSGKKRG FGFVYFQNHD AADKAAVVKF HPIQGHRVEV KKAVPKEDIY SGGGGGGSRS SRGGRGGRGR GGGRDQNGLS KGGGGGYNSY GGYGGGGGGG YNAYGGGGGG SSYGGSDYGN GFGGFGSYSQ HQSSYGPMKS GGGGGGGGSS WGGRSNSGPY RGGYGGGGGY GGSSF