Details for: DDX1
Gene ID: 1653
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DDX1
Ensembl ID: ENSG00000079785
Description: DEAD-box helicase 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 32.75rCSI 81.07%PRS 27.6
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CSI 8.4rCSI 6.52%PRS 28.8
-
CSI 7.28rCSI 17.36%PRS 32.39
-
CSI 6.75rCSI 17.82%PRS 34.86
-
CSI 6.66rCSI 31.9%PRS 26.47
-
CSI 6.56rCSI 23.6%PRS 17.37
-
CSI 5.99rCSI 14.32%PRS 21.36
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CSI 5.93rCSI 5.71%PRS 30.28
-
CSI 5.16rCSI 7.59%PRS 27.27
-
CSI 5.06rCSI 22.5%PRS 28.39
-
CSI 4.98rCSI 7.59%PRS 27.15
-
CSI 4.84rCSI 3.59%PRS 25.28
-
CSI 4.8rCSI 5.03%PRS 27.46
-
CSI 4.76rCSI 10.63%PRS 34.21
-
CSI 4.72rCSI 4.19%PRS 29.3
-
CSI 4.62rCSI 4.37%PRS 30.58
-
CSI 4.61rCSI 14.85%PRS 30.2
-
CSI 4.6rCSI 7.02%PRS 29.68
-
CSI 4.3rCSI 3.89%PRS 26.85
-
CSI 4.18rCSI 5.7%PRS 25.5
-
CSI 4.13rCSI 4.77%PRS 25.51
-
CSI 3.92rCSI 5.6%PRS 32.09
-
CSI 3.7rCSI 5.25%PRS 27.37
-
CSI 3.68rCSI 10.85%PRS 34.09
-
CSI 3.66rCSI 10.42%PRS 31.24
-
CSI 3.64rCSI 14.83%PRS 29.63
-
CSI 3.58rCSI 20.54%PRS 40.44
-
CSI 3.57rCSI 5.27%PRS 44.21
-
CSI 3.47rCSI 6.62%PRS 44.63
-
CSI 3.44rCSI 5.95%PRS 22.66
-
CSI 3.34rCSI 20.87%PRS 23.82
-
CSI 3.21rCSI 18.68%PRS 40.88
-
CSI 3.16rCSI 2.77%PRS 21.66
-
CSI 3.14rCSI 6.45%PRS 27.57
-
CSI 3.02rCSI 6.68%PRS 21.27
-
CSI 3.01rCSI 4.88%PRS 29.15
-
CSI 3rCSI 4.64%PRS 27.69
-
CSI 2.97rCSI 10.56%PRS 43.98
-
CSI 2.92rCSI 4.61%PRS 29.84
-
CSI 2.89rCSI 4.62%PRS 32.14
-
CSI 2.89rCSI 2.66%PRS 34.86
-
CSI 2.89rCSI 2.33%PRS 29.5
-
CSI 2.86rCSI 31.32%PRS 47.31
-
CSI 2.8rCSI 12.11%PRS 47.68
-
CSI 2.78rCSI 8.06%PRS 32.38
-
CSI 2.73rCSI 3.79%PRS 29.56
-
CSI 2.7rCSI 8.67%PRS 38.44
-
CSI 2.69rCSI 4.34%PRS 22.74
-
CSI 2.64rCSI 2.01%PRS 38.32
-
CSI 2.61rCSI 5.84%PRS 18.9
-
CSI 2.58rCSI 3.28%PRS 33.65
-
CSI 2.56rCSI 3.5%PRS 33.09
-
CSI 2.56rCSI 3.5%PRS 41.26
-
CSI 2.48rCSI 1.72%PRS 35.47
-
CSI 2.48rCSI 2.58%PRS 30.08
-
CSI 2.47rCSI 2.08%PRS 44.52
-
CSI 2.43rCSI 2.5%PRS 44.98
-
CSI 2.42rCSI 57.92%PRS 17.37
-
CSI 2.41rCSI 3.87%PRS 19.88
-
CSI 2.37rCSI 2.08%PRS 33.42
-
CSI 2.37rCSI 1.84%PRS 42.58
-
CSI 2.35rCSI 12.66%PRS 44.91
-
CSI 2.34rCSI 5.41%PRS 24.1
-
CSI 2.31rCSI 55.67%PRS 18.17
-
CSI 2.3rCSI 3.66%PRS 24.83
-
CSI 2.27rCSI 4.28%PRS 54.21
-
CSI 2.26rCSI 2.17%PRS 53.14
-
CSI 2.22rCSI 1.49%PRS 36.59
-
CSI 2.21rCSI 3.38%PRS 33.35
-
CSI 2.14rCSI 2.07%PRS 22.2
-
CSI 2.07rCSI 48.21%PRS 51.07
-
CSI 2.07rCSI 2.4%PRS 40.2
-
CSI 2.03rCSI 1.76%PRS 32.68
-
CSI 2rCSI 3.18%PRS 37.58
-
CSI 1.99rCSI 2.88%PRS 38.9
-
CSI 1.94rCSI 2.13%PRS 32.63
-
CSI 1.94rCSI 1.91%PRS 43.33
-
CSI 1.94rCSI 1.29%PRS 33.81
-
CSI 1.89rCSI 4.79%PRS 28.24
-
CSI 1.86rCSI 6.39%PRS 70.25
-
CSI 1.84rCSI 4.19%PRS 25.22
-
CSI 1.83rCSI 2.27%PRS 26.05
-
CSI 1.82rCSI 1.53%PRS 34.17
-
CSI 1.82rCSI 3.2%PRS 28.64
-
CSI 1.81rCSI 1.69%PRS 29.37
-
CSI 1.75rCSI 2.34%PRS 36.54
-
CSI 1.74rCSI 1.81%PRS 30.09
-
CSI 1.73rCSI 4.52%PRS 28.16
-
CSI 1.73rCSI 2.84%PRS 22.93
-
CSI 1.7rCSI 1.35%PRS 20.5
-
CSI 1.7rCSI 2.49%PRS 31.84
-
CSI 1.7rCSI 1.46%PRS 40.35
-
CSI 1.67rCSI 50.19%PRS 55.15
-
CSI 1.67rCSI 1.78%PRS 45.69
-
CSI 1.66rCSI 0.98%PRS 40.85
-
CSI 1.64rCSI 2.11%PRS 27.88
-
CSI 1.64rCSI 4.15%PRS 35.92
-
CSI 1.63rCSI 2.05%PRS 42.04
-
CSI 1.62rCSI 2.08%PRS 28.1
-
CSI 1.62rCSI 2.22%PRS 32.18
-
CSI 0.1rCSI 2.0%PRS 67.6%
-
CSI 0.2rCSI 3.2%PRS 72.3%
-
CSI 0.2rCSI 1.1%PRS 41.3%
-
CSI 0.2rCSI 4.1%PRS 26.1%
-
CSI 0.2rCSI 3.3%PRS 61.0%
-
CSI 0.2rCSI 4.7%PRS 24.8%
-
CSI 0.2rCSI 1.0%PRS 46.8%
-
CSI 0.3rCSI 1.7%PRS 62.4%
-
CSI 0.3rCSI 0.4%PRS 38.2%
-
CSI 0.3rCSI 1.4%PRS 56.2%
-
CSI 0.3rCSI 0.6%PRS 50.7%
-
CSI 0.3rCSI 4.2%PRS 24.3%
-
CSI 0.3rCSI 0.7%PRS 27.2%
-
CSI 0.4rCSI 4.2%PRS 58.9%
-
CSI 0.4rCSI 5.9%PRS 59.5%
-
CSI 0.4rCSI 3.3%PRS 49.5%
-
CSI 0.5rCSI 1.2%PRS 52.0%
-
CSI 0.5rCSI 1.7%PRS 46.1%
-
CSI 0.5rCSI 2.5%PRS 52.2%
-
CSI 0.5rCSI 1.4%PRS 37.5%
-
CSI 0.5rCSI 3.8%PRS 19.8%
-
CSI 0.5rCSI 1.5%PRS 43.7%
-
CSI 0.6rCSI 2.3%PRS 45.7%
-
CSI 0.6rCSI 1.6%PRS 45.2%
-
CSI 0.6rCSI 1.7%PRS 44.7%
-
CSI 0.6rCSI 3.9%PRS 68.8%
-
CSI 0.7rCSI 2.1%PRS 33.5%
-
CSI 0.7rCSI 5.1%PRS 49.4%
-
CSI 0.7rCSI 1.0%PRS 31.3%
-
CSI 0.7rCSI 1.7%PRS 22.8%
-
CSI 0.7rCSI 1.2%PRS 17.7%
-
CSI 0.7rCSI 2.1%PRS 25.9%
-
CSI 0.7rCSI 1.5%PRS 29.5%
-
CSI 0.7rCSI 2.0%PRS 48.1%
-
CSI 0.7rCSI 2.8%PRS 53.2%
-
CSI 0.7rCSI 1.3%PRS 43.6%
-
CSI 0.7rCSI 1.8%PRS 29.5%
-
CSI 0.7rCSI 1.6%PRS 42.7%
-
CSI 0.7rCSI 1.3%PRS 36.9%
-
CSI 0.7rCSI 1.7%PRS 44.5%
-
CSI 0.7rCSI 1.4%PRS 37.0%
-
CSI 0.7rCSI 1.4%PRS 21.9%
-
CSI 0.7rCSI 1.4%PRS 51.0%
-
CSI 0.7rCSI 1.1%PRS 34.8%
-
CSI 0.8rCSI 1.8%PRS 41.5%
-
CSI 0.8rCSI 4.2%PRS 72.8%
-
CSI 0.8rCSI 2.1%PRS 42.3%
-
CSI 0.8rCSI 1.2%PRS 23.2%
-
CSI 0.8rCSI 1.2%PRS 43.2%
-
CSI 0.8rCSI 1.8%PRS 43.9%
-
CSI 0.8rCSI 1.8%PRS 38.4%
-
CSI 0.9rCSI 1.0%PRS 28.4%
-
CSI 0.9rCSI 4.3%PRS 38.8%
-
CSI 0.9rCSI 1.1%PRS 37.5%
-
CSI 0.9rCSI 1.4%PRS 37.1%
-
CSI 0.9rCSI 0.7%PRS 27.8%
-
CSI 0.9rCSI 1.7%PRS 27.6%
-
CSI 0.9rCSI 3.6%PRS 19.1%
-
CSI 1.0rCSI 6.2%PRS 52.9%
-
CSI 1.0rCSI 1.4%PRS 37.7%
-
CSI 1.0rCSI 0.8%PRS 28.0%
-
CSI 1.0rCSI 2.9%PRS 47.3%
-
CSI 1.0rCSI 3.4%PRS 33.9%
-
CSI 1.0rCSI 4.6%PRS 26.0%
-
CSI 1.1rCSI 2.3%PRS 38.4%
-
CSI 1.1rCSI 1.0%PRS 30.4%
-
CSI 1.1rCSI 4.5%PRS 28.0%
-
CSI 1.1rCSI 1.9%PRS 34.0%
-
CSI 1.2rCSI 3.3%PRS 43.3%
-
CSI 1.2rCSI 2.3%PRS 16.9%
-
CSI 1.2rCSI 17.0%PRS 56.6%
-
CSI 1.2rCSI 1.5%PRS 18.9%
-
CSI 1.2rCSI 4.2%PRS 68.8%
-
CSI 1.2rCSI 2.3%PRS 30.4%
-
CSI 1.2rCSI 0.9%PRS 49.3%
-
CSI 1.2rCSI 3.9%PRS 21.7%
-
CSI 1.2rCSI 1.2%PRS 34.3%
-
CSI 1.2rCSI 2.0%PRS 18.3%
-
CSI 1.2rCSI 6.8%PRS 19.0%
-
CSI 1.2rCSI 1.8%PRS 33.3%
-
CSI 1.2rCSI 7.1%PRS 19.3%
-
CSI 1.2rCSI 1.8%PRS 30.2%
-
CSI 1.2rCSI 2.8%PRS 36.3%
-
CSI 1.2rCSI 2.0%PRS 25.1%
-
CSI 1.2rCSI 1.7%PRS 31.5%
-
CSI 1.2rCSI 0.9%PRS 30.9%
-
CSI 1.3rCSI 2.6%PRS 53.0%
-
CSI 1.3rCSI 12.0%PRS 76.1%
-
CSI 1.3rCSI 1.9%PRS 38.1%
-
CSI 1.3rCSI 1.6%PRS 17.2%
-
CSI 1.3rCSI 1.8%PRS 50.4%
-
CSI 1.3rCSI 5.8%PRS 49.4%
-
CSI 1.3rCSI 1.8%PRS 28.4%
-
CSI 1.3rCSI 2.0%PRS 45.1%
-
CSI 1.3rCSI 2.4%PRS 24.6%
-
CSI 1.4rCSI 1.6%PRS 36.0%
-
CSI 1.4rCSI 1.6%PRS 33.2%
-
CSI 1.4rCSI 2.0%PRS 32.9%
-
CSI 1.4rCSI 4.2%PRS 19.1%
-
CSI 1.4rCSI 1.6%PRS 47.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1266991079
Symbol: DDX1_HUMAN
Name: ATP-dependent RNA helicase DDX1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7689221
Title: Amplification of a DEAD box protein gene in retinoblastoma cell lines.
PubMed ID: 7689221
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11598190
Title: Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA.
PubMed ID: 11598190
PubMed ID: 12183465
Title: An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.
PubMed ID: 12183465
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15567440
Title: A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev.
PubMed ID: 15567440
PubMed ID: 18335541
Title: MBNL1 associates with YB-1 in cytoplasmic stress granules.
PubMed ID: 18335541
DOI: 10.1002/jnr.21655
PubMed ID: 18710941
Title: A role for DEAD box 1 at DNA double-strand breaks.
PubMed ID: 18710941
DOI: 10.1128/mcb.01053-08
PubMed ID: 19058135
Title: The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription.
PubMed ID: 19058135
DOI: 10.1002/jcb.22004
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20573827
Title: The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
PubMed ID: 20573827
DOI: 10.1128/jvi.00392-10
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21933836
Title: The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.
PubMed ID: 21933836
DOI: 10.1093/hmg/ddr430
PubMed ID: 21589879
Title: A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication.
PubMed ID: 21589879
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 21311021
Title: HSPC117 is the essential subunit of a human tRNA splicing ligase complex.
PubMed ID: 21311021
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24870230
Title: Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.
PubMed ID: 24870230
DOI: 10.1038/nature13284
PubMed ID: 24608264
Title: hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
PubMed ID: 24608264
PubMed ID: 26030138
Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.
PubMed ID: 26030138
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27105836
Title: Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.
PubMed ID: 27105836
PubMed ID: 28040436
Title: FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
PubMed ID: 28040436
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 26323305
Title: Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein.
PubMed ID: 26323305
Sequence Information:
- Length: 740
- Mass: 82432
- Checksum: C6D0179F83BD8C73
- Sequence:
MAAFSEMGVM PEIAQAVEEM DWLLPTDIQA ESIPLILGGG DVLMAAETGS GKTGAFSIPV IQIVYETLKD QQEGKKGKTT IKTGASVLNK WQMNPYDRGS AFAIGSDGLC CQSREVKEWH GCRATKGLMK GKHYYEVSCH DQGLCRVGWS TMQASLDLGT DKFGFGFGGT GKKSHNKQFD NYGEEFTMHD TIGCYLDIDK GHVKFSKNGK DLGLAFEIPP HMKNQALFPA CVLKNAELKF NFGEEEFKFP PKDGFVALSK APDGYIVKSQ HSGNAQVTQT KFLPNAPKAL IVEPSRELAE QTLNNIKQFK KYIDNPKLRE LLIIGGVAAR DQLSVLENGV DIVVGTPGRL DDLVSTGKLN LSQVRFLVLD EADGLLSQGY SDFINRMHNQ IPQVTSDGKR LQVIVCSATL HSFDVKKLSE KIMHFPTWVD LKGEDSVPDT VHHVVVPVNP KTDRLWERLG KSHIRTDDVH AKDNTRPGAN SPEMWSEAIK ILKGEYAVRA IKEHKMDQAI IFCRTKIDCD NLEQYFIQQG GGPDKKGHQF SCVCLHGDRK PHERKQNLER FKKGDVRFLI CTDVAARGID IHGVPYVINV TLPDEKQNYV HRIGRVGRAE RMGLAISLVA TEKEKVWYHV CSSRGKGCYN TRLKEDGGCT IWYNEMQLLS EIEEHLNCTI SQVEPDIKVP VDEFDGKVTY GQKRAAGGGS YKGHVDILAP TVQELAALEK EAQTSFLHLG YLPNQLFRTF