Details for: HIBCH
Gene ID: 26275
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HIBCH
Ensembl ID: ENSG00000198130
Description: 3-hydroxyisobutyryl-CoA hydrolase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 15.74rCSI 13.05%PRS 42.94
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CSI 13.74rCSI 33.55%PRS 40.56
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CSI 12.94rCSI 9%PRS 52.92
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CSI 11.68rCSI 44.15%PRS 30.15
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CSI 10.39rCSI 14.2%PRS 47.07
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CSI 9.93rCSI 12.35%PRS 27.76
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CSI 9rCSI 12.89%PRS 51.7
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CSI 8.97rCSI 65.94%PRS 32.82
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CSI 8.79rCSI 38.63%PRS 42.24
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CSI 8.2rCSI 12.38%PRS 46.45
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CSI 8.19rCSI 39.23%PRS 45.93
-
CSI 8.12rCSI 29.23%PRS 28.15
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CSI 7.52rCSI 9.65%PRS 40.08
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CSI 7.3rCSI 9.41%PRS 30.1
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CSI 7.3rCSI 5.74%PRS 50.8
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CSI 6.79rCSI 53.98%PRS 67.47
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CSI 6.71rCSI 20.96%PRS 30.39
-
CSI 6.63rCSI 12.44%PRS 63.85
-
CSI 6.37rCSI 11.57%PRS 38.1
-
CSI 6.33rCSI 10.2%PRS 53.26
-
CSI 6.28rCSI 8.55%PRS 57.19
-
CSI 6.1rCSI 20.22%PRS 46.4
-
CSI 6.06rCSI 20.76%PRS 36.27
-
CSI 6.01rCSI 4.46%PRS 57.52
-
CSI 5.9rCSI 7.57%PRS 42.49
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CSI 5.62rCSI 12.81%PRS 43.03
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CSI 5.61rCSI 6.14%PRS 48.3
-
CSI 4.94rCSI 4.86%PRS 59.72
-
CSI 4.88rCSI 15.04%PRS 56.27
-
CSI 4.86rCSI 8.69%PRS 42.83
-
CSI 4.6rCSI 27.06%PRS 30.64
-
CSI 4.58rCSI 25.02%PRS 47.35
-
CSI 4.53rCSI 10.01%PRS 33.18
-
CSI 4.37rCSI 8.78%PRS 34.62
-
CSI 4.35rCSI 7.01%PRS 35.45
-
CSI 4.32rCSI 9.51%PRS 30.43
-
CSI 4.31rCSI 6.32%PRS 44
-
CSI 3.91rCSI 6.24%PRS 38.48
-
CSI 3.9rCSI 3.53%PRS 41.17
-
CSI 3.88rCSI 4.06%PRS 43.96
-
CSI 3.73rCSI 9.64%PRS 40.78
-
CSI 3.67rCSI 2.17%PRS 59.43
-
CSI 3.65rCSI 3.51%PRS 44.91
-
CSI 3.62rCSI 19.03%PRS 52.94
-
CSI 3.57rCSI 6.42%PRS 38.02
-
CSI 3.54rCSI 4.14%PRS 60
-
CSI 3.53rCSI 9.73%PRS 41.22
-
CSI 3.52rCSI 8.04%PRS 38.07
-
CSI 3.51rCSI 2.77%PRS 32.57
-
CSI 3.41rCSI 8.85%PRS 49.44
-
CSI 3.32rCSI 19.15%PRS 46.33
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CSI 3.28rCSI 4.68%PRS 47.07
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CSI 3.25rCSI 3.75%PRS 38.94
-
CSI 3.25rCSI 8.24%PRS 35.33
-
CSI 3.24rCSI 2.78%PRS 53.45
-
CSI 3.22rCSI 2.6%PRS 55.3
-
CSI 3.13rCSI 3.74%PRS 29.21
-
CSI 3.1rCSI 6.95%PRS 29.91
-
CSI 3.05rCSI 4.32%PRS 41.53
-
CSI 3rCSI 4.17%PRS 43.89
-
CSI 3rCSI 14.36%PRS 42.94
-
CSI 2.97rCSI 6.02%PRS 27.58
-
CSI 2.95rCSI 1.96%PRS 48.11
-
CSI 2.94rCSI 70.46%PRS 28.7
-
CSI 2.94rCSI 4.37%PRS 46.97
-
CSI 2.94rCSI 3.02%PRS 62.09
-
CSI 2.93rCSI 10.98%PRS 37.74
-
CSI 2.91rCSI 10.33%PRS 57.03
-
CSI 2.9rCSI 2.21%PRS 55.72
-
CSI 2.9rCSI 69.88%PRS 29.58
-
CSI 2.88rCSI 2.53%PRS 49.32
-
CSI 2.8rCSI 7.46%PRS 36.92
-
CSI 2.78rCSI 2.43%PRS 54.16
-
CSI 2.73rCSI 2.58%PRS 45.36
-
CSI 2.67rCSI 3.7%PRS 49.3
-
CSI 2.67rCSI 5%PRS 34.6
-
CSI 2.67rCSI 4.68%PRS 37.05
-
CSI 2.66rCSI 1.97%PRS 38.18
-
CSI 2.61rCSI 6.12%PRS 53.46
-
CSI 2.58rCSI 3.28%PRS 49.65
-
CSI 2.52rCSI 2.08%PRS 45.37
-
CSI 2.46rCSI 50.13%PRS 37.36
-
CSI 2.45rCSI 3.89%PRS 55.04
-
CSI 2.44rCSI 1.9%PRS 61.19
-
CSI 2.44rCSI 5.07%PRS 42.38
-
CSI 2.43rCSI 49.49%PRS 38.37
-
CSI 2.4rCSI 5.29%PRS 58.85
-
CSI 2.36rCSI 2.77%PRS 48.13
-
CSI 2.33rCSI 3.43%PRS 40.49
-
CSI 2.33rCSI 3.77%PRS 42.9
-
CSI 2.31rCSI 6.17%PRS 37.58
-
CSI 2.28rCSI 3.05%PRS 52.85
-
CSI 2.26rCSI 12.75%PRS 31.21
-
CSI 2.24rCSI 3.45%PRS 46.59
-
CSI 2.24rCSI 1.99%PRS 43.53
-
CSI 2.23rCSI 6.62%PRS 56.07
-
CSI 2.21rCSI 9.83%PRS 43.15
-
CSI 2.18rCSI 7.02%PRS 43.79
-
CSI 2.17rCSI 2.02%PRS 44.25
-
CSI 2.15rCSI 6.03%PRS 58.85
-
CSI 0.2rCSI 2.2%PRS 64.9%
-
CSI 0.3rCSI 1.5%PRS 56.5%
-
CSI 0.3rCSI 4.2%PRS 70.0%
-
CSI 0.3rCSI 1.8%PRS 37.2%
-
CSI 0.3rCSI 3.2%PRS 71.1%
-
CSI 0.3rCSI 2.8%PRS 32.4%
-
CSI 0.4rCSI 2.2%PRS 55.0%
-
CSI 0.4rCSI 2.0%PRS 44.1%
-
CSI 0.4rCSI 2.8%PRS 62.6%
-
CSI 0.4rCSI 4.7%PRS 60.6%
-
CSI 0.4rCSI 1.9%PRS 65.9%
-
CSI 0.5rCSI 0.8%PRS 27.5%
-
CSI 0.5rCSI 1.4%PRS 59.9%
-
CSI 0.5rCSI 0.8%PRS 61.9%
-
CSI 0.5rCSI 0.8%PRS 41.2%
-
CSI 0.5rCSI 3.3%PRS 66.3%
-
CSI 0.6rCSI 2.6%PRS 85.3%
-
CSI 0.6rCSI 5.2%PRS 33.5%
-
CSI 0.6rCSI 2.4%PRS 47.0%
-
CSI 0.6rCSI 3.0%PRS 56.2%
-
CSI 0.6rCSI 2.1%PRS 53.7%
-
CSI 0.7rCSI 4.8%PRS 38.6%
-
CSI 0.7rCSI 3.7%PRS 59.0%
-
CSI 0.7rCSI 2.2%PRS 32.7%
-
CSI 0.7rCSI 0.9%PRS 63.6%
-
CSI 0.7rCSI 5.5%PRS 64.6%
-
CSI 0.7rCSI 4.1%PRS 67.4%
-
CSI 0.7rCSI 7.9%PRS 45.7%
-
CSI 0.8rCSI 2.2%PRS 36.1%
-
CSI 0.8rCSI 1.2%PRS 42.4%
-
CSI 0.8rCSI 0.9%PRS 34.9%
-
CSI 0.8rCSI 4.8%PRS 58.5%
-
CSI 0.8rCSI 3.2%PRS 22.1%
-
CSI 0.8rCSI 1.6%PRS 67.4%
-
CSI 0.9rCSI 13.6%PRS 48.7%
-
CSI 0.9rCSI 3.8%PRS 63.7%
-
CSI 0.9rCSI 1.3%PRS 47.4%
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CSI 0.9rCSI 1.6%PRS 28.3%
-
CSI 0.9rCSI 1.7%PRS 54.6%
-
CSI 0.9rCSI 0.7%PRS 43.3%
-
CSI 0.9rCSI 2.2%PRS 54.6%
-
CSI 0.9rCSI 4.4%PRS 42.2%
-
CSI 0.9rCSI 2.1%PRS 41.8%
-
CSI 0.9rCSI 2.2%PRS 56.6%
-
CSI 1.0rCSI 1.8%PRS 67.7%
-
CSI 1.0rCSI 2.7%PRS 44.6%
-
CSI 1.0rCSI 2.2%PRS 62.1%
-
CSI 1.0rCSI 3.2%PRS 33.6%
-
CSI 1.0rCSI 2.2%PRS 35.0%
-
CSI 1.0rCSI 3.4%PRS 33.2%
-
CSI 1.0rCSI 2.0%PRS 62.1%
-
CSI 1.0rCSI 14.4%PRS 37.0%
-
CSI 1.1rCSI 2.2%PRS 39.0%
-
CSI 1.1rCSI 1.3%PRS 55.8%
-
CSI 1.1rCSI 1.3%PRS 42.5%
-
CSI 1.1rCSI 1.2%PRS 41.7%
-
CSI 1.2rCSI 3.7%PRS 51.9%
-
CSI 1.2rCSI 2.6%PRS 54.3%
-
CSI 1.2rCSI 4.9%PRS 41.9%
-
CSI 1.2rCSI 5.3%PRS 38.1%
-
CSI 1.2rCSI 1.5%PRS 40.4%
-
CSI 1.2rCSI 3.1%PRS 40.4%
-
CSI 1.2rCSI 2.9%PRS 34.2%
-
CSI 1.2rCSI 13.8%PRS 69.6%
-
CSI 1.2rCSI 3.0%PRS 28.4%
-
CSI 1.2rCSI 2.0%PRS 48.2%
-
CSI 1.2rCSI 2.5%PRS 43.8%
-
CSI 1.2rCSI 1.0%PRS 49.4%
-
CSI 1.3rCSI 5.0%PRS 42.9%
-
CSI 1.3rCSI 2.4%PRS 46.5%
-
CSI 1.3rCSI 3.3%PRS 67.5%
-
CSI 1.3rCSI 1.3%PRS 47.2%
-
CSI 1.3rCSI 3.7%PRS 62.0%
-
CSI 1.3rCSI 1.0%PRS 45.0%
-
CSI 1.3rCSI 2.0%PRS 60.7%
-
CSI 1.3rCSI 5.1%PRS 38.0%
-
CSI 1.4rCSI 3.5%PRS 44.2%
-
CSI 1.4rCSI 1.2%PRS 53.8%
-
CSI 1.4rCSI 4.5%PRS 46.5%
-
CSI 1.4rCSI 2.1%PRS 45.1%
-
CSI 1.4rCSI 4.5%PRS 41.4%
-
CSI 1.4rCSI 3.1%PRS 48.3%
-
CSI 1.4rCSI 1.9%PRS 49.2%
-
CSI 1.4rCSI 3.5%PRS 42.5%
-
CSI 1.4rCSI 2.1%PRS 36.1%
-
CSI 1.4rCSI 3.4%PRS 62.3%
-
CSI 1.5rCSI 2.0%PRS 40.9%
-
CSI 1.5rCSI 1.9%PRS 54.0%
-
CSI 1.5rCSI 2.2%PRS 55.6%
-
CSI 1.5rCSI 2.3%PRS 54.4%
-
CSI 1.5rCSI 4.3%PRS 44.4%
-
CSI 1.5rCSI 2.2%PRS 57.9%
-
CSI 1.5rCSI 5.9%PRS 62.6%
-
CSI 1.5rCSI 2.7%PRS 52.9%
-
CSI 1.5rCSI 1.2%PRS 44.9%
-
CSI 1.5rCSI 1.2%PRS 66.4%
-
CSI 1.5rCSI 3.5%PRS 36.5%
-
CSI 1.5rCSI 2.1%PRS 54.3%
-
CSI 1.5rCSI 3.3%PRS 59.4%
-
CSI 1.6rCSI 3.7%PRS 46.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3382916657
Symbol: HIBCH_HUMAN
Name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8824301
Title: Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase.
PubMed ID: 8824301
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 17160907
Title: Mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration.
PubMed ID: 17160907
DOI: 10.1086/510725
Sequence Information:
- Length: 386
- Mass: 43482
- Checksum: 11B0632ED1DF2FFA
- Sequence:
MGQREMWRLM SRFNAFKRTN TILHHLRMSK HTDAAEEVLL EKKGCTGVIT LNRPKFLNAL TLNMIRQIYP QLKKWEQDPE TFLIIIKGAG GKAFCAGGDI RVISEAEKAK QKIAPVFFRE EYMLNNAVGS CQKPYVALIH GITMGGGVGL SVHGQFRVAT EKCLFAMPET AIGLFPDVGG GYFLPRLQGK LGYFLALTGF RLKGRDVYRA GIATHFVDSE KLAMLEEDLL ALKSPSKENI ASVLENYHTE SKIDRDKSFI LEEHMDKINS CFSANTVEEI IENLQQDGSS FALEQLKVIN KMSPTSLKIT LRQLMEGSSK TLQEVLTMEY RLSQACMRGH DFHEGVRAVL IDKDQSPKWK PADLKEVTEE DLNNHFKSLG SSDLKF