Details for: ETNK1

Gene ID: 55500

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ETNK1

Ensembl ID: ENSG00000139163

Description: ethanolamine kinase 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 33.09
    rCSI 55.54%
    PRS 7.1
  • enteroendocrine cell of small intestine CL0009006
    CSI 32.36
    rCSI 71.24%
    PRS 18.57
  • BEST4+ enteroycte CL4030026
    CSI 28.03
    rCSI 34.86%
    PRS 12.8
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 27.02
    rCSI 65.68%
    PRS 6.91
  • foveolar cell of stomach CL0002179
    CSI 26.95
    rCSI 57.36%
    PRS 19.58
  • small intestine goblet cell CL1000495
    CSI 21.13
    rCSI 46.28%
    PRS 16.17
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 19.2
    rCSI 69.09%
    PRS 6.57
  • L6b glutamatergic cortical neuron CL4023038
    CSI 16.71
    rCSI 52.21%
    PRS 7.59
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 16.64
    rCSI 62.89%
    PRS 7.26
  • hepatic stellate cell CL0000632
    CSI 12.85
    rCSI 48.15%
    PRS 10.25
  • Hofbauer cell CL3000001
    CSI 12.56
    rCSI 23.72%
    PRS 15.04
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 12.02
    rCSI 32.4%
    PRS 15.61
  • enterocyte CL0000584
    CSI 11.65
    rCSI 18.79%
    PRS 19.39
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 11.57
    rCSI 68.11%
    PRS 7.45
  • paneth cell CL0000510
    CSI 10.7
    rCSI 15.8%
    PRS 19.06
  • paneth cell of epithelium of small intestine CL1000343
    CSI 10.61
    rCSI 29.72%
    PRS 18.72
  • enterocyte of epithelium of large intestine CL0002071
    CSI 9.49
    rCSI 49.82%
    PRS 21.65
  • M cell of gut CL0000682
    CSI 8.97
    rCSI 9.53%
    PRS 21.5
  • mucous neck cell CL0000651
    CSI 8.66
    rCSI 12.49%
    PRS 19.54
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 7.81
    rCSI 24.42%
    PRS 8.18
  • sncg GABAergic cortical interneuron CL4023015
    CSI 7.8
    rCSI 12.54%
    PRS 7.83
  • alveolar adventitial fibroblast CL4028006
    CSI 7.74
    rCSI 12.22%
    PRS 12.11
  • central nervous system neuron CL2000029
    CSI 7.28
    rCSI 53.48%
    PRS 6.13
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 6.82
    rCSI 12.38%
    PRS 9.9
  • enteroendocrine cell of colon CL0009042
    CSI 6.61
    rCSI 31.01%
    PRS 32.48
  • intestinal epithelial cell CL0002563
    CSI 6.55
    rCSI 6.85%
    PRS 12.76
  • pro-B cell CL0000826
    CSI 6.42
    rCSI 5.32%
    PRS 12.1
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 5.96
    rCSI 10.53%
    PRS 7.08
  • cardiac muscle cell CL0000746
    CSI 5.78
    rCSI 8.29%
    PRS 9.5
  • retinal ganglion cell CL0000740
    CSI 5.57
    rCSI 12.3%
    PRS 8.7
  • pancreatic D cell CL0000173
    CSI 5.56
    rCSI 5.47%
    PRS 13.14
  • renal principal cell CL0005009
    CSI 5.49
    rCSI 14.27%
    PRS 16.31
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 5.48
    rCSI 4.39%
    PRS 21.93
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 5.15
    rCSI 6.41%
    PRS 6.58
  • rod bipolar cell CL0000751
    CSI 5.13
    rCSI 9.21%
    PRS 10.12
  • transit amplifying cell of colon CL0009011
    CSI 4.61
    rCSI 5.41%
    PRS 14.27
  • retinal pigment epithelial cell CL0002586
    CSI 4.21
    rCSI 8.37%
    PRS 12.9
  • enteroendocrine cell CL0000164
    CSI 4.19
    rCSI 5.72%
    PRS 13.43
  • chondrocyte CL0000138
    CSI 4.15
    rCSI 6.6%
    PRS 10.4
  • intestinal crypt stem cell of colon CL0009043
    CSI 4.09
    rCSI 30.71%
    PRS 22.32
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 3.87
    rCSI 3.8%
    PRS 19.09
  • direct pathway medium spiny neuron CL4023026
    CSI 3.62
    rCSI 86.73%
    PRS 5.43
  • neuron CL0000540
    CSI 3.6
    rCSI 9.6%
    PRS 9.45
  • colon goblet cell CL0009039
    CSI 3.57
    rCSI 8.48%
    PRS 18.26
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.56
    rCSI 86.01%
    PRS 6.33
  • ON-bipolar cell CL0000749
    CSI 3.55
    rCSI 5.28%
    PRS 14.76
  • intestine goblet cell CL0019031
    CSI 3.42
    rCSI 3.04%
    PRS 12.13
  • P/D1 enteroendocrine cell CL0002268
    CSI 3.39
    rCSI 18.46%
    PRS 29.99
  • brush cell of tracheobronchial tree CL0002075
    CSI 3.19
    rCSI 9.46%
    PRS 18
  • periportal region hepatocyte CL0019026
    CSI 3.16
    rCSI 12.3%
    PRS 17.04
  • interstitial cell of Cajal CL0002088
    CSI 3.15
    rCSI 4.01%
    PRS 14.08
  • vascular associated smooth muscle cell CL0000359
    CSI 3.1
    rCSI 10.04%
    PRS 14.84
  • subcutaneous adipocyte CL0002521
    CSI 3.09
    rCSI 15.85%
    PRS 9.52
  • blood vessel smooth muscle cell CL0019018
    CSI 3.01
    rCSI 24.46%
    PRS 12.54
  • type EC enteroendocrine cell CL0000577
    CSI 2.98
    rCSI 10.57%
    PRS 19.88
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.94
    rCSI 2.67%
    PRS 18.34
  • lung ciliated cell CL1000271
    CSI 2.82
    rCSI 3.26%
    PRS 8.87
  • glioblast CL0000030
    CSI 2.71
    rCSI 4.32%
    PRS 10.45
  • unswitched memory B cell CL0000970
    CSI 2.7
    rCSI 2.27%
    PRS 19.54
  • respiratory goblet cell CL0002370
    CSI 2.68
    rCSI 29.16%
    PRS 23.44
  • neural progenitor cell CL0011020
    CSI 2.67
    rCSI 11.75%
    PRS 11.84
  • myofibroblast cell CL0000186
    CSI 2.62
    rCSI 3.63%
    PRS 17.46
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.61
    rCSI 1.98%
    PRS 15.83
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 2.6
    rCSI 8%
    PRS 19.06
  • melanocyte CL0000148
    CSI 2.58
    rCSI 1.91%
    PRS 10.78
  • hematopoietic precursor cell CL0008001
    CSI 2.54
    rCSI 2.61%
    PRS 19.72
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 2.47
    rCSI 12.39%
    PRS 15.77
  • cerebral cortex endothelial cell CL1001602
    CSI 2.46
    rCSI 4.26%
    PRS 9.23
  • colon macrophage CL0009038
    CSI 2.38
    rCSI 11.01%
    PRS 25.11
  • diffuse bipolar 6 cell CL4033032
    CSI 2.31
    rCSI 12.17%
    PRS 14.15
  • tuft cell of colon CL0009041
    CSI 2.29
    rCSI 5.34%
    PRS 25.91
  • cardiac endothelial cell CL0010008
    CSI 2.29
    rCSI 9.25%
    PRS 10.86
  • IgG plasma cell CL0000985
    CSI 2.19
    rCSI 2.62%
    PRS 20.8
  • neuroendocrine cell CL0000165
    CSI 2.19
    rCSI 8.47%
    PRS 24.91
  • acinar cell of salivary gland CL0002623
    CSI 2.17
    rCSI 50.52%
    PRS 21.6
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 2.15
    rCSI 1.61%
    PRS 34.6
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.15
    rCSI 2.77%
    PRS 7.42
  • endocardial cell CL0002350
    CSI 2.08
    rCSI 9.98%
    PRS 15.69
  • goblet cell CL0000160
    CSI 2.06
    rCSI 1.95%
    PRS 12.66
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 2.05
    rCSI 4.09%
    PRS 20.09
  • activated type II NK T cell CL0000931
    CSI 2.04
    rCSI 2.3%
    PRS 19.41
  • perivascular cell CL4033054
    CSI 2.02
    rCSI 2.77%
    PRS 13.76
  • ependymal cell CL0000065
    CSI 2.01
    rCSI 4.08%
    PRS 5.14
  • radial glial cell CL0000681
    CSI 1.92
    rCSI 2.67%
    PRS 12.52
  • Mueller cell CL0000636
    CSI 1.91
    rCSI 4.35%
    PRS 10.67
  • mononuclear phagocyte CL0000113
    CSI 1.86
    rCSI 4.1%
    PRS 13.36
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.86
    rCSI 1.89%
    PRS 17.31
  • renal beta-intercalated cell CL0002201
    CSI 1.84
    rCSI 4.37%
    PRS 14.64
  • ciliated epithelial cell CL0000067
    CSI 1.83
    rCSI 1.61%
    PRS 8.79
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.8
    rCSI 4.65%
    PRS 11.29
  • pulmonary capillary endothelial cell CL4028001
    CSI 1.79
    rCSI 3.41%
    PRS 19.38
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.77
    rCSI 10.23%
    PRS 16.13
  • CD14-positive monocyte CL0001054
    CSI 1.75
    rCSI 2.18%
    PRS 17.1
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.71
    rCSI 2.74%
    PRS 13.25
  • corneal epithelial cell CL0000575
    CSI 1.71
    rCSI 4.9%
    PRS 21.81
  • blood vessel endothelial cell CL0000071
    CSI 1.69
    rCSI 3.51%
    PRS 12.11
  • intrahepatic cholangiocyte CL0002538
    CSI 1.69
    rCSI 4.05%
    PRS 22.06
  • midbrain dopaminergic neuron CL2000097
    CSI 1.66
    rCSI 10.65%
    PRS 18.46
  • OFF midget ganglion cell CL4033047
    CSI 1.65
    rCSI 33.67%
    PRS 10.33
  • hepatocyte CL0000182
    CSI 1.64
    rCSI 2.94%
    PRS 11.28
  • alternatively activated macrophage CL0000890
    CSI -7.7
    rCSI -9.7%
    PRS 18.6%
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI -7.7
    rCSI -19.9%
    PRS 32.1%
  • placental villous trophoblast CL2000060
    CSI -6.3
    rCSI -9.8%
    PRS 11.4%
  • naive T cell CL0000898
    CSI -4.0
    rCSI -2.8%
    PRS 17.2%
  • brain vascular cell CL4023072
    CSI -2.4
    rCSI -24.4%
    PRS 11.4%
  • enteric smooth muscle cell CL0002504
    CSI -1.2
    rCSI -1.8%
    PRS 13.7%
  • podocyte CL0000653
    CSI -0.2
    rCSI -0.7%
    PRS 12.0%
  • stromal cell of ovary CL0002132
    CSI 0.0
    rCSI -0.1%
    PRS 20.0%
  • paneth cell of colon CL0009009
    CSI 0.0
    rCSI 0.3%
    PRS 34.5%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.0
    rCSI 0.2%
    PRS 9.6%
  • mesenchymal cell CL0008019
    CSI 0.1
    rCSI 0.3%
    PRS 12.4%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.6%
    PRS 17.7%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.1
    rCSI 0.2%
    PRS 18.5%
  • mesenchymal stem cell CL0000134
    CSI 0.1
    rCSI 1.3%
    PRS 22.0%
  • mesangial cell CL0000650
    CSI 0.1
    rCSI 0.5%
    PRS 16.2%
  • type B pancreatic cell CL0000169
    CSI 0.1
    rCSI 0.3%
    PRS 11.2%
  • medium spiny neuron CL1001474
    CSI 0.1
    rCSI 1.1%
    PRS 3.7%
  • primitive red blood cell CL0002355
    CSI 0.1
    rCSI 0.8%
    PRS 22.8%
  • transit amplifying cell CL0009010
    CSI 0.2
    rCSI 0.2%
    PRS 19.7%
  • megakaryocyte CL0000556
    CSI 0.2
    rCSI 0.7%
    PRS 21.8%
  • nasal mucosa goblet cell CL0002480
    CSI 0.2
    rCSI 0.2%
    PRS 17.9%
  • erythroid progenitor cell CL0000038
    CSI 0.2
    rCSI 1.1%
    PRS 18.8%
  • stromal cell CL0000499
    CSI 0.2
    rCSI 0.6%
    PRS 17.3%
  • tracheobronchial serous cell CL0019001
    CSI 0.2
    rCSI 0.9%
    PRS 23.2%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 0.2
    rCSI 0.4%
    PRS 16.0%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.2
    rCSI 2.5%
    PRS 17.1%
  • Bergmann glial cell CL0000644
    CSI 0.2
    rCSI 0.3%
    PRS 12.4%
  • Cajal-Retzius cell CL0000695
    CSI 0.3
    rCSI 2.1%
    PRS 26.6%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.3
    rCSI 0.3%
    PRS 21.0%
  • mature B cell CL0000785
    CSI 0.3
    rCSI 0.3%
    PRS 15.0%
  • elicited macrophage CL0000861
    CSI 0.3
    rCSI 0.3%
    PRS 13.8%
  • promyelocyte CL0000836
    CSI 0.3
    rCSI 0.4%
    PRS 16.9%
  • extravillous trophoblast CL0008036
    CSI 0.3
    rCSI 0.4%
    PRS 10.6%
  • GABAergic interneuron CL0011005
    CSI 0.3
    rCSI 4.8%
    PRS 5.9%
  • eosinophil CL0000771
    CSI 0.3
    rCSI 2.0%
    PRS 31.4%
  • S cone cell CL0003050
    CSI 0.3
    rCSI 1.4%
    PRS 8.9%
  • forebrain radial glial cell CL0013000
    CSI 0.3
    rCSI 1.1%
    PRS 17.8%
  • flat midget bipolar cell CL4033033
    CSI 0.3
    rCSI 2.4%
    PRS 11.5%
  • retina horizontal cell CL0000745
    CSI 0.3
    rCSI 0.5%
    PRS 11.3%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 0.4
    rCSI 0.7%
    PRS 26.3%
  • mature alpha-beta T cell CL0000791
    CSI 0.4
    rCSI 1.3%
    PRS 20.8%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.4
    rCSI 1.0%
    PRS 13.7%
  • eye photoreceptor cell CL0000287
    CSI 0.4
    rCSI 4.0%
    PRS 31.0%
  • common myeloid progenitor CL0000049
    CSI 0.4
    rCSI 0.3%
    PRS 12.0%
  • diffuse bipolar 3b cell CL4033030
    CSI 0.4
    rCSI 2.4%
    PRS 12.2%
  • acinar cell CL0000622
    CSI 0.4
    rCSI 0.5%
    PRS 15.9%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.4
    rCSI 0.9%
    PRS 19.2%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 0.4
    rCSI 2.4%
    PRS 33.6%
  • centrilobular region hepatocyte CL0019029
    CSI 0.4
    rCSI 1.0%
    PRS 19.5%
  • GABAergic amacrine cell CL4030027
    CSI 0.4
    rCSI 1.4%
    PRS 10.9%
  • peripheral nervous system neuron CL2000032
    CSI 0.4
    rCSI 0.6%
    PRS 10.9%
  • enteroglial cell CL4040002
    CSI 0.4
    rCSI 2.2%
    PRS 22.4%
  • antibody secreting cell CL0000946
    CSI 0.4
    rCSI 1.9%
    PRS 47.7%
  • pancreatic acinar cell CL0002064
    CSI 0.4
    rCSI 0.6%
    PRS 13.2%
  • diffuse bipolar 1 cell CL4033027
    CSI 0.4
    rCSI 3.3%
    PRS 10.7%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.4
    rCSI 0.5%
    PRS 16.2%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.4
    rCSI 1.4%
    PRS 13.1%
  • cardiac neuron CL0010022
    CSI 0.4
    rCSI 1.4%
    PRS 8.7%
  • epithelial cell of lung CL0000082
    CSI 0.4
    rCSI 0.4%
    PRS 11.4%
  • adventitial cell CL0002503
    CSI 0.4
    rCSI 1.1%
    PRS 18.9%
  • pulmonary ionocyte CL0017000
    CSI 0.5
    rCSI 0.6%
    PRS 15.3%
  • pancreatic ductal cell CL0002079
    CSI 0.5
    rCSI 0.9%
    PRS 12.4%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 0.5
    rCSI 0.4%
    PRS 10.7%
  • ON parasol ganglion cell CL4033052
    CSI 0.5
    rCSI 6.6%
    PRS 8.4%
  • glandular epithelial cell CL0000150
    CSI 0.5
    rCSI 1.2%
    PRS 23.7%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 0.5
    rCSI 1.4%
    PRS 17.6%
  • keratinocyte CL0000312
    CSI 0.5
    rCSI 0.4%
    PRS 14.5%
  • amacrine cell CL0000561
    CSI 0.5
    rCSI 1.5%
    PRS 9.5%
  • H2 horizontal cell CL0004218
    CSI 0.5
    rCSI 2.5%
    PRS 13.2%
  • keratocyte CL0002363
    CSI 0.5
    rCSI 1.3%
    PRS 18.2%
  • pancreatic epsilon cell CL0005019
    CSI 0.5
    rCSI 2.5%
    PRS 28.9%
  • conjunctival epithelial cell CL1000432
    CSI 0.5
    rCSI 0.8%
    PRS 12.1%
  • brush cell CL0002204
    CSI 0.6
    rCSI 1.1%
    PRS 31.9%
  • helper T cell CL0000912
    CSI 0.6
    rCSI 0.8%
    PRS 17.0%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 0.6
    rCSI 0.8%
    PRS 11.3%
  • deuterosomal cell CL4033044
    CSI 0.6
    rCSI 1.9%
    PRS 20.4%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 0.6
    rCSI 0.4%
    PRS 12.7%
  • diffuse bipolar 4 cell CL4033031
    CSI 0.6
    rCSI 6.4%
    PRS 12.0%
  • lung pericyte CL0009089
    CSI 0.6
    rCSI 1.5%
    PRS 14.5%
  • group 3 innate lymphoid cell CL0001071
    CSI 0.6
    rCSI 0.4%
    PRS 12.6%
  • erythroblast CL0000765
    CSI 0.6
    rCSI 1.5%
    PRS 20.1%
  • class switched memory B cell CL0000972
    CSI 0.6
    rCSI 0.4%
    PRS 20.3%
  • epithelial cell of proximal tubule CL0002306
    CSI 0.6
    rCSI 1.4%
    PRS 12.1%
  • immature B cell CL0000816
    CSI 0.6
    rCSI 0.4%
    PRS 17.9%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 0.6
    rCSI 2.4%
    PRS 19.9%
  • colon epithelial cell CL0011108
    CSI 0.6
    rCSI 0.6%
    PRS 11.3%
  • diffuse bipolar 2 cell CL4033028
    CSI 0.6
    rCSI 4.8%
    PRS 12.1%
  • mesodermal cell CL0000222
    CSI 0.6
    rCSI 0.8%
    PRS 12.0%
  • glycinergic amacrine cell CL4030028
    CSI 0.6
    rCSI 1.6%
    PRS 12.0%
  • renal interstitial pericyte CL1001318
    CSI 0.6
    rCSI 1.8%
    PRS 11.4%
  • Schwann cell CL0002573
    CSI 0.7
    rCSI 1.8%
    PRS 14.7%
  • mucus secreting cell CL0000319
    CSI 0.7
    rCSI 1.0%
    PRS 15.7%
  • myeloid dendritic cell CL0000782
    CSI 0.7
    rCSI 1.0%
    PRS 17.8%
  • ionocyte CL0005006
    CSI 0.7
    rCSI 0.7%
    PRS 11.1%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.7
    rCSI 3.4%
    PRS 23.8%
  • glial cell CL0000125
    CSI 0.7
    rCSI 2.5%
    PRS 12.4%
  • common lymphoid progenitor CL0000051
    CSI 0.7
    rCSI 0.9%
    PRS 23.1%
  • bronchus fibroblast of lung CL2000093
    CSI 0.7
    rCSI 0.6%
    PRS 12.8%
  • tissue-resident macrophage CL0000864
    CSI 0.7
    rCSI 3.4%
    PRS 25.5%
  • T-helper 17 cell CL0000899
    CSI 0.7
    rCSI 0.6%
    PRS 21.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ETNK1](/details-gene/55500), or Ethanolamine Kinase 1, is a protein-coding gene located on chromosome 12 that encodes a key enzyme in the CDP-ethanolamine pathway. Its primary molecular function is 'Ethanolamine kinase activity' ([GO:0004305](https://www.ebi.ac.uk/QuickGO/term/GO:0004305)), which catalyzes the phosphorylation of ethanolamine, the first committed step in the *de novo* biosynthesis of phosphatidylethanolamine (PE), a major component of cellular membranes ([Link](https://doi.org/10.1074/jbc.m008794200)). Consistent with a role in membrane biogenesis, **Overall** expression data reveal that [ETNK1](/details-gene/55500) is a highly significant gene in metabolically active and secretory cell types, particularly diverse neuronal populations such as [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011) and various specialized epithelial cells of the gastrointestinal tract, including [enteroendocrine cells of the small intestine](/details-cell/CL0009006). ## Cellular Roles and Expression Landscape The expression profile of [ETNK1](/details-gene/55500) points to a specialized role in tissues with high demands for membrane synthesis and turnover. **Overall**, the gene shows its highest significance in two distinct functional groups: central nervous system neurons and gastrointestinal epithelial cells. Within the brain, it is a top marker for multiple neuronal subtypes, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011), [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040), and [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041). This suggests a critical role in maintaining neuronal membrane integrity, potentially related to synaptic vesicle cycling and dendritic arborization. In parallel, [ETNK1](/details-gene/55500) is highly significant in various secretory and absorptive cells of the gut, such as [enteroendocrine cells of the small intestine](/details-cell/CL0009006), [BEST4+ enteroyctes](/details-cell/CL4030026), [foveolar cells of the stomach](/details-cell/CL0002179), and [small intestine goblet cells](/details-cell/CL1000495). This pattern is consistent with its function in providing the PE necessary for the extensive membrane systems of the endoplasmic reticulum and Golgi apparatus, which are vital for protein and mucus secretion in these cells. Conversely, [ETNK1](/details-gene/55500) shows significantly low expression in several immune cell types, including [alternatively activated macrophages](/details-cell/CL0000890) and [lung resident memory CD8-positive, alpha-beta T cells](/details-cell/CL4033039). This low significance in immune lineages suggests that while PE synthesis is a universal cellular process, other kinases or pathways may be more dominant in these specific hematopoietic cells, or their demand for *de novo* PE synthesis is lower compared to neuronal and secretory epithelial cells. ## Pathways and Molecular Function [ETNK1](/details-gene/55500) is a central enzyme in lipid metabolism. Its function is annotated within the 'Glycerophospholipid biosynthesis' pathway ([R-HSA-1483206](https://reactome.org/content/detail/R-HSA-1483206)), and more specifically, the 'Synthesis of PE' ([R-HSA-1483213](https://reactome.org/content/detail/R-HSA-1483213)). As an ethanolamine kinase, it utilizes ATP ([GO:0005524](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)) to phosphorylate ethanolamine, a rate-limiting step for the production of PE via the CDP-ethanolamine pathway. This activity directly contributes to the 'Phosphatidylethanolamine biosynthetic process' ([GO:0006646](https://www.ebi.ac.uk/QuickGO/term/GO:0006646)). Functionally, the protein is primarily localized to the [cytoplasm](/details-cell/GO:0005737) and [cytosol](/details-cell/GO:0005829), where these metabolic reactions occur. The high expression of [ETNK1](/details-gene/55500) in neurons and gut epithelial cells is therefore directly linked to the high demand for PE in these cells for constructing and maintaining the extensive membrane networks required for their specialized functions. ## Research Directions The specific and high-level expression of [ETNK1](/details-gene/55500) in distinct neuronal and epithelial subtypes, contrasted with its low expression in immune cells, provides a foundation for targeted functional studies. While no context-specific data comparing healthy and diseased states are provided, the expression landscape itself suggests several testable hypotheses. 1. The high significance of [ETNK1](/details-gene/55500) in diverse cortical neuron subtypes suggests it is essential for maintaining synaptic health. We hypothesize that reduced [ETNK1](/details-gene/55500) activity impairs synaptic vesicle recycling and dendritic spine maintenance due to insufficient PE synthesis, leading to progressive synaptic dysfunction. 2. In the small intestine, the co-expression of [ETNK1](/details-gene/55500) in both absorptive ([enterocytes](/details-cell/CL0000584)) and secretory cells ([goblet cells](/details-cell/CL1000495), [Paneth cells](/details-cell/CL0000510)) suggests a critical role in gut barrier function. We hypothesize that [ETNK1](/details-gene/55500) deficiency compromises the integrity of the gut epithelial barrier by disrupting both mucus production in goblet cells and the apical membrane integrity of enterocytes, potentially contributing to inflammatory bowel conditions. A key experiment to test the first hypothesis would involve the use of a conditional knockout mouse model (e.g., Camk2a-Cre;Etnk1-flox/flox) to specifically delete [ETNK1](/details-gene/55500) in forebrain glutamatergic neurons. The resulting phenotype could be assessed using a combination of techniques: *in vivo* two-photon imaging to monitor dendritic spine dynamics over time, electrophysiological recordings from hippocampal slices to measure synaptic plasticity (e.g., long-term potentiation), and lipidomic analysis of synaptosome preparations to quantify changes in PE and other phospholipid levels. Given its fundamental role in the biosynthesis of a major membrane phospholipid and its widespread expression in essential healthy tissues like the brain and gut, [ETNK1](/details-gene/55500) is likely a poor candidate for systemic therapeutic inhibition due to the high probability of severe on-target toxicity. However, if specific malignancies are found to have a unique dependency on the CDP-ethanolamine pathway for rapid proliferation (a concept known as "metabolic addiction"), targeted inhibitors of [ETNK1](/details-gene/55500) could hold therapeutic potential in those specific oncological contexts.

Genular Protein ID: 585926411

Symbol: EKI1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11044454

Title: Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.

PubMed ID: 11044454

DOI: 10.1074/jbc.m008794200

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 452
  • Mass: 50968
  • Checksum: 9AF29EAC556ED91F
  • Sequence:
  • MLCGRPRSSS DNRNFLRERA GLSSAAVQTR IGNSAASRRS PAARPPVPAP PALPRGRPGT 
    EGSTSLSAPA VLVVAVAVVV VVVSAVAWAM ANYIHVPPGS PEVPKLNVTV QDQEEHRCRE 
    GALSLLQHLR PHWDPQEVTL QLFTDGITNK LIGCYVGNTM EDVVLVRIYG NKTELLVDRD 
    EEVKSFRVLQ AHGCAPQLYC TFNNGLCYEF IQGEALDPKH VCNPAIFRLI ARQLAKIHAI 
    HAHNGWIPKS NLWLKMGKYF SLIPTGFADE DINKRFLSDI PSSQILQEEM TWMKEILSNL 
    GSPVVLCHND LLCKNIIYNE KQGDVQFIDY EYSGYNYLAY DIGNHFNEFA GVSDVDYSLY 
    PDRELQSQWL RAYLEAYKEF KGFGTEVTEK EVEILFIQVN QFALASHFFW GLWALIQAKY 
    STIEFDFLGY AIVRFNQYFK MKPEVTALKV PE

Genular Protein ID: 1525057238

Symbol: Q86U68_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 169
  • Mass: 18986
  • Checksum: 28DA1CC43F612457
  • Sequence:
  • MANYIHVPPG SPEVPKLNVT VQDQEEHRCR EGALSLLQHL RPHWDPQEVT LQLFTDGITN 
    KLIGCYVGNT MEDVVLVRIY GNKTELLVDR DEEVKSFRVL QAHGCAPQLY CTFNNGLCYE 
    FIQGEALDPK HVCNPAIFSL SSLTLCKGKT TRCFGLTGCR GSRLLLSFF