Details for: NDUFAF3
Gene ID: 25915
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NDUFAF3
Ensembl ID: ENSG00000178057
Description: NADH:ubiquinone oxidoreductase complex assembly factor 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 75.08rCSI 66.02%PRS 13.79
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CSI 74.09rCSI 73.94%PRS 16.18
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CSI 53.48rCSI 48.3%PRS 17.04
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CSI 35.46rCSI 37.14%PRS 20.22
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CSI 32.36rCSI 31.15%PRS 19.62
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CSI 30.72rCSI 24.17%PRS 22.88
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CSI 30.32rCSI 29.82%PRS 20.51
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CSI 30.06rCSI 34.76%PRS 13.94
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CSI 30.02rCSI 43.08%PRS 14.67
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CSI 29.6rCSI 43.31%PRS 20.09
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CSI 28.41rCSI 32.52%PRS 38.26
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CSI 25.75rCSI 22.3%PRS 21.32
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CSI 24.87rCSI 20.11%PRS 18.97
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CSI 24.57rCSI 83.06%PRS 30.31
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CSI 21.95rCSI 50.04%PRS 19.57
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CSI 21.92rCSI 22.91%PRS 19.8
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CSI 21.42rCSI 61.16%PRS 32.23
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CSI 18.45rCSI 23.15%PRS 24.55
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CSI 18.36rCSI 26.48%PRS 26.53
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CSI 18.12rCSI 31.04%PRS 25.73
-
CSI 17.29rCSI 50.05%PRS 21.43
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CSI 16.9rCSI 16.29%PRS 13.66
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CSI 15.91rCSI 35.14%PRS 13.59
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CSI 14rCSI 17.82%PRS 22.02
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CSI 13.91rCSI 14.57%PRS 17.7
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CSI 13.75rCSI 9.14%PRS 22.75
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CSI 13.25rCSI 71.49%PRS 33.24
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CSI 13rCSI 17.72%PRS 16.82
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CSI 12.45rCSI 58.02%PRS 42.03
-
CSI 12.06rCSI 26.69%PRS 17.54
-
CSI 11.63rCSI 23.09%PRS 19.96
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CSI 11.51rCSI 8.92%PRS 18.19
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CSI 11.37rCSI 7.9%PRS 22.65
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CSI 11.27rCSI 21.51%PRS 41.54
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CSI 11.21rCSI 44.62%PRS 32.46
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CSI 11.07rCSI 9.16%PRS 19.23
-
CSI 11.05rCSI 47.94%PRS 32.97
-
CSI 10.52rCSI 61.24%PRS 28.16
-
CSI 10.33rCSI 14.13%PRS 21.47
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CSI 10.31rCSI 11.05%PRS 17.48
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CSI 10.2rCSI 44.89%PRS 17.92
-
CSI 9.74rCSI 14.85%PRS 17.62
-
CSI 9.72rCSI 8.99%PRS 34.07
-
CSI 8.71rCSI 16.93%PRS 19.41
-
CSI 8.7rCSI 7.93%PRS 28.93
-
CSI 8.38rCSI 9.43%PRS 30.24
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CSI 8.29rCSI 6.73%PRS 20.04
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CSI 8.24rCSI 20.14%PRS 18.64
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CSI 8.24rCSI 5.73%PRS 26.9
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CSI 8.23rCSI 42.48%PRS 36.77
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CSI 8.2rCSI 14.46%PRS 24.94
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CSI 7.91rCSI 86.63%PRS 33.66
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CSI 7.9rCSI 9.74%PRS 53.19
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CSI 7.72rCSI 5.78%PRS 30.14
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CSI 7.66rCSI 8.99%PRS 21.97
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CSI 7.64rCSI 7.22%PRS 19.89
-
CSI 7.3rCSI 10.42%PRS 21.33
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CSI 7.29rCSI 9.69%PRS 20.79
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CSI 7.26rCSI 9.29%PRS 63.19
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CSI 7.12rCSI 7.29%PRS 34.89
-
CSI 7.01rCSI 10.77%PRS 26.06
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CSI 6.9rCSI 6.37%PRS 19.62
-
CSI 6.83rCSI 7.13%PRS 19.44
-
CSI 6.72rCSI 10.48%PRS 43.42
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CSI 6.56rCSI 8.93%PRS 28.65
-
CSI 6.43rCSI 9.97%PRS 28.33
-
CSI 6.39rCSI 34.77%PRS 43.9
-
CSI 6.2rCSI 8.12%PRS 27.02
-
CSI 6.16rCSI 10.09%PRS 14.59
-
CSI 6.01rCSI 4.45%PRS 16.51
-
CSI 5.98rCSI 9.13%PRS 19.09
-
CSI 5.77rCSI 20.52%PRS 55.56
-
CSI 5.76rCSI 8.69%PRS 19.15
-
CSI 5.73rCSI 20.1%PRS 32.98
-
CSI 5.54rCSI 5.7%PRS 30.75
-
CSI 5.53rCSI 7.66%PRS 26.8
-
CSI 5.48rCSI 17.79%PRS 22.84
-
CSI 5.35rCSI 12.13%PRS 25.72
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CSI 5.34rCSI 8.6%PRS 14.55
-
CSI 5.31rCSI 4.04%PRS 25.07
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CSI 5.31rCSI 10.13%PRS 30.01
-
CSI 5.25rCSI 15.05%PRS 28.13
-
CSI 5.2rCSI 7.23%PRS 19.41
-
CSI 5.13rCSI 8.32%PRS 19.17
-
CSI 5.1rCSI 6.69%PRS 66.01
-
CSI 5.09rCSI 10.98%PRS 65.41
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CSI 5.08rCSI 12.58%PRS 17.52
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CSI 5rCSI 3.33%PRS 45.7
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CSI 4.96rCSI 7.58%PRS 21.73
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CSI 4.88rCSI 31.38%PRS 41.46
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CSI 4.86rCSI 6.64%PRS 21.02
-
CSI 4.86rCSI 18.49%PRS 18.5
-
CSI 4.85rCSI 3.64%PRS 51.3
-
CSI 4.77rCSI 3.82%PRS 33.86
-
CSI 4.77rCSI 9.9%PRS 18.91
-
CSI 4.75rCSI 7.58%PRS 20.82
-
CSI 4.73rCSI 5.67%PRS 32.79
-
CSI 4.7rCSI 3.96%PRS 30.09
-
CSI 4.65rCSI 6.22%PRS 20.81
-
CSI 4.64rCSI 4.26%PRS 22.18
-
CSI -3.9rCSI -8.6%PRS 21.4%
-
CSI -1.5rCSI -1.7%PRS 33.1%
-
CSI -0.7rCSI -1.2%PRS 31.5%
-
CSI 0.1rCSI 0.3%PRS 14.4%
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CSI 0.1rCSI 0.2%PRS 11.7%
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CSI 0.2rCSI 1.3%PRS 27.8%
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CSI 0.3rCSI 2.5%PRS 55.8%
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CSI 0.3rCSI 6.1%PRS 55.6%
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CSI 0.3rCSI 0.4%PRS 29.6%
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CSI 0.3rCSI 7.1%PRS 80.8%
-
CSI 0.3rCSI 4.7%PRS 69.6%
-
CSI 0.3rCSI 0.4%PRS 36.0%
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CSI 0.3rCSI 0.9%PRS 11.9%
-
CSI 0.3rCSI 0.6%PRS 23.9%
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CSI 0.4rCSI 7.1%PRS 52.5%
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CSI 0.4rCSI 0.4%PRS 22.3%
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CSI 0.4rCSI 4.6%PRS 36.0%
-
CSI 0.4rCSI 6.4%PRS 52.2%
-
CSI 0.4rCSI 3.3%PRS 34.5%
-
CSI 0.5rCSI 5.2%PRS 63.1%
-
CSI 0.5rCSI 5.0%PRS 49.2%
-
CSI 0.5rCSI 3.3%PRS 55.6%
-
CSI 0.6rCSI 2.0%PRS 32.5%
-
CSI 0.6rCSI 2.3%PRS 31.2%
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CSI 0.6rCSI 4.0%PRS 47.3%
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CSI 0.6rCSI 2.8%PRS 39.1%
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CSI 0.6rCSI 0.8%PRS 23.6%
-
CSI 0.6rCSI 2.8%PRS 35.0%
-
CSI 0.7rCSI 1.9%PRS 15.8%
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CSI 0.7rCSI 1.4%PRS 45.8%
-
CSI 0.7rCSI 1.5%PRS 37.8%
-
CSI 0.7rCSI 3.3%PRS 70.1%
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CSI 0.7rCSI 5.9%PRS 62.9%
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CSI 0.8rCSI 3.6%PRS 46.9%
-
CSI 0.8rCSI 3.5%PRS 57.2%
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CSI 0.8rCSI 1.0%PRS 20.2%
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CSI 0.8rCSI 3.1%PRS 37.4%
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CSI 0.8rCSI 1.9%PRS 28.4%
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CSI 0.8rCSI 3.6%PRS 65.9%
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CSI 0.8rCSI 1.3%PRS 16.0%
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CSI 0.8rCSI 12.4%PRS 45.5%
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CSI 0.9rCSI 4.6%PRS 61.6%
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CSI 0.9rCSI 2.1%PRS 28.0%
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CSI 0.9rCSI 0.7%PRS 31.8%
-
CSI 0.9rCSI 1.6%PRS 18.7%
-
CSI 0.9rCSI 2.1%PRS 28.8%
-
CSI 0.9rCSI 21.9%PRS 35.3%
-
CSI 1.0rCSI 6.5%PRS 36.6%
-
CSI 1.0rCSI 10.3%PRS 61.5%
-
CSI 1.0rCSI 6.8%PRS 51.8%
-
CSI 1.0rCSI 22.6%PRS 65.6%
-
CSI 1.0rCSI 2.8%PRS 64.1%
-
CSI 1.1rCSI 2.6%PRS 11.0%
-
CSI 1.1rCSI 10.5%PRS 48.9%
-
CSI 1.1rCSI 3.1%PRS 40.4%
-
CSI 1.1rCSI 2.0%PRS 37.0%
-
CSI 1.1rCSI 2.0%PRS 15.7%
-
CSI 1.1rCSI 1.1%PRS 38.4%
-
CSI 1.1rCSI 2.4%PRS 36.8%
-
CSI 1.2rCSI 1.6%PRS 37.6%
-
CSI 1.2rCSI 1.5%PRS 29.1%
-
CSI 1.2rCSI 3.1%PRS 17.7%
-
CSI 1.2rCSI 3.3%PRS 36.7%
-
CSI 1.3rCSI 1.8%PRS 28.5%
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CSI 1.3rCSI 1.7%PRS 29.8%
-
CSI 1.3rCSI 1.8%PRS 30.0%
-
CSI 1.3rCSI 2.0%PRS 22.6%
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CSI 1.3rCSI 6.7%PRS 61.9%
-
CSI 1.3rCSI 3.2%PRS 30.0%
-
CSI 1.4rCSI 4.6%PRS 63.1%
-
CSI 1.4rCSI 0.9%PRS 23.2%
-
CSI 1.4rCSI 3.3%PRS 48.2%
-
CSI 1.4rCSI 1.2%PRS 23.8%
-
CSI 1.4rCSI 3.4%PRS 21.9%
-
CSI 1.5rCSI 3.3%PRS 18.5%
-
CSI 1.5rCSI 5.2%PRS 30.8%
-
CSI 1.5rCSI 2.7%PRS 28.9%
-
CSI 1.5rCSI 1.2%PRS 33.6%
-
CSI 1.6rCSI 6.3%PRS 39.9%
-
CSI 1.6rCSI 13.0%PRS 19.2%
-
CSI 1.6rCSI 1.9%PRS 18.5%
-
CSI 1.6rCSI 7.0%PRS 34.9%
-
CSI 1.6rCSI 2.9%PRS 17.6%
-
CSI 1.6rCSI 8.8%PRS 33.5%
-
CSI 1.7rCSI 3.4%PRS 41.0%
-
CSI 1.7rCSI 4.5%PRS 30.3%
-
CSI 1.7rCSI 22.5%PRS 54.5%
-
CSI 1.7rCSI 3.5%PRS 31.6%
-
CSI 1.8rCSI 3.1%PRS 11.2%
-
CSI 1.8rCSI 2.7%PRS 17.8%
-
CSI 1.9rCSI 5.5%PRS 43.4%
-
CSI 1.9rCSI 4.0%PRS 30.2%
-
CSI 1.9rCSI 2.4%PRS 16.6%
-
CSI 1.9rCSI 1.5%PRS 17.5%
-
CSI 1.9rCSI 5.0%PRS 24.5%
-
CSI 1.9rCSI 2.1%PRS 21.5%
-
CSI 1.9rCSI 8.6%PRS 18.6%
-
CSI 1.9rCSI 4.9%PRS 23.5%
-
CSI 2.0rCSI 35.6%PRS 52.4%
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CSI 2.0rCSI 1.7%PRS 22.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1787592808
Symbol: NDUF3_HUMAN
Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19463981
Title: Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease.
PubMed ID: 19463981
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27986404
Title: Mutations in mitochondrial complex I assembly factor NDUFAF3 cause Leigh syndrome.
PubMed ID: 27986404
Sequence Information:
- Length: 184
- Mass: 20350
- Checksum: FCFF7B0CB6ADBCD8
- Sequence:
MATALALRSL YRARPSLRCP PVELPWAPRR GHRLSPADDE LYQRTRISLL QREAAQAMYI DSYNSRGFMI NGNRVLGPCA LLPHSVVQWN VGSHQDITED SFSLFWLLEP RIEIVVVGTG DRTERLQSQV LQAMRQRGIA VEVQDTPNAC ATFNFLCHEG RVTGAALIPP PGGTSLTSLG QAAQ
Genular Protein ID: 2170835456
Symbol: A4FU71_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 127
- Mass: 13842
- Checksum: 4D795EDA0408C242
- Sequence:
MYIDSYNSRG FMINGNRVLG PCALLPHSVV QWNVGSHQDI TEDSFSLFWL LEPRIEIVVV GTGDRTERLQ SQVLQAMRQR GIAVEVQDTP NACATFNFLC HEGRVTGAAL IPPPGGTSLT SLGQAAQ
Genular Protein ID: 3700458268
Symbol: Q9Y3Z0_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 127
- Mass: 13866
- Checksum: 486D5EDA0408C242
- Sequence:
MYIDSYNSRG FMINGNRVLG PCALLPHSVV QWNVGSHQDI TEDSFSLFWL LEPRIEIVVV GTGDRTERLQ SQVLQAMRQR GIAVEVQDTP NACATFNFLC HEGRVTGAAL IPPPGGTSHT SLGQAAQ