Details for: PTRHD1
Gene ID: 391356
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PTRHD1
Ensembl ID: ENSG00000184924
Description: peptidyl-tRNA hydrolase domain containing 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 40.06rCSI 41.87%PRS 31.71
-
CSI 34.28rCSI 30.96%PRS 28.5
-
CSI 32.84rCSI 31.67%PRS 23.75
-
CSI 25rCSI 20.21%PRS 31.34
-
CSI 22.74rCSI 19.69%PRS 34.51
-
CSI 16.91rCSI 26.13%PRS 29.46
-
CSI 16.52rCSI 24.44%PRS 35.22
-
CSI 15.75rCSI 10.47%PRS 35.54
-
CSI 15.14rCSI 19%PRS 39.45
-
CSI 14.61rCSI 25.02%PRS 40.05
-
CSI 13.15rCSI 15.44%PRS 34.78
-
CSI 12.64rCSI 17.22%PRS 59.69
-
CSI 11.88rCSI 28.24%PRS 43.32
-
CSI 11.78rCSI 24.22%PRS 29.01
-
CSI 11.34rCSI 14.03%PRS 27.74
-
CSI 11.18rCSI 16.13%PRS 40.62
-
CSI 10.62rCSI 11.12%PRS 29.13
-
CSI 10.09rCSI 9.19%PRS 44.99
-
CSI 9.73rCSI 12.23%PRS 44.06
-
CSI 9.71rCSI 21.68%PRS 36.33
-
CSI 9.68rCSI 9.91%PRS 49.75
-
CSI 9.61rCSI 6.69%PRS 42.39
-
CSI 8.83rCSI 20.04%PRS 37.99
-
CSI 8.81rCSI 45.5%PRS 54.23
-
CSI 8.02rCSI 5.57%PRS 37.51
-
CSI 7.73rCSI 25.06%PRS 35.51
-
CSI 7.67rCSI 6.81%PRS 30.91
-
CSI 7.26rCSI 11.64%PRS 62.8
-
CSI 7.03rCSI 8.56%PRS 37.83
-
CSI 6.93rCSI 5.75%PRS 29.72
-
CSI 6.79rCSI 9.33%PRS 52.05
-
CSI 6.43rCSI 9.84%PRS 46.97
-
CSI 6.4rCSI 7.4%PRS 23.48
-
CSI 6.3rCSI 9.94%PRS 31.7
-
CSI 6.29rCSI 4.95%PRS 36.83
-
CSI 6.23rCSI 11.32%PRS 45.72
-
CSI 6.04rCSI 4.52%PRS 45.2
-
CSI 5.71rCSI 8.72%PRS 49.04
-
CSI 5.68rCSI 11.24%PRS 60.33
-
CSI 5.56rCSI 8.21%PRS 46.5
-
CSI 5.5rCSI 8.53%PRS 42.18
-
CSI 5.44rCSI 5.03%PRS 51
-
CSI 5.31rCSI 23.38%PRS 27.29
-
CSI 5.16rCSI 7.14%PRS 38.5
-
CSI 5.04rCSI 5.03%PRS 26.68
-
CSI 4.72rCSI 25.49%PRS 46.45
-
CSI 4.67rCSI 3.9%PRS 58.2
-
CSI 4.56rCSI 7.39%PRS 30.68
-
CSI 4.52rCSI 3.62%PRS 51.07
-
CSI 4.49rCSI 3.41%PRS 40.46
-
CSI 4.42rCSI 4.55%PRS 47.12
-
CSI 4.27rCSI 32.07%PRS 51.37
-
CSI 4.25rCSI 6.85%PRS 42.21
-
CSI 4.1rCSI 10.16%PRS 29.36
-
CSI 4.08rCSI 13.81%PRS 43.15
-
CSI 4.02rCSI 17.42%PRS 47.55
-
CSI 4rCSI 3.95%PRS 72.06
-
CSI 3.98rCSI 4.15%PRS 31.76
-
CSI 3.93rCSI 5.04%PRS 29.72
-
CSI 3.84rCSI 6.33%PRS 35.92
-
CSI 3.82rCSI 5.87%PRS 37.25
-
CSI 3.8rCSI 8.08%PRS 39.64
-
CSI 3.8rCSI 6.06%PRS 26.62
-
CSI 3.8rCSI 3.59%PRS 32.26
-
CSI 3.79rCSI 11.2%PRS 35.82
-
CSI 3.79rCSI 3.33%PRS 35.34
-
CSI 3.65rCSI 4.36%PRS 49.93
-
CSI 3.65rCSI 4.88%PRS 33.25
-
CSI 3.57rCSI 6.94%PRS 32.3
-
CSI 3.57rCSI 13.88%PRS 49.14
-
CSI 3.56rCSI 15.64%PRS 51.05
-
CSI 3.54rCSI 2.47%PRS 32.78
-
CSI 3.46rCSI 19.82%PRS 42.23
-
CSI 3.45rCSI 4.59%PRS 34.37
-
CSI 3.4rCSI 4.33%PRS 35.63
-
CSI 3.32rCSI 4.54%PRS 34.95
-
CSI 3.32rCSI 3.06%PRS 32.31
-
CSI 3.3rCSI 2.45%PRS 43.19
-
CSI 3.3rCSI 6.77%PRS 54.57
-
CSI 3.24rCSI 16.26%PRS 40.25
-
CSI 3.21rCSI 3.15%PRS 63.42
-
CSI 3.2rCSI 3.98%PRS 41.5
-
CSI 3.2rCSI 3.24%PRS 78.89
-
CSI 3.17rCSI 3.23%PRS 42.84
-
CSI 3.16rCSI 4.31%PRS 33.89
-
CSI 3.1rCSI 8.89%PRS 45.6
-
CSI 3.1rCSI 5.59%PRS 58.58
-
CSI 3.07rCSI 3.94%PRS 35.64
-
CSI 3.04rCSI 4.38%PRS 44.79
-
CSI 3rCSI 3.47%PRS 27.18
-
CSI 2.97rCSI 3.59%PRS 37.14
-
CSI 2.97rCSI 3.69%PRS 33.26
-
CSI 2.95rCSI 6.5%PRS 34.79
-
CSI 2.92rCSI 4.64%PRS 39.66
-
CSI 2.89rCSI 4.23%PRS 40.28
-
CSI 2.84rCSI 2.74%PRS 32.04
-
CSI 2.75rCSI 2.85%PRS 36.29
-
CSI 2.75rCSI 2.41%PRS 39.92
-
CSI 2.67rCSI 2.24%PRS 35.98
-
CSI 2.6rCSI 1.75%PRS 38.82
-
CSI 0.2rCSI 3.4%PRS 80.0%
-
CSI 0.2rCSI 0.9%PRS 71.3%
-
CSI 0.2rCSI 1.1%PRS 43.2%
-
CSI 0.2rCSI 5.6%PRS 53.3%
-
CSI 0.3rCSI 4.5%PRS 72.8%
-
CSI 0.3rCSI 3.2%PRS 52.5%
-
CSI 0.3rCSI 6.1%PRS 86.1%
-
CSI 0.4rCSI 1.4%PRS 45.6%
-
CSI 0.4rCSI 3.0%PRS 61.4%
-
CSI 0.5rCSI 4.1%PRS 50.9%
-
CSI 0.6rCSI 0.5%PRS 55.4%
-
CSI 0.7rCSI 19.9%PRS 56.6%
-
CSI 0.7rCSI 3.0%PRS 54.4%
-
CSI 0.8rCSI 5.0%PRS 63.9%
-
CSI 0.8rCSI 4.5%PRS 67.5%
-
CSI 0.9rCSI 3.1%PRS 49.0%
-
CSI 0.9rCSI 4.7%PRS 47.3%
-
CSI 0.9rCSI 2.5%PRS 39.5%
-
CSI 1.0rCSI 5.2%PRS 74.0%
-
CSI 1.0rCSI 1.2%PRS 49.3%
-
CSI 1.0rCSI 1.9%PRS 29.3%
-
CSI 1.1rCSI 3.9%PRS 70.5%
-
CSI 1.1rCSI 2.4%PRS 52.4%
-
CSI 1.1rCSI 2.5%PRS 44.8%
-
CSI 1.1rCSI 1.5%PRS 53.1%
-
CSI 1.1rCSI 1.8%PRS 26.3%
-
CSI 1.2rCSI 5.3%PRS 54.8%
-
CSI 1.2rCSI 3.1%PRS 54.1%
-
CSI 1.2rCSI 2.6%PRS 22.6%
-
CSI 1.2rCSI 6.5%PRS 47.8%
-
CSI 1.2rCSI 4.0%PRS 40.1%
-
CSI 1.2rCSI 3.0%PRS 46.7%
-
CSI 1.2rCSI 16.4%PRS 67.3%
-
CSI 1.2rCSI 2.3%PRS 52.5%
-
CSI 1.3rCSI 2.2%PRS 38.9%
-
CSI 1.3rCSI 33.2%PRS 79.2%
-
CSI 1.3rCSI 3.0%PRS 31.0%
-
CSI 1.3rCSI 2.9%PRS 45.7%
-
CSI 1.4rCSI 2.1%PRS 35.3%
-
CSI 1.4rCSI 2.4%PRS 18.9%
-
CSI 1.4rCSI 1.3%PRS 37.0%
-
CSI 1.4rCSI 2.1%PRS 28.8%
-
CSI 1.4rCSI 1.9%PRS 42.7%
-
CSI 1.5rCSI 1.3%PRS 23.0%
-
CSI 1.5rCSI 2.8%PRS 61.0%
-
CSI 1.5rCSI 1.8%PRS 30.0%
-
CSI 1.5rCSI 2.2%PRS 45.5%
-
CSI 1.5rCSI 2.7%PRS 47.0%
-
CSI 1.5rCSI 4.4%PRS 34.1%
-
CSI 1.6rCSI 2.7%PRS 24.1%
-
CSI 1.6rCSI 1.2%PRS 41.8%
-
CSI 1.6rCSI 2.5%PRS 31.5%
-
CSI 1.6rCSI 3.1%PRS 55.4%
-
CSI 1.6rCSI 4.3%PRS 36.8%
-
CSI 1.7rCSI 1.9%PRS 54.4%
-
CSI 1.7rCSI 4.9%PRS 46.7%
-
CSI 1.7rCSI 4.9%PRS 45.5%
-
CSI 1.8rCSI 7.8%PRS 30.0%
-
CSI 1.8rCSI 9.1%PRS 70.9%
-
CSI 1.8rCSI 1.3%PRS 33.4%
-
CSI 1.8rCSI 1.9%PRS 29.0%
-
CSI 1.8rCSI 2.0%PRS 47.1%
-
CSI 1.9rCSI 8.0%PRS 49.2%
-
CSI 1.9rCSI 1.5%PRS 51.4%
-
CSI 1.9rCSI 2.2%PRS 42.0%
-
CSI 1.9rCSI 1.7%PRS 38.6%
-
CSI 2.0rCSI 5.8%PRS 56.4%
-
CSI 2.0rCSI 3.2%PRS 24.2%
-
CSI 2.0rCSI 1.7%PRS 31.7%
-
CSI 2.0rCSI 5.1%PRS 29.7%
-
CSI 2.1rCSI 3.5%PRS 56.7%
-
CSI 2.1rCSI 1.6%PRS 21.8%
-
CSI 2.1rCSI 3.8%PRS 60.3%
-
CSI 2.1rCSI 1.8%PRS 41.8%
-
CSI 2.1rCSI 3.0%PRS 33.9%
-
CSI 2.2rCSI 2.7%PRS 62.4%
-
CSI 2.2rCSI 3.2%PRS 33.3%
-
CSI 2.2rCSI 3.1%PRS 31.3%
-
CSI 2.2rCSI 4.0%PRS 26.2%
-
CSI 2.2rCSI 3.4%PRS 32.2%
-
CSI 2.3rCSI 1.7%PRS 30.7%
-
CSI 2.3rCSI 2.2%PRS 45.2%
-
CSI 2.3rCSI 22.6%PRS 60.4%
-
CSI 2.3rCSI 14.9%PRS 54.4%
-
CSI 2.4rCSI 3.7%PRS 58.7%
-
CSI 2.4rCSI 3.6%PRS 36.8%
-
CSI 2.4rCSI 3.4%PRS 39.2%
-
CSI 2.4rCSI 3.6%PRS 34.6%
-
CSI 2.4rCSI 4.8%PRS 23.5%
-
CSI 2.4rCSI 1.4%PRS 43.1%
-
CSI 2.5rCSI 3.6%PRS 33.2%
-
CSI 2.5rCSI 1.9%PRS 29.6%
-
CSI 2.5rCSI 8.6%PRS 67.4%
-
CSI 2.5rCSI 8.8%PRS 47.9%
-
CSI 2.5rCSI 3.5%PRS 26.9%
-
CSI 2.6rCSI 3.9%PRS 39.2%
-
CSI 2.6rCSI 2.0%PRS 45.0%
-
CSI 2.6rCSI 1.9%PRS 48.6%
-
CSI 2.6rCSI 2.2%PRS 46.8%
-
CSI 2.6rCSI 1.8%PRS 38.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1075101248
Symbol: PTRD1_HUMAN
Name: Peptidyl-tRNA hydrolase domain-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27235175
Title: Expression, purification, and buffer solubility optimization of the putative human peptidyl-tRNA hydrolase PTRHD1.
PubMed ID: 27235175
PubMed ID: 30398675
Title: PTRHD1 Loss-of-function mutation in an african family with juvenile-onset Parkinsonism and intellectual disability.
PubMed ID: 30398675
DOI: 10.1002/mds.27501
PubMed ID: 34765690
Title: Biallelic PTRHD1 Frameshift Variants Associated with Intellectual Disability, Spasticity, and Parkinsonism.
PubMed ID: 34765690
DOI: 10.1002/mdc3.13342
PubMed ID: 27134041
Title: Mutation in ADORA1 identified as likely cause of early-onset parkinsonism and cognitive dysfunction.
PubMed ID: 27134041
DOI: 10.1002/mds.26627
PubMed ID: 27753167
Title: PTRHD1 (C2orf79) mutations lead to autosomal-recessive intellectual disability and parkinsonism.
PubMed ID: 27753167
DOI: 10.1002/mds.26824
PubMed ID: 34816696
Title: The PTRHD1 Mutation in Intellectual Disability.
PubMed ID: 34816696
PubMed ID: 38286424
Title: A Homozygous PTRHD1 Missense Variant (p.Arg122Gln) in an Individual with Intellectual Disability, Generalized Epilepsy, and Juvenile Parkinsonism.
PubMed ID: 38286424
DOI: 10.1055/a-2256-0722
Sequence Information:
- Length: 140
- Mass: 15805
- Checksum: 3AD1C82F3A9CF80B
- Sequence:
MHRGVGPAFR VVRKMAASGA EPQVLVQYLV LRKDLSQAPF SWPAGALVAQ ACHAATAALH THRDHPHTAA YLQELGRMRK VVLEAPDETT LKELAETLQQ KNIDHMLWLE QPENIATCIA LRPYPKEEVG QYLKKFRLFK