Details for: PHKB
Gene ID: 5257
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PHKB
Ensembl ID: ENSG00000102893
Description: phosphorylase kinase regulatory subunit beta
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 48.66rCSI 62.73%PRS 17.88
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CSI 39.85rCSI 49.58%PRS 16.25
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CSI 36.84rCSI 44.01%PRS 17.09
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CSI 32.52rCSI 52.3%PRS 18.8
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CSI 29.57rCSI 52.23%PRS 16.81
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CSI 26.2rCSI 63.68%PRS 16.87
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CSI 23.17rCSI 40.08%PRS 21.57
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CSI 21.86rCSI 68.31%PRS 18.12
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CSI 21.45rCSI 19.04%PRS 27.95
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CSI 21.03rCSI 79.47%PRS 18.01
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CSI 20.96rCSI 46.3%PRS 20.19
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CSI 20.27rCSI 72.95%PRS 16.41
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CSI 19.61rCSI 32.91%PRS 17.28
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CSI 19.51rCSI 20.91%PRS 25.96
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CSI 19.3rCSI 16.95%PRS 31.92
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CSI 17.89rCSI 55.96%PRS 19.71
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CSI 15.49rCSI 35.43%PRS 27.44
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CSI 15.48rCSI 23.79%PRS 34.6
-
CSI 14.7rCSI 15.62%PRS 44.15
-
CSI 13.87rCSI 28.79%PRS 27.55
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CSI 13.3rCSI 15.23%PRS 50.93
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CSI 12.83rCSI 15.62%PRS 34.39
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CSI 12.68rCSI 74.66%PRS 18.16
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CSI 11.56rCSI 8.59%PRS 39.63
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CSI 10.93rCSI 17.63%PRS 39.37
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CSI 10.56rCSI 77.63%PRS 18.51
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CSI 10.39rCSI 27.67%PRS 24.16
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CSI 10.3rCSI 16.43%PRS 23.98
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CSI 9.95rCSI 17.05%PRS 36.74
-
CSI 9.58rCSI 8.79%PRS 33.3
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CSI 9.49rCSI 13.95%PRS 25.96
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CSI 9.04rCSI 12.97%PRS 22.06
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CSI 8.97rCSI 18.98%PRS 50.47
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CSI 8.94rCSI 18.14%PRS 15.78
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CSI 8.58rCSI 12.68%PRS 31.83
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CSI 8.5rCSI 10.91%PRS 26.75
-
CSI 8.45rCSI 15.94%PRS 35.39
-
CSI 8.26rCSI 14.79%PRS 26.2
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CSI 8.15rCSI 9.42%PRS 20.91
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CSI 7.93rCSI 17.37%PRS 36.75
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CSI 7.89rCSI 7.59%PRS 28.9
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CSI 7.27rCSI 7.45%PRS 46.93
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CSI 7.17rCSI 16.01%PRS 32.72
-
CSI 7.16rCSI 58.25%PRS 26.19
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CSI 7.14rCSI 18.1%PRS 21.57
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CSI 7.12rCSI 18%PRS 34.32
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CSI 7.01rCSI 13.14%PRS 20.77
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CSI 6.52rCSI 8.91%PRS 30.72
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CSI 6.52rCSI 5.59%PRS 39.98
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CSI 6.47rCSI 9.88%PRS 45.76
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CSI 6.15rCSI 7.67%PRS 37.87
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CSI 6.06rCSI 33.13%PRS 37.37
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CSI 6.04rCSI 13.79%PRS 24.07
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CSI 5.89rCSI 4.54%PRS 26.42
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CSI 5.87rCSI 6.89%PRS 31.79
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CSI 5.82rCSI 21.82%PRS 23.66
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CSI 5.67rCSI 7.88%PRS 28.19
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CSI 5.63rCSI 8.23%PRS 29.85
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CSI 5.57rCSI 6.68%PRS 45.78
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CSI 5.49rCSI 9.67%PRS 27.24
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CSI 5.43rCSI 12.95%PRS 31.04
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CSI 5.32rCSI 6.83%PRS 26.76
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CSI 5.27rCSI 4.98%PRS 29.22
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CSI 5.23rCSI 10.39%PRS 29
-
CSI 5.19rCSI 6%PRS 24.24
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CSI 5.18rCSI 20.04%PRS 48.65
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CSI 5.06rCSI 13.09%PRS 25.83
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CSI 5rCSI 15.4%PRS 39.92
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CSI 4.89rCSI 11.28%PRS 22.94
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CSI 4.84rCSI 7.98%PRS 32.62
-
CSI 4.84rCSI 7.84%PRS 27.82
-
CSI 4.76rCSI 67.5%PRS 23.03
-
CSI 4.74rCSI 12.57%PRS 40.76
-
CSI 4.71rCSI 22.07%PRS 58.04
-
CSI 4.63rCSI 7.58%PRS 21.81
-
CSI 4.59rCSI 6.83%PRS 31.51
-
CSI 4.54rCSI 17.15%PRS 30.57
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CSI 4.49rCSI 9.02%PRS 20.94
-
CSI 4.49rCSI 3.63%PRS 39.83
-
CSI 4.46rCSI 8.02%PRS 23.44
-
CSI 4.45rCSI 3.46%PRS 40.63
-
CSI 4.45rCSI 9.8%PRS 31.61
-
CSI 4.4rCSI 8.38%PRS 42.97
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CSI 4.39rCSI 3.47%PRS 19.45
-
CSI 4.38rCSI 5.86%PRS 30.13
-
CSI 4.27rCSI 3.97%PRS 28.02
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CSI 4.25rCSI 6.84%PRS 21.61
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CSI 4.24rCSI 23.51%PRS 57.07
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CSI 4.21rCSI 6.51%PRS 26.36
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CSI 4.19rCSI 4.31%PRS 43.13
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CSI 4.14rCSI 13.71%PRS 31.28
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CSI 4.08rCSI 3.59%PRS 20.59
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CSI 4.06rCSI 9.71%PRS 20.13
-
CSI 4.05rCSI 17.79%PRS 26.44
-
CSI 3.96rCSI 24.73%PRS 22.62
-
CSI 3.96rCSI 9.79%PRS 26.2
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CSI 3.95rCSI 13.52%PRS 24.01
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CSI 3.74rCSI 5.53%PRS 42.44
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CSI 3.65rCSI 11.69%PRS 24.5
-
CSI 3.62rCSI 5.19%PRS 36.2
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CSI 0.1rCSI 0.6%PRS 49.2%
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CSI 0.2rCSI 1.0%PRS 39.5%
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CSI 0.2rCSI 1.3%PRS 39.1%
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CSI 0.3rCSI 2.1%PRS 54.9%
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CSI 0.3rCSI 1.8%PRS 50.5%
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CSI 0.4rCSI 5.4%PRS 57.9%
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CSI 0.5rCSI 3.4%PRS 27.6%
-
CSI 0.5rCSI 0.5%PRS 29.7%
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CSI 0.5rCSI 2.3%PRS 49.1%
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CSI 0.5rCSI 1.8%PRS 42.5%
-
CSI 0.5rCSI 0.8%PRS 28.3%
-
CSI 0.5rCSI 3.6%PRS 28.4%
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CSI 0.6rCSI 4.2%PRS 28.2%
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CSI 0.6rCSI 4.4%PRS 29.1%
-
CSI 0.6rCSI 5.2%PRS 67.6%
-
CSI 0.6rCSI 3.0%PRS 29.6%
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CSI 0.6rCSI 2.4%PRS 44.3%
-
CSI 0.6rCSI 0.8%PRS 15.7%
-
CSI 0.6rCSI 2.9%PRS 19.7%
-
CSI 0.7rCSI 2.0%PRS 22.2%
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CSI 0.7rCSI 5.2%PRS 47.6%
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CSI 0.7rCSI 3.1%PRS 27.1%
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CSI 0.7rCSI 4.5%PRS 38.6%
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CSI 0.7rCSI 1.3%PRS 41.8%
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CSI 0.7rCSI 6.0%PRS 28.8%
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CSI 0.8rCSI 4.4%PRS 28.8%
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CSI 0.8rCSI 3.0%PRS 51.7%
-
CSI 0.8rCSI 8.0%PRS 33.0%
-
CSI 0.8rCSI 2.3%PRS 31.0%
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CSI 0.8rCSI 5.8%PRS 28.1%
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CSI 0.8rCSI 3.9%PRS 28.9%
-
CSI 0.8rCSI 4.3%PRS 30.5%
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CSI 0.9rCSI 1.8%PRS 38.1%
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CSI 0.9rCSI 3.9%PRS 47.6%
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CSI 1.0rCSI 1.5%PRS 37.4%
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CSI 1.0rCSI 2.4%PRS 39.1%
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CSI 1.0rCSI 1.7%PRS 35.8%
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CSI 1.1rCSI 2.9%PRS 35.9%
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CSI 1.1rCSI 4.3%PRS 44.8%
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CSI 1.1rCSI 2.4%PRS 49.2%
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CSI 1.1rCSI 3.7%PRS 62.4%
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CSI 1.2rCSI 4.8%PRS 39.2%
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CSI 1.2rCSI 5.8%PRS 37.3%
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CSI 1.2rCSI 6.2%PRS 44.1%
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CSI 1.2rCSI 5.6%PRS 51.6%
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CSI 1.2rCSI 1.5%PRS 24.8%
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CSI 1.2rCSI 1.2%PRS 51.5%
-
CSI 1.3rCSI 1.2%PRS 24.0%
-
CSI 1.3rCSI 3.6%PRS 41.2%
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CSI 1.3rCSI 1.7%PRS 49.2%
-
CSI 1.3rCSI 2.7%PRS 42.1%
-
CSI 1.3rCSI 2.0%PRS 25.9%
-
CSI 1.3rCSI 1.2%PRS 25.5%
-
CSI 1.3rCSI 3.0%PRS 25.9%
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CSI 1.3rCSI 2.4%PRS 35.5%
-
CSI 1.4rCSI 4.0%PRS 27.1%
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CSI 1.4rCSI 3.6%PRS 33.6%
-
CSI 1.4rCSI 3.7%PRS 39.2%
-
CSI 1.4rCSI 2.1%PRS 30.6%
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CSI 1.4rCSI 4.0%PRS 42.0%
-
CSI 1.4rCSI 7.2%PRS 71.4%
-
CSI 1.4rCSI 1.5%PRS 28.7%
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CSI 1.4rCSI 2.8%PRS 29.0%
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CSI 1.5rCSI 2.1%PRS 26.0%
-
CSI 1.5rCSI 1.3%PRS 31.2%
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CSI 1.5rCSI 3.2%PRS 21.3%
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CSI 1.5rCSI 3.6%PRS 39.7%
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CSI 1.6rCSI 2.1%PRS 30.8%
-
CSI 1.6rCSI 1.9%PRS 27.1%
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CSI 1.6rCSI 4.2%PRS 28.2%
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CSI 1.6rCSI 3.6%PRS 41.0%
-
CSI 1.6rCSI 4.2%PRS 34.3%
-
CSI 1.6rCSI 7.2%PRS 24.9%
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CSI 1.7rCSI 2.1%PRS 32.2%
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CSI 1.7rCSI 2.4%PRS 41.4%
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CSI 1.7rCSI 2.1%PRS 32.1%
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CSI 1.7rCSI 2.3%PRS 40.1%
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CSI 1.7rCSI 1.8%PRS 32.8%
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CSI 1.7rCSI 2.4%PRS 27.2%
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CSI 1.8rCSI 6.7%PRS 25.7%
-
CSI 1.8rCSI 2.6%PRS 36.5%
-
CSI 1.8rCSI 10.3%PRS 33.0%
-
CSI 1.8rCSI 2.6%PRS 41.7%
-
CSI 1.9rCSI 2.4%PRS 35.8%
-
CSI 1.9rCSI 9.1%PRS 32.5%
-
CSI 2.0rCSI 4.4%PRS 17.9%
-
CSI 2.0rCSI 2.5%PRS 30.0%
-
CSI 2.0rCSI 3.1%PRS 33.3%
-
CSI 2.0rCSI 12.3%PRS 55.9%
-
CSI 2.1rCSI 6.7%PRS 32.4%
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CSI 2.1rCSI 2.5%PRS 33.5%
-
CSI 2.1rCSI 10.1%PRS 24.9%
-
CSI 2.1rCSI 1.7%PRS 33.4%
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CSI 2.2rCSI 1.9%PRS 34.8%
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CSI 2.2rCSI 2.9%PRS 24.4%
-
CSI 2.2rCSI 3.4%PRS 39.3%
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CSI 2.2rCSI 1.5%PRS 32.5%
-
CSI 2.2rCSI 1.8%PRS 29.1%
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CSI 2.2rCSI 4.7%PRS 37.3%
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CSI 2.2rCSI 5.3%PRS 42.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1034760022
Symbol: KPBB_HUMAN
Name: Phosphorylase b kinase regulatory subunit beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8681948
Title: Structure of the human gene encoding the phosphorylase kinase beta subunit (PHKB).
PubMed ID: 8681948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 9326319
Title: Autosomal recessive phosphorylase kinase deficiency in liver, caused by mutations in the gene encoding the beta subunit (PHKB).
PubMed ID: 9326319
DOI: 10.1086/515502
PubMed ID: 9402963
Title: Phosphorylase-kinase-deficient liver glycogenosis with an unusual biochemical phenotype in blood cells associated with a missense mutation in the beta subunit gene (PHKB).
PubMed ID: 9402963
PubMed ID: 12825073
Title: Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases.
PubMed ID: 12825073
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 1093
- Mass: 124884
- Checksum: 48F05EE306195472
- Sequence:
MAGAAGLTAE VSWKVLERRA RTKRSGSVYE PLKSINLPRP DNETLWDKLD HYYRIVKSTL LLYQSPTTGL FPTKTCGGDQ KAKIQDSLYC AAGAWALALA YRRIDDDKGR THELEHSAIK CMRGILYCYM RQADKVQQFK QDPRPTTCLH SVFNVHTGDE LLSYEEYGHL QINAVSLYLL YLVEMISSGL QIIYNTDEVS FIQNLVFCVE RVYRVPDFGV WERGSKYNNG STELHSSSVG LAKAALEAIN GFNLFGNQGC SWSVIFVDLD AHNRNRQTLC SLLPRESRSH NTDAALLPCI SYPAFALDDE VLFSQTLDKV VRKLKGKYGF KRFLRDGYRT SLEDPNRCYY KPAEIKLFDG IECEFPIFFL YMMIDGVFRG NPKQVQEYQD LLTPVLHHTT EGYPVVPKYY YVPADFVEYE KNNPGSQKRF PSNCGRDGKL FLWGQALYII AKLLADELIS PKDIDPVQRY VPLKDQRNVS MRFSNQGPLE NDLVVHVALI AESQRLQVFL NTYGIQTQTP QQVEPIQIWP QQELVKAYLQ LGINEKLGLS GRPDRPIGCL GTSKIYRILG KTVVCYPIIF DLSDFYMSQD VFLLIDDIKN ALQFIKQYWK MHGRPLFLVL IREDNIRGSR FNPILDMLAA LKKGIIGGVK VHVDRLQTLI SGAVVEQLDF LRISDTEELP EFKSFEELEP PKHSKVKRQS STPSAPELGQ QPDVNISEWK DKPTHEILQK LNDCSCLASQ AILLGILLKR EGPNFITKEG TVSDHIERVY RRAGSQKLWL AVRYGAAFTQ KFSSSIAPHI TTFLVHGKQV TLGAFGHEEE VISNPLSPRV IQNIIYYKCN THDEREAVIQ QELVIHIGWI ISNNPELFSG MLKIRIGWII HAMEYELQIR GGDKPALDLY QLSPSEVKQL LLDILQPQQN GRCWLNRRQI DGSLNRTPTG FYDRVWQILE RTPNGIIVAG KHLPQQPTLS DMTMYEMNFS LLVEDTLGNI DQPQYRQIVV ELLMVVSIVL ERNPELEFQD KVDLDRLVKE AFNEFQKDQS RLKEIEKQDD MTSFYNTPPL GKRGTCSYLT KAVMNLLLEG EVKPNNDDPC LIS