DCTN3 | ENSG00000137100 | NCBI 11258

Details for: DCTN3

Gene ID: 11258

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DCTN3

Ensembl ID: ENSG00000137100

Description: dynactin subunit 3

Cell Significance Landscape

Display Count:

Associated with

Adaptive immune system
(R-HSA-1280218)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Asparagine n-linked glycosylation
(R-HSA-446203)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Er to golgi anterograde transport
(R-HSA-199977)
G2/m transition
(R-HSA-69275)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Centrosome
(GO:0005813)
Cleavage furrow
(GO:0032154)
Cytoskeleton-dependent cytokinesis
(GO:0061640)
Cytosol
(GO:0005829)
Dynactin complex
(GO:0005869)
Kinetochore
(GO:0000776)
Microtubule-based process
(GO:0007017)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Nucleolus
(GO:0005730)
Perinuclear region of cytoplasm
(GO:0048471)
Protein binding
(GO:0005515)
Spindle
(GO:0005819)
Structural molecule activity
(GO:0005198)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

peripheral nervous system neuron CL2000032

CSI 48.21

rCSI 65.68%

PRS 40.68
pancreatic D cell CL0000173

CSI 46.33

rCSI 45.56%

PRS 50.12
pancreatic A cell CL0000171

CSI 44.64

rCSI 46.77%

PRS 50.7
lung neuroendocrine cell CL1000223

CSI 26.59

rCSI 39.33%

PRS 52.83
pulmonary alveolar type 2 cell CL0002063

CSI 25.32

rCSI 39.28%

PRS 56.95
ciliated epithelial cell CL0000067

CSI 22.13

rCSI 19.46%

PRS 36.68
secretory cell CL0000151

CSI 21.86

rCSI 22.81%

PRS 48.12
retinal cone cell CL0000573

CSI 20.01

rCSI 32.21%

PRS 38.24
vascular associated smooth muscle cell CL0000359

CSI 19.62

rCSI 63.65%

PRS 50.13
microcirculation associated smooth muscle cell CL0008035

CSI 19.47

rCSI 56.38%

PRS 49.9
tracheobronchial smooth muscle cell CL0019019

CSI 19.1

rCSI 33.68%

PRS 55.98
respiratory suprabasal cell CL4033048

CSI 18.98

rCSI 24.34%

PRS 52.43
promonocyte CL0000559

CSI 18.91

rCSI 32.4%

PRS 57.01
keratinocyte CL0000312

CSI 18.63

rCSI 15.62%

PRS 52.48
forebrain radial glial cell CL0013000

CSI 18.58

rCSI 59.61%

PRS 54.96
fraction A pre-pro B cell CL0002045

CSI 17.76

rCSI 20.32%

PRS 70.03
retinal ganglion cell CL0000740

CSI 16.83

rCSI 37.19%

PRS 35.67
fallopian tube secretory epithelial cell CL4030006

CSI 16.75

rCSI 16.12%

PRS 47.95
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 16.33

rCSI 27.94%

PRS 68.05
endothelial cell of lymphatic vessel CL0002138

CSI 15.62

rCSI 30.96%

PRS 68.82
retina horizontal cell CL0000745

CSI 15.39

rCSI 23.46%

PRS 44.19
large pre-B-II cell CL0000957

CSI 14.69

rCSI 41.93%

PRS 61.8
mononuclear phagocyte CL0000113

CSI 14.58

rCSI 32.1%

PRS 51.63
type B pancreatic cell CL0000169

CSI 13.69

rCSI 30.31%

PRS 45.11
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 13.21

rCSI 12.03%

PRS 62.6
pancreatic PP cell CL0002275

CSI 12.79

rCSI 50.91%

PRS 62.93
CD14-positive, CD16-positive monocyte CL0002397

CSI 12.5

rCSI 16.38%

PRS 60.87
alveolar macrophage CL0000583

CSI 11.21

rCSI 18.47%

PRS 53.11
elicited macrophage CL0000861

CSI 11.17

rCSI 10.26%

PRS 55.28
common dendritic progenitor CL0001029

CSI 11.02

rCSI 13.83%

PRS 57.53
activated type II NK T cell CL0000931

CSI 10.94

rCSI 12.31%

PRS 64.13
granulocyte monocyte progenitor cell CL0000557

CSI 10.55

rCSI 9.14%

PRS 51.61
enterocyte CL0000584

CSI 10.18

rCSI 16.42%

PRS 55.42
OFF-bipolar cell CL0000750

CSI 10.18

rCSI 13.92%

PRS 56.97
glutamatergic neuron CL0000679

CSI 9.51

rCSI 19.54%

PRS 41.25
effector CD4-positive, alpha-beta T cell CL0001044

CSI 9.43

rCSI 27.05%

PRS 65.72
Cajal-Retzius cell CL0000695

CSI 9.28

rCSI 72.71%

PRS 63.28
hematopoietic precursor cell CL0008001

CSI 9.26

rCSI 9.52%

PRS 65.67
cerebral cortex GABAergic interneuron CL0010011

CSI 8.82

rCSI 26.03%

PRS 51.55
primitive red blood cell CL0002355

CSI 8.56

rCSI 46.21%

PRS 61.98
pancreatic ductal cell CL0002079

CSI 8.49

rCSI 16.51%

PRS 49.76
double negative thymocyte CL0002489

CSI 8.39

rCSI 5.83%

PRS 56.73
duct epithelial cell CL0000068

CSI 8.17

rCSI 11.95%

PRS 50.85
pulmonary ionocyte CL0017000

CSI 8.14

rCSI 9.91%

PRS 55.25
perivascular cell CL4033054

CSI 8.07

rCSI 11.03%

PRS 52.7
pancreatic stellate cell CL0002410

CSI 7.94

rCSI 46.22%

PRS 58.32
placental villous trophoblast CL2000060

CSI 7.93

rCSI 12.26%

PRS 45.32
intestine goblet cell CL0019031

CSI 7.72

rCSI 6.85%

PRS 46.51
enteroendocrine cell CL0000164

CSI 7.69

rCSI 10.51%

PRS 50.09
erythrocyte CL0000232

CSI 7.55

rCSI 17.13%

PRS 52.81
mesenchymal stem cell CL0000134

CSI 7.53

rCSI 82.45%

PRS 63.5
ciliated cell CL0000064

CSI 7.5

rCSI 12.15%

PRS 45.86
melanocyte CL0000148

CSI 7.42

rCSI 5.5%

PRS 41.15
plasmablast CL0000980

CSI 7.4

rCSI 5.82%

PRS 54.08
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 7.37

rCSI 8.51%

PRS 41.78
activated CD4-positive, alpha-beta T cell CL0000896

CSI 7.35

rCSI 6.8%

PRS 67.84
T follicular helper cell CL0002038

CSI 7.24

rCSI 5.42%

PRS 62.16
neuroblast (sensu Vertebrata) CL0000031

CSI 7.14

rCSI 9.17%

PRS 45.52
colon epithelial cell CL0011108

CSI 7.13

rCSI 7.47%

PRS 44.65
muscle cell CL0000187

CSI 7.11

rCSI 14.59%

PRS 69.27
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 6.91

rCSI 4.61%

PRS 72.5
podocyte CL0000653

CSI 6.7

rCSI 29.78%

PRS 46.44
inhibitory interneuron CL0000498

CSI 6.41

rCSI 14.8%

PRS 38.83
bronchus fibroblast of lung CL2000093

CSI 6.36

rCSI 5.17%

PRS 48.2
pancreatic acinar cell CL0002064

CSI 6.33

rCSI 8.41%

PRS 52.63
epithelial cell of lung CL0000082

CSI 6.19

rCSI 5.13%

PRS 46.2
myofibroblast cell CL0000186

CSI 6.15

rCSI 8.52%

PRS 51.95
radial glial cell CL0000681

CSI 6.14

rCSI 8.53%

PRS 46.96
mucus secreting cell CL0000319

CSI 6.05

rCSI 9.61%

PRS 58.49
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 6.05

rCSI 8.57%

PRS 44.49
astrocyte of the cerebral cortex CL0002605

CSI 5.86

rCSI 13.14%

PRS 32.42
luminal cell of prostate epithelium CL0002340

CSI 5.84

rCSI 31.39%

PRS 62.61
mammary gland epithelial cell CL0002327

CSI 5.82

rCSI 20.43%

PRS 62.63
memory T cell CL0000813

CSI 5.72

rCSI 11.03%

PRS 76.96
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 5.57

rCSI 5.47%

PRS 63.03
CD4-positive, alpha-beta thymocyte CL0000810

CSI 5.46

rCSI 4.37%

PRS 68.93
pulmonary capillary endothelial cell CL4028001

CSI 5.45

rCSI 10.4%

PRS 64.63
naive T cell CL0000898

CSI 5.39

rCSI 3.75%

PRS 60.73
lung secretory cell CL1000272

CSI 5.36

rCSI 13.26%

PRS 45.58
luminal epithelial cell of mammary gland CL0002326

CSI 5.25

rCSI 9.55%

PRS 64.04
adventitial cell CL0002503

CSI 5.24

rCSI 12.52%

PRS 57.84
pro-B cell CL0000826

CSI 5.24

rCSI 4.34%

PRS 48.75
amacrine cell CL0000561

CSI 5.21

rCSI 15.11%

PRS 38.88
megakaryocyte-erythroid progenitor cell CL0000050

CSI 5.16

rCSI 4.66%

PRS 44.27
interneuron CL0000099

CSI 5.16

rCSI 10.36%

PRS 37.41
acinar cell CL0000622

CSI 5.15

rCSI 7.55%

PRS 59.04
neural crest cell CL0011012

CSI 5.11

rCSI 4.04%

PRS 35.34
CD14-low, CD16-positive monocyte CL0002396

CSI 5.06

rCSI 3.9%

PRS 46.6
erythroid lineage cell CL0000764

CSI 5.03

rCSI 32.36%

PRS 68.77
transit amplifying cell of colon CL0009011

CSI 5.01

rCSI 5.88%

PRS 50.94
mesodermal cell CL0000222

CSI 5.01

rCSI 6.01%

PRS 45.64
stem cell CL0000034

CSI 4.99

rCSI 4.81%

PRS 38.32
CD8-positive, alpha-beta memory T cell CL0000909

CSI 4.95

rCSI 5.17%

PRS 76.03
class switched memory B cell CL0000972

CSI 4.95

rCSI 3.69%

PRS 65.62
precursor B cell CL0000817

CSI 4.88

rCSI 4.28%

PRS 57.44
non-classical monocyte CL0000875

CSI 4.64

rCSI 7.44%

PRS 74.9
promyelocyte CL0000836

CSI 4.63

rCSI 6.67%

PRS 57.54
stromal cell of ovary CL0002132

CSI 4.59

rCSI 12.61%

PRS 62.96
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 4.57

rCSI 3.43%

PRS 78.8
CD14-positive monocyte CL0001054

CSI 4.52

rCSI 5.63%

PRS 58.87

Merkel cell CL0000242

CSI 0.2

rCSI 4.0%

PRS 91.9%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.0%

PRS 59.3%
megakaryocyte progenitor cell CL0000553

CSI 0.2

rCSI 4.1%

PRS 80.7%
pre-conventional dendritic cell CL0002010

CSI 0.3

rCSI 3.3%

PRS 79.8%
peptic cell CL0000155

CSI 0.3

rCSI 2.6%

PRS 73.1%
lung microvascular endothelial cell CL2000016

CSI 0.3

rCSI 5.2%

PRS 70.8%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 3.0%

PRS 67.0%
antibody secreting cell CL0000946

CSI 0.4

rCSI 1.7%

PRS 86.6%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.4

rCSI 2.4%

PRS 71.5%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.4

rCSI 2.1%

PRS 71.3%
blood vessel smooth muscle cell CL0019018

CSI 0.4

rCSI 3.5%

PRS 42.1%
epithelial cell of nephron CL1000449

CSI 0.4

rCSI 4.2%

PRS 85.7%
vasa recta ascending limb cell CL1001131

CSI 0.5

rCSI 2.1%

PRS 72.7%
eosinophil CL0000771

CSI 0.5

rCSI 3.2%

PRS 77.9%
neuroplacodal cell CL0000032

CSI 0.5

rCSI 4.5%

PRS 63.8%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.5

rCSI 0.8%

PRS 31.7%
enteroendocrine cell of colon CL0009042

CSI 0.5

rCSI 2.5%

PRS 71.8%
chondrocyte CL0000138

CSI 0.6

rCSI 0.9%

PRS 40.6%
L6b glutamatergic cortical neuron CL4023038

CSI 0.6

rCSI 1.8%

PRS 32.9%
bronchial goblet cell CL1000312

CSI 0.6

rCSI 2.3%

PRS 68.1%
helper T cell CL0000912

CSI 0.6

rCSI 0.8%

PRS 55.7%
basophil mast progenitor cell CL0002028

CSI 0.7

rCSI 3.5%

PRS 83.3%
colon macrophage CL0009038

CSI 0.7

rCSI 3.3%

PRS 69.6%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.7

rCSI 1.7%

PRS 30.7%
paneth cell CL0000510

CSI 0.7

rCSI 1.1%

PRS 65.1%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.7%

PRS 65.9%
basophil CL0000767

CSI 0.7

rCSI 1.5%

PRS 68.1%
tracheobronchial serous cell CL0019001

CSI 0.7

rCSI 3.2%

PRS 63.7%
natural T-regulatory cell CL0000903

CSI 0.8

rCSI 1.5%

PRS 80.3%
type EC enteroendocrine cell CL0000577

CSI 0.8

rCSI 2.8%

PRS 59.8%
regular atrial cardiac myocyte CL0002129

CSI 0.8

rCSI 2.6%

PRS 46.8%
intestinal tuft cell CL0019032

CSI 0.9

rCSI 1.3%

PRS 52.3%
hair follicular keratinocyte CL2000092

CSI 0.9

rCSI 15.1%

PRS 79.6%
germinal center B cell CL0000844

CSI 0.9

rCSI 2.6%

PRS 69.3%
mature B cell CL0000785

CSI 0.9

rCSI 0.8%

PRS 57.3%
intestinal crypt stem cell of colon CL0009043

CSI 0.9

rCSI 6.7%

PRS 67.2%
ventricular cardiac muscle cell CL2000046

CSI 0.9

rCSI 3.1%

PRS 78.1%
mature alpha-beta T cell CL0000791

CSI 0.9

rCSI 3.3%

PRS 67.0%
tracheal goblet cell CL1000329

CSI 0.9

rCSI 2.0%

PRS 66.3%
retinal pigment epithelial cell CL0002586

CSI 0.9

rCSI 1.8%

PRS 46.6%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 1.0

rCSI 4.3%

PRS 81.2%
thymocyte CL0000893

CSI 1.0

rCSI 3.4%

PRS 82.4%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.0

rCSI 3.0%

PRS 35.3%
foveolar cell of stomach CL0002179

CSI 1.0

rCSI 2.1%

PRS 62.1%
sncg GABAergic cortical interneuron CL4023015

CSI 1.0

rCSI 1.7%

PRS 33.8%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.1

rCSI 0.7%

PRS 58.5%
retinal blood vessel endothelial cell CL0002585

CSI 1.1

rCSI 1.7%

PRS 51.7%
dendritic cell, human CL0001056

CSI 1.1

rCSI 1.7%

PRS 54.9%
neuroendocrine cell CL0000165

CSI 1.1

rCSI 4.2%

PRS 65.2%
kidney epithelial cell CL0002518

CSI 1.1

rCSI 2.2%

PRS 70.2%
endothelial cell of uterus CL0009095

CSI 1.2

rCSI 8.4%

PRS 71.4%
epithelial cell of esophagus CL0002252

CSI 1.2

rCSI 11.5%

PRS 72.8%
retinal bipolar neuron CL0000748

CSI 1.2

rCSI 2.2%

PRS 37.3%
cardiac muscle cell CL0000746

CSI 1.2

rCSI 1.7%

PRS 38.8%
enteroendocrine cell of small intestine CL0009006

CSI 1.2

rCSI 2.7%

PRS 62.3%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.2

rCSI 3.2%

PRS 43.7%
pulmonary artery endothelial cell CL1001568

CSI 1.2

rCSI 1.7%

PRS 60.4%
glycinergic amacrine cell CL4030028

CSI 1.3

rCSI 3.3%

PRS 47.0%
vein endothelial cell of respiratory system CL4033008

CSI 1.3

rCSI 8.7%

PRS 65.4%
acinar cell of salivary gland CL0002623

CSI 1.3

rCSI 29.7%

PRS 70.3%
myelocyte CL0002193

CSI 1.3

rCSI 8.4%

PRS 79.1%
glandular epithelial cell CL0000150

CSI 1.3

rCSI 3.5%

PRS 69.7%
late pro-B cell CL0002048

CSI 1.3

rCSI 3.3%

PRS 77.4%
respiratory hillock cell CL4030023

CSI 1.4

rCSI 2.4%

PRS 62.7%
IgG plasma cell CL0000985

CSI 1.4

rCSI 1.7%

PRS 66.5%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.4

rCSI 1.7%

PRS 67.9%
intermediate monocyte CL0002393

CSI 1.4

rCSI 2.1%

PRS 49.8%
glial cell CL0000125

CSI 1.4

rCSI 5.4%

PRS 40.6%
neural progenitor cell CL0011020

CSI 1.4

rCSI 6.3%

PRS 40.7%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.4

rCSI 2.6%

PRS 41.1%
alternatively activated macrophage CL0000890

CSI 1.5

rCSI 1.9%

PRS 61.0%
myoepithelial cell CL0000185

CSI 1.5

rCSI 3.8%

PRS 56.1%
myeloid dendritic cell CL0000782

CSI 1.5

rCSI 2.2%

PRS 64.0%
transit amplifying cell CL0009010

CSI 1.5

rCSI 2.3%

PRS 63.5%
mucous neck cell CL0000651

CSI 1.6

rCSI 2.3%

PRS 60.9%
Langerhans cell CL0000453

CSI 1.6

rCSI 2.5%

PRS 64.7%
cerebral cortex endothelial cell CL1001602

CSI 1.6

rCSI 2.8%

PRS 38.4%
stromal cell CL0000499

CSI 1.7

rCSI 4.7%

PRS 47.0%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.7

rCSI 2.1%

PRS 30.0%
conjunctival epithelial cell CL1000432

CSI 1.7

rCSI 2.6%

PRS 48.2%
progenitor cell CL0011026

CSI 1.7

rCSI 3.7%

PRS 50.8%
pro-T cell CL0000827

CSI 1.8

rCSI 41.2%

PRS 93.3%
sst GABAergic cortical interneuron CL4023017

CSI 1.8

rCSI 2.3%

PRS 32.6%
M cell of gut CL0000682

CSI 1.8

rCSI 1.9%

PRS 61.9%
T-helper 17 cell CL0000899

CSI 1.8

rCSI 1.5%

PRS 69.7%
nasal mucosa goblet cell CL0002480

CSI 1.9

rCSI 2.1%

PRS 57.6%
CD4-positive helper T cell CL0000492

CSI 1.9

rCSI 1.4%

PRS 60.3%
group 2 innate lymphoid cell CL0001069

CSI 1.9

rCSI 10.3%

PRS 81.2%
renal alpha-intercalated cell CL0005011

CSI 1.9

rCSI 2.6%

PRS 56.1%
club cell CL0000158

CSI 2.0

rCSI 2.9%

PRS 46.4%
mesenchymal cell CL0008019

CSI 2.0

rCSI 5.1%

PRS 43.3%
granulocyte CL0000094

CSI 2.0

rCSI 3.1%

PRS 56.8%
vascular leptomeningeal cell CL4023051

CSI 2.0

rCSI 3.6%

PRS 40.0%
smooth muscle cell CL0000192

CSI 2.1

rCSI 4.9%

PRS 60.5%
Mueller cell CL0000636

CSI 2.1

rCSI 4.8%

PRS 40.9%
Bergmann glial cell CL0000644

CSI 2.1

rCSI 2.9%

PRS 43.6%
erythroid progenitor cell CL0000038

CSI 2.1

rCSI 12.0%

PRS 58.2%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.1

rCSI 3.3%

PRS 74.2%
endocrine cell CL0000163

CSI 2.2

rCSI 11.0%

PRS 81.6%
primordial germ cell CL0000670

CSI 2.2

rCSI 10.8%

PRS 85.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its expression specificity (CSI Z-Score), [DCTN3](/details-gene/11258) (dynactin subunit 3) does not emerge as a defining marker for any particular cell type. Instead, its broad expression profile across diverse lineages is consistent with its established role as a core component of the dynactin complex. This complex is a crucial regulator of the dynein motor protein, playing a fundamental role in essential cellular processes such as intracellular transport, cell division, and cytoskeleton organization. The data suggests that [DCTN3](/details-gene/11258) functions as a housekeeping gene, providing a basal level of activity required by a wide variety of cells. ## Cellular Roles and Expression Landscape The expression pattern of [DCTN3](/details-gene/11258), when evaluated for cell-type specificity, underscores its role as a ubiquitously required cellular component. In the **Overall** context, the gene exhibits no statistically significant enrichment in any cell type, as indicated by CSI (Z-SCORE) values of 0.00 and non-significant p-values (p > 0.05) across all listed cells. This lack of specificity is further supported by moderate Percentile Rank Scores (PRS), which cluster around the 40th-60th percentile, indicating that its expression is neither exceptionally high nor low in these contexts. The gene is detected in a functionally diverse set of cells, including [peripheral nervous system neuron](/details-cell/CL2000032), [pancreatic A cell](/details-cell/CL0000171), [pulmonary alveolar type 2 cell](/details-cell/CL0002063), and [vascular associated smooth muscle cell](/details-cell/CL0000359). This broad but non-specific expression pattern is highly consistent with its function as part of the dynactin complex, which is essential for microtubule-based transport mechanisms common to nearly all eukaryotic cells. Rather than defining a cell's unique identity, [DCTN3](/details-gene/11258) appears to support fundamental "housekeeping" activities essential for cell maintenance and division. ## Pathways and Molecular Function The functional annotations for [DCTN3](/details-gene/11258) strongly align with its ubiquitous expression pattern and its identity as a core structural protein. As a subunit of the '[Dynactin complex](/details-go/GO:0005869)', its primary role is linked to '[Microtubule-based process](/details-go/GO:0007017)'. This is reflected in its involvement in a multitude of fundamental cellular events. The gene is heavily implicated in cell division, as shown by its association with the Reactome pathways '[Cell cycle, mitotic](/details-pathway/R-HSA-69278)' and '[M phase](/details-pathway/R-HSA-68886)', as well as GO terms like '[Mitotic cell cycle](/details-go/GO:0000278)'. Its localization to key mitotic structures such as the '[Spindle](/details-go/GO:0005819)', '[Kinetochore](/details-go/GO:0000776)', and '[Midbody](/details-go/GO:0030496)' reinforces this role, consistent with research that localizes the dynactin complex to the midbody of dividing cells ([PubMed: 9722614](https://pubmed.ncbi.nlm.nih.gov/9722614)). Furthermore, [DCTN3](/details-gene/11258) is integral to '[Vesicle-mediated transport](/details-pathway/R-HSA-5653656)', including processes like '[ER to golgi anterograde transport](/details-pathway/R-HSA-199977)' and even specialized immune pathways such as '[MHC class ii antigen presentation](/details-pathway/R-HSA-2132295)'. This highlights the dynactin complex's broad utility in trafficking various forms of intracellular cargo, a function required across the diverse cell types where [DCTN3](/details-gene/11258) is expressed. ## Research Directions The available data is limited to an **Overall** context, precluding a comparative analysis between different biological states (e.g., healthy versus disease). However, the gene's fundamental role in microtubule-based transport and cell division suggests several testable hypotheses. **Testable Hypotheses:** 1. **Hypothesis:** Although not specifically expressed, [DCTN3](/details-gene/11258) is essential for the specialized, long-distance axonal transport in neurons. Subtle reductions in its function could lead to deficits in cargo delivery, contributing to neurodegenerative pathology. * **Experimental Approach:** Utilize CRISPR-Cas9 to introduce mutations found in neurodegenerative diseases into an iPSC-derived motor neuron model. Assess the velocity, processivity, and directionality of fluorescently-tagged mitochondria and synaptic vesicle precursors using live-cell imaging and kymograph analysis. 2. **Hypothesis:** In professional antigen-presenting cells (APCs), the efficiency of '[MHC class ii antigen presentation](/details-pathway/R-HSA-2132295)' is critically dependent on [DCTN3](/details-gene/11258)-mediated transport of MHC-II-containing vesicles to the cell surface. Impaired [DCTN3](/details-gene/11258) function would blunt T-cell activation, not by altering gene expression, but by disrupting intracellular trafficking. * **Experimental Approach:** Use siRNA to transiently knock down [DCTN3](/details-gene/11258) in a human dendritic cell line. Following stimulation with a specific antigen, quantify the surface levels of peptide-MHC-II complexes using flow cytometry and assess the cells' ability to activate antigen-specific CD4+ T cells in a co-culture assay. 3. **Hypothesis:** In secretory cells, such as the [pancreatic A cell](/details-cell/CL0000171), [DCTN3](/details-gene/11258) is rate-limiting for the transport and polarized release of hormone-containing secretory granules. * **Experimental Approach:** Generate a conditional knockout of [DCTN3](/details-gene/11258) in a pancreatic alpha cell line (e.g., AlphaTC1-6). Use total internal reflection fluorescence (TIRF) microscopy to visualize the docking and fusion of fluorescently-tagged glucagon vesicles at the plasma membrane following stimulation. Quantify hormone release via ELISA. **Therapeutic Potential:** As a core component of the essential dynactin complex, systemic inhibition of [DCTN3](/details-gene/11258) would likely result in significant toxicity due to its role in cell division and transport in healthy tissues. However, its fundamental role in microtubule-based transport makes it a potential point of interest for diseases characterized by trafficking defects, such as amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Therapeutic strategies would likely need to be indirect, focusing on modulating the interaction of the dynactin complex with cell-type-specific cargo adaptors rather than targeting [DCTN3](/details-gene/11258) itself, thereby offering a more targeted intervention with a potentially wider therapeutic window.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dynactin subunit 3
X6RLR1_HUMAN

Genular Protein ID: 2226696297

Symbol: DCTN3_HUMAN

Name: Dynactin subunit 3

UniProtKB Accession Codes:

O75935 A6NII7 B2RBM5 Q5T1I5 Q5T1I7 Q5T8G3 Q9BPU8

Database IDs:

Citations:

PubMed ID: 9722614

Title: Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells.

PubMed ID: 9722614

DOI: 10.1083/jcb.142.4.1023

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

Length: 186
Mass: 21119
Checksum: 70A0B26E24603A77
Sequence:

MAGLTDLQRL QARVEELERW VYGPGGARGS RKVADGLVKV QVALGNISSK RERVKILYKK 
IEDLIKYLDP EYIDRIAIPD ASKLQFILAE EQFILSQVAL LEQVNALVPM LDSAHIKAVP 
EHAARLQRLA QIHIQQQDQC VEITEESKAL LEEYNKTTML LSKQFVQWDE LLCQLEAATQ 
VKPAEE

Genular Protein ID: 495124001

Symbol: X6RLR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

X6RLR1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

Length: 176
Mass: 19952
Checksum: AD9E89A3DAA410AD
Sequence:

MAGLTDLQRL QARVEELERW VYGPGGARGS RKVADGLVKV QVALGNISSK RERVKILYKK 
IEDLIKYLDP EYIDRIAIPD ASKLQFILAE EQFILSQVAL LEQVNALVPM LDSAHIKAVP 
EHAARLQRLA QIHIQQQIPI LTLTYNQTML LSKQFVQWDE LLCQLEAATQ VKPAEE

Details for: DCTN3

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. PubMed ID: 9722614

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

PubMed ID: 9722614

PubMed ID: 14702039

PubMed ID: 15164053

PubMed ID: 15489334

PubMed ID: 21269460

PubMed ID: 22814378

PubMed ID: 11237011

PubMed ID: 15164053

PubMed ID: 15496913

PubMed ID: 21269460

PubMed ID: 22814378