Details for: BRWD1
Gene ID: 54014
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: BRWD1
Ensembl ID: ENSG00000185658
Description: bromodomain and WD repeat domain containing 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 56.89rCSI 70.77%PRS 9.32
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CSI 53.78rCSI 69.34%PRS 10.53
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CSI 50.86rCSI 85.38%PRS 10.02
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CSI 48.17rCSI 77.46%PRS 10.89
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CSI 45.64rCSI 54.51%PRS 9.82
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CSI 43.19rCSI 76.27%PRS 10
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CSI 35.12rCSI 85.35%PRS 9.84
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CSI 30.99rCSI 67.22%PRS 10.8
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CSI 27.89rCSI 74.27%PRS 13.89
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CSI 27.49rCSI 85.91%PRS 10.72
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CSI 27.3rCSI 85.37%PRS 11.49
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CSI 24.22rCSI 87.17%PRS 9.39
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CSI 22.97rCSI 86.82%PRS 10.29
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CSI 22.27rCSI 76.29%PRS 14.67
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CSI 21.9rCSI 52.39%PRS 10.2
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CSI 21.85rCSI 56.48%PRS 15.88
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CSI 19.47rCSI 27.94%PRS 13.21
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CSI 15.83rCSI 52.02%PRS 9.76
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CSI 15.25rCSI 67.03%PRS 14.09
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CSI 14.56rCSI 33.29%PRS 16.53
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CSI 14.28rCSI 84.07%PRS 10.49
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CSI 13.88rCSI 30.4%PRS 22.8
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CSI 13.45rCSI 34.95%PRS 22.16
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CSI 13.11rCSI 20.84%PRS 14.45
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CSI 12.41rCSI 50.07%PRS 15.26
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CSI 12.08rCSI 21.95%PRS 14.05
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CSI 11.62rCSI 85.38%PRS 9.48
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CSI 11.52rCSI 25.45%PRS 12.19
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CSI 10.38rCSI 16.71%PRS 13.07
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CSI 10.16rCSI 24.23%PRS 19.85
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CSI 10.12rCSI 50.32%PRS 18.14
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CSI 10.02rCSI 8.3%PRS 17.22
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CSI 9.57rCSI 25.8%PRS 22.02
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CSI 9.5rCSI 24.1%PRS 12.9
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CSI 9.25rCSI 28.49%PRS 25.49
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CSI 8.85rCSI 33.15%PRS 14.43
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CSI 8.54rCSI 69.44%PRS 17.34
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CSI 8.11rCSI 16.1%PRS 18.1
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CSI 7.86rCSI 9.72%PRS 14.92
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CSI 7.67rCSI 20.5%PRS 14.11
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CSI 7.37rCSI 10.45%PRS 15.85
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CSI 6.99rCSI 10.8%PRS 15.92
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CSI 6.57rCSI 17.12%PRS 16.74
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CSI 6.53rCSI 5.49%PRS 27.27
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CSI 6.41rCSI 5.13%PRS 30.57
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CSI 6.28rCSI 4.39%PRS 18.06
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CSI 6.24rCSI 41.4%PRS 17.42
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CSI 6.04rCSI 41.12%PRS 17.15
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CSI 5.91rCSI 50.9%PRS 7.3
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CSI 5.64rCSI 9.29%PRS 20.07
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CSI 5.56rCSI 7.44%PRS 22.45
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CSI 5.53rCSI 9.74%PRS 16.69
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CSI 5.18rCSI 27.22%PRS 29.5
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CSI 5.15rCSI 20.41%PRS 23.03
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CSI 4.87rCSI 10.77%PRS 15.8
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CSI 4.87rCSI 21.41%PRS 16.23
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CSI 4.84rCSI 11.83%PRS 16.82
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CSI 4.8rCSI 6.56%PRS 27.03
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CSI 4.79rCSI 53.86%PRS 41
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CSI 4.74rCSI 27.98%PRS 17.63
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CSI 4.7rCSI 25.68%PRS 27.48
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CSI 4.54rCSI 29.04%PRS 43.8
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CSI 4.52rCSI 3.43%PRS 22.47
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CSI 4.5rCSI 8.43%PRS 12.2
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CSI 4.45rCSI 14.34%PRS 17.9
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CSI 4.43rCSI 9.75%PRS 12.2
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CSI 4.3rCSI 7.04%PRS 13.1
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CSI 4.29rCSI 5.34%PRS 18.02
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CSI 4.26rCSI 3.16%PRS 14.95
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CSI 4.13rCSI 8.48%PRS 16.96
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CSI 4.12rCSI 16.01%PRS 23.29
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CSI 4.09rCSI 83.29%PRS 13.21
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CSI 4.05rCSI 82.5%PRS 14.22
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CSI 3.87rCSI 5.48%PRS 23.49
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CSI 3.75rCSI 10.72%PRS 29.88
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CSI 3.75rCSI 31.52%PRS 17.37
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CSI 3.72rCSI 58.69%PRS 12.27
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CSI 3.72rCSI 52.77%PRS 12.4
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CSI 3.7rCSI 28.63%PRS 17.69
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CSI 3.68rCSI 88.01%PRS 8.28
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CSI 3.64rCSI 87.72%PRS 9.23
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CSI 3.51rCSI 4.06%PRS 14.93
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CSI 3.5rCSI 9.13%PRS 26.37
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CSI 3.5rCSI 6.05%PRS 12.98
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CSI 3.47rCSI 7.91%PRS 14.64
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CSI 3.46rCSI 5.52%PRS 14.63
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CSI 3.43rCSI 3.17%PRS 17.55
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CSI 3.3rCSI 10.7%PRS 20.69
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CSI 3.19rCSI 4.43%PRS 17.49
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CSI 3.18rCSI 4.53%PRS 19.21
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CSI 3.08rCSI 7.11%PRS 13.7
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CSI 3.08rCSI 6.39%PRS 16.99
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CSI 2.93rCSI 2.2%PRS 46.8
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CSI 2.91rCSI 3.74%PRS 16.62
-
CSI 2.91rCSI 2.5%PRS 28.39
-
CSI 2.91rCSI 14.35%PRS 23.09
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CSI 2.84rCSI 6.24%PRS 19.12
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CSI 2.81rCSI 3.3%PRS 19.92
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CSI 2.68rCSI 7.77%PRS 13.01
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CSI 2.68rCSI 1.88%PRS 40.99
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CSI -8.3rCSI -8.2%PRS 26.7%
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CSI -6.9rCSI -4.8%PRS 24.1%
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CSI -2.1rCSI -1.6%PRS 15.7%
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CSI -1.9rCSI -4.7%PRS 17.2%
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CSI -1.2rCSI -6.7%PRS 30.3%
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CSI -0.8rCSI -0.9%PRS 21.6%
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CSI -0.6rCSI -0.8%PRS 23.3%
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CSI -0.2rCSI -0.4%PRS 23.1%
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CSI 0.0rCSI 0.1%PRS 30.5%
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CSI 0.0rCSI 0.3%PRS 35.3%
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CSI 0.1rCSI 1.0%PRS 41.0%
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CSI 0.1rCSI 0.4%PRS 24.9%
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CSI 0.1rCSI 1.0%PRS 58.9%
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CSI 0.1rCSI 0.3%PRS 32.3%
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CSI 0.1rCSI 0.5%PRS 33.2%
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CSI 0.1rCSI 0.4%PRS 29.6%
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CSI 0.1rCSI 0.2%PRS 22.0%
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CSI 0.1rCSI 0.3%PRS 29.3%
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CSI 0.1rCSI 0.2%PRS 25.9%
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CSI 0.1rCSI 0.7%PRS 26.0%
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CSI 0.1rCSI 0.3%PRS 36.4%
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CSI 0.1rCSI 1.6%PRS 32.4%
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CSI 0.2rCSI 0.3%PRS 22.3%
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CSI 0.2rCSI 0.9%PRS 35.3%
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CSI 0.2rCSI 1.2%PRS 37.7%
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CSI 0.2rCSI 1.1%PRS 22.5%
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CSI 0.2rCSI 0.3%PRS 12.5%
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CSI 0.2rCSI 1.6%PRS 32.9%
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CSI 0.2rCSI 7.2%PRS 38.0%
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CSI 0.2rCSI 0.4%PRS 17.1%
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CSI 0.2rCSI 0.3%PRS 18.6%
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CSI 0.2rCSI 3.8%PRS 41.2%
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CSI 0.3rCSI 1.5%PRS 25.5%
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CSI 0.3rCSI 1.7%PRS 42.9%
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CSI 0.3rCSI 2.4%PRS 57.8%
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CSI 0.3rCSI 1.2%PRS 9.2%
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CSI 0.3rCSI 0.3%PRS 20.3%
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CSI 0.3rCSI 0.5%PRS 21.4%
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CSI 0.3rCSI 0.5%PRS 18.7%
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CSI 0.3rCSI 0.3%PRS 19.8%
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CSI 0.3rCSI 2.1%PRS 38.2%
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CSI 0.3rCSI 1.0%PRS 24.7%
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CSI 0.3rCSI 0.2%PRS 20.7%
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CSI 0.4rCSI 1.0%PRS 28.1%
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CSI 0.4rCSI 2.7%PRS 30.9%
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CSI 0.4rCSI 0.3%PRS 19.5%
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CSI 0.4rCSI 0.9%PRS 46.9%
-
CSI 0.4rCSI 1.1%PRS 19.3%
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CSI 0.4rCSI 0.3%PRS 21.3%
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CSI 0.4rCSI 2.1%PRS 19.5%
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CSI 0.4rCSI 2.2%PRS 30.7%
-
CSI 0.4rCSI 0.8%PRS 17.4%
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CSI 0.5rCSI 2.5%PRS 40.5%
-
CSI 0.5rCSI 0.3%PRS 17.9%
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CSI 0.5rCSI 2.0%PRS 30.0%
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CSI 0.5rCSI 0.9%PRS 28.7%
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CSI 0.5rCSI 0.5%PRS 17.9%
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CSI 0.5rCSI 0.9%PRS 22.5%
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CSI 0.5rCSI 1.4%PRS 26.4%
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CSI 0.5rCSI 2.8%PRS 8.4%
-
CSI 0.5rCSI 0.7%PRS 27.0%
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CSI 0.5rCSI 0.5%PRS 18.2%
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CSI 0.5rCSI 3.6%PRS 18.9%
-
CSI 0.5rCSI 0.8%PRS 19.5%
-
CSI 0.5rCSI 1.2%PRS 17.6%
-
CSI 0.5rCSI 1.5%PRS 25.1%
-
CSI 0.5rCSI 0.5%PRS 31.6%
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CSI 0.5rCSI 1.2%PRS 19.6%
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CSI 0.5rCSI 1.9%PRS 27.7%
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CSI 0.5rCSI 2.4%PRS 54.0%
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CSI 0.6rCSI 0.8%PRS 27.6%
-
CSI 0.6rCSI 2.2%PRS 23.0%
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CSI 0.6rCSI 1.1%PRS 45.4%
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CSI 0.6rCSI 0.6%PRS 14.5%
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CSI 0.6rCSI 2.8%PRS 43.1%
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CSI 0.6rCSI 1.4%PRS 25.3%
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CSI 0.6rCSI 0.6%PRS 15.3%
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CSI 0.6rCSI 2.8%PRS 55.1%
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CSI 0.6rCSI 2.4%PRS 28.0%
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CSI 0.6rCSI 3.9%PRS 51.9%
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CSI 0.6rCSI 2.1%PRS 20.6%
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CSI 0.6rCSI 1.0%PRS 21.8%
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CSI 0.7rCSI 2.2%PRS 11.8%
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CSI 0.7rCSI 1.0%PRS 19.5%
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CSI 0.7rCSI 3.2%PRS 17.6%
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CSI 0.7rCSI 1.0%PRS 25.7%
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CSI 0.7rCSI 0.6%PRS 18.0%
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CSI 0.7rCSI 3.3%PRS 44.8%
-
CSI 0.8rCSI 0.8%PRS 20.0%
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CSI 0.8rCSI 1.0%PRS 22.0%
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CSI 0.8rCSI 7.5%PRS 62.2%
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CSI 0.8rCSI 0.6%PRS 30.2%
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CSI 0.8rCSI 1.7%PRS 33.4%
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CSI 0.8rCSI 1.2%PRS 15.6%
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CSI 0.8rCSI 1.9%PRS 27.1%
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CSI 0.8rCSI 1.2%PRS 19.7%
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CSI 0.8rCSI 1.2%PRS 18.0%
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CSI 0.8rCSI 1.5%PRS 33.3%
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CSI 0.8rCSI 3.2%PRS 4.8%
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CSI 0.8rCSI 0.7%PRS 19.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2705549466
Symbol: BRWD1_HUMAN
Name: Bromodomain and WD repeat-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12359327
Title: Characterisation and expression analysis of the WDR9 gene, located in the Down critical region-2 of the human chromosome 21.
PubMed ID: 12359327
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9480850
Title: High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2.
PubMed ID: 9480850
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21834987
Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.
PubMed ID: 21834987
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25593309
Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.
PubMed ID: 25593309
PubMed ID: 33389130
Title: Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia.
PubMed ID: 33389130
PubMed ID: 22464331
Title: Histone recognition and large-scale structural analysis of the human bromodomain family.
PubMed ID: 22464331
Sequence Information:
- Length: 2320
- Mass: 262936
- Checksum: 109714D79B9057E9
- Sequence:
MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR RILGHLSAVY CVAFDRTGHR IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN TMIAAGSCDK IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM YFLGFEAPEK IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL EWRSILLDMA TRISGDLSSE EERFMKPKVT MIAWNQNDSI VVTAVNDHVL KVWNSYTGQL LHNLMGHADE VFVLETHPFD SRIMLSAGHD GSIFIWDITK GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL LIFGFGCSKP YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP ESSILDGMIR QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ SPPNIGLRRS GQVEGVRQMH QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI FRKLEDFRLE KGEEERNLYI IGRKRKTLQL SHKSDSVVLV SQSRQRTCRR KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS EEDEWRSDRK SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT TLRKSPFVPQ MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR DQELVKIVGI RYEVGPPTLC CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI DFLVLRQFYD EARQRNWQSC DRFRSIIDDA WWFGTVLSQE PYQPQYPDSH FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV TTDELEKLLY KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA KKITDQLLKF IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR VHDGKKSIRA TNYVESNWKK QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY RDIIDTPMDF GTVRETLDAG NYDSPLEFCK DIRLIFSNAK AYTPNKRSKI YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ RQNCKGDSQP NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE SKESSRARES SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK RVYLSDSDNN SLETGEILKA RAGNNRKVLR KCAAVAANKI KLMSDVEENS SSESVCSGRK LPHRNASAVA RKKLLHNSED EQSLKSEIEE EELKDENQLL PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS HTPAPSKTKF LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN CDPIAMSQCS SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK RVCSSDSDSS LQVVKKSSKA RTGLLRITRR CAATAANKIK LMSDVEDVSL ENVHTRSKNG RKKPLHLACT TAKKKLSDCE GSVHCEVPSE QYACEGKPPD PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA PSKRKSSSVT SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR PDTSSKSSDL GSVTESDIDC TDNTKTKRRK TKGKAKVVRK EFVPRDREPN TKVRTCMHNQ KDAVQMPSET LKAKMVPEKV PRRCATVAAN KIKIMSNLKE TISGPENVWI RKSSRKLPHR NASAAAKKKL LNVYKEDDTT INSESEKELE DINRKMLFLR GFRSWKENAQ