Details for: CUL5
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 31.18rCSI 52.34%PRS 15.16
-
CSI 24.46rCSI 59.45%PRS 14.86
-
CSI 21.17rCSI 34.04%PRS 16.54
-
CSI 21.13rCSI 20.75%PRS 38.59
-
CSI 19.88rCSI 62.14%PRS 16.03
-
CSI 17.55rCSI 63.16%PRS 14.34
-
CSI 15.21rCSI 57.49%PRS 15.76
-
CSI 11.59rCSI 20.48%PRS 14.91
-
CSI 10.81rCSI 8.01%PRS 21.59
-
CSI 10.68rCSI 62.91%PRS 15.93
-
CSI 9.73rCSI 11.66%PRS 42.5
-
CSI 8.84rCSI 13.65%PRS 23.61
-
CSI 8.33rCSI 11.81%PRS 23.28
-
CSI 8.21rCSI 19.57%PRS 27.97
-
CSI 8.17rCSI 25.56%PRS 17.35
-
CSI 7.96rCSI 29.82%PRS 21.12
-
CSI 7.81rCSI 9.73%PRS 34.51
-
CSI 7.42rCSI 13.48%PRS 21.41
-
CSI 7.18rCSI 14.25%PRS 26.02
-
CSI 6.89rCSI 9.58%PRS 25.41
-
CSI 6.88rCSI 8.83%PRS 24.08
-
CSI 6.53rCSI 35.68%PRS 35.4
-
CSI 6.03rCSI 5.81%PRS 26.05
-
CSI 6rCSI 9.53%PRS 32.26
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CSI 5.97rCSI 12.96%PRS 18.47
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CSI 5.81rCSI 42.69%PRS 15.83
-
CSI 5.61rCSI 8.96%PRS 21.42
-
CSI 5.57rCSI 14.39%PRS 23.24
-
CSI 5.54rCSI 45.04%PRS 24.04
-
CSI 5.47rCSI 4.1%PRS 38.81
-
CSI 5.45rCSI 12.06%PRS 23.23
-
CSI 5.37rCSI 3.74%PRS 35.31
-
CSI 5.31rCSI 54.95%PRS 26.65
-
CSI 5.11rCSI 10.6%PRS 24.89
-
CSI 5.09rCSI 7.82%PRS 30.25
-
CSI 5.07rCSI 6.31%PRS 14.23
-
CSI 4.34rCSI 6.13%PRS 34.75
-
CSI 4.33rCSI 11.44%PRS 29.93
-
CSI 4.32rCSI 5.9%PRS 27.8
-
CSI 4.26rCSI 3.06%PRS 34.59
-
CSI 4.19rCSI 3.47%PRS 25.6
-
CSI 4.18rCSI 14.32%PRS 21.57
-
CSI 4.16rCSI 35.87%PRS 14.35
-
CSI 4.03rCSI 3.01%PRS 41.19
-
CSI 3.93rCSI 4.04%PRS 39.73
-
CSI 3.89rCSI 6.4%PRS 29.58
-
CSI 3.87rCSI 10.32%PRS 21.68
-
CSI 3.86rCSI 3.4%PRS 18.41
-
CSI 3.7rCSI 11.83%PRS 21.12
-
CSI 3.69rCSI 5.49%PRS 28.99
-
CSI 3.69rCSI 6.6%PRS 23.32
-
CSI 3.53rCSI 3.03%PRS 37.72
-
CSI 3.53rCSI 7.46%PRS 47.28
-
CSI 3.48rCSI 4.65%PRS 32.14
-
CSI 3.45rCSI 4.45%PRS 15.8
-
CSI 3.44rCSI 54.25%PRS 24.77
-
CSI 3.41rCSI 3.94%PRS 21.78
-
CSI 3.4rCSI 3.07%PRS 22.97
-
CSI 3.39rCSI 6.88%PRS 13.75
-
CSI 3.36rCSI 19.39%PRS 30.48
-
CSI 3.34rCSI 5.86%PRS 19.42
-
CSI 3.32rCSI 6.22%PRS 18.33
-
CSI 3.32rCSI 2.68%PRS 36.91
-
CSI 3.3rCSI 7.29%PRS 18
-
CSI 3.23rCSI 16.56%PRS 27.11
-
CSI 3.23rCSI 2.44%PRS 34.38
-
CSI 3.18rCSI 76.16%PRS 13.92
-
CSI 3.17rCSI 2.46%PRS 24.44
-
CSI 3.14rCSI 75.75%PRS 14.83
-
CSI 3.13rCSI 15.57%PRS 26.84
-
CSI 3.05rCSI 2.32%PRS 33.36
-
CSI 3.04rCSI 3.63%PRS 14.98
-
CSI 2.99rCSI 6%PRS 18.65
-
CSI 2.95rCSI 4.02%PRS 21.88
-
CSI 2.92rCSI 6.74%PRS 20.3
-
CSI 2.85rCSI 4.88%PRS 49.06
-
CSI 2.85rCSI 7.41%PRS 31.23
-
CSI 2.78rCSI 2.06%PRS 36.55
-
CSI 2.73rCSI 3.73%PRS 28.35
-
CSI 2.72rCSI 7.23%PRS 37.64
-
CSI 2.69rCSI 3.46%PRS 24.17
-
CSI 2.68rCSI 10.41%PRS 33.59
-
CSI 2.67rCSI 10.89%PRS 25.46
-
CSI 2.67rCSI 6.96%PRS 23.66
-
CSI 2.66rCSI 10.73%PRS 23.36
-
CSI 2.65rCSI 5.83%PRS 28.76
-
CSI 2.62rCSI 2.02%PRS 23.61
-
CSI 2.6rCSI 5.92%PRS 25.62
-
CSI 2.56rCSI 1.78%PRS 30.38
-
CSI 2.56rCSI 2.02%PRS 17.31
-
CSI 2.47rCSI 4.01%PRS 25.18
-
CSI 2.45rCSI 1.91%PRS 36.91
-
CSI 2.39rCSI 6.99%PRS 61.61
-
CSI 2.38rCSI 1.97%PRS 23.92
-
CSI 2.36rCSI 1.57%PRS 29.75
-
CSI 2.35rCSI 2.17%PRS 26.29
-
CSI 2.35rCSI 4.22%PRS 20.85
-
CSI 2.34rCSI 3.44%PRS 23.14
-
CSI 2.32rCSI 1.95%PRS 39.38
-
CSI 2.32rCSI 2.95%PRS 28.93
-
CSI 0.2rCSI 1.0%PRS 36.6%
-
CSI 0.2rCSI 0.4%PRS 46.5%
-
CSI 0.3rCSI 2.0%PRS 45.9%
-
CSI 0.3rCSI 0.5%PRS 38.0%
-
CSI 0.3rCSI 4.0%PRS 52.7%
-
CSI 0.3rCSI 1.5%PRS 47.3%
-
CSI 0.3rCSI 0.9%PRS 40.1%
-
CSI 0.4rCSI 2.7%PRS 26.6%
-
CSI 0.4rCSI 0.3%PRS 30.0%
-
CSI 0.4rCSI 8.5%PRS 45.5%
-
CSI 0.4rCSI 2.7%PRS 25.3%
-
CSI 0.4rCSI 1.5%PRS 40.9%
-
CSI 0.4rCSI 4.5%PRS 27.6%
-
CSI 0.4rCSI 3.6%PRS 18.2%
-
CSI 0.4rCSI 3.1%PRS 25.5%
-
CSI 0.4rCSI 0.6%PRS 23.2%
-
CSI 0.5rCSI 1.9%PRS 35.1%
-
CSI 0.5rCSI 2.9%PRS 19.9%
-
CSI 0.5rCSI 2.1%PRS 17.1%
-
CSI 0.5rCSI 2.8%PRS 26.4%
-
CSI 0.5rCSI 1.1%PRS 30.7%
-
CSI 0.5rCSI 1.4%PRS 38.3%
-
CSI 0.5rCSI 2.6%PRS 41.1%
-
CSI 0.5rCSI 0.9%PRS 33.7%
-
CSI 0.5rCSI 3.4%PRS 26.2%
-
CSI 0.5rCSI 3.6%PRS 25.9%
-
CSI 0.5rCSI 2.4%PRS 23.9%
-
CSI 0.6rCSI 6.2%PRS 54.4%
-
CSI 0.6rCSI 4.2%PRS 44.3%
-
CSI 0.6rCSI 0.8%PRS 27.6%
-
CSI 0.6rCSI 2.8%PRS 26.5%
-
CSI 0.6rCSI 2.6%PRS 44.5%
-
CSI 0.6rCSI 3.2%PRS 28.4%
-
CSI 0.6rCSI 1.7%PRS 23.4%
-
CSI 0.6rCSI 2.0%PRS 25.8%
-
CSI 0.6rCSI 2.5%PRS 31.9%
-
CSI 0.7rCSI 1.9%PRS 31.2%
-
CSI 0.7rCSI 2.0%PRS 19.6%
-
CSI 0.7rCSI 1.9%PRS 32.4%
-
CSI 0.7rCSI 3.5%PRS 33.7%
-
CSI 0.7rCSI 3.4%PRS 48.6%
-
CSI 0.7rCSI 0.6%PRS 26.3%
-
CSI 0.8rCSI 1.1%PRS 26.7%
-
CSI 0.8rCSI 1.3%PRS 46.1%
-
CSI 0.8rCSI 1.4%PRS 19.0%
-
CSI 0.8rCSI 2.6%PRS 17.2%
-
CSI 0.8rCSI 1.9%PRS 39.2%
-
CSI 0.8rCSI 0.7%PRS 31.8%
-
CSI 0.8rCSI 1.2%PRS 38.7%
-
CSI 0.8rCSI 0.8%PRS 27.0%
-
CSI 0.8rCSI 1.2%PRS 37.0%
-
CSI 0.9rCSI 1.8%PRS 35.5%
-
CSI 0.9rCSI 3.2%PRS 23.5%
-
CSI 0.9rCSI 1.0%PRS 18.7%
-
CSI 0.9rCSI 4.9%PRS 15.2%
-
CSI 0.9rCSI 1.3%PRS 37.7%
-
CSI 0.9rCSI 1.4%PRS 28.7%
-
CSI 0.9rCSI 2.0%PRS 33.2%
-
CSI 0.9rCSI 1.9%PRS 35.6%
-
CSI 0.9rCSI 1.0%PRS 35.6%
-
CSI 0.9rCSI 1.4%PRS 42.5%
-
CSI 0.9rCSI 2.7%PRS 28.1%
-
CSI 1.0rCSI 2.3%PRS 36.8%
-
CSI 1.0rCSI 1.0%PRS 29.7%
-
CSI 1.0rCSI 2.5%PRS 30.9%
-
CSI 1.0rCSI 2.5%PRS 23.4%
-
CSI 1.0rCSI 2.0%PRS 55.0%
-
CSI 1.0rCSI 3.2%PRS 36.2%
-
CSI 1.0rCSI 2.3%PRS 15.8%
-
CSI 1.0rCSI 2.0%PRS 54.0%
-
CSI 1.1rCSI 3.5%PRS 18.1%
-
CSI 1.1rCSI 0.9%PRS 25.5%
-
CSI 1.1rCSI 2.5%PRS 46.0%
-
CSI 1.1rCSI 1.7%PRS 25.8%
-
CSI 1.1rCSI 3.2%PRS 37.7%
-
CSI 1.1rCSI 7.0%PRS 17.8%
-
CSI 1.1rCSI 2.3%PRS 24.0%
-
CSI 1.1rCSI 2.7%PRS 17.4%
-
CSI 1.2rCSI 3.0%PRS 36.6%
-
CSI 1.2rCSI 2.7%PRS 29.6%
-
CSI 1.2rCSI 1.3%PRS 26.0%
-
CSI 1.2rCSI 1.9%PRS 25.3%
-
CSI 1.2rCSI 1.5%PRS 30.3%
-
CSI 1.2rCSI 3.6%PRS 23.8%
-
CSI 1.2rCSI 3.2%PRS 19.2%
-
CSI 1.3rCSI 4.1%PRS 29.7%
-
CSI 1.3rCSI 3.0%PRS 35.9%
-
CSI 1.3rCSI 13.4%PRS 30.7%
-
CSI 1.3rCSI 2.7%PRS 39.0%
-
CSI 1.3rCSI 3.7%PRS 27.5%
-
CSI 1.3rCSI 1.6%PRS 31.2%
-
CSI 1.3rCSI 9.3%PRS 39.9%
-
CSI 1.3rCSI 0.9%PRS 31.3%
-
CSI 1.3rCSI 2.1%PRS 19.3%
-
CSI 1.3rCSI 2.1%PRS 21.2%
-
CSI 1.3rCSI 2.0%PRS 36.1%
-
CSI 1.3rCSI 2.1%PRS 25.3%
-
CSI 1.3rCSI 1.8%PRS 24.5%
-
CSI 1.3rCSI 2.0%PRS 28.1%
-
CSI 1.3rCSI 5.3%PRS 9.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1666697845
Symbol: CUL5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9037604
Title: Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23.
PubMed ID: 9037604
DOI: 10.1101/gr.7.1.71
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10230407
Title: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
PubMed ID: 10230407
PubMed ID: 10597293
Title: Covalent modification of all members of human cullin family proteins by NEDD8.
PubMed ID: 10597293
PubMed ID: 11384984
Title: Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
PubMed ID: 11384984
PubMed ID: 12186903
Title: Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.
PubMed ID: 12186903
PubMed ID: 15574592
Title: Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.
PubMed ID: 15574592
DOI: 10.1101/gad.1249904
PubMed ID: 15601820
Title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
PubMed ID: 15601820
DOI: 10.1101/gad.1252404
PubMed ID: 16325183
Title: ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
PubMed ID: 16325183
PubMed ID: 16636053
Title: A zinc-binding region in Vif binds Cul5 and determines cullin selection.
PubMed ID: 16636053
PubMed ID: 18562529
Title: Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly.
PubMed ID: 18562529
DOI: 10.1128/jvi.00767-08
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19920177
Title: Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.
PubMed ID: 19920177
PubMed ID: 20532212
Title: The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.
PubMed ID: 20532212
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21119685
Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
PubMed ID: 21119685
DOI: 10.1038/cr.2010.165
PubMed ID: 21199876
Title: Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.
PubMed ID: 21199876
PubMed ID: 21697472
Title: Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.
PubMed ID: 21697472
DOI: 10.1128/jvi.00733-11
PubMed ID: 22190037
Title: Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection.
PubMed ID: 22190037
DOI: 10.1038/nature10693
PubMed ID: 24076655
Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
PubMed ID: 24076655
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23201271
Title: Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.
PubMed ID: 23201271
PubMed ID: 24337577
Title: Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.
PubMed ID: 24337577
PubMed ID: 26041281
Title: Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation.
PubMed ID: 26041281
DOI: 10.1128/jvi.00799-15
PubMed ID: 21980433
Title: The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
PubMed ID: 21980433
PubMed ID: 25505247
Title: Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
PubMed ID: 25505247
PubMed ID: 26906416
Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
PubMed ID: 26906416
DOI: 10.1242/jcs.181784
PubMed ID: 27910872
Title: SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate beta-TrCP1 via K11-linkage for degradation.
PubMed ID: 27910872
DOI: 10.1038/srep37441
PubMed ID: 28292928
Title: Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.
PubMed ID: 28292928
PubMed ID: 31387940
Title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
PubMed ID: 31387940
PubMed ID: 32200094
Title: Cul5-type ubiquitin ligase KLHDC1 contributes to the elimination of truncated SELENOS produced by failed UGA/Sec decoding.
PubMed ID: 32200094
PubMed ID: 33268465
Title: The mechanism of NEDD8 activation of CUL5 Ubiquitin E3 ligases.
PubMed ID: 33268465
PubMed ID: 35486881
Title: Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins.
PubMed ID: 35486881
PubMed ID: 35633597
Title: UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.
PubMed ID: 35633597
PubMed ID: 38574733
Title: The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells.
PubMed ID: 38574733
PubMed ID: 38418882
Title: The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.
PubMed ID: 38418882
PubMed ID: 18805092
Title: Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
PubMed ID: 18805092
PubMed ID: 23897481
Title: Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.
PubMed ID: 23897481
PubMed ID: 24402281
Title: Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex by HIV-1 Vif.
PubMed ID: 24402281
DOI: 10.1038/nature12884
PubMed ID: 32513959
Title: Structure and dynamics of the ASB9 CUL-RING E3 ligase.
PubMed ID: 32513959
PubMed ID: 34518685
Title: CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.
PubMed ID: 34518685
PubMed ID: 37640699
Title: Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
PubMed ID: 37640699
Sequence Information:
- Length: 780
- Mass: 90955
- Checksum: 57463CB4ED76E303
- Sequence:
MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLKE EEKRALRYLE TRRECNSVEA LMECCVNALV TSFKETILAE CQGMIKRNET EKLHLMFSLM DKVPNGIEPM LKDLEEHIIS AGLADMVAAA ETITTDSEKY VEQLLTLFNR FSKLVKEAFQ DDPRFLTARD KAYKAVVNDA TIFKLELPLK QKGVGLKTQP ESKCPELLAN YCDMLLRKTP LSKKLTSEEI EAKLKEVLLV LKYVQNKDVF MRYHKAHLTR RLILDISADS EIEENMVEWL REVGMPADYV NKLARMFQDI KVSEDLNQAF KEMHKNNKLA LPADSVNIKI LNAGAWSRSS EKVFVSLPTE LEDLIPEVEE FYKKNHSGRK LHWHHLMSNG IITFKNEVGQ YDLEVTTFQL AVLFAWNQRP REKISFENLK LATELPDAEL RRTLWSLVAF PKLKRQVLLY EPQVNSPKDF TEGTLFSVNQ EFSLIKNAKV QKRGKINLIG RLQLTTERMR EEENEGIVQL RILRTQEAII QIMKMRKKIS NAQLQTELVE ILKNMFLPQK KMIKEQIEWL IEHKYIRRDE SDINTFIYMA