USP8 | ENSG00000138592 | NCBI 9101

Details for: USP8

Associated with

Deubiquitination
(R-HSA-5688426)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Downregulation of erbb2:erbb3 signaling
(R-HSA-1358803)
Metabolism of proteins
(R-HSA-392499)
Negative regulation of met activity
(R-HSA-6807004)
Post-translational protein modification
(R-HSA-597592)
Regulation of fzd by ubiquitination
(R-HSA-4641263)
Signaling by erbb2
(R-HSA-1227986)
Signaling by met
(R-HSA-6806834)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Ub-specific processing proteases
(R-HSA-5689880)
Cadherin binding
(GO:0045296)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Early endosome
(GO:0005769)
Endosome membrane
(GO:0010008)
Endosome organization
(GO:0007032)
Glutamatergic synapse
(GO:0098978)
K48-linked deubiquitinase activity
(GO:1990380)
K63-linked deubiquitinase activity
(GO:0061578)
Midbody
(GO:0030496)
Mitotic cytokinesis
(GO:0000281)
Negative regulation of lysosomal protein catabolic process
(GO:1905166)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid fibril formation
(GO:1905908)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Protein k48-linked deubiquitination
(GO:0071108)
Protein k63-linked deubiquitination
(GO:0070536)
Proteolysis
(GO:0006508)
Ras protein signal transduction
(GO:0007265)
Regulation of protein catabolic process at postsynapse, modulating synaptic transmission
(GO:0099576)
Regulation of protein localization
(GO:0032880)
Regulation of protein stability
(GO:0031647)
Sh3 domain binding
(GO:0017124)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD4-positive helper T cell CL0000492

CSI 25.15

rCSI 19.02%

PRS 36.84
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 8.19

rCSI 29.46%

PRS 15.87
M cell of gut CL0000682

CSI 7.98

rCSI 8.48%

PRS 43.3
podocyte CL0000653

CSI 6.24

rCSI 27.72%

PRS 26.38
neuroblast (sensu Vertebrata) CL0000031

CSI 5.28

rCSI 6.78%

PRS 26.05
pulmonary ionocyte CL0017000

CSI 5.14

rCSI 6.25%

PRS 33.61
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 5.02

rCSI 6.89%

PRS 47.99
early lymphoid progenitor CL0000936

CSI 4.93

rCSI 4.33%

PRS 31.07
unswitched memory B cell CL0000970

CSI 4.91

rCSI 4.13%

PRS 41.64
Schwann cell CL0002573

CSI 4.76

rCSI 13.54%

PRS 29.41
lung ciliated cell CL1000271

CSI 4.68

rCSI 5.42%

PRS 20.31
mesodermal cell CL0000222

CSI 4.63

rCSI 5.55%

PRS 26.39
Bergmann glial cell CL0000644

CSI 4.46

rCSI 6.1%

PRS 26.59
intestine goblet cell CL0019031

CSI 4.41

rCSI 3.91%

PRS 27.32
differentiation-committed oligodendrocyte precursor CL4023059

CSI 4.23

rCSI 7.68%

PRS 23.5
enterocyte of epithelium of large intestine CL0002071

CSI 4.05

rCSI 21.27%

PRS 43.37
CD8-positive, alpha-beta memory T cell CL0000909

CSI 3.8

rCSI 3.97%

PRS 62.87
small intestine goblet cell CL1000495

CSI 3.78

rCSI 8.28%

PRS 35.8
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.67

rCSI 5.21%

PRS 25.34
ionocyte CL0005006

CSI 3.58

rCSI 3.84%

PRS 25.19
cerebral cortex neuron CL0010012

CSI 3.56

rCSI 14.49%

PRS 27.68
ciliated epithelial cell CL0000067

CSI 3.53

rCSI 3.11%

PRS 20.01
cerebral cortex endothelial cell CL1001602

CSI 3.34

rCSI 5.77%

PRS 20.96
microcirculation associated smooth muscle cell CL0008035

CSI 3.11

rCSI 9.02%

PRS 30.29
immature B cell CL0000816

CSI 3.06

rCSI 2.28%

PRS 38.67
intestinal crypt stem cell of small intestine CL0009017

CSI 3.02

rCSI 8.15%

PRS 35.02
placental villous trophoblast CL2000060

CSI 2.95

rCSI 4.56%

PRS 25.63
perivascular cell CL4033054

CSI 2.92

rCSI 3.99%

PRS 30.71
brush cell of tracheobronchial tree CL0002075

CSI 2.89

rCSI 8.56%

PRS 36.9
squamous epithelial cell CL0000076

CSI 2.8

rCSI 6.64%

PRS 32.83
alveolar type 1 fibroblast cell CL4028004

CSI 2.78

rCSI 3.05%

PRS 30.4
hematopoietic multipotent progenitor cell CL0000837

CSI 2.77

rCSI 6.66%

PRS 41.91
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.69

rCSI 4.2%

PRS 54.88
mature B cell CL0000785

CSI 2.68

rCSI 2.33%

PRS 33.92
direct pathway medium spiny neuron CL4023026

CSI 2.61

rCSI 62.54%

PRS 15.68
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.59

rCSI 10.1%

PRS 43.73
cytotoxic T cell CL0000910

CSI 2.55

rCSI 14.6%

PRS 38.88
Cajal-Retzius cell CL0000695

CSI 2.52

rCSI 19.72%

PRS 47.41
intestinal crypt stem cell of colon CL0009043

CSI 2.51

rCSI 18.85%

PRS 46.65
adventitial cell CL0002503

CSI 2.44

rCSI 5.83%

PRS 38.96
astrocyte of the cerebral cortex CL0002605

CSI 2.43

rCSI 5.44%

PRS 17.35
hepatocyte CL0000182

CSI 2.41

rCSI 4.31%

PRS 25.46
indirect pathway medium spiny neuron CL4023029

CSI 2.4

rCSI 57.97%

PRS 16.53
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.39

rCSI 1.71%

PRS 37
pvalb GABAergic cortical interneuron CL4023018

CSI 2.34

rCSI 2.91%

PRS 15.72
interstitial cell of Cajal CL0002088

CSI 2.33

rCSI 2.96%

PRS 31.26
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.31

rCSI 24.49%

PRS 32.45
skin fibroblast CL0002620

CSI 2.3

rCSI 1.98%

PRS 38.61
myofibroblast cell CL0000186

CSI 2.27

rCSI 3.14%

PRS 35.25
Hofbauer cell CL3000001

CSI 2.25

rCSI 4.24%

PRS 34.45
class switched memory B cell CL0000972

CSI 2.2

rCSI 1.64%

PRS 43.75
melanocyte CL0000148

CSI 2.17

rCSI 1.61%

PRS 23.42
paneth cell CL0000510

CSI 2.16

rCSI 3.18%

PRS 41.52
mesangial cell CL0000650

CSI 2.12

rCSI 8.64%

PRS 38.08
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.02

rCSI 1.62%

PRS 46.23
naive B cell CL0000788

CSI 1.99

rCSI 1.71%

PRS 39.33
lung pericyte CL0009089

CSI 1.99

rCSI 5.24%

PRS 32.43
acinar cell of salivary gland CL0002623

CSI 1.95

rCSI 45.42%

PRS 48.4
pulmonary alveolar type 1 cell CL0002062

CSI 1.92

rCSI 11.05%

PRS 32.47
double-positive, alpha-beta thymocyte CL0000809

CSI 1.91

rCSI 1.95%

PRS 38.07
pancreatic acinar cell CL0002064

CSI 1.89

rCSI 2.51%

PRS 30.01
midzonal region hepatocyte CL0019028

CSI 1.86

rCSI 4.36%

PRS 37.47
radial glial cell CL0000681

CSI 1.85

rCSI 2.57%

PRS 27.44
transit amplifying cell of colon CL0009011

CSI 1.82

rCSI 2.14%

PRS 30.98
monocyte CL0000576

CSI 1.8

rCSI 3.25%

PRS 56.44
BEST4+ enteroycte CL4030026

CSI 1.8

rCSI 2.24%

PRS 29.17
activated type II NK T cell CL0000931

CSI 1.79

rCSI 2.01%

PRS 41.9
brush cell CL0002204

CSI 1.77

rCSI 3.5%

PRS 57.16
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.71

rCSI 1.15%

PRS 33.85
goblet cell CL0000160

CSI 1.69

rCSI 1.59%

PRS 28.46
enterocyte of epithelium of small intestine CL1000334

CSI 1.66

rCSI 25.75%

PRS 57.14
plasmablast CL0000980

CSI 1.64

rCSI 1.29%

PRS 32.54
double negative thymocyte CL0002489

CSI 1.64

rCSI 1.14%

PRS 32.88
cerebellar granule cell CL0001031

CSI 1.62

rCSI 2.38%

PRS 25.29
myeloid dendritic cell CL0000782

CSI 1.62

rCSI 2.35%

PRS 40.47
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 1.62

rCSI 1.47%

PRS 40.22
kidney interstitial alternatively activated macrophage CL1000695

CSI 1.59

rCSI 4.16%

PRS 25.94
inflammatory macrophage CL0000863

CSI 1.59

rCSI 2.72%

PRS 51.67
periportal region hepatocyte CL0019026

CSI 1.58

rCSI 6.14%

PRS 36.35
myeloid leukocyte CL0000766

CSI 1.57

rCSI 1.44%

PRS 28.32
alpha-beta T cell CL0000789

CSI 1.56

rCSI 1.82%

PRS 38.21
respiratory hillock cell CL4030023

CSI 1.55

rCSI 2.77%

PRS 42.63
Kupffer cell CL0000091

CSI 1.55

rCSI 3.54%

PRS 26.69
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.54

rCSI 2.59%

PRS 16.72
stem cell CL0000034

CSI 1.53

rCSI 1.48%

PRS 20.34
Mueller cell CL0000636

CSI 1.53

rCSI 3.5%

PRS 23.43
interneuron CL0000099

CSI 1.52

rCSI 3.05%

PRS 20.34
precursor B cell CL0000817

CSI 1.51

rCSI 1.33%

PRS 35.4
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.51

rCSI 4.34%

PRS 40.24
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.51

rCSI 2.58%

PRS 48.15
paneth cell of epithelium of small intestine CL1000343

CSI 1.48

rCSI 4.14%

PRS 41.05
effector CD8-positive, alpha-beta T cell CL0001050

CSI 1.48

rCSI 1.12%

PRS 35.75
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.47

rCSI 0.87%

PRS 38.05
transit amplifying cell of small intestine CL0009012

CSI 1.46

rCSI 6.4%

PRS 46.69
transitional stage B cell CL0000818

CSI 1.46

rCSI 4.76%

PRS 61.77
erythrocyte CL0000232

CSI 1.45

rCSI 3.29%

PRS 34.31
hepatic stellate cell CL0000632

CSI 1.44

rCSI 5.4%

PRS 23
renal alpha-intercalated cell CL0005011

CSI 1.44

rCSI 1.93%

PRS 34.33
group 3 innate lymphoid cell CL0001071

CSI 1.44

rCSI 1.08%

PRS 29.13
lung macrophage CL1001603

CSI 1.43

rCSI 3.19%

PRS 31.83

mesenchymal stem cell CL0000134

CSI 0.0

rCSI 0.4%

PRS 45.2%
megakaryocyte CL0000556

CSI 0.1

rCSI 0.5%

PRS 43.7%
vein endothelial cell of respiratory system CL4033008

CSI 0.2

rCSI 1.1%

PRS 48.4%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 3.7%

PRS 24.2%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 4.7%

PRS 22.9%
GABAergic interneuron CL0011005

CSI 0.2

rCSI 3.7%

PRS 27.7%
mesenchymal cell CL0008019

CSI 0.2

rCSI 0.6%

PRS 26.5%
erythroid progenitor cell CL0000038

CSI 0.3

rCSI 1.4%

PRS 38.3%
ON parasol ganglion cell CL4033052

CSI 0.3

rCSI 3.8%

PRS 22.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.3

rCSI 0.5%

PRS 16.3%
eosinophil CL0000771

CSI 0.3

rCSI 1.8%

PRS 60.1%
medium spiny neuron CL1001474

CSI 0.3

rCSI 2.4%

PRS 16.6%
type EC enteroendocrine cell CL0000577

CSI 0.3

rCSI 1.0%

PRS 41.8%
luminal epithelial cell of mammary gland CL0002326

CSI 0.3

rCSI 0.6%

PRS 40.9%
tracheobronchial serous cell CL0019001

CSI 0.3

rCSI 1.4%

PRS 45.3%
tracheal goblet cell CL1000329

CSI 0.3

rCSI 0.7%

PRS 48.3%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.3

rCSI 0.4%

PRS 30.9%
large pre-B-II cell CL0000957

CSI 0.4

rCSI 1.0%

PRS 42.5%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 2.0%

PRS 54.2%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.4

rCSI 1.2%

PRS 19.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.4

rCSI 1.4%

PRS 17.4%
pancreatic epsilon cell CL0005019

CSI 0.4

rCSI 1.8%

PRS 53.1%
type B pancreatic cell CL0000169

CSI 0.4

rCSI 0.9%

PRS 25.2%
respiratory goblet cell CL0002370

CSI 0.4

rCSI 4.4%

PRS 48.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.4

rCSI 2.4%

PRS 17.6%
pancreatic stellate cell CL0002410

CSI 0.4

rCSI 2.4%

PRS 38.6%
respiratory epithelial cell CL0002368

CSI 0.4

rCSI 2.6%

PRS 67.0%
pancreatic PP cell CL0002275

CSI 0.4

rCSI 1.8%

PRS 43.5%
enteroglial cell CL4040002

CSI 0.5

rCSI 2.4%

PRS 40.5%
fibroblast of breast CL4006000

CSI 0.5

rCSI 2.0%

PRS 55.9%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.5

rCSI 1.1%

PRS 27.5%
deuterosomal cell CL4033044

CSI 0.5

rCSI 1.6%

PRS 39.9%
colon macrophage CL0009038

CSI 0.5

rCSI 2.3%

PRS 50.6%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.5

rCSI 1.5%

PRS 39.0%
keratocyte CL0002363

CSI 0.5

rCSI 1.2%

PRS 38.3%
neural progenitor cell CL0011020

CSI 0.5

rCSI 2.2%

PRS 24.4%
parietal epithelial cell CL1000452

CSI 0.5

rCSI 1.4%

PRS 22.9%
alveolar adventitial fibroblast CL4028006

CSI 0.5

rCSI 0.8%

PRS 27.5%
T-helper 17 cell CL0000899

CSI 0.5

rCSI 0.4%

PRS 46.4%
mucus secreting cell CL0000319

CSI 0.6

rCSI 0.9%

PRS 34.8%
retinal cone cell CL0000573

CSI 0.6

rCSI 0.9%

PRS 21.0%
retinal bipolar neuron CL0000748

CSI 0.6

rCSI 1.1%

PRS 20.1%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.6

rCSI 1.9%

PRS 19.1%
syncytiotrophoblast cell CL0000525

CSI 0.6

rCSI 1.7%

PRS 45.9%
basophil CL0000767

CSI 0.6

rCSI 1.3%

PRS 49.6%
pulmonary artery endothelial cell CL1001568

CSI 0.6

rCSI 0.8%

PRS 39.3%
alternatively activated macrophage CL0000890

CSI 0.6

rCSI 0.8%

PRS 39.8%
stromal cell CL0000499

CSI 0.6

rCSI 1.8%

PRS 32.7%
helper T cell CL0000912

CSI 0.6

rCSI 0.9%

PRS 36.9%
keratinocyte CL0000312

CSI 0.7

rCSI 0.5%

PRS 31.9%
foveolar cell of stomach CL0002179

CSI 0.7

rCSI 1.4%

PRS 41.3%
retinal pigment epithelial cell CL0002586

CSI 0.7

rCSI 1.3%

PRS 28.2%
alveolar macrophage CL0000583

CSI 0.7

rCSI 1.1%

PRS 31.8%
IgG plasma cell CL0000985

CSI 0.7

rCSI 0.8%

PRS 44.8%
extravillous trophoblast CL0008036

CSI 0.7

rCSI 0.9%

PRS 24.1%
intestinal epithelial cell CL0002563

CSI 0.7

rCSI 0.7%

PRS 28.0%
dopaminergic neuron CL0000700

CSI 0.7

rCSI 3.9%

PRS 17.2%
follicular B cell CL0000843

CSI 0.7

rCSI 2.5%

PRS 68.0%
club cell CL0000158

CSI 0.7

rCSI 1.0%

PRS 30.0%
tuft cell of colon CL0009041

CSI 0.7

rCSI 1.6%

PRS 48.3%
endothelial cell of placenta CL0009092

CSI 0.7

rCSI 3.5%

PRS 36.3%
kidney connecting tubule epithelial cell CL1000768

CSI 0.7

rCSI 1.8%

PRS 21.0%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.7

rCSI 1.8%

PRS 25.1%
VIP GABAergic cortical interneuron CL4023016

CSI 0.7

rCSI 0.9%

PRS 16.6%
promonocyte CL0000559

CSI 0.7

rCSI 1.2%

PRS 35.9%
choroid plexus epithelial cell CL0000706

CSI 0.7

rCSI 1.2%

PRS 21.2%
L6b glutamatergic cortical neuron CL4023038

CSI 0.7

rCSI 2.3%

PRS 17.6%
renal interstitial pericyte CL1001318

CSI 0.8

rCSI 2.1%

PRS 25.6%
regular ventricular cardiac myocyte CL0002131

CSI 0.8

rCSI 4.7%

PRS 21.9%
epicardial adipocyte CL1000309

CSI 0.8

rCSI 2.4%

PRS 31.8%
vascular leptomeningeal cell CL4023051

CSI 0.8

rCSI 1.3%

PRS 21.5%
glandular epithelial cell CL0000150

CSI 0.8

rCSI 2.0%

PRS 49.3%
lung secretory cell CL1000272

CSI 0.8

rCSI 1.9%

PRS 25.5%
Langerhans cell CL0000453

CSI 0.8

rCSI 1.2%

PRS 44.8%
enteroendocrine cell of colon CL0009042

CSI 0.8

rCSI 3.6%

PRS 57.3%
amacrine cell CL0000561

CSI 0.8

rCSI 2.3%

PRS 21.6%
colon goblet cell CL0009039

CSI 0.8

rCSI 1.9%

PRS 39.0%
innate lymphoid cell CL0001065

CSI 0.8

rCSI 1.6%

PRS 37.6%
retinal ganglion cell CL0000740

CSI 0.8

rCSI 1.8%

PRS 19.6%
mucous neck cell CL0000651

CSI 0.8

rCSI 1.2%

PRS 41.0%
OFF-bipolar cell CL0000750

CSI 0.8

rCSI 1.1%

PRS 39.1%
intermediate monocyte CL0002393

CSI 0.8

rCSI 1.2%

PRS 27.9%
hematopoietic stem cell CL0000037

CSI 0.8

rCSI 0.6%

PRS 31.8%
forebrain radial glial cell CL0013000

CSI 0.8

rCSI 2.7%

PRS 36.3%
enteroendocrine cell of small intestine CL0009006

CSI 0.8

rCSI 1.8%

PRS 40.1%
tracheobronchial smooth muscle cell CL0019019

CSI 0.8

rCSI 1.5%

PRS 34.6%
respiratory suprabasal cell CL4033048

CSI 0.8

rCSI 1.1%

PRS 31.3%
duct epithelial cell CL0000068

CSI 0.8

rCSI 1.2%

PRS 29.0%
granulocyte monocyte progenitor cell CL0000557

CSI 0.9

rCSI 0.7%

PRS 30.4%
common dendritic progenitor CL0001029

CSI 0.9

rCSI 1.1%

PRS 34.9%
renal beta-intercalated cell CL0002201

CSI 0.9

rCSI 2.0%

PRS 30.2%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.9

rCSI 2.1%

PRS 16.4%
renal principal cell CL0005009

CSI 0.9

rCSI 2.2%

PRS 33.4%
GABAergic neuron CL0000617

CSI 0.9

rCSI 2.9%

PRS 20.0%
peripheral nervous system neuron CL2000032

CSI 0.9

rCSI 1.2%

PRS 23.7%
inhibitory interneuron CL0000498

CSI 0.9

rCSI 2.0%

PRS 22.3%
pancreatic ductal cell CL0002079

CSI 0.9

rCSI 1.7%

PRS 28.1%
lung neuroendocrine cell CL1000223

CSI 0.9

rCSI 1.3%

PRS 31.0%
basal cell CL0000646

CSI 0.9

rCSI 1.2%

PRS 29.4%
T-helper 1 cell CL0000545

CSI 0.9

rCSI 1.6%

PRS 56.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its specificity using the CSI (Z-Score), [USP8](/details-gene/9101) is identified not as a cell-type specific marker, but as a ubiquitously expressed gene with a fundamental role in cellular maintenance. The consistently low CSI (Z-SCORE) and non-significant p-values across a diverse range of cell types suggest its function is essential for core biological processes common to many lineages. As a deubiquitinating enzyme, [USP8](/details-gene/9101) is critically involved in protein turnover, endosomal sorting, and the regulation of key signaling pathways, consistent with its broad expression profile. ## Cellular Roles and Expression Landscape The expression pattern of [USP8](/details-gene/9101), when evaluated for cell-type specificity, underscores its role as a housekeeping gene rather than a distinctive cellular marker. In the **Overall** context, the CSI (Z-SCORE) is 0.00 with non-significant p-values (>0.2) across all top-ranked cell types. This lack of statistical significance indicates that its expression is not uniquely enriched in any particular cell. The diverse list of cells where it is detected, including immune cells like [CD4-positive helper T cell](/details-cell/CL0000492), neuronal cells like [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041), and specialized epithelial cells such as [podocyte](/details-cell/CL0000653) and [pulmonary ionocyte](/details-cell/CL0017000), further highlights its widespread and non-specific expression. This profile is consistent with a gene whose product is required for fundamental cellular operations. Its function as a deubiquitinase is essential for processes like receptor downregulation and protein quality control, which are vital for the survival and function of nearly all cells (PubMed: 16520378, DOI: 10.1074/jbc.m512615200). The gene's percentile rank scores (PRS) are moderate, typically falling between 15% and 48%, confirming that while it is expressed, it does not stand out as being particularly specific to any given cell type. Therefore, the primary conclusion from this specificity analysis is that the biological significance of [USP8](/details-gene/9101) lies in its universal role in cellular protein homeostasis, not in defining a unique cellular identity. ## Pathways and Molecular Function The functional annotations for [USP8](/details-gene/9101) align perfectly with its ubiquitous expression pattern, pointing to its involvement in core cellular machinery. Its primary molecular function is [Cysteine-type deubiquitinase activity](/details-go/GO0004843), enabling it to remove ubiquitin chains from substrate proteins and regulate their fate. This activity is central to the [Deubiquitination](/details-reactome/R-HSA-5688426) pathway and the broader process of [Metabolism of proteins](/details-reactome/R-HSA-392499). [USP8](/details-gene/9101) is a key regulator of major signaling pathways essential for diverse cell types. Its involvement in [Signaling by receptor tyrosine kinases](/details-reactome/R-HSA-9006934), including the downregulation of ERBB2 and MET signaling ([R-HSA-8863795](https://reactome.org/content/detail/R-HSA-8863795), [R-HSA-6807004](https://reactome.org/content/detail/R-HSA-6807004)), is critical for controlling cell growth and proliferation. Furthermore, its role in the [Signaling by wnt](/details-reactome/R-HSA-195721) pathway demonstrates its importance in developmental and homeostatic processes. Its localization to the [Cytoplasm](/details-go/GO0005737), [Early endosome](/details-go/GO0005769), and specialized structures like the [Postsynaptic density](/details-go/GO0014069) reflects its broad functional scope, from managing protein turnover in endosomal compartments (PubMed: 17711858, DOI: 10.1074/jbc.m704009200) to participating in fundamental cell division processes like [Mitotic cytokinesis](/details-go/GO0000281) (PubMed: 18329369, DOI: 10.1016/j.cell.2008.01.012). ## Research Directions The ubiquitous expression of [USP8](/details-gene/9101) suggests that its functional specificity is not regulated at the transcriptional level but rather through post-translational modifications or context-dependent protein-protein interactions. The lack of cross-context data in this analysis prevents direct observation of its regulation, but its known functions provide a foundation for several testable hypotheses. 1. **Hypothesis:** The catalytic activity of USP8 is differentially regulated across cell lineages through cell-type specific phosphorylation, altering its substrate affinity. While its mRNA levels are stable, its functional impact may vary significantly between, for instance, a T cell responding to an antigen and a neuron maintaining synaptic homeostasis. This is supported by evidence of its phosphorylation during T cell receptor signaling (PubMed: 19690332, DOI: 10.1126/scisignal.2000007). * **Experimental Approach:** Utilize quantitative mass spectrometry-based phosphoproteomics to compare the phosphorylation patterns of USP8 protein isolated from different primary cell types (e.g., [CD4-positive helper T cell](/details-cell/CL0000492) vs. primary cortical neurons) under basal and stimulated conditions. This would identify cell-type specific regulatory phosphorylation sites. 2. **Hypothesis:** The broad role of USP8 is executed through distinct sets of interaction partners and substrates that are unique to specific cellular contexts. In immune cells, USP8 may primarily target components of the TCR signaling complex for deubiquitination, while in neuronal cells, its main substrates could be neurotransmitter receptors or synaptic scaffolding proteins. * **Experimental Approach:** Perform proximity-dependent biotinylation (e.g., BioID) or co-immunoprecipitation followed by mass spectrometry (IP-MS) using cell-type specific promoters to drive expression of tagged USP8 in distinct cell lines (e.g., Jurkat T cells vs. SH-SY5Y neuroblastoma cells) to map its context-specific interactome. 3. **Hypothesis:** Pathogenic mutations in [USP8](/details-gene/9101) lead to cell-type specific disease phenotypes by disrupting the degradation of a limited subset of critical substrates. For example, mutations causing Cushing's disease may specifically stabilize receptors driving hormone production in pituitary cells without globally disrupting protein homeostasis in other tissues. * **Experimental Approach:** Introduce known disease-associated [USP8](/details-gene/9101) mutations into relevant cell models (e.g., pituitary adenoma cells) using CRISPR/Cas9 gene editing. Subsequently, perform quantitative ubiquitin proteomics (di-Gly remnant profiling) to identify the specific substrates that are aberrantly deubiquitinated, thereby revealing the precise molecular mechanism of the cell-type specific pathology. **Therapeutic Potential:** Due to its essential housekeeping functions, systemic inhibition of [USP8](/details-gene/9101) is likely to be highly toxic. However, its role in stabilizing key oncoproteins (e.g., ERBB family receptors) and signaling components makes it an attractive target in oncology and other diseases. A more viable therapeutic strategy would involve developing agents that disrupt specific disease-relevant protein-protein interactions of USP8, rather than inhibiting its catalytic activity directly. Such an approach could selectively block the deubiquitination of a specific substrate (e.g., an oncoprotein), offering a therapeutic window with reduced off-target effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Deubiquitinating enzyme 8
A8K8N5_HUMAN

Genular Protein ID: 2126001726

Symbol: UBP8_HUMAN

Name: Deubiquitinating enzyme 8

UniProtKB Accession Codes:

P40818 B4DKA8 Q2TB31 Q7Z3U2 Q86VA0 Q8IWI7

Database IDs:

Citations:

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9628861

Title: UBPY: a growth-regulated human ubiquitin isopeptidase.

PubMed ID: 9628861

DOI: 10.1093/emboj/17.12.3241

PubMed ID: 16520378

Title: The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.

PubMed ID: 16520378

DOI: 10.1074/jbc.m512615200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17711858

Title: The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.

PubMed ID: 17711858

DOI: 10.1074/jbc.m704009200

PubMed ID: 18329369

Title: Final stages of cytokinesis and midbody ring formation are controlled by BRUCE.

PubMed ID: 18329369

DOI: 10.1016/j.cell.2008.01.012

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19427866

Title: Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.

PubMed ID: 19427866

DOI: 10.1016/j.febslet.2009.04.049

PubMed ID: 19129480

Title: Essential role of hIST1 in cytokinesis.

PubMed ID: 19129480

DOI: 10.1091/mbc.e08-05-0474

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27302062

Title: The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.

PubMed ID: 27302062

DOI: 10.1074/jbc.m116.718023

PubMed ID: 30065070

Title: Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.

PubMed ID: 30065070

DOI: 10.15252/embj.201899347

PubMed ID: 17035239

Title: Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).

PubMed ID: 17035239

DOI: 10.1074/jbc.m606704200

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

PubMed ID: 28505279

Title: Somatic USP8 gene mutations are a common cause of pediatric Cushing disease.

PubMed ID: 28505279

DOI: 10.1210/jc.2017-00161

Sequence Information:

Length: 1118
Mass: 127523
Checksum: 8B884B7A842F9A9A
Sequence:

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY 
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE EAERLSESLK LRYEEAEVRK 
KLEEKDRQEE AQRLQQKRQE TGREDGGTLA KGSLENVLDS KDKTQKSNGE KNEKCETKEK 
GAITAKELYT MMTDKNISLI IMDARRMQDY QDSCILHSLS VPEEAISPGV TASWIEAHLP 
DDSKDTWKKR GNVEYVVLLD WFSSAKDLQI GTTLRSLKDA LFKWESKTVL RNEPLVLEGG 
YENWLLCYPQ YTTNAKVTPP PRRQNEEVSI SLDFTYPSLE ESIPSKPAAQ TPPASIEVDE 
NIELISGQNE RMGPLNISTP VEPVAASKSD VSPIIQPVPS IKNVPQIDRT KKPAVKLPEE 
HRIKSESTNH EQQSPQSGKV IPDRSTKPVV FSPTLMLTDE EKARIHAETA LLMEKNKQEK 
ELRERQQEEQ KEKLRKEEQE QKAKKKQEAE ENEITEKQQK AKEEMEKKES EQAKKEDKET 
SAKRGKEITG VKRQSKSEHE TSDAKKSVED RGKRCPTPEI QKKSTGDVPH TSVTGDSGSG 
KPFKIKGQPE SGILRTGTFR EDTDDTERNK AQREPLTRAR SEEMGRIVPG LPSGWAKFLD 
PITGTFRYYH SPTNTVHMYP PEMAPSSAPP STPPTHKAKP QIPAERDREP SKLKRSYSSP 
DITQAIQEEE KRKPTVTPTV NRENKPTCYP KAEISRLSAS QIRNLNPVFG GSGPALTGLR 
NLGNTCYMNS ILQCLCNAPH LADYFNRNCY QDDINRSNLL GHKGEVAEEF GIIMKALWTG 
QYRYISPKDF KITIGKINDQ FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH 
LDDFKAAEHA WQKHKQLNES IIVALFQGQF KSTVQCLTCH KKSRTFEAFM YLSLPLASTS 
KCTLQDCLRL FSKEEKLTDN NRFYCSHCRA RRDSLKKIEI WKLPPVLLVH LKRFSYDGRW 
KQKLQTSVDF PLENLDLSQY VIGPKNNLKK YNLFSVSNHY GGLDGGHYTA YCKNAARQRW 
FKFDDHEVSD ISVSSVKSSA AYILFYTSLG PRVTDVAT

Genular Protein ID: 3038699211

Symbol: A8K8N5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8N5

Database IDs:

Sequence Information:

Length: 1118
Mass: 127493
Checksum: 85C18B8D6F7E74EA
Sequence:

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKSYVHSA LKIFKTAEEC RLDRDEERAY 
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPGNIKKAVE EAERLSESLK LRYEEAEVRK 
KLEEKDRQEE AQRLQQKRQE TGREDGGTLA KGSLENVLDS KDKTQKSNGE KNEKCETKEK 
GAITAKELYT MMTDKNISLI IMDARRMQDY QDSCILHSLS VPEEAISPGV TASWIEAHLP 
DDSKDTWKKR GNVEYVVLLD WFSSAKDLQI GTTLRSLKDA LFKWESKTVL RNEPLVLEGG 
YENWLLCYPQ YTTNAKVTPP PRRQNEEVSI SLDFTYPSLE ESIPSKPAAQ TPPASIEVDE 
NIELISGQNE RMGPLNISTP VEPVAASKSD VSPIIQPVPS IKNVPQIDRT KKPAVKLPEE 
HRIKSESTNH EQQSPQSGKV IPGRSTKPVV FSPTLMLTDE EKARIHAETA LLMEKNKQEK 
ELRERQQEEQ KEKLRKEEQE QKAKKKQEAE ENEITEKQQK AKEEMEKKES EQVKKEDKET 
SAKRGKEITG VKRQSKSEHE TSDAKKSVED RGKRCPTPEI QKKSTGDVPH TSVTGDSGSG 
KPFKIKGQPE SGILRTGTFR EDTDDTERNK AQREPLTRAR SEEMGRIVPG LPSGWAKFLD 
PITGTFRYYH SPTNTVHMYP PEMAPSSAPP STPPTHKAKP QIPAERDREP SKLKRSYSSP 
DITQAIQEEE KRKPTVTPTV NRENKPTCYP KAEISRLSAS QIRNLNPVFG GSGPALTGLR 
NLGNTCYMNS ILQCLCNAPH LADYFNRNCY QDDINRSNLL GHKGEVAEEF GIIMKALWTG 
QYRYISPKDF KITIGKINDQ FAGYSQQDSQ ELLLFLMDGL HEDLNKADNR KRYKEENNDH 
LDDFKAAEHA WQKHKQLNES IIVALFQGQF KSTVQCLTCH KKSRTFEAFM YLSLPLASTS 
KCTLQDCLRL FSKEEKLTDN NRFYCSHCRA RRDSLKKIEI WKLPPVLLVH LKRFSYDGRW 
KQKLQTSVDF PLENLDLSQY VIGPKNNLKK YNLFSVSNHY GGLDGGHYTA YCKNAARQRW 
FKFDDHEVSD ISVSSVKSSA AYILFYTSLG PRVTDVAT

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Primary visual cortex UBERON0002436
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: USP8

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7584044

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Analysis of the DNA sequence and duplication history of human chromosome 15. PubMed ID: 16572171

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

UBPY: a growth-regulated human ubiquitin isopeptidase. PubMed ID: 9628861

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. PubMed ID: 16520378

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. PubMed ID: 17711858

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. PubMed ID: 18329369

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. PubMed ID: 19427866

Essential role of hIST1 in cytokinesis. PubMed ID: 19129480

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation. PubMed ID: 27302062

Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis. PubMed ID: 30065070

Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). PubMed ID: 17035239

Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. PubMed ID: 24482476

Somatic USP8 gene mutations are a common cause of pediatric Cushing disease. PubMed ID: 28505279